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Umbilical Vasculitis

MedGen UID:
856842
•Concept ID:
C3897248
•
Disease or Syndrome
Synonym: Acute Umbilical Vasculitis

Definition

A neutrophilic infiltrate arising from fetal vessels of the umbilical cord into the umbilical vessel wall and oriented towards the amniotic cavity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUmbilical Vasculitis

Professional guidelines

PubMed

Stem cell therapy for treatment of thromboangiitis obliterans (Buerger's disease).
Cacione DG, do Carmo Novaes F, Moreno DH
Cochrane Database Syst Rev 2018 Oct 31;10(10):CD012794. doi: 10.1002/14651858.CD012794.pub2. PMID: 30378681Free PMC Article
Endothelial cells present an innate resistance to glucocorticoid treatment: implications for therapy of primary vasculitis.
Koenen P, Barczyk K, Wolf M, Roth J, Viemann D
Ann Rheum Dis 2012 May;71(5):729-36. Epub 2011 Dec 27 doi: 10.1136/annrheumdis-2011-200530. PMID: 22203687
Placental pathology in asphyxiated newborns meeting the criteria for therapeutic hypothermia.
Wintermark P, Boyd T, Gregas MC, Labrecque M, Hansen A
Am J Obstet Gynecol 2010 Dec;203(6):579.e1-9. Epub 2010 Sep 20 doi: 10.1016/j.ajog.2010.08.024. PMID: 20851370

Recent clinical studies

Etiology

Clinically relevant umbilical cord inflammation identified based on CD15-associated vasculitis patterning.
Hatano Y, Tamada M, Shiga T, Niwa A, Kanayama T, Noguchi K, Morishige KI, Tomita H, Hara A
Placenta 2021 May;108:39-46. Epub 2021 Mar 19 doi: 10.1016/j.placenta.2021.03.008. PMID: 33813362
Histopathology of the fetal inflammatory response to intra-amniotic pathogens.
Salafia CM, Misra DP
Semin Fetal Neonatal Med 2020 Aug;25(4):101128. Epub 2020 Aug 28 doi: 10.1016/j.siny.2020.101128. PMID: 32928678
Placental and uterine pathology in women undergoing peripartum hysterectomy.
Hernandez JS, Nuangchamnong N, Ziadie M, Wendel GD Jr, Sheffield JS
Obstet Gynecol 2012 Jun;119(6):1137-42. doi: 10.1097/AOG.0b013e318253d78a. PMID: 22617577
Intrauterine inflammation, neonatal sepsis, and chronic lung disease: a 13-year hospital cohort study.
Lahra MM, Beeby PJ, Jeffery HE
Pediatrics 2009 May;123(5):1314-9. doi: 10.1542/peds.2008-0656. PMID: 19403497
Fetal vasculitis in preterm newborns: interrelationships, modifiers, and antecedents.
Dammann O, Allred EN, Leviton A, Shen-Schwarz S, Heller D, Genest DR, Collins MH
Placenta 2004 Nov;25(10):788-96. doi: 10.1016/j.placenta.2004.03.004. PMID: 15451193

Diagnosis

Histopathology of the fetal inflammatory response to intra-amniotic pathogens.
Salafia CM, Misra DP
Semin Fetal Neonatal Med 2020 Aug;25(4):101128. Epub 2020 Aug 28 doi: 10.1016/j.siny.2020.101128. PMID: 32928678
Intrauterine inflammation, neonatal sepsis, and chronic lung disease: a 13-year hospital cohort study.
Lahra MM, Beeby PJ, Jeffery HE
Pediatrics 2009 May;123(5):1314-9. doi: 10.1542/peds.2008-0656. PMID: 19403497
Maternal versus fetal inflammation and respiratory distress syndrome: a 10-year hospital cohort study.
Lahra MM, Beeby PJ, Jeffery HE
Arch Dis Child Fetal Neonatal Ed 2009 Jan;94(1):F13-6. Epub 2008 May 7 doi: 10.1136/adc.2007.135889. PMID: 18463119
Fetal but not maternal serum cytokine levels correlate with histologic acute placental inflammation.
Salafia CM, Sherer DM, Spong CY, Lencki S, Eglinton GS, Parkash V, Marley E, Lage JM
Am J Perinatol 1997 Aug;14(7):419-22. doi: 10.1055/s-2007-994172. PMID: 9263563
Umbilical cord 'pseudo-vasculitis' following second trimester fetal death: a clinicopathological and immunohistochemical study of 13 cases.
Genest DR, Granter S, Pinkus GS
Histopathology 1997 Jun;30(6):563-9. doi: 10.1046/j.1365-2559.1997.5750808.x. PMID: 9205861

Therapy

Fetal but not maternal serum cytokine levels correlate with histologic acute placental inflammation.
Salafia CM, Sherer DM, Spong CY, Lencki S, Eglinton GS, Parkash V, Marley E, Lage JM
Am J Perinatol 1997 Aug;14(7):419-22. doi: 10.1055/s-2007-994172. PMID: 9263563

Prognosis

Vitelline Vessel Remnant-Derived Funisitis Is a Sensitive and Specific Predictor of Histological Evidence of Amniotic Fluid Infection.
De Guzman JK, Yu W, Koning L, Horn C, Wright JR Jr
Pediatr Dev Pathol 2021 Nov-Dec;24(6):551-553. Epub 2021 Jul 21 doi: 10.1177/10935266211033271. PMID: 34284663
Fetal vasculitis in preterm newborns: interrelationships, modifiers, and antecedents.
Dammann O, Allred EN, Leviton A, Shen-Schwarz S, Heller D, Genest DR, Collins MH
Placenta 2004 Nov;25(10):788-96. doi: 10.1016/j.placenta.2004.03.004. PMID: 15451193
A fetal response to chorioamnionitis is associated with early survival after preterm birth.
Lahra MM, Jeffery HE
Am J Obstet Gynecol 2004 Jan;190(1):147-51. doi: 10.1016/j.ajog.2003.07.012. PMID: 14749651
Fetal breathing movements within 24 hours of delivery in prematurity are related to histologic and clinical evidence of amnionitis.
Sherer DM, Spong CY, Salafia CM
Am J Perinatol 1997 Jul;14(6):337-40. doi: 10.1055/s-2007-994156. PMID: 9217954
Decreased amniotic fluid volume at < 32 weeks of gestation is associated with decreased fetal movements.
Sherer DM, Spong CY, Minior VK, Salafia CM
Am J Perinatol 1996 Nov;13(8):479-82. doi: 10.1055/s-2007-994431. PMID: 8989478

Clinical prediction guides

Clinically relevant umbilical cord inflammation identified based on CD15-associated vasculitis patterning.
Hatano Y, Tamada M, Shiga T, Niwa A, Kanayama T, Noguchi K, Morishige KI, Tomita H, Hara A
Placenta 2021 May;108:39-46. Epub 2021 Mar 19 doi: 10.1016/j.placenta.2021.03.008. PMID: 33813362
Maternal versus fetal inflammation and respiratory distress syndrome: a 10-year hospital cohort study.
Lahra MM, Beeby PJ, Jeffery HE
Arch Dis Child Fetal Neonatal Ed 2009 Jan;94(1):F13-6. Epub 2008 May 7 doi: 10.1136/adc.2007.135889. PMID: 18463119
Fetal vasculitis in preterm newborns: interrelationships, modifiers, and antecedents.
Dammann O, Allred EN, Leviton A, Shen-Schwarz S, Heller D, Genest DR, Collins MH
Placenta 2004 Nov;25(10):788-96. doi: 10.1016/j.placenta.2004.03.004. PMID: 15451193
Fetal but not maternal serum cytokine levels correlate with histologic acute placental inflammation.
Salafia CM, Sherer DM, Spong CY, Lencki S, Eglinton GS, Parkash V, Marley E, Lage JM
Am J Perinatol 1997 Aug;14(7):419-22. doi: 10.1055/s-2007-994172. PMID: 9263563
Decreased amniotic fluid volume at < 32 weeks of gestation is associated with decreased fetal movements.
Sherer DM, Spong CY, Minior VK, Salafia CM
Am J Perinatol 1996 Nov;13(8):479-82. doi: 10.1055/s-2007-994431. PMID: 8989478

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