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Growing teratoma syndrome

MedGen UID:
856083
Concept ID:
C3891714
Neoplastic Process
Synonyms: Growing Teratoma Syndrome; growing teratoma syndrome; GTS
SNOMED CT: Growing teratoma syndrome (1260180004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017807
Orphanet: ORPHA314613

Definition

A rare neoplastic disorder characterized by benign metastatic masses increasing in size and number after chemotherapy for non-seminomatous germ cell tumors of testis or ovary. It may present at any time after chemotherapy, with a median occurrence within 24 months after treatment completion. Per definition, the resected specimen exclusively contains mature teratoma components, and serum tumor markers have normalized. The retroperitoneum is the most common site, although almost any other localization has been reported. Increased tumor size may cause mechanical compression of vital organs, with renal dysfunction, bowel ischemia and biliary obstruction as major complications. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrowing teratoma syndrome

Professional guidelines

PubMed

Chen RL, Liu CC, Ip PP, Fang LH, Shih LS, Chen LY
Pediatr Blood Cancer 2022 Aug;69(8):e29781. Epub 2022 May 20 doi: 10.1002/pbc.29781. PMID: 35593015
Wang D, Zhu S, Jia C, Cao D, Wu M, Shen K, Yang J, Pan L, Cheng N, Xiang Y
Gynecol Oncol 2020 Apr;157(1):94-100. Epub 2020 Jan 15 doi: 10.1016/j.ygyno.2019.12.042. PMID: 31954532
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736

Recent clinical studies

Etiology

Sponholz S, Chalepaki Ntelli K, Karaindros G, Schirren M, Lorch A, Hiester A, Albers P, Schirren J
World J Urol 2021 Jul;39(7):2579-2585. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03503-6. PMID: 33128597
Wang D, Zhu S, Jia C, Cao D, Wu M, Shen K, Yang J, Pan L, Cheng N, Xiang Y
Gynecol Oncol 2020 Apr;157(1):94-100. Epub 2020 Jan 15 doi: 10.1016/j.ygyno.2019.12.042. PMID: 31954532
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Lee DJ, Djaladat H, Tadros NN, Movassaghi M, Tejura T, Duddalwar V, Daneshmand S
Int J Urol 2014 Sep;21(9):905-8. Epub 2014 Apr 21 doi: 10.1111/iju.12466. PMID: 24750260

Diagnosis

Shahnam A, Sayer R, Herbst U, Sharma R, Yoon WH, Dinihan T, Gao B
Curr Oncol 2022 Jun 7;29(6):4148-4154. doi: 10.3390/curroncol29060331. PMID: 35735440Free PMC Article
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Hanafy AK, Mujtaba B, Yedururi S, Jensen CT, Sanchez R, Austin MT, Morani AC
Abdom Radiol (NY) 2020 Feb;45(2):520-536. doi: 10.1007/s00261-019-02316-5. PMID: 31745573
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Magudia K, Menias CO, Bhalla S, Katabathina VS, Craig JW, Hammer MM
Radiographics 2019 Jul-Aug;39(4):1019-1035. Epub 2019 May 24 doi: 10.1148/rg.2019180050. PMID: 31125295

Therapy

Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Imran H, Siddiqui AH, Wilson F, Pashankar F
J Pediatr Hematol Oncol 2020 Oct;42(7):e630-e633. doi: 10.1097/MPH.0000000000001525. PMID: 31205224
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Paffenholz P, Pfister D, Matveev V, Heidenreich A
Urol Oncol 2018 Dec;36(12):529.e23-529.e30. Epub 2018 Nov 13 doi: 10.1016/j.urolonc.2018.09.012. PMID: 30446456
Tanaka K, Toyokawa G, Tagawa T, Ijichi K, Haratake N, Hirai F, Oda Y, Maehara Y
Anticancer Res 2018 May;38(5):3115-3118. doi: 10.21873/anticanres.12571. PMID: 29715149

Prognosis

Semiz HS, Sahin H, Unal S, Atici SD, Kose MF, Zeren EH
J Coll Physicians Surg Pak 2022 Dec;32(12):SS122-SS124. doi: 10.29271/jcpsp.2022.Supp0.SS122. PMID: 36597312
Wang D, Zhu S, Jia C, Cao D, Wu M, Shen K, Yang J, Pan L, Cheng N, Xiang Y
Gynecol Oncol 2020 Apr;157(1):94-100. Epub 2020 Jan 15 doi: 10.1016/j.ygyno.2019.12.042. PMID: 31954532
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Karam JA, Raj GV
Urology 2009 Oct;74(4):783-4. Epub 2009 Aug 3 doi: 10.1016/j.urology.2009.03.026. PMID: 19647298

Clinical prediction guides

Li S, Su N, Jia C, Zhang X, Yin M, Yang J
Curr Oncol 2022 Sep 4;29(9):6364-6372. doi: 10.3390/curroncol29090501. PMID: 36135070Free PMC Article
Shahnam A, Sayer R, Herbst U, Sharma R, Yoon WH, Dinihan T, Gao B
Curr Oncol 2022 Jun 7;29(6):4148-4154. doi: 10.3390/curroncol29060331. PMID: 35735440Free PMC Article
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327

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