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Group B Streptococcal Infection, Early-Onset

MedGen UID:
858601
•Concept ID:
C3899007
•
Disease or Syndrome
Synonym: GBS Infection, Early-Onset

Definition

Infection of an infant from birth to less than seven days of life caused by Group B Streptococcus (Streptococcus agalactiae) from a colonized mother. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGroup B Streptococcal Infection, Early-Onset

Professional guidelines

PubMed

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Intrapartum antibiotic prophylaxis for women who are screened positive for group B streptococcal colonisation: Clinical compliance with the guideline.
Braye K, Ferguson J, Ball J, Foureur M
Aust N Z J Obstet Gynaecol 2021 Dec;61(6):870-875. Epub 2021 May 13 doi: 10.1111/ajo.13370. PMID: 33987829
Group B streptococcal screening, intrapartum antibiotic prophylaxis, and neonatal early-onset infection rates in an Australian local health district: 2006-2016.
Braye K, Foureur M, de Waal K, Jones M, Putt E, Ferguson J
PLoS One 2019;14(4):e0214295. Epub 2019 Apr 4 doi: 10.1371/journal.pone.0214295. PMID: 30946761Free PMC Article

Recent clinical studies

Etiology

Early-Onset Sepsis in Newborns.
Briggs-Steinberg C, Roth P
Pediatr Rev 2023 Jan 1;44(1):14-22. doi: 10.1542/pir.2020-001164. PMID: 36587021
Prevention of Group B Streptococcal Early-Onset Disease in Newborns: ACOG Committee Opinion, Number 797.
Obstet Gynecol 2020 Feb;135(2):e51-e72. doi: 10.1097/AOG.0000000000003668. PMID: 31977795
Management of Infants at Risk for Group B Streptococcal Disease.
Puopolo KM, Lynfield R, Cummings JJ; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2019 Aug;144(2) Epub 2019 Jul 8 doi: 10.1542/peds.2019-1881. PMID: 31285392
Group B Streptococcus (Streptococcus agalactiae).
Raabe VN, Shane AL
Microbiol Spectr 2019 Mar;7(2) doi: 10.1128/microbiolspec.GPP3-0007-2018. PMID: 30900541Free PMC Article
Perinatal Group B Streptococcal Infections: Virulence Factors, Immunity, and Prevention Strategies.
Vornhagen J, Adams Waldorf KM, Rajagopal L
Trends Microbiol 2017 Nov;25(11):919-931. Epub 2017 Jun 17 doi: 10.1016/j.tim.2017.05.013. PMID: 28633864Free PMC Article

Diagnosis

Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Early-Onset Sepsis in Newborns.
Briggs-Steinberg C, Roth P
Pediatr Rev 2023 Jan 1;44(1):14-22. doi: 10.1542/pir.2020-001164. PMID: 36587021
Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Prevention of Group B Streptococcal Early-Onset Disease in Newborns: ACOG Committee Opinion, Number 797.
Obstet Gynecol 2020 Feb;135(2):e51-e72. doi: 10.1097/AOG.0000000000003668. PMID: 31977795
Management of Infants at Risk for Group B Streptococcal Disease.
Puopolo KM, Lynfield R, Cummings JJ; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES
Pediatrics 2019 Aug;144(2) Epub 2019 Jul 8 doi: 10.1542/peds.2019-1881. PMID: 31285392

Therapy

Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Early-Onset Sepsis in Newborns.
Briggs-Steinberg C, Roth P
Pediatr Rev 2023 Jan 1;44(1):14-22. doi: 10.1542/pir.2020-001164. PMID: 36587021
Neonatal sepsis: within and beyond China.
Dong Y, Basmaci R, Titomanlio L, Sun B, Mercier JC
Chin Med J (Engl) 2020 Sep 20;133(18):2219-2228. doi: 10.1097/CM9.0000000000000935. PMID: 32826609Free PMC Article
Group B Streptococcus (Streptococcus agalactiae).
Raabe VN, Shane AL
Microbiol Spectr 2019 Mar;7(2) doi: 10.1128/microbiolspec.GPP3-0007-2018. PMID: 30900541Free PMC Article
Perinatal Group B Streptococcal Infections: Virulence Factors, Immunity, and Prevention Strategies.
Vornhagen J, Adams Waldorf KM, Rajagopal L
Trends Microbiol 2017 Nov;25(11):919-931. Epub 2017 Jun 17 doi: 10.1016/j.tim.2017.05.013. PMID: 28633864Free PMC Article

Prognosis

Progress in Diagnosis and Treatment of Neonatal Sepsis: A Review Article.
Yadav P, Yadav SK
JNMA J Nepal Med Assoc 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324. PMID: 35633256Free PMC Article
Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden.
Gonçalves BP, Procter SR, Paul P, Chandna J, Lewin A, Seedat F, Koukounari A, Dangor Z, Leahy S, Santhanam S, John HB, Bramugy J, Bardají A, Abubakar A, Nasambu C, Libster R, Sánchez Yanotti C, Horváth-Puhó E, Sørensen HT, van de Beek D, Bijlsma MW, Gardner WM, Kassebaum N, Trotter C, Bassat Q, Madhi SA, Lambach P, Jit M, Lawn JE; GBS Danish and Dutch collaborative group for long term outcomes; GBS Low and Middle Income Countries collaborative group for long term outcomes; GBS Scientific Advisory Group, epidemiological sub-group; CHAMPS team
Lancet Glob Health 2022 Jun;10(6):e807-e819. Epub 2022 Apr 28 doi: 10.1016/S2214-109X(22)00093-6. PMID: 35490693Free PMC Article
Neonatal sepsis: within and beyond China.
Dong Y, Basmaci R, Titomanlio L, Sun B, Mercier JC
Chin Med J (Engl) 2020 Sep 20;133(18):2219-2228. doi: 10.1097/CM9.0000000000000935. PMID: 32826609Free PMC Article
Group B Streptococci: Declining Incidence in Infants in Germany.
Wicker E, Lander F, Weidemann F, Hufnagel M, Berner R, Krause G
Pediatr Infect Dis J 2019 May;38(5):516-519. doi: 10.1097/INF.0000000000002115. PMID: 29846301
Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses.
Madrid L, Seale AC, Kohli-Lynch M, Edmond KM, Lawn JE, Heath PT, Madhi SA, Baker CJ, Bartlett L, Cutland C, Gravett MG, Ip M, Le Doare K, Rubens CE, Saha SK, Sobanjo-Ter Meulen A, Vekemans J, Schrag S; Infant GBS Disease Investigator Group
Clin Infect Dis 2017 Nov 6;65(suppl_2):S160-S172. doi: 10.1093/cid/cix656. PMID: 29117326Free PMC Article

Clinical prediction guides

Perinatal risk factors for neonatal early-onset sepsis: a meta-analysis of observational studies.
Guo L, Han W, Su Y, Wang N, Chen X, Ma J, Liang J, Hao L, Ren C
J Matern Fetal Neonatal Med 2023 Dec;36(2):2259049. Epub 2023 Sep 24 doi: 10.1080/14767058.2023.2259049. PMID: 37743349
Early-Onset Sepsis in Newborns.
Briggs-Steinberg C, Roth P
Pediatr Rev 2023 Jan 1;44(1):14-22. doi: 10.1542/pir.2020-001164. PMID: 36587021
Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden.
Gonçalves BP, Procter SR, Paul P, Chandna J, Lewin A, Seedat F, Koukounari A, Dangor Z, Leahy S, Santhanam S, John HB, Bramugy J, Bardají A, Abubakar A, Nasambu C, Libster R, Sánchez Yanotti C, Horváth-Puhó E, Sørensen HT, van de Beek D, Bijlsma MW, Gardner WM, Kassebaum N, Trotter C, Bassat Q, Madhi SA, Lambach P, Jit M, Lawn JE; GBS Danish and Dutch collaborative group for long term outcomes; GBS Low and Middle Income Countries collaborative group for long term outcomes; GBS Scientific Advisory Group, epidemiological sub-group; CHAMPS team
Lancet Glob Health 2022 Jun;10(6):e807-e819. Epub 2022 Apr 28 doi: 10.1016/S2214-109X(22)00093-6. PMID: 35490693Free PMC Article
Group B Streptococcus (Streptococcus agalactiae).
Raabe VN, Shane AL
Microbiol Spectr 2019 Mar;7(2) doi: 10.1128/microbiolspec.GPP3-0007-2018. PMID: 30900541Free PMC Article
Diagnostic accuracy of polymerase chain reaction for intrapartum detection of group B streptococcus colonization.
Helmig RB, Gertsen JB
Acta Obstet Gynecol Scand 2017 Sep;96(9):1070-1074. Epub 2017 Jun 22 doi: 10.1111/aogs.13169. PMID: 28504863

Recent systematic reviews

Clinical Characteristics and Treatment Strategies for Group B Streptococcus (GBS) Infection in Pediatrics: A Systematic Review.
Alotaibi NM, Alroqi S, Alharbi A, Almutiri B, Alshehry M, Almutairi R, Alotaibi N, Althoubiti A, Alanezi A, Alatawi N, Almutairi H, Alhmadi M, Almutairi R, Alshammari M
Medicina (Kaunas) 2023 Jul 9;59(7) doi: 10.3390/medicina59071279. PMID: 37512090Free PMC Article
Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses.
Madrid L, Seale AC, Kohli-Lynch M, Edmond KM, Lawn JE, Heath PT, Madhi SA, Baker CJ, Bartlett L, Cutland C, Gravett MG, Ip M, Le Doare K, Rubens CE, Saha SK, Sobanjo-Ter Meulen A, Vekemans J, Schrag S; Infant GBS Disease Investigator Group
Clin Infect Dis 2017 Nov 6;65(suppl_2):S160-S172. doi: 10.1093/cid/cix656. PMID: 29117326Free PMC Article
Risk of Early-Onset Neonatal Group B Streptococcal Disease With Maternal Colonization Worldwide: Systematic Review and Meta-analyses.
Russell NJ, Seale AC, O'Sullivan C, Le Doare K, Heath PT, Lawn JE, Bartlett L, Cutland C, Gravett M, Ip M, Madhi SA, Rubens CE, Saha SK, Schrag S, Sobanjo-Ter Meulen A, Vekemans J, Baker CJ
Clin Infect Dis 2017 Nov 6;65(suppl_2):S152-S159. doi: 10.1093/cid/cix655. PMID: 29117325Free PMC Article
Intrapartum antibiotics for known maternal Group B streptococcal colonization.
Ohlsson A, Shah VS
Cochrane Database Syst Rev 2014 Jun 10;(6):CD007467. doi: 10.1002/14651858.CD007467.pub4. PMID: 24915629
Neonatal infections: group B streptococcus.
Heath PT, Jardine LA
BMJ Clin Evid 2014 Feb 28;2014 PMID: 24580886Free PMC Article

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