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Refractory Childhood Hodgkin Lymphoma

MedGen UID:
857323
Concept ID:
C3897729
Neoplastic Process

Definition

Hodgkin lymphoma that occurs during childhood and is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Childhood Hodgkin Lymphoma

Professional guidelines

PubMed

Barth MJ, Minard-Colin V
Br J Haematol 2019 Jun;185(6):1111-1124. Epub 2019 Jan 30 doi: 10.1111/bjh.15783. PMID: 30701541
Kobayashi R, Sunami S, Mitsui T, Nakazawa A, Koga Y, Mori T, Tanaka F, Ueyama J, Osumi T, Fukano R, Ohki K, Sekimizu M, Mori T; Lymphoma Committee; Japanese Pediatric Leukemia/Lymphoma Study Group
Pediatr Int 2015 Aug;57(4):523-34. doi: 10.1111/ped.12725. PMID: 26096060
El-Mallawany NK, Cairo MS
Clin Adv Hematol Oncol 2015 Feb;13(2):113-23. PMID: 25774481

Recent clinical studies

Etiology

Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Barth MJ, Minard-Colin V
Br J Haematol 2019 Jun;185(6):1111-1124. Epub 2019 Jan 30 doi: 10.1111/bjh.15783. PMID: 30701541
Galardy PJ, Bedekovics T, Hermiston ML
Br J Haematol 2016 May;173(4):625-36. Epub 2016 Mar 27 doi: 10.1111/bjh.14016. PMID: 27019108
Dokmanović L, Rodić P, Krstovski N, Lazić J, Dragana J
Srp Arh Celok Lek 2014 Jul-Aug;142(7-8):498-504. doi: 10.2298/sarh1408498d. PMID: 25233700

Diagnosis

Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Galardy PJ, Bedekovics T, Hermiston ML
Br J Haematol 2016 May;173(4):625-36. Epub 2016 Mar 27 doi: 10.1111/bjh.14016. PMID: 27019108
El-Mallawany NK, Cairo MS
Clin Adv Hematol Oncol 2015 Feb;13(2):113-23. PMID: 25774481
Allen CE, Kelly KM, Bollard CM
Pediatr Clin North Am 2015 Feb;62(1):139-65. doi: 10.1016/j.pcl.2014.09.010. PMID: 25435117Free PMC Article
Dokmanović L, Rodić P, Krstovski N, Lazić J, Dragana J
Srp Arh Celok Lek 2014 Jul-Aug;142(7-8):498-504. doi: 10.2298/sarh1408498d. PMID: 25233700

Therapy

Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458
Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Galardy PJ, Bedekovics T, Hermiston ML
Br J Haematol 2016 May;173(4):625-36. Epub 2016 Mar 27 doi: 10.1111/bjh.14016. PMID: 27019108
El-Mallawany NK, Cairo MS
Clin Adv Hematol Oncol 2015 Feb;13(2):113-23. PMID: 25774481

Prognosis

Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458
Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Galardy PJ, Bedekovics T, Hermiston ML
Br J Haematol 2016 May;173(4):625-36. Epub 2016 Mar 27 doi: 10.1111/bjh.14016. PMID: 27019108
Gandhi MK, Tellam JT, Khanna R
Br J Haematol 2004 May;125(3):267-81. doi: 10.1111/j.1365-2141.2004.04902.x. PMID: 15086409

Clinical prediction guides

Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group
N Engl J Med 2020 Jun 4;382(23):2207-2219. doi: 10.1056/NEJMoa1915315. PMID: 32492302Free PMC Article
O'Rourke E, Malone A, O'Marcaigh A, Storey L, Betts D, McDermott M, Smith OP
Ir Med J 2020 Jan 16;113(1):6. PMID: 32298568
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Kesik V, Ataş E, Karakükcü M, Aksoylar S, Erbey F, Taçyıldız N, Küpesiz A, Öniz H, Ünal E, Kansoy S, Öztürk G, Elli M, Kaya Z, Ünal E, Hazar V, Yılmaz Bengoa Ş, Karasu G, Atay D, Dağdemir A, Ören H, Koçak Ü, Yeşilipek MA
Turk J Haematol 2016 Dec 1;33(4):265-272. Epub 2016 Apr 18 doi: 10.4274/tjh.2015.0280. PMID: 27094103Free PMC Article
Goldstein LJ
Curr Probl Cancer 1995 Mar-Apr;19(2):65-124. PMID: 7600845

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