U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Familial Idiopathic Short Stature

MedGen UID:
858751
•Concept ID:
C3899157
•
Finding

Definition

Idiopathic short stature in a child when either one or both parents is short in stature. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFamilial Idiopathic Short Stature

Professional guidelines

PubMed

Management of Short Stature: Use of Growth Hormone in GH-Deficient and non-GH-Deficient Conditions.
Vyas V, Menon RK
Indian J Pediatr 2021 Dec;88(12):1203-1208. Epub 2021 Oct 5 doi: 10.1007/s12098-021-03892-5. PMID: 34609657
A genetic approach to evaluation of short stature of undetermined cause.
Murray PG, Clayton PE, Chernausek SD
Lancet Diabetes Endocrinol 2018 Jul;6(7):564-574. Epub 2018 Feb 1 doi: 10.1016/S2213-8587(18)30034-2. PMID: 29397377
Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence.
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article

Recent clinical studies

Etiology

Short children with familial short stature show enhancement of somatotroph secretion but normal IGF-I levels.
Bellone S, Corneli G, Bellone J, Baffoni C, Rovere S, de Sanctis C, Bona G, Ghigo E, Aimaretti G
J Endocrinol Invest 2002 May;25(5):426-30. doi: 10.1007/BF03344032. PMID: 12035938

Diagnosis

Novel heterozygous mutation in the SHOX gene leading to familial idiopathic short stature: A case report and literature review.
Liu L, Li J, Li J, Hu H, Liu J, Tang P
Medicine (Baltimore) 2023 Oct 13;102(41):e35471. doi: 10.1097/MD.0000000000035471. PMID: 37832088Free PMC Article
Short children with familial short stature show enhancement of somatotroph secretion but normal IGF-I levels.
Bellone S, Corneli G, Bellone J, Baffoni C, Rovere S, de Sanctis C, Bona G, Ghigo E, Aimaretti G
J Endocrinol Invest 2002 May;25(5):426-30. doi: 10.1007/BF03344032. PMID: 12035938

Therapy

Novel heterozygous mutation in the SHOX gene leading to familial idiopathic short stature: A case report and literature review.
Liu L, Li J, Li J, Hu H, Liu J, Tang P
Medicine (Baltimore) 2023 Oct 13;102(41):e35471. doi: 10.1097/MD.0000000000035471. PMID: 37832088Free PMC Article

Prognosis

Novel heterozygous mutation in the SHOX gene leading to familial idiopathic short stature: A case report and literature review.
Liu L, Li J, Li J, Hu H, Liu J, Tang P
Medicine (Baltimore) 2023 Oct 13;102(41):e35471. doi: 10.1097/MD.0000000000035471. PMID: 37832088Free PMC Article

Clinical prediction guides

Short children with familial short stature show enhancement of somatotroph secretion but normal IGF-I levels.
Bellone S, Corneli G, Bellone J, Baffoni C, Rovere S, de Sanctis C, Bona G, Ghigo E, Aimaretti G
J Endocrinol Invest 2002 May;25(5):426-30. doi: 10.1007/BF03344032. PMID: 12035938

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...