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Osteosclerotic plasma cell myeloma

MedGen UID:
857662
Concept ID:
C3898068
Neoplastic Process
Synonyms: Osteosclerotic Multiple Myeloma; osteosclerotic multiple myeloma; osteosclerotic myeloma; Osteosclerotic Plasma Cell Myeloma; osteosclerotic plasma cell myeloma
 
Monarch Initiative: MONDO:0004815

Definition

A plasma cell neoplasm associated with osteosclerotic and fibrotic changes in the bone trabeculae. Often, the lymph nodes show changes resembling the plasma cell variant of Castleman disease. It is often part of POEMS syndrome which is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteosclerotic plasma cell myeloma

Professional guidelines

PubMed

Gorson KC
J Clin Apher 1999;14(3):149-53. doi: 10.1002/(sici)1098-1101(1999)14:3<149::aid-jca8>3.0.co;2-9. PMID: 10540371

Recent clinical studies

Etiology

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Diagnosis

Shelly S, Dubey D, Mills JR, Klein CJ
Handb Clin Neurol 2024;200:239-273. doi: 10.1016/B978-0-12-823912-4.00020-7. PMID: 38494281
Warsame R, Yanamandra U, Kapoor P
Curr Hematol Malig Rep 2017 Apr;12(2):85-95. doi: 10.1007/s11899-017-0367-0. PMID: 28299525
Korde N, Maric I
Semin Hematol 2011 Jan;48(1):13-21. doi: 10.1053/j.seminhematol.2010.11.004. PMID: 21232654Free PMC Article
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Semin Diagn Pathol 1988 Nov;5(4):346-64. PMID: 2464187

Therapy

D'Souza A, Lacy M, Gertz M, Kumar S, Buadi F, Hayman S, Dingli D, Zeldenrust S, Kyle R, Ansell S, Inwards D, Johnston P, Micallef I, Porrata L, Litzow M, Gastineau D, Hogan W, Dispenzieri A
Blood 2012 Jul 5;120(1):56-62. Epub 2012 May 18 doi: 10.1182/blood-2012-04-423178. PMID: 22611150
McCarthy HS, Marshall MJ
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Dispenzieri A
Hematology Am Soc Hematol Educ Program 2005:360-7. doi: 10.1182/asheducation-2005.1.360. PMID: 16304404
Gorson KC
J Clin Apher 1999;14(3):149-53. doi: 10.1002/(sici)1098-1101(1999)14:3<149::aid-jca8>3.0.co;2-9. PMID: 10540371
Kelly JJ Jr, Kyle RA, Miles JM, Dyck PJ
Neurology 1983 Feb;33(2):202-10. doi: 10.1212/wnl.33.2.202. PMID: 6296727

Prognosis

Warsame R, Yanamandra U, Kapoor P
Curr Hematol Malig Rep 2017 Apr;12(2):85-95. doi: 10.1007/s11899-017-0367-0. PMID: 28299525
Dispenzieri A
Hematology Am Soc Hematol Educ Program 2005:360-7. doi: 10.1182/asheducation-2005.1.360. PMID: 16304404
Lacy MQ, Gertz MA, Hanson CA, Inwards DJ, Kyle RA
Am J Hematol 1997 Dec;56(4):288-93. doi: 10.1002/(sici)1096-8652(199712)56:4<288::aid-ajh16>3.0.co;2-5. PMID: 9395194
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Bosch EP, Smith BE
Med Clin North Am 1993 Jan;77(1):125-39. doi: 10.1016/s0025-7125(16)30276-0. PMID: 8380479

Clinical prediction guides

Gruber R
Wien Med Wochenschr 2012 Sep;162(17-18):370-3. Epub 2012 Jul 14 doi: 10.1007/s10354-012-0110-3. PMID: 22797871
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Driedger H, Pruzanski W
Medicine (Baltimore) 1980 Jul;59(4):301-10. doi: 10.1097/00005792-198007000-00005. PMID: 6248719

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