IDH2 Gene Mutation

MedGen UID:: 858418
•Concept ID:: C3898824
•: Cell or Molecular Dysfunction

Synonyms:

Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial Gene Mutation; Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial Gene Mutation

Definition

A change in the nucleotide sequence of the IDH2 gene. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIDH2 Gene Mutation

Molecular Abnormality
- Molecular Sequence Variation
  - Molecular Genetic Variation
    - Gene Abnormality
      - IDH Gene Family Mutation
        IDH2 Gene Mutation
        Deleterious IDH2 Gene Mutation
        IDH2 NM_002168.3:c.418C>G
        IDH2 NM_002168.3:c.418C>T
        IDH2 NM_002168.3:c.419G>A
        IDH2 NM_002168.3:c.419G>T
        IDH2 NM_002168.3:c.514A>G
        IDH2 NM_002168.3:c.514A>T
        IDH2 NM_002168.3:c.515G>A
        IDH2 NM_002168.3:c.515G>T
        IDH2 NM_002168.3:c.515_516delinsAA
        IDH2 NM_002168.3:c.516G>C
        IDH2 NM_002168.3:c.516G>T

Professional guidelines

PubMed

Dual-Genotype Diffuse Low-Grade Glioma: Is It Really Time to Abandon Oligoastrocytoma As a Distinct Entity?

Barresi V, Lionti S, Valori L, Gallina G, Caffo M, Rossi S
J Neuropathol Exp Neurol 2017 May 1;76(5):342-346. doi: 10.1093/jnen/nlx024. PMID: 28419269

See all (1)

Recent clinical studies

Diagnosis

Dual-Genotype Diffuse Low-Grade Glioma: Is It Really Time to Abandon Oligoastrocytoma As a Distinct Entity?

Barresi V, Lionti S, Valori L, Gallina G, Caffo M, Rossi S
J Neuropathol Exp Neurol 2017 May 1;76(5):342-346. doi: 10.1093/jnen/nlx024. PMID: 28419269

Molecular classification of gliomas.

Masui K, Mischel PS, Reifenberger G
Handb Clin Neurol 2016;134:97-120. doi: 10.1016/B978-0-12-802997-8.00006-2. PMID: 26948350

See all (2)

Prognosis

Dual-Genotype Diffuse Low-Grade Glioma: Is It Really Time to Abandon Oligoastrocytoma As a Distinct Entity?

Barresi V, Lionti S, Valori L, Gallina G, Caffo M, Rossi S
J Neuropathol Exp Neurol 2017 May 1;76(5):342-346. doi: 10.1093/jnen/nlx024. PMID: 28419269

Molecular classification of gliomas.

Masui K, Mischel PS, Reifenberger G
Handb Clin Neurol 2016;134:97-120. doi: 10.1016/B978-0-12-802997-8.00006-2. PMID: 26948350

Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China.

Zhang CB, Bao ZS, Wang HJ, Yan W, Liu YW, Li MY, Zhang W, Chen L, Jiang T
J Cancer Res Clin Oncol 2014 Jan;140(1):45-51. Epub 2013 Oct 23 doi: 10.1007/s00432-013-1519-9. PMID: 24149775

See all (3)

Clinical prediction guides

Molecular classification of gliomas.

Masui K, Mischel PS, Reifenberger G
Handb Clin Neurol 2016;134:97-120. doi: 10.1016/B978-0-12-802997-8.00006-2. PMID: 26948350

See all (1)

MedGen

National Center for Biotechnology Information

Send to:

IDH2 Gene Mutation

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Diagnosis

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity