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Growing teratoma syndrome

MedGen UID:
856083
•Concept ID:
C3891714
•
Neoplastic Process
Synonyms: Growing Teratoma Syndrome; growing teratoma syndrome; GTS
SNOMED CT: Growing teratoma syndrome (1260180004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017807
Orphanet: ORPHA314613

Definition

A rare neoplastic disorder characterized by benign metastatic masses increasing in size and number after chemotherapy for non-seminomatous germ cell tumors of testis or ovary. It may present at any time after chemotherapy, with a median occurrence within 24 months after treatment completion. Per definition, the resected specimen exclusively contains mature teratoma components, and serum tumor markers have normalized. The retroperitoneum is the most common site, although almost any other localization has been reported. Increased tumor size may cause mechanical compression of vital organs, with renal dysfunction, bowel ischemia and biliary obstruction as major complications. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrowing teratoma syndrome

Professional guidelines

PubMed

Peri-treatment adverse events of primary mediastinal non-seminomatous germ cell tumors.
Chen RL, Liu CC, Ip PP, Fang LH, Shih LS, Chen LY
Pediatr Blood Cancer 2022 Aug;69(8):e29781. Epub 2022 May 20 doi: 10.1002/pbc.29781. PMID: 35593015
Management, Treatment, and Molecular Background of the Growing Teratoma Syndrome.
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Successful Treatment of Growing Teratoma Syndrome of the Lung by Surgical Resection: A Case Report and Literature Review.
Tanaka K, Toyokawa G, Tagawa T, Ijichi K, Haratake N, Hirai F, Oda Y, Maehara Y
Anticancer Res 2018 May;38(5):3115-3118. doi: 10.21873/anticanres.12571. PMID: 29715149

Recent clinical studies

Etiology

A case series and literature review on 98 pediatric patients of germ cell tumor developing growing teratoma syndrome.
Hsieh MY, Chen HH, Lee CY, Hung GY, Chang TY, Chen SH, Lai JY, Jaing TH, Cheng CN, Chen JS, Tsai HL, Yu TY, Hou MH, Ho CY, Yen HJ
Cancer Med 2023 Jun;12(12):13256-13269. Epub 2023 May 4 doi: 10.1002/cam4.6017. PMID: 37140211Free PMC Article
Diagnosis and management of growing teratoma syndrome after ovarian immature teratoma: A single center experience.
Wang D, Zhu S, Jia C, Cao D, Wu M, Shen K, Yang J, Pan L, Cheng N, Xiang Y
Gynecol Oncol 2020 Apr;157(1):94-100. Epub 2020 Jan 15 doi: 10.1016/j.ygyno.2019.12.042. PMID: 31954532
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Growing teratoma syndrome: clinical and radiographic characteristics.
Lee DJ, Djaladat H, Tadros NN, Movassaghi M, Tejura T, Duddalwar V, Daneshmand S
Int J Urol 2014 Sep;21(9):905-8. Epub 2014 Apr 21 doi: 10.1111/iju.12466. PMID: 24750260

Diagnosis

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Imaging in pediatric ovarian tumors.
Hanafy AK, Mujtaba B, Yedururi S, Jensen CT, Sanchez R, Austin MT, Morani AC
Abdom Radiol (NY) 2020 Feb;45(2):520-536. doi: 10.1007/s00261-019-02316-5. PMID: 31745573
Management, Treatment, and Molecular Background of the Growing Teratoma Syndrome.
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Unusual Imaging Findings Associated with Germ Cell Tumors.
Magudia K, Menias CO, Bhalla S, Katabathina VS, Craig JW, Hammer MM
Radiographics 2019 Jul-Aug;39(4):1019-1035. Epub 2019 May 24 doi: 10.1148/rg.2019180050. PMID: 31125295
Growing teratoma syndrome: clinical and radiographic characteristics.
Lee DJ, Djaladat H, Tadros NN, Movassaghi M, Tejura T, Duddalwar V, Daneshmand S
Int J Urol 2014 Sep;21(9):905-8. Epub 2014 Apr 21 doi: 10.1111/iju.12466. PMID: 24750260

Therapy

Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature.
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Growing Teratoma Syndrome After Chemotherapy For Ovarian Immature Teratoma.
Imran H, Siddiqui AH, Wilson F, Pashankar F
J Pediatr Hematol Oncol 2020 Oct;42(7):e630-e633. doi: 10.1097/MPH.0000000000001525. PMID: 31205224
Management, Treatment, and Molecular Background of the Growing Teratoma Syndrome.
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Diagnosis and management of the growing teratoma syndrome: A single-center experience and review of the literature.
Paffenholz P, Pfister D, Matveev V, Heidenreich A
Urol Oncol 2018 Dec;36(12):529.e23-529.e30. Epub 2018 Nov 13 doi: 10.1016/j.urolonc.2018.09.012. PMID: 30446456
Successful Treatment of Growing Teratoma Syndrome of the Lung by Surgical Resection: A Case Report and Literature Review.
Tanaka K, Toyokawa G, Tagawa T, Ijichi K, Haratake N, Hirai F, Oda Y, Maehara Y
Anticancer Res 2018 May;38(5):3115-3118. doi: 10.21873/anticanres.12571. PMID: 29715149

Prognosis

Immature Teratoma with Growing Teratoma Syndrome and Gliomatosis Peritonei Coexistence.
Semiz HS, Sahin H, Unal S, Atici SD, Kose MF, Zeren EH
J Coll Physicians Surg Pak 2022 Dec;32(12):SS122-SS124. doi: 10.29271/jcpsp.2022.Supp0.SS122. PMID: 36597312
Diagnosis and management of growing teratoma syndrome after ovarian immature teratoma: A single center experience.
Wang D, Zhu S, Jia C, Cao D, Wu M, Shen K, Yang J, Pan L, Cheng N, Xiang Y
Gynecol Oncol 2020 Apr;157(1):94-100. Epub 2020 Jan 15 doi: 10.1016/j.ygyno.2019.12.042. PMID: 31954532
Management, Treatment, and Molecular Background of the Growing Teratoma Syndrome.
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Diagnosis and management of the growing teratoma syndrome: A single-center experience and review of the literature.
Paffenholz P, Pfister D, Matveev V, Heidenreich A
Urol Oncol 2018 Dec;36(12):529.e23-529.e30. Epub 2018 Nov 13 doi: 10.1016/j.urolonc.2018.09.012. PMID: 30446456
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327

Clinical prediction guides

Significance of Ultra-Radical Surgery in Extensive Metastatic Ovarian Growing Teratoma Syndrome.
Li S, Wang T, Du H, Tang H, Zhang T, Zhang R, Zhang X, Yang J
Oncology 2023;101(12):773-781. Epub 2023 Aug 9 doi: 10.1159/000533411. PMID: 38096801
Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review.
Shahnam A, Sayer R, Herbst U, Sharma R, Yoon WH, Dinihan T, Gao B
Curr Oncol 2022 Jun 7;29(6):4148-4154. doi: 10.3390/curroncol29060331. PMID: 35735440Free PMC Article
Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature.
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Testicular teratomas: a growing problem?
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327

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