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Orbital Melanoma

MedGen UID:
857683
•Concept ID:
C3898089
•
Neoplastic Process

Definition

A melanoma that arises from the structures of the orbit. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbital Melanoma

Professional guidelines

PubMed

New Translational Research in the Medical Management of Orbital Melanoma.
Dagi Glass L, Sullivan R, Freitag SK
Semin Ophthalmol 2016;31(1-2):53-8. doi: 10.3109/08820538.2015.1114849. PMID: 26959130
Orbital metastasis: clinical features, management and outcome.
Valenzuela AA, Archibald CW, Fleming B, Ong L, O'Donnell B, Crompton J J, Selva D, McNab AA, Sullivan TJ
Orbit 2009;28(2-3):153-9. doi: 10.1080/01676830902897470. PMID: 19839900

Recent clinical studies

Etiology

Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.
Liu X, Yue H, Jiang S, Kong L, Xu Y, Chen Y, Wang C, Wang Y, Zhu X, Kong Y, Zhang X, Qian J, Luo Z
Cancer Med 2023 Aug;12(15):16163-16172. Epub 2023 Jul 6 doi: 10.1002/cam4.6273. PMID: 37409486Free PMC Article
Extrascleral extension of choroidal melanoma after iodine-125 brachytherapy treatment: a case series.
Mustak H, Lo C, Cohen LM, Tran A, Almanzor R, McCannel TA, Goldberg RA, Rootman DB
Eye (Lond) 2023 Feb;37(2):249-255. Epub 2022 Jan 5 doi: 10.1038/s41433-021-01861-y. PMID: 34987200Free PMC Article
Primary orbital melanoma: A report of a case and comprehensive review of the literature.
Adetunji MO, McGeehan B, Lee V, Maguire MG, Briceño CA
Orbit 2021 Dec;40(6):461-469. Epub 2020 Sep 9 doi: 10.1080/01676830.2020.1818265. PMID: 32900269Free PMC Article
Primary orbital melanoma: a case series and literature review.
Figueira E, Rajak S, McKelvie P, Kalantzis G, Ismail A, Gonzales M, James C, McNab A, Selva D
Orbit 2018 Oct;37(5):352-357. Epub 2018 Feb 1 doi: 10.1080/01676830.2017.1423354. PMID: 29388848
Orbital melanoma.
Furdova A, Chynoransky M, Krajcova P
Bratisl Lek Listy 2011;112(8):466-8. PMID: 21863619

Diagnosis

Primary orbital melanoma arising in an atypical diffuse (plaque-like) blue naevus/melanocytosis: a case report and review of literature.
Dickens TA, Franchina M, Gajdatsy A, Mesbah Ardakani N
BMC Ophthalmol 2021 Dec 9;21(1):425. doi: 10.1186/s12886-021-02176-y. PMID: 34886849Free PMC Article
Primary orbital melanoma: A report of a case and comprehensive review of the literature.
Adetunji MO, McGeehan B, Lee V, Maguire MG, Briceño CA
Orbit 2021 Dec;40(6):461-469. Epub 2020 Sep 9 doi: 10.1080/01676830.2020.1818265. PMID: 32900269Free PMC Article
Primary orbital melanoma: a case series and literature review.
Figueira E, Rajak S, McKelvie P, Kalantzis G, Ismail A, Gonzales M, James C, McNab A, Selva D
Orbit 2018 Oct;37(5):352-357. Epub 2018 Feb 1 doi: 10.1080/01676830.2017.1423354. PMID: 29388848
Orbital melanoma.
Furdova A, Chynoransky M, Krajcova P
Bratisl Lek Listy 2011;112(8):466-8. PMID: 21863619
Ocular melanoma: relatively rare but requiring respect.
Shields CL, Shields JA
Clin Dermatol 2009 Jan-Feb;27(1):122-33. doi: 10.1016/j.clindermatol.2008.09.010. PMID: 19095158

Therapy

Treatment response and recurrence of conjunctival melanoma with orbital invasion treated with immune checkpoint inhibitors: case report and literature review.
Alhammad FA, Alburayk KB, Albadri KS, Butt SA, Azam F
Orbit 2024 Feb;43(1):49-57. Epub 2023 Apr 13 doi: 10.1080/01676830.2023.2191273. PMID: 37052129
Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.
Liu X, Yue H, Jiang S, Kong L, Xu Y, Chen Y, Wang C, Wang Y, Zhu X, Kong Y, Zhang X, Qian J, Luo Z
Cancer Med 2023 Aug;12(15):16163-16172. Epub 2023 Jul 6 doi: 10.1002/cam4.6273. PMID: 37409486Free PMC Article
Radiation therapy for deep periocular cancer treatments when protons are unavailable: is combining electrons and orthovoltage therapy beneficial?
Martell K, Poirier Y, Zhang T, Hudson A, Spencer D, Jacso F, Hayashi R, Banerjee R, Khan R, Wolfe N, Voroney JP
J Radiat Res 2018 Sep 1;59(5):593-603. doi: 10.1093/jrr/rry045. PMID: 30053071Free PMC Article
New Translational Research in the Medical Management of Orbital Melanoma.
Dagi Glass L, Sullivan R, Freitag SK
Semin Ophthalmol 2016;31(1-2):53-8. doi: 10.3109/08820538.2015.1114849. PMID: 26959130
Plaque radiotherapy for selected orbital malignancies: preliminary observations: the 2002 Montgomery Lecture, part 2.
Shields JA, Shields CL, Freire JE, Brady LW, Komarnicky L
Ophthalmic Plast Reconstr Surg 2003 Mar;19(2):91-5. doi: 10.1097/01.IOP.0000056020.66654.33. PMID: 12644752

Prognosis

Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.
Liu X, Yue H, Jiang S, Kong L, Xu Y, Chen Y, Wang C, Wang Y, Zhu X, Kong Y, Zhang X, Qian J, Luo Z
Cancer Med 2023 Aug;12(15):16163-16172. Epub 2023 Jul 6 doi: 10.1002/cam4.6273. PMID: 37409486Free PMC Article
Extrascleral extension of choroidal melanoma after iodine-125 brachytherapy treatment: a case series.
Mustak H, Lo C, Cohen LM, Tran A, Almanzor R, McCannel TA, Goldberg RA, Rootman DB
Eye (Lond) 2023 Feb;37(2):249-255. Epub 2022 Jan 5 doi: 10.1038/s41433-021-01861-y. PMID: 34987200Free PMC Article
Genetic Profiling of Primary Orbital Melanoma: An Analysis of 6 Cases with Clinicopathologic Correlation.
Mudhar HS, Doherty RE, Salvi SM, Currie ZI, Tan JH, Sisley K
Ophthalmology 2019 Jul;126(7):1045-1052. Epub 2018 Dec 31 doi: 10.1016/j.ophtha.2018.12.047. PMID: 30605742
Primary orbital melanoma: a case series and literature review.
Figueira E, Rajak S, McKelvie P, Kalantzis G, Ismail A, Gonzales M, James C, McNab A, Selva D
Orbit 2018 Oct;37(5):352-357. Epub 2018 Feb 1 doi: 10.1080/01676830.2017.1423354. PMID: 29388848
Ocular melanoma: relatively rare but requiring respect.
Shields CL, Shields JA
Clin Dermatol 2009 Jan-Feb;27(1):122-33. doi: 10.1016/j.clindermatol.2008.09.010. PMID: 19095158

Clinical prediction guides

Extrascleral extension of choroidal melanoma after iodine-125 brachytherapy treatment: a case series.
Mustak H, Lo C, Cohen LM, Tran A, Almanzor R, McCannel TA, Goldberg RA, Rootman DB
Eye (Lond) 2023 Feb;37(2):249-255. Epub 2022 Jan 5 doi: 10.1038/s41433-021-01861-y. PMID: 34987200Free PMC Article
Genetic Alterations in Melanocytoma Associated with Oculodermal Melanocytosis: Molecular Characteristics.
Claxton MR, Dalvin LA, Guo R, Tooley AA
Ophthalmic Plast Reconstr Surg 2022 May-Jun 01;38(3):e77-e80. Epub 2021 Dec 16 doi: 10.1097/IOP.0000000000002115. PMID: 34919071
Primary Orbital Melanoma: An Investigation of a Rare Malignancy Using the National Cancer Database.
Caplan IF, Prasad A, Carey RM, Brody RM, Cannady SB, Rajasekaran K, Bur AM, Lukens JN, Briceño CA, Newman JG, Brant JA
Laryngoscope 2021 Aug;131(8):1790-1797. Epub 2021 Feb 11 doi: 10.1002/lary.29428. PMID: 33570180
Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis.
Rose AM, Luo R, Radia UK, Kalirai H, Thornton S, Luthert PJ, Jayasena CN, Verity DH, Coupland SE, Rose GE
BMC Cancer 2018 Dec 17;18(1):1262. doi: 10.1186/s12885-018-5190-z. PMID: 30558566Free PMC Article
7T MR of intracranial pathology: Preliminary observations and comparisons to 3T and 1.5T.
Obusez EC, Lowe M, Oh SH, Wang I, Jennifer Bullen, Ruggieri P, Hill V, Lockwood D, Emch T, Moon D, Loy G, Lee J, Kiczek M, Manoj Massand, Statsevych V, Stultz T, Jones SE
Neuroimage 2018 Mar;168:459-476. Epub 2016 Nov 30 doi: 10.1016/j.neuroimage.2016.11.030. PMID: 27915116

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