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Organic Growth Hormone Deficiency

MedGen UID:
857666
•Concept ID:
C3898072
•
Finding

Definition

Growth hormone deficiency due to an identifiable biological cause. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrganic Growth Hormone Deficiency

Professional guidelines

PubMed

Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
Kim JH, Kim SJ, Lee J, Shin CH, Seo JY
PLoS One 2021;16(7):e0252283. Epub 2021 Jul 19 doi: 10.1371/journal.pone.0252283. PMID: 34280192Free PMC Article

Recent clinical studies

Etiology

Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
Kim JH, Kim SJ, Lee J, Shin CH, Seo JY
PLoS One 2021;16(7):e0252283. Epub 2021 Jul 19 doi: 10.1371/journal.pone.0252283. PMID: 34280192Free PMC Article
Adolescent boys with constitutional delay of growth and puberty grow faster than patients with organic growth hormone deficiency.
Binder G, Lehrian TJ, Hoffmann E, Blumenstock G, Rahmaoui A, Trzaskoma B, Reinehr T
Clin Endocrinol (Oxf) 2021 Feb;94(2):237-241. Epub 2020 Nov 10 doi: 10.1111/cen.14358. PMID: 33113160
Children with organic growth hormone deficiency have elevated cortisol responses to stimuli.
Finkelstein JW, Rusovici DE, Green E, Foreman S, Kulin HE, D'Arcangelo MR, Kemezys R
J Clin Endocrinol Metab 2001 Jun;86(6):2854-6. doi: 10.1210/jcem.86.6.7594. PMID: 11397899
Growth response in the first year of growth hormone treatment in prepubertal children with organic growth hormone deficiency: a comparison with idiopathic growth hormone deficiency. The Executive Scientific Committee of the Kabi International Growth Study.
Price DA, Ranke MB, Guilbaud O
Acta Paediatr Scand Suppl 1990;370:131-7; discussion 138. doi: 10.1111/j.1651-2227.1990.tb11690.x. PMID: 2260451
Parental heights of children with idiopathic growth hormone deficiency: analysis from the Kabi International Growth Study.
Acta Paediatr Scand Suppl 1989;356:178-80. PMID: 2683572

Diagnosis

Adolescent boys with constitutional delay of growth and puberty grow faster than patients with organic growth hormone deficiency.
Binder G, Lehrian TJ, Hoffmann E, Blumenstock G, Rahmaoui A, Trzaskoma B, Reinehr T
Clin Endocrinol (Oxf) 2021 Feb;94(2):237-241. Epub 2020 Nov 10 doi: 10.1111/cen.14358. PMID: 33113160
Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests.
Maghnie M, Uga E, Temporini F, Di Iorgi N, Secco A, Tinelli C, Papalia A, Casini MR, Loche S
Eur J Endocrinol 2005 May;152(5):735-41. doi: 10.1530/eje.1.01911. PMID: 15879359
Lessons from the national cooperative growth study.
Wyatt D
Eur J Endocrinol 2004 Aug;151 Suppl 1:S55-9. doi: 10.1530/eje.0.151s055. PMID: 15339245
Children with organic growth hormone deficiency have elevated cortisol responses to stimuli.
Finkelstein JW, Rusovici DE, Green E, Foreman S, Kulin HE, D'Arcangelo MR, Kemezys R
J Clin Endocrinol Metab 2001 Jun;86(6):2854-6. doi: 10.1210/jcem.86.6.7594. PMID: 11397899
Growth response in the first year of growth hormone treatment in prepubertal children with organic growth hormone deficiency: a comparison with idiopathic growth hormone deficiency. The Executive Scientific Committee of the Kabi International Growth Study.
Price DA, Ranke MB, Guilbaud O
Acta Paediatr Scand Suppl 1990;370:131-7; discussion 138. doi: 10.1111/j.1651-2227.1990.tb11690.x. PMID: 2260451

Therapy

Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
Kim JH, Kim SJ, Lee J, Shin CH, Seo JY
PLoS One 2021;16(7):e0252283. Epub 2021 Jul 19 doi: 10.1371/journal.pone.0252283. PMID: 34280192Free PMC Article
Long-term therapy with recombinant human growth hormone (Saizen) in children with idiopathic and organic growth hormone deficiency.
Bercu BB, Murray FT, Frasier SD, Rudlin C, O'Dea LS, Brentzel J, Hanson B, Landy H
Endocrine 2001 Jun;15(1):43-9. doi: 10.1385/endo:15:1:043. PMID: 11572324
Efficacy of growth hormone replacement therapy in children with organic growth hormone deficiency after cranial irradiation.
Vassilopoulou-Sellin, Klein MJ, Moore BD 3rd, Reid HL, Ater J, Zietz HA
Horm Res 1995;43(5):188-93. doi: 10.1159/000184276. PMID: 7782048
Growth response in the first year of growth hormone treatment in prepubertal children with organic growth hormone deficiency: a comparison with idiopathic growth hormone deficiency. The Executive Scientific Committee of the Kabi International Growth Study.
Price DA, Ranke MB, Guilbaud O
Acta Paediatr Scand Suppl 1990;370:131-7; discussion 138. doi: 10.1111/j.1651-2227.1990.tb11690.x. PMID: 2260451
Parental heights of children with idiopathic growth hormone deficiency: analysis from the Kabi International Growth Study.
Acta Paediatr Scand Suppl 1989;356:178-80. PMID: 2683572

Prognosis

Adolescent boys with constitutional delay of growth and puberty grow faster than patients with organic growth hormone deficiency.
Binder G, Lehrian TJ, Hoffmann E, Blumenstock G, Rahmaoui A, Trzaskoma B, Reinehr T
Clin Endocrinol (Oxf) 2021 Feb;94(2):237-241. Epub 2020 Nov 10 doi: 10.1111/cen.14358. PMID: 33113160
Growth response in the first year of growth hormone treatment in prepubertal children with organic growth hormone deficiency: a comparison with idiopathic growth hormone deficiency. The Executive Scientific Committee of the Kabi International Growth Study.
Price DA, Ranke MB, Guilbaud O
Acta Paediatr Scand Suppl 1990;370:131-7; discussion 138. doi: 10.1111/j.1651-2227.1990.tb11690.x. PMID: 2260451

Clinical prediction guides

Adolescent boys with constitutional delay of growth and puberty grow faster than patients with organic growth hormone deficiency.
Binder G, Lehrian TJ, Hoffmann E, Blumenstock G, Rahmaoui A, Trzaskoma B, Reinehr T
Clin Endocrinol (Oxf) 2021 Feb;94(2):237-241. Epub 2020 Nov 10 doi: 10.1111/cen.14358. PMID: 33113160
Association between decreased klotho blood levels and organic growth hormone deficiency in children with growth impairment.
Wolf I, Shahmoon S, Ben Ami M, Levy-Shraga Y, Mazor-Aronovitch K, Pinhas-Hamiel O, Yeshayahu Y, Hemi R, Kanety H, Rubinek T, Modan-Moses D
PLoS One 2014;9(9):e107174. Epub 2014 Sep 8 doi: 10.1371/journal.pone.0107174. PMID: 25198618Free PMC Article
Long-term therapy with recombinant human growth hormone (Saizen) in children with idiopathic and organic growth hormone deficiency.
Bercu BB, Murray FT, Frasier SD, Rudlin C, O'Dea LS, Brentzel J, Hanson B, Landy H
Endocrine 2001 Jun;15(1):43-9. doi: 10.1385/endo:15:1:043. PMID: 11572324
Growth response in the first year of growth hormone treatment in prepubertal children with organic growth hormone deficiency: a comparison with idiopathic growth hormone deficiency. The Executive Scientific Committee of the Kabi International Growth Study.
Price DA, Ranke MB, Guilbaud O
Acta Paediatr Scand Suppl 1990;370:131-7; discussion 138. doi: 10.1111/j.1651-2227.1990.tb11690.x. PMID: 2260451
Birth data for patients who later develop growth hormone deficiency: preliminary analysis of a national register. The Executive Scientific Committee of the Kabi International Growth Study and the Swedish Paediatric Study Group for Growth Hormone Treatment.
Albertsson-Wikland K, Niklasson A, Karlberg P
Acta Paediatr Scand Suppl 1990;370:115-20; discussion 121. doi: 10.1111/j.1651-2227.1990.tb11687.x. PMID: 2260449

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