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Hepatocellular Carcinoma by BCLC Stage

MedGen UID:
858482
•Concept ID:
C3898888
•
Neoplastic Process
Synonyms: Barcelona Clinic Liver Cancer Staging for Hepatocellular Carcinoma; BCLC Staging for Hepatocellular Carcinoma; Hepatocellular Carcinoma Barcelona Clinic Liver Cancer Staging; Hepatocellular Carcinoma BCLC Staging; Hepatocellular Carcinoma by Barcelona Clinic Liver Cancer Stage

Definition

A staging classification system for hepatocellular carcinoma that uses variables related to tumor stage, liver functional status, physical status, and cancer-related symptoms, and links the stages with a treatment algorithm. (HPB (Oxford) 2005; 7(1):35-41) [from NCI]

Professional guidelines

PubMed

New concepts in the treatment of hepatocellular carcinoma.
Sidali S, Trépo E, Sutter O, Nault JC
United European Gastroenterol J 2022 Sep;10(7):765-774. Epub 2022 Aug 16 doi: 10.1002/ueg2.12286. PMID: 35975347Free PMC Article
BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update.
Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, Kelley RK, Galle PR, Mazzaferro V, Salem R, Sangro B, Singal AG, Vogel A, Fuster J, Ayuso C, Bruix J
J Hepatol 2022 Mar;76(3):681-693. Epub 2021 Nov 19 doi: 10.1016/j.jhep.2021.11.018. PMID: 34801630Free PMC Article
Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence.
Raoul JL, Forner A, Bolondi L, Cheung TT, Kloeckner R, de Baere T
Cancer Treat Rev 2019 Jan;72:28-36. Epub 2018 Nov 12 doi: 10.1016/j.ctrv.2018.11.002. PMID: 30447470

Recent clinical studies

Etiology

Advances in post-operative prognostic models for hepatocellular carcinoma.
He Z, She X, Liu Z, Gao X, Lu LU, Huang J, Lu C, Lin Y, Liang R, Ye J
J Zhejiang Univ Sci B 2023 Mar 15;24(3):191-206. doi: 10.1631/jzus.B2200067. PMID: 36915996Free PMC Article
Clinical practice guidelines and real-life practice in hepatocellular carcinoma: A Taiwan perspective.
Su TH, Wu CH, Liu TH, Ho CM, Liu CJ
Clin Mol Hepatol 2023 Apr;29(2):230-241. Epub 2023 Jan 30 doi: 10.3350/cmh.2022.0421. PMID: 36710607Free PMC Article
Comprehensive Review of Hepatocellular Carcinoma in India: Current Challenges and Future Directions.
Shetty VV, Kellarai A
JCO Glob Oncol 2022 Oct;8:e2200118. doi: 10.1200/GO.22.00118. PMID: 36198133Free PMC Article
TARE in Hepatocellular Carcinoma: From the Right to the Left of BCLC.
Guiu B, Garin E, Allimant C, Edeline J, Salem R
Cardiovasc Intervent Radiol 2022 Nov;45(11):1599-1607. Epub 2022 Feb 11 doi: 10.1007/s00270-022-03072-8. PMID: 35149884
Optimizing the management of intermediate-stage hepatocellular carcinoma: Current trends and prospects.
Torimura T, Iwamoto H
Clin Mol Hepatol 2021 Apr;27(2):236-245. Epub 2020 Dec 3 doi: 10.3350/cmh.2020.0204. PMID: 33317248Free PMC Article

Diagnosis

New concepts in the treatment of hepatocellular carcinoma.
Sidali S, Trépo E, Sutter O, Nault JC
United European Gastroenterol J 2022 Sep;10(7):765-774. Epub 2022 Aug 16 doi: 10.1002/ueg2.12286. PMID: 35975347Free PMC Article
Goals and targets for personalized therapy for HCC.
Couri T, Pillai A
Hepatol Int 2019 Mar;13(2):125-137. Epub 2019 Jan 1 doi: 10.1007/s12072-018-9919-1. PMID: 30600478
Molecular therapies and precision medicine for hepatocellular carcinoma.
Llovet JM, Montal R, Sia D, Finn RS
Nat Rev Clin Oncol 2018 Oct;15(10):599-616. doi: 10.1038/s41571-018-0073-4. PMID: 30061739
Diagnosis and staging of hepatocellular carcinoma (HCC): current guidelines.
Ayuso C, Rimola J, Vilana R, Burrel M, Darnell A, García-Criado Á, Bianchi L, Belmonte E, Caparroz C, Barrufet M, Bruix J, Brú C
Eur J Radiol 2018 Apr;101:72-81. Epub 2018 Jan 31 doi: 10.1016/j.ejrad.2018.01.025. PMID: 29571804
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749

Therapy

New concepts in the treatment of hepatocellular carcinoma.
Sidali S, Trépo E, Sutter O, Nault JC
United European Gastroenterol J 2022 Sep;10(7):765-774. Epub 2022 Aug 16 doi: 10.1002/ueg2.12286. PMID: 35975347Free PMC Article
Recent Updates of Transarterial Chemoembolilzation in Hepatocellular Carcinoma.
Chang Y, Jeong SW, Young Jang J, Jae Kim Y
Int J Mol Sci 2020 Oct 31;21(21) doi: 10.3390/ijms21218165. PMID: 33142892Free PMC Article
Goals and targets for personalized therapy for HCC.
Couri T, Pillai A
Hepatol Int 2019 Mar;13(2):125-137. Epub 2019 Jan 1 doi: 10.1007/s12072-018-9919-1. PMID: 30600478
Molecular therapies and precision medicine for hepatocellular carcinoma.
Llovet JM, Montal R, Sia D, Finn RS
Nat Rev Clin Oncol 2018 Oct;15(10):599-616. doi: 10.1038/s41571-018-0073-4. PMID: 30061739
Hepatocellular carcinoma.
Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G
Nat Rev Dis Primers 2016 Apr 14;2:16018. doi: 10.1038/nrdp.2016.18. PMID: 27158749

Prognosis

New concepts in the treatment of hepatocellular carcinoma.
Sidali S, Trépo E, Sutter O, Nault JC
United European Gastroenterol J 2022 Sep;10(7):765-774. Epub 2022 Aug 16 doi: 10.1002/ueg2.12286. PMID: 35975347Free PMC Article
TARE in Hepatocellular Carcinoma: From the Right to the Left of BCLC.
Guiu B, Garin E, Allimant C, Edeline J, Salem R
Cardiovasc Intervent Radiol 2022 Nov;45(11):1599-1607. Epub 2022 Feb 11 doi: 10.1007/s00270-022-03072-8. PMID: 35149884
Incidence of Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression.
Orci LA, Sanduzzi-Zamparelli M, Caballol B, Sapena V, Colucci N, Torres F, Bruix J, Reig M, Toso C
Clin Gastroenterol Hepatol 2022 Feb;20(2):283-292.e10. Epub 2021 May 28 doi: 10.1016/j.cgh.2021.05.002. PMID: 33965578
Management of HCC.
de Lope CR, Tremosini S, Forner A, Reig M, Bruix J
J Hepatol 2012;56 Suppl 1:S75-87. doi: 10.1016/S0168-8278(12)60009-9. PMID: 22300468
Prognosis of hepatocellular carcinoma: the BCLC staging classification.
Llovet JM, Brú C, Bruix J
Semin Liver Dis 1999;19(3):329-38. doi: 10.1055/s-2007-1007122. PMID: 10518312

Clinical prediction guides

Clinical practice guidelines and real-life practice in hepatocellular carcinoma: A Japanese perspective.
Koga H, Iwamoto H, Suzuki H, Shimose S, Nakano M, Kawaguchi T
Clin Mol Hepatol 2023 Apr;29(2):242-251. Epub 2023 Mar 20 doi: 10.3350/cmh.2023.0102. PMID: 36941079Free PMC Article
Advances in post-operative prognostic models for hepatocellular carcinoma.
He Z, She X, Liu Z, Gao X, Lu LU, Huang J, Lu C, Lin Y, Liang R, Ye J
J Zhejiang Univ Sci B 2023 Mar 15;24(3):191-206. doi: 10.1631/jzus.B2200067. PMID: 36915996Free PMC Article
BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update.
Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, Kelley RK, Galle PR, Mazzaferro V, Salem R, Sangro B, Singal AG, Vogel A, Fuster J, Ayuso C, Bruix J
J Hepatol 2022 Mar;76(3):681-693. Epub 2021 Nov 19 doi: 10.1016/j.jhep.2021.11.018. PMID: 34801630Free PMC Article
Recent Updates of Transarterial Chemoembolilzation in Hepatocellular Carcinoma.
Chang Y, Jeong SW, Young Jang J, Jae Kim Y
Int J Mol Sci 2020 Oct 31;21(21) doi: 10.3390/ijms21218165. PMID: 33142892Free PMC Article
Management of HCC.
de Lope CR, Tremosini S, Forner A, Reig M, Bruix J
J Hepatol 2012;56 Suppl 1:S75-87. doi: 10.1016/S0168-8278(12)60009-9. PMID: 22300468

Recent systematic reviews

Liver resection versus transarterial chemoembolisation for the treatment of intermediate hepatocellular carcinoma: a systematic review and meta-analysis.
Bogdanovic A, Djokic Kovac J, Zdujic P, Djindjic U, Dugalic V
Int J Surg 2023 May 1;109(5):1439-1446. doi: 10.1097/JS9.0000000000000344. PMID: 37222718Free PMC Article
HCC surveillance improves early detection, curative treatment receipt, and survival in patients with cirrhosis: A meta-analysis.
Singal AG, Zhang E, Narasimman M, Rich NE, Waljee AK, Hoshida Y, Yang JD, Reig M, Cabibbo G, Nahon P, Parikh ND, Marrero JA
J Hepatol 2022 Jul;77(1):128-139. Epub 2022 Feb 6 doi: 10.1016/j.jhep.2022.01.023. PMID: 35139400Free PMC Article
Systematic review and meta-analysis of validated prognostic models for resected hepatocellular carcinoma patients.
Beumer BR, Buettner S, Galjart B, van Vugt JLA, de Man RA, IJzermans JNM, Koerkamp BG
Eur J Surg Oncol 2022 Mar;48(3):492-499. Epub 2021 Sep 21 doi: 10.1016/j.ejso.2021.09.012. PMID: 34602315
Incidence of Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression.
Orci LA, Sanduzzi-Zamparelli M, Caballol B, Sapena V, Colucci N, Torres F, Bruix J, Reig M, Toso C
Clin Gastroenterol Hepatol 2022 Feb;20(2):283-292.e10. Epub 2021 May 28 doi: 10.1016/j.cgh.2021.05.002. PMID: 33965578
Management of people with intermediate-stage hepatocellular carcinoma: an attempted network meta-analysis.
Roccarina D, Majumdar A, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 10;3(3):CD011649. doi: 10.1002/14651858.CD011649.pub2. PMID: 28281295Free PMC Article

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