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Normal Virilization

MedGen UID:
857716
•Concept ID:
C3898122
•
Finding

Definition

The normal development of male secondary sexual characteristics (such as hirsutism, deepening of the voice) in pubertal boys due to testosterone effects. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNormal Virilization

Professional guidelines

PubMed

Management of Growth Disorders in Puberty: GH, GnRHa, and Aromatase Inhibitors: A Clinical Review.
Mauras N, Ross J, Mericq V
Endocr Rev 2023 Jan 12;44(1):1-13. doi: 10.1210/endrev/bnac014. PMID: 35639981

Recent clinical studies

Etiology

Long-term follow-up of a child with Klinefelter syndrome and achondroplasia from infancy to 16 years.
Arditi JD, Thomaidis L, Frysira H, Doulgeraki A, Chrousos GP, Kanaka-Gantenbein C
J Pediatr Endocrinol Metab 2017 Jul 26;30(7):797-803. doi: 10.1515/jpem-2016-0362. PMID: 28672740
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up.
Raffin-Sanson ML, Oudet B, Salenave S, Brailly-Tabard S, Pehuet M, Christin-Maitre S, Morel Y, Young J
Eur J Endocrinol 2013 Apr;168(4):K45-50. Epub 2013 Mar 15 doi: 10.1530/EJE-12-1055. PMID: 23384712
45,X/46,XY mosaicism: phenotypic characteristics, growth, and reproductive function--a retrospective longitudinal study.
Lindhardt Johansen M, Hagen CP, Rajpert-De Meyts E, Kjærgaard S, Petersen BL, Skakkebæk NE, Main KM, Juul A
J Clin Endocrinol Metab 2012 Aug;97(8):E1540-9. Epub 2012 May 17 doi: 10.1210/jc.2012-1388. PMID: 22605431
An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys.
Mauras N, Welch S, Rini A, Klein KO
J Pediatr Endocrinol Metab 2004 Dec;17(12):1597-606. doi: 10.1515/jpem.2004.17.12.1597. PMID: 15645693
Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion.
MacLean HE, Warne GL, Zajac JD
J Neurol Sci 1996 Feb;135(2):149-57. doi: 10.1016/0022-510x(95)00284-9. PMID: 8867071

Diagnosis

Isolated follicle-stimulating hormone (FSH) deficiency in two infertile men without FSH β gene mutation: Case report and literature review.
Rougier C, Hieronimus S, Panaïa-Ferrari P, Lahlou N, Paris F, Fenichel P
Ann Endocrinol (Paris) 2019 Sep;80(4):234-239. Epub 2019 Jul 8 doi: 10.1016/j.ando.2019.06.002. PMID: 31439307
Long-term follow-up of a child with Klinefelter syndrome and achondroplasia from infancy to 16 years.
Arditi JD, Thomaidis L, Frysira H, Doulgeraki A, Chrousos GP, Kanaka-Gantenbein C
J Pediatr Endocrinol Metab 2017 Jul 26;30(7):797-803. doi: 10.1515/jpem-2016-0362. PMID: 28672740
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up.
Raffin-Sanson ML, Oudet B, Salenave S, Brailly-Tabard S, Pehuet M, Christin-Maitre S, Morel Y, Young J
Eur J Endocrinol 2013 Apr;168(4):K45-50. Epub 2013 Mar 15 doi: 10.1530/EJE-12-1055. PMID: 23384712

Therapy

Management of Growth Disorders in Puberty: GH, GnRHa, and Aromatase Inhibitors: A Clinical Review.
Mauras N, Ross J, Mericq V
Endocr Rev 2023 Jan 12;44(1):1-13. doi: 10.1210/endrev/bnac014. PMID: 35639981
45,X/46,XY mosaicism: phenotypic characteristics, growth, and reproductive function--a retrospective longitudinal study.
Lindhardt Johansen M, Hagen CP, Rajpert-De Meyts E, Kjærgaard S, Petersen BL, Skakkebæk NE, Main KM, Juul A
J Clin Endocrinol Metab 2012 Aug;97(8):E1540-9. Epub 2012 May 17 doi: 10.1210/jc.2012-1388. PMID: 22605431
An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys.
Mauras N, Welch S, Rini A, Klein KO
J Pediatr Endocrinol Metab 2004 Dec;17(12):1597-606. doi: 10.1515/jpem.2004.17.12.1597. PMID: 15645693
Successful gonadotrophin treatment of hypogonadism in postoperative patients with macroprolactinoma and persistent hyperprolactinaemia.
Isurugi K, Kajiwara T, Hosaka Y, Minowada S
Int J Androl 1993 Oct;16(5):306-10. doi: 10.1111/j.1365-2605.1993.tb01196.x. PMID: 8276523

Prognosis

Long-term follow-up of a child with Klinefelter syndrome and achondroplasia from infancy to 16 years.
Arditi JD, Thomaidis L, Frysira H, Doulgeraki A, Chrousos GP, Kanaka-Gantenbein C
J Pediatr Endocrinol Metab 2017 Jul 26;30(7):797-803. doi: 10.1515/jpem-2016-0362. PMID: 28672740
A man with a DAX1/NR0B1 mutation, normal puberty, and an intact hypothalamic-pituitary-gonadal axis but deteriorating oligospermia during long-term follow-up.
Raffin-Sanson ML, Oudet B, Salenave S, Brailly-Tabard S, Pehuet M, Christin-Maitre S, Morel Y, Young J
Eur J Endocrinol 2013 Apr;168(4):K45-50. Epub 2013 Mar 15 doi: 10.1530/EJE-12-1055. PMID: 23384712
An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys.
Mauras N, Welch S, Rini A, Klein KO
J Pediatr Endocrinol Metab 2004 Dec;17(12):1597-606. doi: 10.1515/jpem.2004.17.12.1597. PMID: 15645693
Successful gonadotrophin treatment of hypogonadism in postoperative patients with macroprolactinoma and persistent hyperprolactinaemia.
Isurugi K, Kajiwara T, Hosaka Y, Minowada S
Int J Androl 1993 Oct;16(5):306-10. doi: 10.1111/j.1365-2605.1993.tb01196.x. PMID: 8276523

Clinical prediction guides

45,X/46,XY mosaicism: phenotypic characteristics, growth, and reproductive function--a retrospective longitudinal study.
Lindhardt Johansen M, Hagen CP, Rajpert-De Meyts E, Kjærgaard S, Petersen BL, Skakkebæk NE, Main KM, Juul A
J Clin Endocrinol Metab 2012 Aug;97(8):E1540-9. Epub 2012 May 17 doi: 10.1210/jc.2012-1388. PMID: 22605431
An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys.
Mauras N, Welch S, Rini A, Klein KO
J Pediatr Endocrinol Metab 2004 Dec;17(12):1597-606. doi: 10.1515/jpem.2004.17.12.1597. PMID: 15645693
Testicular degeneration in three patients with the persistent müllerian duct syndrome.
Imbeaud S, Rey R, Berta P, Chaussain JL, Wit JM, Lustig RH, De Vroede MA, Picard JY, Josso N
Eur J Pediatr 1995 Mar;154(3):187-90. doi: 10.1007/BF01954268. PMID: 7758514

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