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Growing teratoma syndrome

MedGen UID:
856083
Concept ID:
C3891714
Neoplastic Process
Synonyms: Growing Teratoma Syndrome; growing teratoma syndrome; GTS
SNOMED CT: Growing teratoma syndrome (1260180004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017807
Orphanet: ORPHA314613

Definition

A rare neoplastic disorder characterized by benign metastatic masses increasing in size and number after chemotherapy for non-seminomatous germ cell tumors of testis or ovary. It may present at any time after chemotherapy, with a median occurrence within 24 months after treatment completion. Per definition, the resected specimen exclusively contains mature teratoma components, and serum tumor markers have normalized. The retroperitoneum is the most common site, although almost any other localization has been reported. Increased tumor size may cause mechanical compression of vital organs, with renal dysfunction, bowel ischemia and biliary obstruction as major complications. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrowing teratoma syndrome

Professional guidelines

PubMed

Yang X, Li J, Chin J, Kanesvaran R
Eur Urol Focus 2024 May;10(3):377-379. Epub 2024 Aug 3 doi: 10.1016/j.euf.2024.05.006. PMID: 39098447
Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Tanaka K, Toyokawa G, Tagawa T, Ijichi K, Haratake N, Hirai F, Oda Y, Maehara Y
Anticancer Res 2018 May;38(5):3115-3118. doi: 10.21873/anticanres.12571. PMID: 29715149

Recent clinical studies

Etiology

Li S, Wang T, Du H, Tang H, Zhang T, Zhang R, Zhang X, Yang J
Oncology 2023;101(12):773-781. Epub 2023 Aug 9 doi: 10.1159/000533411. PMID: 38096801
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Saba A, Khan RS, Ismail H
J Pak Med Assoc 2018 Jun;68(6):945-946. PMID: 30323365
Iwata H, Mori Y, Takagi H, Shirahashi K, Shinoda J, Shimokawa K, Hirose H
J Thorac Cardiovasc Surg 2004 Jan;127(1):291-3. doi: 10.1016/s0022-5223(03)01300-x. PMID: 14752454
Jeffery GM, Theaker JM, Lee AH, Blaquiere RM, Smart CJ, Mead GM
Br J Urol 1991 Feb;67(2):195-202. doi: 10.1111/j.1464-410x.1991.tb15109.x. PMID: 2004236

Diagnosis

Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Pendlebury A, Rischin D, Ireland-Jenkin K, Toner GC, Grant P
J Clin Oncol 2015 Aug 20;33(24):e99-100. Epub 2014 Apr 7 doi: 10.1200/JCO.2013.49.8998. PMID: 24711556
Karam JA, Raj GV
Urology 2009 Oct;74(4):783-4. Epub 2009 Aug 3 doi: 10.1016/j.urology.2009.03.026. PMID: 19647298
Tangjitgamol S, Manusirivithaya S, Leelahakorn S, Thawaramara T, Suekwatana P, Sheanakul C
Int J Gynecol Cancer 2006 Jan-Feb;16 Suppl 1:384-90. doi: 10.1111/j.1525-1438.2006.00492.x. PMID: 16515629
Basheda SG, Gephardt G, Meeker DP
Chest 1991 Jul;100(1):259-60. doi: 10.1378/chest.100.1.259. PMID: 2060358

Therapy

Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Saba A, Khan RS, Ismail H
J Pak Med Assoc 2018 Jun;68(6):945-946. PMID: 30323365
Tangjitgamol S, Manusirivithaya S, Leelahakorn S, Thawaramara T, Suekwatana P, Sheanakul C
Int J Gynecol Cancer 2006 Jan-Feb;16 Suppl 1:384-90. doi: 10.1111/j.1525-1438.2006.00492.x. PMID: 16515629
Iwata H, Mori Y, Takagi H, Shirahashi K, Shinoda J, Shimokawa K, Hirose H
J Thorac Cardiovasc Surg 2004 Jan;127(1):291-3. doi: 10.1016/s0022-5223(03)01300-x. PMID: 14752454
Jeffery GM, Theaker JM, Lee AH, Blaquiere RM, Smart CJ, Mead GM
Br J Urol 1991 Feb;67(2):195-202. doi: 10.1111/j.1464-410x.1991.tb15109.x. PMID: 2004236

Prognosis

Hiester A, Nettersheim D, Nini A, Lusch A, Albers P
Urol Clin North Am 2019 Aug;46(3):419-427. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.008. PMID: 31277736
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327
Karam JA, Raj GV
Urology 2009 Oct;74(4):783-4. Epub 2009 Aug 3 doi: 10.1016/j.urology.2009.03.026. PMID: 19647298
Iwata H, Mori Y, Takagi H, Shirahashi K, Shinoda J, Shimokawa K, Hirose H
J Thorac Cardiovasc Surg 2004 Jan;127(1):291-3. doi: 10.1016/s0022-5223(03)01300-x. PMID: 14752454
Jeffery GM, Theaker JM, Lee AH, Blaquiere RM, Smart CJ, Mead GM
Br J Urol 1991 Feb;67(2):195-202. doi: 10.1111/j.1464-410x.1991.tb15109.x. PMID: 2004236

Clinical prediction guides

Li S, Wang T, Du H, Tang H, Zhang T, Zhang R, Zhang X, Yang J
Oncology 2023;101(12):773-781. Epub 2023 Aug 9 doi: 10.1159/000533411. PMID: 38096801
Ogiwara H
Childs Nerv Syst 2023 Sep;39(9):2349-2352. Epub 2022 Oct 1 doi: 10.1007/s00381-022-05676-4. PMID: 36181520
Shahnam A, Sayer R, Herbst U, Sharma R, Yoon WH, Dinihan T, Gao B
Curr Oncol 2022 Jun 7;29(6):4148-4154. doi: 10.3390/curroncol29060331. PMID: 35735440Free PMC Article
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Michalski W, Jonska-Gmyrek J, Poniatowska G, Kucharz J, Stelmasiak P, Nietupski K, Sadowska M, Demkow T, Wiechno P
Med Oncol 2018 Oct 26;35(12):153. doi: 10.1007/s12032-018-1215-3. PMID: 30367327

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