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Mixed Morphea

MedGen UID:
857874
•Concept ID:
C3898280
•
Disease or Syndrome

Definition

The presence of more than one variant of morphea in a single patient. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed Morphea

Professional guidelines

PubMed

S2k guideline: Diagnosis and therapy of localized scleroderma.
Kreuter A, Moinzadeh P, Kinberger M, Horneff G, Worm M, Werner RN, Hammacher A, Krieg T, Wenzel J, Oeschger M, Weibel L, Müllegger R, Hunzelmann N
J Dtsch Dermatol Ges 2024 Apr;22(4):605-620. Epub 2024 Mar 1 doi: 10.1111/ddg.15328. PMID: 38426689
Management of rheumatic and autoimmune blistering disease in pregnancy and postpartum.
Wan J, Imadojemu S, Werth VP
Clin Dermatol 2016 May-Jun;34(3):344-52. Epub 2016 Feb 9 doi: 10.1016/j.clindermatol.2016.02.006. PMID: 27265072

Recent clinical studies

Etiology

Extracutaneous involvement is common and associated with prolonged disease activity and greater impact in juvenile localized scleroderma.
Li SC, Higgins GC, Chen M, Torok KS, Rabinovich CE, Stewart K, Laxer RM, Pope E, Haines KA, Punaro M, O'Neil KM; Childhood Arthritis and Rheumatology Research Alliance Localized Scleroderma Clinical and Ultrasound Study group
Rheumatology (Oxford) 2021 Dec 1;60(12):5724-5733. doi: 10.1093/rheumatology/keab238. PMID: 33711155
An Evaluation of the Performance of Current Morphea Subtype Classifications.
Prasad S, Zhu JL, Schollaert-Fitch K, Torok KS, Jacobe HT
JAMA Dermatol 2021 Apr 1;157(4):1-8. doi: 10.1001/jamadermatol.2020.5809. PMID: 33595618Free PMC Article
A retrospective study on clinical subtypes and management of morphea in 10 Italian Dermatological Units.
Virdi A, Patrizi A, Cambiaghi S, Diociaiuti A, El Hachem M, Schena D, Bassi A, Bonamonte D, Brazzelli V, Belloni Fortina A, Pepe P, DI Lernia V, Neri I
Ital J Dermatol Venerol 2021 Aug;156(4):446-454. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06632-8. PMID: 33070566
Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article

Diagnosis

Extracutaneous involvement is common and associated with prolonged disease activity and greater impact in juvenile localized scleroderma.
Li SC, Higgins GC, Chen M, Torok KS, Rabinovich CE, Stewart K, Laxer RM, Pope E, Haines KA, Punaro M, O'Neil KM; Childhood Arthritis and Rheumatology Research Alliance Localized Scleroderma Clinical and Ultrasound Study group
Rheumatology (Oxford) 2021 Dec 1;60(12):5724-5733. doi: 10.1093/rheumatology/keab238. PMID: 33711155
An Evaluation of the Performance of Current Morphea Subtype Classifications.
Prasad S, Zhu JL, Schollaert-Fitch K, Torok KS, Jacobe HT
JAMA Dermatol 2021 Apr 1;157(4):1-8. doi: 10.1001/jamadermatol.2020.5809. PMID: 33595618Free PMC Article
A retrospective study on clinical subtypes and management of morphea in 10 Italian Dermatological Units.
Virdi A, Patrizi A, Cambiaghi S, Diociaiuti A, El Hachem M, Schena D, Bassi A, Bonamonte D, Brazzelli V, Belloni Fortina A, Pepe P, DI Lernia V, Neri I
Ital J Dermatol Venerol 2021 Aug;156(4):446-454. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06632-8. PMID: 33070566
Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article
Scleroderma and dentistry: Two case reports.
Dixit S, Kalkur C, Sattur AP, Bornstein MM, Melton F
J Med Case Rep 2016 Oct 24;10(1):297. doi: 10.1186/s13256-016-1086-1. PMID: 27776552Free PMC Article

Therapy

A retrospective study on clinical subtypes and management of morphea in 10 Italian Dermatological Units.
Virdi A, Patrizi A, Cambiaghi S, Diociaiuti A, El Hachem M, Schena D, Bassi A, Bonamonte D, Brazzelli V, Belloni Fortina A, Pepe P, DI Lernia V, Neri I
Ital J Dermatol Venerol 2021 Aug;156(4):446-454. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06632-8. PMID: 33070566
Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article

Prognosis

Extracutaneous involvement is common and associated with prolonged disease activity and greater impact in juvenile localized scleroderma.
Li SC, Higgins GC, Chen M, Torok KS, Rabinovich CE, Stewart K, Laxer RM, Pope E, Haines KA, Punaro M, O'Neil KM; Childhood Arthritis and Rheumatology Research Alliance Localized Scleroderma Clinical and Ultrasound Study group
Rheumatology (Oxford) 2021 Dec 1;60(12):5724-5733. doi: 10.1093/rheumatology/keab238. PMID: 33711155

Clinical prediction guides

Extracutaneous involvement is common and associated with prolonged disease activity and greater impact in juvenile localized scleroderma.
Li SC, Higgins GC, Chen M, Torok KS, Rabinovich CE, Stewart K, Laxer RM, Pope E, Haines KA, Punaro M, O'Neil KM; Childhood Arthritis and Rheumatology Research Alliance Localized Scleroderma Clinical and Ultrasound Study group
Rheumatology (Oxford) 2021 Dec 1;60(12):5724-5733. doi: 10.1093/rheumatology/keab238. PMID: 33711155
An Evaluation of the Performance of Current Morphea Subtype Classifications.
Prasad S, Zhu JL, Schollaert-Fitch K, Torok KS, Jacobe HT
JAMA Dermatol 2021 Apr 1;157(4):1-8. doi: 10.1001/jamadermatol.2020.5809. PMID: 33595618Free PMC Article
A retrospective study on clinical subtypes and management of morphea in 10 Italian Dermatological Units.
Virdi A, Patrizi A, Cambiaghi S, Diociaiuti A, El Hachem M, Schena D, Bassi A, Bonamonte D, Brazzelli V, Belloni Fortina A, Pepe P, DI Lernia V, Neri I
Ital J Dermatol Venerol 2021 Aug;156(4):446-454. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06632-8. PMID: 33070566
Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article

Recent systematic reviews

Interventions for morphea.
Albuquerque JV, Andriolo BN, Vasconcellos MR, Civile VT, Lyddiatt A, Trevisani VF
Cochrane Database Syst Rev 2019 Jul 16;7(7):CD005027. doi: 10.1002/14651858.CD005027.pub5. PMID: 31309547Free PMC Article

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