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Osteosclerotic plasma cell myeloma

MedGen UID:
857662
•Concept ID:
C3898068
•
Neoplastic Process
Synonyms: Osteosclerotic Multiple Myeloma; osteosclerotic multiple myeloma; osteosclerotic myeloma; Osteosclerotic Plasma Cell Myeloma; osteosclerotic plasma cell myeloma
 
Monarch Initiative: MONDO:0004815

Definition

A plasma cell neoplasm associated with osteosclerotic and fibrotic changes in the bone trabeculae. Often, the lymph nodes show changes resembling the plasma cell variant of Castleman disease. It is often part of POEMS syndrome which is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteosclerotic plasma cell myeloma

Professional guidelines

PubMed

Clinical features, evaluation, and treatment of patients with polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS).
Gorson KC
J Clin Apher 1999;14(3):149-53. doi: 10.1002/(sici)1098-1101(1999)14:3<149::aid-jca8>3.0.co;2-9. PMID: 10540371

Recent clinical studies

Etiology

The role of radiotherapy in the management of POEMS syndrome.
Suh YG, Kim YS, Suh CO, Kim YR, Cheong JW, Kim JS, Cho J
Radiat Oncol 2014 Nov 28;9:265. doi: 10.1186/s13014-014-0265-8. PMID: 25431020Free PMC Article
Paraproteinaemic neuropathies.
Miescher GC, Steck AJ
Baillieres Clin Neurol 1996 Mar;5(1):219-32. PMID: 8732209
Peripheral neuropathies associated with monoclonal proteins.
Bosch EP, Smith BE
Med Clin North Am 1993 Jan;77(1):125-39. doi: 10.1016/s0025-7125(16)30276-0. PMID: 8380479
Plasma-cell dyscrasia with polyneuropathy. The spectrum of POEMS syndrome.
Miralles GD, O'Fallon JR, Talley NJ
N Engl J Med 1992 Dec 31;327(27):1919-23. doi: 10.1056/NEJM199212313272705. PMID: 1333569
Osteosclerotic myeloma with polyneuropathy and hypocalcemia.
Ludescher C, Grünewald K, Fend F, Dietze O, Thaler J, Schmid KW
Blut 1989 Apr;58(4):207-10. doi: 10.1007/BF00320775. PMID: 2539870

Diagnosis

Paraneoplastic neuropathies and peripheral nerve hyperexcitability disorders.
Shelly S, Dubey D, Mills JR, Klein CJ
Handb Clin Neurol 2024;200:239-273. doi: 10.1016/B978-0-12-823912-4.00020-7. PMID: 38494281
POEMS Syndrome: an Enigma.
Warsame R, Yanamandra U, Kapoor P
Curr Hematol Malig Rep 2017 Apr;12(2):85-95. doi: 10.1007/s11899-017-0367-0. PMID: 28299525
Myelomagenesis: capturing early microenvironment changes.
Korde N, Maric I
Semin Hematol 2011 Jan;48(1):13-21. doi: 10.1053/j.seminhematol.2010.11.004. PMID: 21232654Free PMC Article
POEMS Syndrome.
Dispenzieri A
Hematology Am Soc Hematol Educ Program 2005:360-7. doi: 10.1182/asheducation-2005.1.360. PMID: 16304404
Paraproteinaemic neuropathies.
Miescher GC, Steck AJ
Baillieres Clin Neurol 1996 Mar;5(1):219-32. PMID: 8732209

Therapy

Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience.
D'Souza A, Lacy M, Gertz M, Kumar S, Buadi F, Hayman S, Dingli D, Zeldenrust S, Kyle R, Ansell S, Inwards D, Johnston P, Micallef I, Porrata L, Litzow M, Gastineau D, Hogan W, Dispenzieri A
Blood 2012 Jul 5;120(1):56-62. Epub 2012 May 18 doi: 10.1182/blood-2012-04-423178. PMID: 22611150
Dickkopf-1 as a potential therapeutic target in Paget's disease of bone.
McCarthy HS, Marshall MJ
Expert Opin Ther Targets 2010 Feb;14(2):221-30. doi: 10.1517/14728220903525720. PMID: 20055719
POEMS Syndrome.
Dispenzieri A
Hematology Am Soc Hematol Educ Program 2005:360-7. doi: 10.1182/asheducation-2005.1.360. PMID: 16304404
Clinical features, evaluation, and treatment of patients with polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS).
Gorson KC
J Clin Apher 1999;14(3):149-53. doi: 10.1002/(sici)1098-1101(1999)14:3<149::aid-jca8>3.0.co;2-9. PMID: 10540371
Osteosclerotic myeloma and peripheral neuropathy.
Kelly JJ Jr, Kyle RA, Miles JM, Dyck PJ
Neurology 1983 Feb;33(2):202-10. doi: 10.1212/wnl.33.2.202. PMID: 6296727

Prognosis

POEMS Syndrome: an Enigma.
Warsame R, Yanamandra U, Kapoor P
Curr Hematol Malig Rep 2017 Apr;12(2):85-95. doi: 10.1007/s11899-017-0367-0. PMID: 28299525
POEMS Syndrome.
Dispenzieri A
Hematology Am Soc Hematol Educ Program 2005:360-7. doi: 10.1182/asheducation-2005.1.360. PMID: 16304404
Osteosclerotic myeloma and 'POEMS' syndrome.
Schey S
Blood Rev 1996 Jun;10(2):75-80. doi: 10.1016/s0268-960x(96)90035-1. PMID: 8813338
Paraproteinaemic neuropathies.
Miescher GC, Steck AJ
Baillieres Clin Neurol 1996 Mar;5(1):219-32. PMID: 8732209
Peripheral neuropathies associated with monoclonal proteins.
Bosch EP, Smith BE
Med Clin North Am 1993 Jan;77(1):125-39. doi: 10.1016/s0025-7125(16)30276-0. PMID: 8380479

Clinical prediction guides

Reader's digest of the pathophysiology of bone metastases.
Gruber R
Wien Med Wochenschr 2012 Sep;162(17-18):370-3. Epub 2012 Jul 14 doi: 10.1007/s10354-012-0110-3. PMID: 22797871
Therapeutic trial of plasma exchange in osteosclerotic myeloma associated with the POEMS syndrome.
Silberstein LE, Duggan D, Berkman EM
J Clin Apher 1985;2(3):253-7. doi: 10.1002/jca.2920020309. PMID: 2993255
Axonal attenuation and secondary segmental demyelination in myeloma neuropathies.
Ohi T, Kyle RA, Dyck PJ
Ann Neurol 1985 Mar;17(3):255-61. doi: 10.1002/ana.410170306. PMID: 2986526
Osteosclerotic myeloma with polyneuropathy.
Reitan JB, Pape E, Fosså SD, Julsrud OJ, Slettnes ON, Solheim OP
Acta Med Scand 1980;208(1-2):137-44. doi: 10.1111/j.0954-6820.1980.tb01167.x. PMID: 6254342
Plasma cell neoplasia with peripheral polyneuropathy. A study of five cases and a review of the literature.
Driedger H, Pruzanski W
Medicine (Baltimore) 1980 Jul;59(4):301-10. doi: 10.1097/00005792-198007000-00005. PMID: 6248719

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