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Neonatal Spell

MedGen UID:
857740
•Concept ID:
C3898146
•
Disease or Syndrome
Synonym: Neonatal Spells

Definition

Cardiorespiratory events that are characterized by variable combinations of cessation of breathing, decrease in blood oxygen saturation, and decreased heart rate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Spell

Professional guidelines

PubMed

Staring Spells: An Age-based Approach Toward Differential Diagnosis.
Goenka A, Reyes I, Fonseca LD, George MC, Stolfi A, Kumar G
J Child Neurol 2023 Feb;38(1-2):64-77. Epub 2022 Nov 13 doi: 10.1177/08830738221134552. PMID: 36373696
Hyperekplexia: Report on phenotype and genotype of 16 Jordanian patients.
Masri A, Chung SK, Rees MI
Brain Dev 2017 Apr;39(4):306-311. Epub 2016 Nov 11 doi: 10.1016/j.braindev.2016.10.010. PMID: 27843043
Management Issues in Intensive Care Units for Infants and Children with Heart Disease.
Iyer PU
Indian J Pediatr 2015 Dec;82(12):1164-71. Epub 2015 Nov 6 doi: 10.1007/s12098-015-1914-0. PMID: 26542311

Recent clinical studies

Etiology

Missed Opportunities and the Impact of the Pandemic.
Sabapathy T, Bansal R, Bojorquez L, Salley B, Gianakon JG, Gelineau-Morel R, Nyp SS
J Dev Behav Pediatr 2022 Apr 1;43(3):176-179. Epub 2022 Jan 26 doi: 10.1097/DBP.0000000000001065. PMID: 35085180Free PMC Article
Paediatric anterior larynx: presentations, associations and a review of the literature.
Smaily H, El-Hakim I, El-Hakim H
Clin Otolaryngol 2022 Mar;47(2):313-318. Epub 2022 Jan 13 doi: 10.1111/coa.13908. PMID: 34954910
Cold spell and mortality in 31 Chinese capital cities: Definitions, vulnerability and implications.
Chen J, Yang J, Zhou M, Yin P, Wang B, Liu J, Chen Z, Song X, Ou CQ, Liu Q
Environ Int 2019 Jul;128:271-278. Epub 2019 May 6 doi: 10.1016/j.envint.2019.04.049. PMID: 31071590
A systematic approach to autoinflammatory syndromes: a spelling booklet for the beginner.
Rigante D
Expert Rev Clin Immunol 2017 Jun;13(6):571-597. Epub 2017 Feb 1 doi: 10.1080/1744666X.2017.1280396. PMID: 28064547
Paroxysmal nonepileptic events in infancy, childhood, and adolescence.
Luat AF, Kamat D, Sivaswamy L
Pediatr Ann 2015 Feb;44(2):e18-23. doi: 10.3928/00904481-20150203-07. PMID: 25658214

Diagnosis

Interoception in Practice: The Gut-Brain Connection.
Genovese A, Moore T, Haynes PC, Augustyn M
J Dev Behav Pediatr 2022 Oct-Nov 01;43(8):489-491. Epub 2022 Aug 30 doi: 10.1097/DBP.0000000000001121. PMID: 36040816
Missed Opportunities and the Impact of the Pandemic.
Sabapathy T, Bansal R, Bojorquez L, Salley B, Gianakon JG, Gelineau-Morel R, Nyp SS
J Dev Behav Pediatr 2022 Apr 1;43(3):176-179. Epub 2022 Jan 26 doi: 10.1097/DBP.0000000000001065. PMID: 35085180Free PMC Article
Paediatric anterior larynx: presentations, associations and a review of the literature.
Smaily H, El-Hakim I, El-Hakim H
Clin Otolaryngol 2022 Mar;47(2):313-318. Epub 2022 Jan 13 doi: 10.1111/coa.13908. PMID: 34954910
Breath-holding spells.
Breningstall GN
Pediatr Neurol 1996 Feb;14(2):91-7. doi: 10.1016/0887-8994(96)00006-9. PMID: 8703234
Apnea monitors--1982.
Stark AR
Med Instrum 1982 May-Jun;16(3):160-2. PMID: 7109998

Therapy

Are we over-treating hypoxic spells in preterm infants?
Conlon S, Di Fiore JM, Martin RJ
Semin Fetal Neonatal Med 2021 Jun;26(3):101227. Epub 2021 Mar 8 doi: 10.1016/j.siny.2021.101227. PMID: 33736905
The epileptology of alternating hemiplegia of childhood.
Uchitel J, Helseth A, Prange L, McLean M, Ghusayni R, Sachdev M, Hunanyan A, Mikati MA
Neurology 2019 Sep 24;93(13):e1248-e1259. Epub 2019 Sep 4 doi: 10.1212/WNL.0000000000008159. PMID: 31484714
Cold spell and mortality in 31 Chinese capital cities: Definitions, vulnerability and implications.
Chen J, Yang J, Zhou M, Yin P, Wang B, Liu J, Chen Z, Song X, Ou CQ, Liu Q
Environ Int 2019 Jul;128:271-278. Epub 2019 May 6 doi: 10.1016/j.envint.2019.04.049. PMID: 31071590
Update on pertussis in children.
Heininger U
Expert Rev Anti Infect Ther 2010 Feb;8(2):163-73. doi: 10.1586/eri.09.124. PMID: 20109046
The effects of benzodiazepine use during pregnancy and lactation.
McElhatton PR
Reprod Toxicol 1994 Nov-Dec;8(6):461-75. doi: 10.1016/0890-6238(94)90029-9. PMID: 7881198

Prognosis

Cold spell and mortality in 31 Chinese capital cities: Definitions, vulnerability and implications.
Chen J, Yang J, Zhou M, Yin P, Wang B, Liu J, Chen Z, Song X, Ou CQ, Liu Q
Environ Int 2019 Jul;128:271-278. Epub 2019 May 6 doi: 10.1016/j.envint.2019.04.049. PMID: 31071590
Maternal immunization: A call to accelerate progress.
Bardají A, MacDonald NE, Omer SB, Aguado T
Vaccine 2019 May 16;37(22):2882-2883. Epub 2019 Apr 20 doi: 10.1016/j.vaccine.2019.04.031. PMID: 31014962
Conal septal morphometrics can identify higher risk neonates with tetralogy of Fallot.
Uppu SC, Dyamenahalli U, Sachdeva R, Imamura M, Morrow WR, Gossett JM, Swearingen CJ, Vyas HV
J Am Soc Echocardiogr 2013 Feb;26(2):200-7. Epub 2012 Dec 6 doi: 10.1016/j.echo.2012.10.020. PMID: 23218966
Evolution and natural history of chronic lung disease of prematurity.
Hulsmann AR, van den Anker JN
Monaldi Arch Chest Dis 1997 Jun;52(3):272-7. PMID: 9270256
Pertussis in neonates.
Christie CD, Baltimore RS
Am J Dis Child 1989 Oct;143(10):1199-202. doi: 10.1001/archpedi.1989.02150220097027. PMID: 2801662

Clinical prediction guides

Academic skills after brain injury: A lifespan perspective.
Sullivan AW, Bowren MD, Bruss J, Tranel D, Demir-Lira ÖE
Neuropsychology 2022 Jul;36(5):419-432. Epub 2022 Apr 14 doi: 10.1037/neu0000806. PMID: 35420857Free PMC Article
Non-Epileptic Paroxysmal Events: Clinical features and diagnostic differences with epileptic seizures. A Single Tertiary Centre Study.
Sullo F, Venti V, Catania R, Smilari P, Greco F, Pustorino E, Fiumara A, Raucci U, Falsaperla R, Marino S, Pavone P
Clin Neurol Neurosurg 2021 Aug;207:106739. Epub 2021 Jun 8 doi: 10.1016/j.clineuro.2021.106739. PMID: 34157509
The epileptology of alternating hemiplegia of childhood.
Uchitel J, Helseth A, Prange L, McLean M, Ghusayni R, Sachdev M, Hunanyan A, Mikati MA
Neurology 2019 Sep 24;93(13):e1248-e1259. Epub 2019 Sep 4 doi: 10.1212/WNL.0000000000008159. PMID: 31484714
Conal septal morphometrics can identify higher risk neonates with tetralogy of Fallot.
Uppu SC, Dyamenahalli U, Sachdeva R, Imamura M, Morrow WR, Gossett JM, Swearingen CJ, Vyas HV
J Am Soc Echocardiogr 2013 Feb;26(2):200-7. Epub 2012 Dec 6 doi: 10.1016/j.echo.2012.10.020. PMID: 23218966
The Baller-Gerold syndrome.
Van Maldergem L, Verloes A, Lejeune L, Gillerot Y
J Med Genet 1992 Apr;29(4):266-8. doi: 10.1136/jmg.29.4.266. PMID: 1583650Free PMC Article

Recent systematic reviews

Gestational diabetes mellitus and its associated factors in Ethiopia: a systematic review and meta-analysis.
Beyene FY, Kassa BG, Mihretie GN, Ayele AD
Eur J Med Res 2023 Mar 15;28(1):125. doi: 10.1186/s40001-023-01088-5. PMID: 36922857Free PMC Article
Cognitive, motor, behavioural and academic performances of children born preterm: a meta-analysis and systematic review involving 64 061 children.
Allotey J, Zamora J, Cheong-See F, Kalidindi M, Arroyo-Manzano D, Asztalos E, van der Post J, Mol BW, Moore D, Birtles D, Khan KS, Thangaratinam S
BJOG 2018 Jan;125(1):16-25. Epub 2017 Oct 11 doi: 10.1111/1471-0528.14832. PMID: 29024294
Impact of ambient temperature on children's health: a systematic review.
Xu Z, Etzel RA, Su H, Huang C, Guo Y, Tong S
Environ Res 2012 Aug;117:120-31. Epub 2012 Jul 23 doi: 10.1016/j.envres.2012.07.002. PMID: 22831555

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