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Recurrent Childhood Non-Hodgkin Lymphoma

MedGen UID:
857343
•Concept ID:
C3897749
•
Neoplastic Process

Definition

The reemergence of non-Hodgkin lymphoma in childhood after a period of remission. [from NCI]

Professional guidelines

PubMed

Mycosis fungoides in pediatric population: comprehensive review on epidemiology, clinical presentation, and management.
Kothari R, Szepietowski JC, Bagot M, Sandhu S, Patil A, Grabbe S, Goldust M
Int J Dermatol 2022 Dec;61(12):1458-1466. Epub 2022 Feb 22 doi: 10.1111/ijd.16098. PMID: 35193164
Pharmacotherapeutic Management of Pediatric Lymphoma.
Mauz-Körholz C, Ströter N, Baumann J, Botzen A, Körholz K, Körholz D
Paediatr Drugs 2018 Feb;20(1):43-57. doi: 10.1007/s40272-017-0265-x. PMID: 29127674
Management of pediatric non-Hodgkin's lymphoma.
Blay JY, Louis D, Bouffet E, Thiesse P, Biron P, Favrot MC, Brunat-Mentigny M, Philip T
Blood Rev 1991 Jun;5(2):90-7. doi: 10.1016/0268-960x(91)90040-j. PMID: 1912759

Recent clinical studies

Etiology

Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Infective dermatitis.
Trope BM, Lenzi ME
Clin Dermatol 2009 May-Jun;27(3):281-4. doi: 10.1016/j.clindermatol.2008.10.007. PMID: 19362690
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164
Lymphoblastic leukaemia and non-Hodgkin's lymphoma.
Lilleyman JS, Pinkerton CR
Br Med Bull 1996 Oct;52(4):742-63. doi: 10.1093/oxfordjournals.bmb.a011580. PMID: 9039729

Diagnosis

Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Adult-Onset Atopic Dermatitis.
Silverberg JI
J Allergy Clin Immunol Pract 2019 Jan;7(1):28-33. doi: 10.1016/j.jaip.2018.09.029. PMID: 30598180
Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.
Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846Free PMC Article
Diagnosis and treatment of childhood non-hodgkin lymphoma.
Reiter A
Hematology Am Soc Hematol Educ Program 2007:285-96. doi: 10.1182/asheducation-2007.1.285. PMID: 18024642
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

Therapy

Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR).
Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458
Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial.
Shah NN, Johnson BD, Schneider D, Zhu F, Szabo A, Keever-Taylor CA, Krueger W, Worden AA, Kadan MJ, Yim S, Cunningham A, Hamadani M, Fenske TS, Dropulić B, Orentas R, Hari P
Nat Med 2020 Oct;26(10):1569-1575. Epub 2020 Oct 5 doi: 10.1038/s41591-020-1081-3. PMID: 33020647
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Pharmacotherapeutic Management of Pediatric Lymphoma.
Mauz-Körholz C, Ströter N, Baumann J, Botzen A, Körholz K, Körholz D
Paediatr Drugs 2018 Feb;20(1):43-57. doi: 10.1007/s40272-017-0265-x. PMID: 29127674
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

Prognosis

Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR).
Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.
Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846Free PMC Article
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Lymphoblastic leukaemia and non-Hodgkin's lymphoma.
Lilleyman JS, Pinkerton CR
Br Med Bull 1996 Oct;52(4):742-63. doi: 10.1093/oxfordjournals.bmb.a011580. PMID: 9039729

Clinical prediction guides

Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas.
Jakša R, Karolová J, Svatoň M, Kazantsev D, Grajciarová M, Pokorná E, Tonar Z, Klánová M, Winkowska L, Maláriková D, Vočková P, Forsterová K, Renešová N, Dolníková A, Nožičková K, Dundr P, Froňková E, Trněný M, Klener P
Lab Invest 2022 Sep;102(9):957-965. Epub 2022 Apr 29 doi: 10.1038/s41374-022-00784-w. PMID: 35488033Free PMC Article
Outcome and prognostic factors in childhood B non-Hodgkin lymphoma from India: Report by the Indian Pediatric Oncology Group (InPOG-NHL-16-01 study).
Rahiman EA, Bakhshi S, Deepam Pushpam, Ramamoorthy J, Das A, Ghara N, Kalra M, Kapoor G, Meena JP, Siddaigarhi S, Thulkar S, Sharma MC, Srinivasan R, Trehan A
Pediatr Hematol Oncol 2022 Aug;39(5):391-405. Epub 2022 Jan 3 doi: 10.1080/08880018.2021.2002485. PMID: 34978257
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma.
Miles RR, Shah RK, Frazer JK
Br J Haematol 2016 May;173(4):582-96. Epub 2016 Mar 11 doi: 10.1111/bjh.14011. PMID: 26969846Free PMC Article
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

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