U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Placental Villous Fibrosis

MedGen UID:
857486
•Concept ID:
C3897892
•
Finding

Definition

Increased density of placental villous stroma, often with decreased capillarization compared to what would be expected for gestational age. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlacental Villous Fibrosis

Recent clinical studies

Etiology

New insights into the etiopathology of placenta accreta spectrum.
Jauniaux E, Jurkovic D, Hussein AM, Burton GJ
Am J Obstet Gynecol 2022 Sep;227(3):384-391. Epub 2022 Mar 3 doi: 10.1016/j.ajog.2022.02.038. PMID: 35248577
Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature.
Venceslau EM, Guida JP, Amaral E, Modena JLP, Costa ML
Rev Bras Ginecol Obstet 2020 Sep;42(9):577-585. Epub 2020 Jun 19 doi: 10.1055/s-0040-1712126. PMID: 32559805Free PMC Article
Placental infectious villitis versus villitis of unknown etiology.
Stanek J
Pol J Pathol 2017;68(1):55-65. doi: 10.5114/pjp.2017.67616. PMID: 28547981
Racial disparity in placental pathology in the collaborative perinatal project.
Chen Y, Huang L, Zhang H, Klebanoff M, Yang Z, Zhang J
Int J Clin Exp Pathol 2015;8(11):15042-54. Epub 2015 Nov 1 PMID: 26823843Free PMC Article
Placental pathology in fetal growth restriction.
Vedmedovska N, Rezeberga D, Teibe U, Melderis I, Donders GG
Eur J Obstet Gynecol Reprod Biol 2011 Mar;155(1):36-40. Epub 2010 Dec 23 doi: 10.1016/j.ejogrb.2010.11.017. PMID: 21183268

Diagnosis

Definition and Quantification of Three-Dimensional Imaging Targets to Phenotype Pre-Eclampsia Subtypes: An Exploratory Study.
Hermans S, Pilon J, Eschweiler D, Stegmaier J, Severens-Rijvers CAH, Al-Nasiry S, van Zandvoort M, Kapsokalyvas D
Int J Mol Sci 2023 Feb 7;24(4) doi: 10.3390/ijms24043240. PMID: 36834652Free PMC Article
Histological Assessment of the Placenta Accreta Spectrum Diagnosed with a 33-MHz Linear Probe during Cesarean Section.
Hasegawa J, Furuya N, Doi M, Koike J, Homma C, Nieda M, Nishimura Y, Suzuki N
Ultrasound Med Biol 2022 Jun;48(6):1151-1156. Epub 2022 Mar 21 doi: 10.1016/j.ultrasmedbio.2022.02.010. PMID: 35331578
New insights into the etiopathology of placenta accreta spectrum.
Jauniaux E, Jurkovic D, Hussein AM, Burton GJ
Am J Obstet Gynecol 2022 Sep;227(3):384-391. Epub 2022 Mar 3 doi: 10.1016/j.ajog.2022.02.038. PMID: 35248577
Placental infectious villitis versus villitis of unknown etiology.
Stanek J
Pol J Pathol 2017;68(1):55-65. doi: 10.5114/pjp.2017.67616. PMID: 28547981
Antenatal corticosteroids and placental histology in preterm birth.
Ghidini A, Pezzullo JC, Sylvestre G, Lembet A, Salafia CM
Placenta 2001 May;22(5):412-7. doi: 10.1053/plac.2001.0649. PMID: 11373151

Therapy

Prospective evaluation of impact of post-Cesarean section uterine scarring in perinatal diagnosis of placenta accreta spectrum disorder.
Hussein AM, Elbarmelgy RA, Elbarmelgy RM, Thabet MM, Jauniaux E
Ultrasound Obstet Gynecol 2022 Apr;59(4):474-482. Epub 2022 Mar 8 doi: 10.1002/uog.23732. PMID: 34225385Free PMC Article
Macroscopic and microscopic findings of the placenta in women with polycystic ovary syndrome.
Palomba S, Russo T, Falbo A, Di Cello A, Tolino A, Tucci L, La Sala GB, Zullo F
Hum Reprod 2013 Oct;28(10):2838-47. Epub 2013 Jun 11 doi: 10.1093/humrep/det250. PMID: 23756703
Placental pathology in fetal growth restriction.
Vedmedovska N, Rezeberga D, Teibe U, Melderis I, Donders GG
Eur J Obstet Gynecol Reprod Biol 2011 Mar;155(1):36-40. Epub 2010 Dec 23 doi: 10.1016/j.ejogrb.2010.11.017. PMID: 21183268
The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Beneficial Effects of Antenatal Repeated Steroids study: impact of repeated doses of antenatal corticosteroids on placental growth and histologic findings.
Sawady J, Mercer BM, Wapner RJ, Zhao Y, Sorokin Y, Johnson F, Dudley DJ, Spong CY, Peaceman AM, Leveno KJ, Harper M, Caritis SN, Miodovnik M, Thorp JM, Ramin S, Carpenter MW, Rouse DJ; National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network
Am J Obstet Gynecol 2007 Sep;197(3):281.e1-8. doi: 10.1016/j.ajog.2007.06.041. PMID: 17826421
Antenatal corticosteroids and placental histology in preterm birth.
Ghidini A, Pezzullo JC, Sylvestre G, Lembet A, Salafia CM
Placenta 2001 May;22(5):412-7. doi: 10.1053/plac.2001.0649. PMID: 11373151

Prognosis

Integrated Placental Modelling of Histology with Gene Expression to Identify Functional Impact on Fetal Growth.
Yong HEJ, Maksym K, Yusoff MAB, Salazar-Petres E, Nazarenko T, Zaikin A, David AL, Hillman SL, Sferruzzi-Perri AN
Cells 2023 Apr 6;12(7) doi: 10.3390/cells12071093. PMID: 37048166Free PMC Article
Placental pathology in fetal growth restriction.
Vedmedovska N, Rezeberga D, Teibe U, Melderis I, Donders GG
Eur J Obstet Gynecol Reprod Biol 2011 Mar;155(1):36-40. Epub 2010 Dec 23 doi: 10.1016/j.ejogrb.2010.11.017. PMID: 21183268
The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Beneficial Effects of Antenatal Repeated Steroids study: impact of repeated doses of antenatal corticosteroids on placental growth and histologic findings.
Sawady J, Mercer BM, Wapner RJ, Zhao Y, Sorokin Y, Johnson F, Dudley DJ, Spong CY, Peaceman AM, Leveno KJ, Harper M, Caritis SN, Miodovnik M, Thorp JM, Ramin S, Carpenter MW, Rouse DJ; National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network
Am J Obstet Gynecol 2007 Sep;197(3):281.e1-8. doi: 10.1016/j.ajog.2007.06.041. PMID: 17826421
Microscopic investigation of villi from chorionic villous sampling.
Vis C, Everhardt E, te Velde J, Exalto N
Hum Reprod 1998 Oct;13(1O):2954-7. doi: 10.1093/humrep/13.10.2954. PMID: 9804261
Structural analysis of placental terminal villi from growth-restricted pregnancies with abnormal umbilical artery Doppler waveforms.
Macara L, Kingdom JC, Kaufmann P, Kohnen G, Hair J, More IA, Lyall F, Greer IA
Placenta 1996 Jan;17(1):37-48. doi: 10.1016/s0143-4004(05)80642-3. PMID: 8710812

Clinical prediction guides

Integrated Placental Modelling of Histology with Gene Expression to Identify Functional Impact on Fetal Growth.
Yong HEJ, Maksym K, Yusoff MAB, Salazar-Petres E, Nazarenko T, Zaikin A, David AL, Hillman SL, Sferruzzi-Perri AN
Cells 2023 Apr 6;12(7) doi: 10.3390/cells12071093. PMID: 37048166Free PMC Article
Clinicopathological study and immunohistochemical analysis of expression of annexin A5 and apelin in human placentae of gestational diabetes mellitus.
Dasgupta S, Banerjee U, Mukhopadhyay P, Maity P, Saha S, Das B
Diabetes Metab Syndr 2022 Mar;16(3):102435. Epub 2022 Feb 23 doi: 10.1016/j.dsx.2022.102435. PMID: 35245857
Racial disparity in placental pathology in the collaborative perinatal project.
Chen Y, Huang L, Zhang H, Klebanoff M, Yang Z, Zhang J
Int J Clin Exp Pathol 2015;8(11):15042-54. Epub 2015 Nov 1 PMID: 26823843Free PMC Article
Macroscopic and microscopic findings of the placenta in women with polycystic ovary syndrome.
Palomba S, Russo T, Falbo A, Di Cello A, Tolino A, Tucci L, La Sala GB, Zullo F
Hum Reprod 2013 Oct;28(10):2838-47. Epub 2013 Jun 11 doi: 10.1093/humrep/det250. PMID: 23756703
Placental pathology in discordant twins.
Eberle AM, Levesque D, Vintzileos AM, Egan JF, Tsapanos V, Salafia CM
Am J Obstet Gynecol 1993 Oct;169(4):931-5. doi: 10.1016/0002-9378(93)90029-i. PMID: 8238151

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...