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Moderate Bronchopulmonary Dysplasia

MedGen UID:
857873
Concept ID:
C3898279
Disease or Syndrome

Definition

A chronic lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates exposed to supplemental oxygen for at least 28 days. For infants born before 32 weeks gestation with moderate BPD, there is a supplemental oxygen requirement of less than 30% at 36 weeks postmenstrual age or earlier discharge. For infants born after 32 weeks with moderate BPD, there is a supplemental oxygen requirement of less than 30% at 56 days post-natal age or at earlier discharge. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate Bronchopulmonary Dysplasia

Professional guidelines

PubMed

Jensen EA, Wiener LE, Rysavy MA, Dysart KC, Gantz MG, Eichenwald EC, Greenberg RG, Harmon HM, Laughon MM, Watterberg KL, Walsh MC, Yoder BA, Lorch SA, DeMauro SB; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JAMA Netw Open 2023 May 1;6(5):e2312277. doi: 10.1001/jamanetworkopen.2023.12277. PMID: 37155165Free PMC Article
Weisz DE, Giesinger RE
Semin Fetal Neonatal Med 2018 Aug;23(4):255-266. Epub 2018 Mar 7 doi: 10.1016/j.siny.2018.03.003. PMID: 29636280
Baraldi E, Lanari M, Manzoni P, Rossi GA, Vandini S, Rimini A, Romagnoli C, Colonna P, Biondi A, Biban P, Chiamenti G, Bernardini R, Picca M, Cappa M, Magazzù G, Catassi C, Urbino AF, Memo L, Donzelli G, Minetti C, Paravati F, Di Mauro G, Festini F, Esposito S, Corsello G
Ital J Pediatr 2014 Oct 24;40:65. doi: 10.1186/1824-7288-40-65. PMID: 25344148Free PMC Article

Recent clinical studies

Etiology

Yum SK, Lee JH
Pediatr Neonatol 2023 Sep;64(5):570-576. Epub 2023 Mar 15 doi: 10.1016/j.pedneo.2022.12.014. PMID: 36967292
Zübarioğlu AU, Dursun M
Indian J Pediatr 2021 Sep;88(9):905-911. Epub 2021 Apr 16 doi: 10.1007/s12098-021-03691-y. PMID: 33860883
Kurata H, Ochiai M, Inoue H, Ichiyama M, Yasuoka K, Fujiyoshi J, Matsushita Y, Honjo S, Sakai Y, Ohga S; Neonatal Research Network of Japan
Pediatr Pulmonol 2019 Jan;54(1):53-60. Epub 2018 Dec 7 doi: 10.1002/ppul.24200. PMID: 30525314
Greenough A, Dimitriou G, Bhat RY, Broughton S, Hannam S, Rafferty GF, Leipälä JA
Eur J Pediatr 2005 Sep;164(9):583-6. Epub 2005 Jun 4 doi: 10.1007/s00431-005-1706-z. PMID: 15937699
Dugas MA, Nguyen D, Frenette L, Lachance C, St-Onge O, Fougères A, Bélanger S, Caouette G, Proulx E, Racine MC, Piedboeuf B
Pediatrics 2005 May;115(5):e566-72. Epub 2005 Apr 15 doi: 10.1542/peds.2004-0951. PMID: 15833887

Diagnosis

Yoo HS, Sung SI, Jung YJ, Lee MS, Han YM, Ahn SY, Chang YS, Park WS
Yonsei Med J 2015 Jul;56(4):998-1006. doi: 10.3349/ymj.2015.56.4.998. PMID: 26069123Free PMC Article
Farhath S, He Z, Nakhla T, Saslow J, Soundar S, Camacho J, Stahl G, Shaffer S, Mehta DI, Aghai ZH
Pediatrics 2008 Feb;121(2):e253-9. doi: 10.1542/peds.2007-0056. PMID: 18245400

Therapy

Höck M, Brunner B, Rier V, Thöni S, Trawöger R, Geiger R, Schermer E, Karall T, Kiechl-Kohlendorfer U
Pediatr Neonatol 2020 Feb;61(1):84-91. Epub 2019 Jul 3 doi: 10.1016/j.pedneo.2019.06.011. PMID: 31345732
Dugas MA, Nguyen D, Frenette L, Lachance C, St-Onge O, Fougères A, Bélanger S, Caouette G, Proulx E, Racine MC, Piedboeuf B
Pediatrics 2005 May;115(5):e566-72. Epub 2005 Apr 15 doi: 10.1542/peds.2004-0951. PMID: 15833887

Prognosis

Kurata H, Ochiai M, Inoue H, Ichiyama M, Yasuoka K, Fujiyoshi J, Matsushita Y, Honjo S, Sakai Y, Ohga S; Neonatal Research Network of Japan
Pediatr Pulmonol 2019 Jan;54(1):53-60. Epub 2018 Dec 7 doi: 10.1002/ppul.24200. PMID: 30525314
Yoo HS, Sung SI, Jung YJ, Lee MS, Han YM, Ahn SY, Chang YS, Park WS
Yonsei Med J 2015 Jul;56(4):998-1006. doi: 10.3349/ymj.2015.56.4.998. PMID: 26069123Free PMC Article
Greenough A, Dimitriou G, Bhat RY, Broughton S, Hannam S, Rafferty GF, Leipälä JA
Eur J Pediatr 2005 Sep;164(9):583-6. Epub 2005 Jun 4 doi: 10.1007/s00431-005-1706-z. PMID: 15937699

Clinical prediction guides

van Heugten M, van Onzenoort-Bokken L
Pediatr Emerg Care 2021 Dec 1;37(12):e866-e867. doi: 10.1097/PEC.0000000000002472. PMID: 34101683
Greenough A, Dimitriou G, Bhat RY, Broughton S, Hannam S, Rafferty GF, Leipälä JA
Eur J Pediatr 2005 Sep;164(9):583-6. Epub 2005 Jun 4 doi: 10.1007/s00431-005-1706-z. PMID: 15937699
Dugas MA, Nguyen D, Frenette L, Lachance C, St-Onge O, Fougères A, Bélanger S, Caouette G, Proulx E, Racine MC, Piedboeuf B
Pediatrics 2005 May;115(5):e566-72. Epub 2005 Apr 15 doi: 10.1542/peds.2004-0951. PMID: 15833887
Mayhew JF, Bourke DL, Guinee WS
Can J Anaesth 1987 Nov;34(6):627-31. doi: 10.1007/BF03010525. PMID: 3677290

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