U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sinonasal Adenocarcinoma, Intestinal-Type

MedGen UID:
858303
•Concept ID:
C3898709
•
Neoplastic Process
Synonyms: Enteric-Type Sinonasal Adenocarcinoma; Intestinal-Type Sinonasal Adenocarcinoma; Nasal Cavity and Paranasal Sinus Adenocarcinoma, Intestinal-Type

Definition

An adenocarcinoma that arises from the nasal cavity and paranasal sinuses. Histologically it resembles intestinal adenocarcinoma. It is associated with lengthy occupational exposure to dust. [from NCI]

Professional guidelines

PubMed

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Patterns of recurrences in sinonasal cancers undergoing an endoscopic surgery-based treatment: Results of the MUSES* on 940 patients: *MUlti-institutional collaborative Study on Endoscopically treated Sinonasal cancers.
Arosio AD, Bernasconi DP, Valsecchi MG, Pacifico C, Battaglia P, Bignami M, Ferrari M, Mattavelli D, Rampinelli V, Tomasoni M, Schreiber A, Gualtieri T, Piazza C, Magrini SM, Tartaro T, Molteni M, Lambertoni A, Sileo G, Bossi P, Orlandi E, Bertazzoni G, Fiaux-Camous D, Jourdaine C, Verillaud B, Herman P, Nicolai P, Castelnuovo P, Turri-Zanoni M
Oral Oncol 2022 Nov;134:106123. Epub 2022 Sep 26 doi: 10.1016/j.oraloncology.2022.106123. PMID: 36174456
The role of systemic therapy in the management of sinonasal cancer: A critical review.
Bossi P, Saba NF, Vermorken JB, Strojan P, Pala L, de Bree R, Rodrigo JP, Lopez F, Hanna EY, Haigentz M, Takes RP, Slootweg PJ, Silver CE, Rinaldo A, Ferlito A
Cancer Treat Rev 2015 Dec;41(10):836-43. Epub 2015 Jul 31 doi: 10.1016/j.ctrv.2015.07.004. PMID: 26255226

Recent clinical studies

Etiology

Signaling Pathways mTOR and ERK as Therapeutic Targets in Sinonasal Intestinal-Type Adenocarcinoma.
Codina-Martínez H, Lorenzo-Guerra SL, Cabal VN, García-Marín R, Suárez-Fernández L, Vivanco B, Sánchez-Fernández P, López F, Llorente JL, Hermsen MA
Int J Mol Sci 2023 Oct 12;24(20) doi: 10.3390/ijms242015110. PMID: 37894790Free PMC Article
Sinonasal intestinal- and non-intestinal-type adenocarcinoma in China: a retrospective study of 14 cases.
Li G, Shi Y, Liu Q, Zhang H, Xue K, Song X, Gu Y, Sun X, Dai Q, Yu H
Acta Otolaryngol 2023 Feb;143(2):185-190. Epub 2023 Feb 13 doi: 10.1080/00016489.2023.2175032. PMID: 36780311
Sinonasal Non-Intestinal-Type Adenocarcinoma: A Retrospective Review of 22 Patients.
Bignami M, Lepera D, Volpi L, Lambertoni A, Arosio A, Pistochini A, Nicolai P, Castelnuovo P
World Neurosurg 2018 Dec;120:e962-e969. Epub 2018 Sep 6 doi: 10.1016/j.wneu.2018.08.201. PMID: 30196179
Intestinal-type adenocarcinoma of the sinonasal tract: an update.
Rampinelli V, Ferrari M, Nicolai P
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):115-121. doi: 10.1097/MOO.0000000000000445. PMID: 29389737
Nonsalivary sinonasal adenocarcinoma.
Alessi DM, Trapp TK, Fu YS, Calcaterra TC
Arch Otolaryngol Head Neck Surg 1988 Sep;114(9):996-9. doi: 10.1001/archotol.1988.01860210062016. PMID: 3408582

Diagnosis

A Comprehensive Update on Intestinal- and Non-Intestinal-Type Adenocarcinomas.
Vander Poorten V, Jorissen M
Adv Otorhinolaryngol 2020;84:137-153. Epub 2020 Jul 30 doi: 10.1159/000457934. PMID: 32731230
Intestinal-Type Adenocarcinoma: Classification, Immunophenotype, Molecular Features and Differential Diagnosis.
Leivo I
Head Neck Pathol 2017 Sep;11(3):295-300. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0800-7. PMID: 28321774Free PMC Article
Glandular Neoplasia of the Sinonasal Tract.
Stelow EB
Surg Pathol Clin 2017 Mar;10(1):89-102. doi: 10.1016/j.path.2016.10.004. PMID: 28153137
Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment.
Hoeben A, van de Winkel L, Hoebers F, Kross K, Driessen C, Slootweg P, Tjan-Heijnen VC, van Herpen C
Head Neck 2016 Oct;38(10):1564-70. Epub 2016 May 25 doi: 10.1002/hed.24416. PMID: 27224655
Sinonasal Adenocarcinoma: Update on Classification, Immunophenotype and Molecular Features.
Leivo I
Head Neck Pathol 2016 Mar;10(1):68-74. Epub 2016 Feb 1 doi: 10.1007/s12105-016-0694-9. PMID: 26830399Free PMC Article

Therapy

Signaling Pathways mTOR and ERK as Therapeutic Targets in Sinonasal Intestinal-Type Adenocarcinoma.
Codina-Martínez H, Lorenzo-Guerra SL, Cabal VN, García-Marín R, Suárez-Fernández L, Vivanco B, Sánchez-Fernández P, López F, Llorente JL, Hermsen MA
Int J Mol Sci 2023 Oct 12;24(20) doi: 10.3390/ijms242015110. PMID: 37894790Free PMC Article
5-fluorouracil with oxaliplatin and/or irinotecan for advanced sinonasal intestinal-type adenocarcinoma (ITAC).
Sarradin V, Betrian S, Chaltiel L, Brac De La Perriere C, Delord JP
Bull Cancer 2023 Feb;110(2):168-173. Epub 2022 Nov 10 doi: 10.1016/j.bulcan.2022.10.004. PMID: 36372589
MiR-126 in intestinal-type sinonasal adenocarcinomas: exosomal transfer of MiR-126 promotes anti-tumour responses.
Tomasetti M, Re M, Monaco F, Gaetani S, Rubini C, Bertini A, Pasquini E, Bersaglieri C, Bracci M, Staffolani S, Colomba M, Gregorini A, Valentino M, Tagliabracci A, Bovenzi M, Neuzil J, Amati M, Santarelli L
BMC Cancer 2018 Sep 17;18(1):896. doi: 10.1186/s12885-018-4801-z. PMID: 30223817Free PMC Article
The role of systemic therapy in the management of sinonasal cancer: A critical review.
Bossi P, Saba NF, Vermorken JB, Strojan P, Pala L, de Bree R, Rodrigo JP, Lopez F, Hanna EY, Haigentz M, Takes RP, Slootweg PJ, Silver CE, Rinaldo A, Ferlito A
Cancer Treat Rev 2015 Dec;41(10):836-43. Epub 2015 Jul 31 doi: 10.1016/j.ctrv.2015.07.004. PMID: 26255226
Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review.
Llorente JL, Pérez-Escuredo J, Alvarez-Marcos C, Suárez C, Hermsen M
Eur Arch Otorhinolaryngol 2009 Jan;266(1):1-7. Epub 2008 Jun 17 doi: 10.1007/s00405-008-0749-y. PMID: 18560862

Prognosis

A Comprehensive Update on Intestinal- and Non-Intestinal-Type Adenocarcinomas.
Vander Poorten V, Jorissen M
Adv Otorhinolaryngol 2020;84:137-153. Epub 2020 Jul 30 doi: 10.1159/000457934. PMID: 32731230
HER2 status in sinonasal intestinal-type adenocarcinoma.
Maffeis V, Cappellesso R, Zanon A, Cazzador D, Emanuelli E, Martini A, Fassina A
Pathol Res Pract 2019 Jun;215(6):152432. Epub 2019 Apr 28 doi: 10.1016/j.prp.2019.04.024. PMID: 31047725
Intestinal-type adenocarcinoma of the sinonasal tract: an update.
Rampinelli V, Ferrari M, Nicolai P
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):115-121. doi: 10.1097/MOO.0000000000000445. PMID: 29389737
Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment.
Hoeben A, van de Winkel L, Hoebers F, Kross K, Driessen C, Slootweg P, Tjan-Heijnen VC, van Herpen C
Head Neck 2016 Oct;38(10):1564-70. Epub 2016 May 25 doi: 10.1002/hed.24416. PMID: 27224655
Nonsalivary sinonasal adenocarcinoma.
Alessi DM, Trapp TK, Fu YS, Calcaterra TC
Arch Otolaryngol Head Neck Surg 1988 Sep;114(9):996-9. doi: 10.1001/archotol.1988.01860210062016. PMID: 3408582

Clinical prediction guides

HER2 status in sinonasal intestinal-type adenocarcinoma.
Maffeis V, Cappellesso R, Zanon A, Cazzador D, Emanuelli E, Martini A, Fassina A
Pathol Res Pract 2019 Jun;215(6):152432. Epub 2019 Apr 28 doi: 10.1016/j.prp.2019.04.024. PMID: 31047725
Metastatic behaviour of sinonasal adenocarcinomas of the intestinal type (ITAC).
Donhuijsen K, Kollecker I, Petersen P, Gaßler N, Schulze J, Schroeder HG
Eur Arch Otorhinolaryngol 2016 Mar;273(3):649-54. Epub 2015 Mar 10 doi: 10.1007/s00405-015-3596-7. PMID: 25753257
Wnt-pathway activation in intestinal-type sinonasal adenocarcinoma.
Díaz-Molina JP, Llorente JL, Vivanco B, Martínez-Camblor P, Fresno MF, Pérez-Escuredo J, Álvarez-Marcos C, Hermsen MA
Rhinology 2011 Dec;49(5):593-9. doi: 10.4193/Rhino.11.037. PMID: 22125792
Pulmonary intestinal-type adenocarcinoma does not show enteric differentiation by immunohistochemical study.
Yousem SA
Mod Pathol 2005 Jun;18(6):816-21. doi: 10.1038/modpathol.3800358. PMID: 15605076
Nonsalivary sinonasal adenocarcinoma.
Alessi DM, Trapp TK, Fu YS, Calcaterra TC
Arch Otolaryngol Head Neck Surg 1988 Sep;114(9):996-9. doi: 10.1001/archotol.1988.01860210062016. PMID: 3408582

Recent systematic reviews

Tumors of the Nose and Paranasal Sinuses: Promoting Factors and Molecular Mechanisms-A Systematic Review.
Lucidi D, Cantaffa C, Miglio M, Spina F, Alicandri Ciufelli M, Marchioni A, Marchioni D
Int J Mol Sci 2023 Jan 31;24(3) doi: 10.3390/ijms24032670. PMID: 36768990Free PMC Article
Decreasing recurrence and increasing survival rates in patients of ethmoid or sphenoid intestinal-type adenocarcinomas: Systematic review and meta-analysis with 1126 cases.
Huang EI, Lu A, Tsai YT, Wang TC, Chuang HC, Chen WC, Chen PT
Medicine (Baltimore) 2021 Oct 8;100(40):e27341. doi: 10.1097/MD.0000000000027341. PMID: 34622832Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...