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Oral Complication

MedGen UID:
857686
•Concept ID:
C3898092
•
Pathologic Function

Definition

Any oral disorder occurring as a consequence of injury to the mouth and lips. [from NCI]

Professional guidelines

PubMed

Surgical management of bisphosphonate-related osteonecrosis of the jaw in oncologic patients: a challenging problem.
Eckardt AM, Lemound J, Lindhorst D, Rana M, Gellrich NC
Anticancer Res 2011 Jun;31(6):2313-8. PMID: 21737657
Dental management of chemoradiation patients.
Chung EM, Sung EC
J Calif Dent Assoc 2006 Sep;34(9):735-42. PMID: 17022298
Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment.
Migliorati CA, Siegel MA, Elting LS
Lancet Oncol 2006 Jun;7(6):508-14. doi: 10.1016/S1470-2045(06)70726-4. PMID: 16750501

Recent clinical studies

Etiology

Probability of oral complications of radiotherapy and chemotherapy for head and neck cancer.
Coelho LHM, Silva CLA, Pedra RC, Rosado LPL, Verner FS, Aquino SN
Gen Dent 2021 Jul-Aug;69(4):70-74. PMID: 34185672
Oral Care for Hematopoietic Stem Cell Transplantation Patients: A Narrative Review.
Samim F, Ten Böhmer KL, Koppelmans RGA, Raber-Durlacher JE, Epstein JB
Oral Health Prev Dent 2019;17(5):413-423. doi: 10.3290/j.ohpd.a43271. PMID: 31612159
Medication-Related Osteonecrosis of the Jaws.
Migliorati CA, Brennan MT, Peterson DE
J Natl Cancer Inst Monogr 2019 Aug 1;2019(53) doi: 10.1093/jncimonographs/lgz009. PMID: 31425596
Periodontitis: oral complication of diabetes.
Preshaw PM, Bissett SM
Endocrinol Metab Clin North Am 2013 Dec;42(4):849-67. Epub 2013 Sep 4 doi: 10.1016/j.ecl.2013.05.012. PMID: 24286953
Paresthesias in dentistry.
Moore PA, Haas DA
Dent Clin North Am 2010 Oct;54(4):715-30. doi: 10.1016/j.cden.2010.06.016. PMID: 20831934

Diagnosis

Using Electronic Dental Records to Assess Osteoradionecrosis Risk in Irradiated Head and Neck Cancer.
Saenthaveesuk P, Kiat-Amnuay S, Walji MF
JDR Clin Trans Res 2023 Jul;8(3):244-256. Epub 2022 Apr 15 doi: 10.1177/23800844221089549. PMID: 35426343
Impact of oral mucositis on oral-health-related quality of life of patients diagnosed with cancer.
Barkokebas A, Silva IH, de Andrade SC, Carvalho AA, Gueiros LA, Paiva SM, Leão JC
J Oral Pathol Med 2015 Oct;44(9):746-51. Epub 2014 Oct 25 doi: 10.1111/jop.12282. PMID: 25345344
Resource utilization in cancer patients with bisphosphonate-associated osteonecrosis of the jaw.
Najm MS, Solomon DH, Woo SB, Treister NS
Oral Dis 2014 Jan;20(1):94-9. Epub 2013 Feb 19 doi: 10.1111/odi.12080. PMID: 23419136Free PMC Article
Extensive dental caries in patients with oral chronic graft-versus-host disease.
Castellarin P, Stevenson K, Biasotto M, Yuan A, Woo SB, Treister NS
Biol Blood Marrow Transplant 2012 Oct;18(10):1573-9. Epub 2012 Apr 16 doi: 10.1016/j.bbmt.2012.04.009. PMID: 22516054
Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper.
Migliorati CA, Casiglia J, Epstein J, Jacobsen PL, Siegel MA, Woo SB
J Am Dent Assoc 2005 Dec;136(12):1658-68. doi: 10.14219/jada.archive.2005.0108. PMID: 16383047

Therapy

Chemotherapy-Induced Oral Complications and Prophylaxis Strategies.
Śledzińska A, Śledzińska P, Bebyn M, Komisarek O
Cancer Invest 2023 May;41(5):432-455. Epub 2023 Apr 20 doi: 10.1080/07357907.2023.2188558. PMID: 36892292
Probability of oral complications of radiotherapy and chemotherapy for head and neck cancer.
Coelho LHM, Silva CLA, Pedra RC, Rosado LPL, Verner FS, Aquino SN
Gen Dent 2021 Jul-Aug;69(4):70-74. PMID: 34185672
Medication-Related Osteonecrosis of the Jaws.
Migliorati CA, Brennan MT, Peterson DE
J Natl Cancer Inst Monogr 2019 Aug 1;2019(53) doi: 10.1093/jncimonographs/lgz009. PMID: 31425596
Periodontitis: oral complication of diabetes.
Preshaw PM, Bissett SM
Endocrinol Metab Clin North Am 2013 Dec;42(4):849-67. Epub 2013 Sep 4 doi: 10.1016/j.ecl.2013.05.012. PMID: 24286953
Paresthesias in dentistry.
Moore PA, Haas DA
Dent Clin North Am 2010 Oct;54(4):715-30. doi: 10.1016/j.cden.2010.06.016. PMID: 20831934

Prognosis

Thalidomide attenuates oral epithelial cell apoptosis and pro-inflammatory cytokines secretion induced by radiotherapy via the miR-9-3p/NFATC2/NF-κB axis.
Liang L, Chen L, Liu G, Jiang L, Que L, Chen J, Wang R, Zhu H
Biochem Biophys Res Commun 2022 May 7;603:102-108. Epub 2022 Mar 7 doi: 10.1016/j.bbrc.2022.03.030. PMID: 35279460
Medication-Related Osteonecrosis of the Jaws.
Migliorati CA, Brennan MT, Peterson DE
J Natl Cancer Inst Monogr 2019 Aug 1;2019(53) doi: 10.1093/jncimonographs/lgz009. PMID: 31425596
Elucidating the role of hyposalivation and autoimmunity in oral candidiasis.
Billings M, Dye BA, Iafolla T, Grisius M, Alevizos I
Oral Dis 2017 Apr;23(3):387-394. Epub 2017 Feb 8 doi: 10.1111/odi.12626. PMID: 27998016Free PMC Article
Amoxicillin prophylaxis in oral surgery.
Sixou M, Burban J, Lakhssassi N, Duran D, De Mello G, Quéro J
Rev Stomatol Chir Maxillofac 2012 Nov;113(5):358-64. Epub 2012 Oct 1 doi: 10.1016/j.stomax.2011.12.017. PMID: 23036921
Osteonecrosis of the jaw: an update and review of recommendations.
Novince CM, Ward BB, McCauley LK
Cells Tissues Organs 2009;189(1-4):275-83. Epub 2008 Sep 1 doi: 10.1159/000152915. PMID: 18765930

Clinical prediction guides

Using Electronic Dental Records to Assess Osteoradionecrosis Risk in Irradiated Head and Neck Cancer.
Saenthaveesuk P, Kiat-Amnuay S, Walji MF
JDR Clin Trans Res 2023 Jul;8(3):244-256. Epub 2022 Apr 15 doi: 10.1177/23800844221089549. PMID: 35426343
Thalidomide attenuates oral epithelial cell apoptosis and pro-inflammatory cytokines secretion induced by radiotherapy via the miR-9-3p/NFATC2/NF-κB axis.
Liang L, Chen L, Liu G, Jiang L, Que L, Chen J, Wang R, Zhu H
Biochem Biophys Res Commun 2022 May 7;603:102-108. Epub 2022 Mar 7 doi: 10.1016/j.bbrc.2022.03.030. PMID: 35279460
Factors associated with oral health-related quality of life in patients with diabetes.
Azogui-Lévy S, Dray-Spira R, Attal S, Hartemann A, Anagnostou F, Azerad J
Aust Dent J 2018 Jun;63(2):163-169. Epub 2018 Jan 15 doi: 10.1111/adj.12577. PMID: 29140554
Elucidating the role of hyposalivation and autoimmunity in oral candidiasis.
Billings M, Dye BA, Iafolla T, Grisius M, Alevizos I
Oral Dis 2017 Apr;23(3):387-394. Epub 2017 Feb 8 doi: 10.1111/odi.12626. PMID: 27998016Free PMC Article
Oral complication risks after invasive and non-invasive dental procedures in HIV-positive patients.
Campo J, Cano J, del Romero J, Hernando V, Rodríguez C, Bascones A
Oral Dis 2007 Jan;13(1):110-6. doi: 10.1111/j.1601-0825.2006.01262.x. PMID: 17241440

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