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Secondary Central Nervous System Hodgkin Lymphoma

MedGen UID:
857243
•Concept ID:
C3897649
•
Neoplastic Process

Definition

A Hodgkin lymphoma that has spread to the central nervous system following the initial presentation in another nodal or extranodal site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Central Nervous System Hodgkin Lymphoma

Professional guidelines

PubMed

Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
Zing N, Fischer T, Federico M, Chiattone C, Ferreri AJM
Crit Rev Oncol Hematol 2021 Nov;167:103496. Epub 2021 Oct 12 doi: 10.1016/j.critrevonc.2021.103496. PMID: 34653598
Central Nervous System Lymphoma: Approach to Diagnosis and Treatment.
Correia CE, Schaff LR, Grommes C
Cancer J 2020 May/Jun;26(3):241-252. doi: 10.1097/PPO.0000000000000449. PMID: 32496457
Management of adults with Burkitt lymphoma.
Gastwirt JP, Roschewski M
Clin Adv Hematol Oncol 2018 Dec;16(12):812-822. PMID: 30843890

Recent clinical studies

Etiology

Central Nervous System Lymphoma.
Shah T, Venur VA
Semin Neurol 2023 Dec;43(6):825-832. Epub 2023 Nov 23 doi: 10.1055/s-0043-1776783. PMID: 37995744
CAR T-cell therapy in large B cell lymphoma.
Boardman AP, Salles G
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):112-118. doi: 10.1002/hon.3153. PMID: 37294963Free PMC Article
Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
Zing N, Fischer T, Federico M, Chiattone C, Ferreri AJM
Crit Rev Oncol Hematol 2021 Nov;167:103496. Epub 2021 Oct 12 doi: 10.1016/j.critrevonc.2021.103496. PMID: 34653598
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Scordo M, Wang TP, Ahn KW, Chen Y, Ahmed S, Awan FT, Beitinjaneh A, Chen A, Chow VA, Dholaria B, Epperla N, Farooq U, Ghosh N, Grover N, Hamad N, Hildebrandt GC, Holmberg L, Hong S, Inwards DJ, Jimenez-Jimenez A, Karmali R, Kenkre VP, Khimani F, Klyuchnikov E, Krem MM, Munshi PN, Nieto Y, Prestidge T, Ramakrishnan Geethakumari P, Rezvani AR, Riedell PA, Seo S, Shah NN, Solh M, Yared JA, Kharfan-Dabaja MA, Herrera A, Hamadani M, Sauter CS
JAMA Oncol 2021 Jul 1;7(7):993-1003. doi: 10.1001/jamaoncol.2021.1074. PMID: 33956047Free PMC Article
Aggressive Non-Hodgkin lymphomas: risk factors and treatment of central nervous system recurrence.
Santambrogio E, Nicolosi M, Vassallo F, Castellino A, Novo M, Chiappella A, Vitolo U
Expert Rev Hematol 2019 Sep;12(9):787-796. Epub 2019 Aug 8 doi: 10.1080/17474086.2019.1643232. PMID: 31305170

Diagnosis

Central Nervous System Lymphoma.
Shah T, Venur VA
Semin Neurol 2023 Dec;43(6):825-832. Epub 2023 Nov 23 doi: 10.1055/s-0043-1776783. PMID: 37995744
Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
Zing N, Fischer T, Federico M, Chiattone C, Ferreri AJM
Crit Rev Oncol Hematol 2021 Nov;167:103496. Epub 2021 Oct 12 doi: 10.1016/j.critrevonc.2021.103496. PMID: 34653598
Central Nervous System Lymphoma: Approach to Diagnosis and Treatment.
Correia CE, Schaff LR, Grommes C
Cancer J 2020 May/Jun;26(3):241-252. doi: 10.1097/PPO.0000000000000449. PMID: 32496457
Aggressive Non-Hodgkin lymphomas: risk factors and treatment of central nervous system recurrence.
Santambrogio E, Nicolosi M, Vassallo F, Castellino A, Novo M, Chiappella A, Vitolo U
Expert Rev Hematol 2019 Sep;12(9):787-796. Epub 2019 Aug 8 doi: 10.1080/17474086.2019.1643232. PMID: 31305170
Central Nervous System Involvement of Natural Killer and T Cell Neoplasms.
Aaroe AE, Nevel KS
Curr Oncol Rep 2019 Mar 27;21(5):40. doi: 10.1007/s11912-019-0794-2. PMID: 30919085

Therapy

CAR T-cell therapy in large B cell lymphoma.
Boardman AP, Salles G
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):112-118. doi: 10.1002/hon.3153. PMID: 37294963Free PMC Article
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Scordo M, Wang TP, Ahn KW, Chen Y, Ahmed S, Awan FT, Beitinjaneh A, Chen A, Chow VA, Dholaria B, Epperla N, Farooq U, Ghosh N, Grover N, Hamad N, Hildebrandt GC, Holmberg L, Hong S, Inwards DJ, Jimenez-Jimenez A, Karmali R, Kenkre VP, Khimani F, Klyuchnikov E, Krem MM, Munshi PN, Nieto Y, Prestidge T, Ramakrishnan Geethakumari P, Rezvani AR, Riedell PA, Seo S, Shah NN, Solh M, Yared JA, Kharfan-Dabaja MA, Herrera A, Hamadani M, Sauter CS
JAMA Oncol 2021 Jul 1;7(7):993-1003. doi: 10.1001/jamaoncol.2021.1074. PMID: 33956047Free PMC Article
Central Nervous System Lymphoma: Approach to Diagnosis and Treatment.
Correia CE, Schaff LR, Grommes C
Cancer J 2020 May/Jun;26(3):241-252. doi: 10.1097/PPO.0000000000000449. PMID: 32496457
Central Nervous System Lymphoma.
Chukwueke UN, Nayak L
Hematol Oncol Clin North Am 2019 Aug;33(4):597-611. Epub 2019 May 10 doi: 10.1016/j.hoc.2019.03.008. PMID: 31229157

Prognosis

Central Nervous System Lymphoma.
Shah T, Venur VA
Semin Neurol 2023 Dec;43(6):825-832. Epub 2023 Nov 23 doi: 10.1055/s-0043-1776783. PMID: 37995744
Lymphomas of Central Nervous System.
Yokogami K, Azuma M, Takeshima H, Hirai T
Adv Exp Med Biol 2023;1405:527-543. doi: 10.1007/978-3-031-23705-8_20. PMID: 37452952
Central Nervous System Lymphoma: Approach to Diagnosis and Treatment.
Correia CE, Schaff LR, Grommes C
Cancer J 2020 May/Jun;26(3):241-252. doi: 10.1097/PPO.0000000000000449. PMID: 32496457
Central Nervous System Lymphoma.
Chukwueke UN, Nayak L
Hematol Oncol Clin North Am 2019 Aug;33(4):597-611. Epub 2019 May 10 doi: 10.1016/j.hoc.2019.03.008. PMID: 31229157
Central Nervous System Involvement of Natural Killer and T Cell Neoplasms.
Aaroe AE, Nevel KS
Curr Oncol Rep 2019 Mar 27;21(5):40. doi: 10.1007/s11912-019-0794-2. PMID: 30919085

Clinical prediction guides

Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Distinct miRNA Expression Signatures of Primary and Secondary Central Nervous System Lymphomas.
Sebestyén E, Nagy Á, Marosvári D, Rajnai H, Kajtár B, Deák B, Matolcsy A, Brandner S, Storhoff J, Chen N, Bagó AG, Bödör C, Reiniger L
J Mol Diagn 2022 Mar;24(3):224-240. Epub 2021 Dec 22 doi: 10.1016/j.jmoldx.2021.11.005. PMID: 34954119
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Scordo M, Wang TP, Ahn KW, Chen Y, Ahmed S, Awan FT, Beitinjaneh A, Chen A, Chow VA, Dholaria B, Epperla N, Farooq U, Ghosh N, Grover N, Hamad N, Hildebrandt GC, Holmberg L, Hong S, Inwards DJ, Jimenez-Jimenez A, Karmali R, Kenkre VP, Khimani F, Klyuchnikov E, Krem MM, Munshi PN, Nieto Y, Prestidge T, Ramakrishnan Geethakumari P, Rezvani AR, Riedell PA, Seo S, Shah NN, Solh M, Yared JA, Kharfan-Dabaja MA, Herrera A, Hamadani M, Sauter CS
JAMA Oncol 2021 Jul 1;7(7):993-1003. doi: 10.1001/jamaoncol.2021.1074. PMID: 33956047Free PMC Article
Aggressive Non-Hodgkin lymphomas: risk factors and treatment of central nervous system recurrence.
Santambrogio E, Nicolosi M, Vassallo F, Castellino A, Novo M, Chiappella A, Vitolo U
Expert Rev Hematol 2019 Sep;12(9):787-796. Epub 2019 Aug 8 doi: 10.1080/17474086.2019.1643232. PMID: 31305170
Secondary central nervous system lymphoma.
Tomita N, Kodama F, Kanamori H, Motomura S, Ishigatsubo Y
Int J Hematol 2006 Aug;84(2):128-35. doi: 10.1532/IJH97.06091. PMID: 16926134

Recent systematic reviews

Chimeric Antigen Receptor T-Cell (CAR T-Cell) Therapy for Primary and Secondary Central Nervous System Lymphoma: A Systematic Review of Literature.
Asghar N, Masood A, Dhaliwal A, Khurana S, Davis J, Hashmi H, Husnain M
Clin Lymphoma Myeloma Leuk 2023 Jan;23(1):15-21. Epub 2022 Oct 7 doi: 10.1016/j.clml.2022.09.008. PMID: 36328891
Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Efficacy and Safety of Axicabtagene Ciloleucel and Tisagenlecleucel Administration in Lymphoma Patients With Secondary CNS Involvement: A Systematic Review.
Wu X, Zhang X, Xun R, Liu M, Sun Z, Huang J
Front Immunol 2021;12:693200. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693200. PMID: 34290712Free PMC Article
Movement disorders in primary central nervous system lymphoma: two unreported cases and a review of literature.
Grillo P, DI Giuliano F, Massa R, Mercuri NB, Schirinzi T
Neurol Sci 2021 Mar;42(3):905-910. Epub 2021 Jan 14 doi: 10.1007/s10072-020-04985-3. PMID: 33443666
Prevention and treatment of central nervous system involvement by non-Hodgkin's lymphoma: a review of the literature.
Colocci N, Glantz M, Recht L
Semin Neurol 2004 Dec;24(4):395-404. doi: 10.1055/s-2004-861534. PMID: 15637651

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