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Early Rheumatoid Arthritis

MedGen UID:
858872
•Concept ID:
C3899278
•
Disease or Syndrome

Definition

Recent diagnosis of rheumatoid arthritis (usually within one to two years of onset) during which treatment may be more effective and possibly improve the disease course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly Rheumatoid Arthritis

Professional guidelines

PubMed

Rheumatoid Arthritis: Early Diagnosis and Treatment.
Cush JJ
Rheum Dis Clin North Am 2022 May;48(2):537-547. doi: 10.1016/j.rdc.2022.02.010. PMID: 35400377
Rheumatoid Arthritis: Early Diagnosis and Treatment.
Cush JJ
Med Clin North Am 2021 Mar;105(2):355-365. doi: 10.1016/j.mcna.2020.10.006. PMID: 33589108
Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis.
Demoruelle MK, Deane KD
Curr Rheumatol Rep 2012 Oct;14(5):472-80. doi: 10.1007/s11926-012-0275-1. PMID: 22773387Free PMC Article

Recent clinical studies

Etiology

Role of IFN-α in Rheumatoid Arthritis.
Lin CMA, Isaacs JD, Cooles FAH
Curr Rheumatol Rep 2024 Feb;26(2):37-52. Epub 2023 Dec 5 doi: 10.1007/s11926-023-01125-6. PMID: 38051494Free PMC Article
Widespread non-joint pain in early rheumatoid arthritis.
Schelin M, Westerlind H, Lindqvist J, Englid E, Israelsson L, Skillgate E, Klareskog L, Alfredsson L, Lampa J
Scand J Rheumatol 2021 Jul;50(4):271-279. Epub 2021 Feb 25 doi: 10.1080/03009742.2020.1846778. PMID: 33629632
Should ultrasound be used routinely in the diagnosis of rheumatoid arthritis?
Boylan M
Ir J Med Sci 2020 May;189(2):735-748. Epub 2019 Oct 23 doi: 10.1007/s11845-019-02096-3. PMID: 31646431
Treatment of early rheumatoid arthritis: concepts in management.
Haraoui B, Pope J
Semin Arthritis Rheum 2011 Apr;40(5):371-88. Epub 2011 Feb 4 doi: 10.1016/j.semarthrit.2010.10.004. PMID: 21295822
Early rheumatoid arthritis.
Scott DL
Br Med Bull 2007;81-82:97-114. Epub 2007 May 31 doi: 10.1093/bmb/ldm011. PMID: 17540693

Diagnosis

Rheumatoid Arthritis: Early Diagnosis and Treatment.
Cush JJ
Rheum Dis Clin North Am 2022 May;48(2):537-547. doi: 10.1016/j.rdc.2022.02.010. PMID: 35400377
Rheumatoid Arthritis: Early Diagnosis and Treatment.
Cush JJ
Med Clin North Am 2021 Mar;105(2):355-365. doi: 10.1016/j.mcna.2020.10.006. PMID: 33589108
Three hematologic/immune system-specific expressed genes are considered as the potential biomarkers for the diagnosis of early rheumatoid arthritis through bioinformatics analysis.
Cheng Q, Chen X, Wu H, Du Y
J Transl Med 2021 Jan 6;19(1):18. doi: 10.1186/s12967-020-02689-y. PMID: 33407587Free PMC Article
Rheumatoid factors: clinical applications.
Ingegnoli F, Castelli R, Gualtierotti R
Dis Markers 2013;35(6):727-34. Epub 2013 Nov 13 doi: 10.1155/2013/726598. PMID: 24324289Free PMC Article
Early rheumatoid arthritis.
Machold KP, Nell V, Stamm T, Aletaha D, Smolen JS
Curr Opin Rheumatol 2006 May;18(3):282-8. doi: 10.1097/01.bor.0000218950.27483.80. PMID: 16582693

Therapy

Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial.
Østergaard M, van Vollenhoven RF, Rudin A, Hetland ML, Heiberg MS, Nordström DC, Nurmohamed MT, Gudbjornsson B, Ørnbjerg LM, Bøyesen P, Lend K, Hørslev-Petersen K, Uhlig T, Sokka T, Grondal G, Krabbe S, Lindqvist J, Gjertsson I, Glinatsi D, Kapetanovic MC, Aga AB, Faustini F, Parmanne P, Lorenzen T, Giovanni C, Back J, Hendricks O, Vedder D, Rannio T, Grenholm E, Ljoså MK, Brodin E, Lindegaard H, Söderbergh A, Rizk M, Kastbom A, Larsson P, Uhrenholt L, Just SA, Stevens DJ, Bay Laurbjerg T, Bakland G, Olsen IC, Haavardsholm EA, Lampa J; NORD-STAR study group
Ann Rheum Dis 2023 Oct;82(10):1286-1295. Epub 2023 Jul 9 doi: 10.1136/ard-2023-224116. PMID: 37423647
Rheumatoid Arthritis: Early Diagnosis and Treatment.
Cush JJ
Rheum Dis Clin North Am 2022 May;48(2):537-547. doi: 10.1016/j.rdc.2022.02.010. PMID: 35400377
Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial.
Hetland ML, Haavardsholm EA, Rudin A, Nordström D, Nurmohamed M, Gudbjornsson B, Lampa J, Hørslev-Petersen K, Uhlig T, Grondal G, Østergaard M, Heiberg MS, Twisk J, Lend K, Krabbe S, Hyldstrup LH, Lindqvist J, Hultgård Ekwall AK, Grøn KL, Kapetanovic M, Faustini F, Tuompo R, Lorenzen T, Cagnotto G, Baecklund E, Hendricks O, Vedder D, Sokka-Isler T, Husmark T, Ljoså MA, Brodin E, Ellingsen T, Söderbergh A, Rizk M, Olsson ÅR, Larsson P, Uhrenholt L, Just SA, Stevens DJ, Laurberg TB, Bakland G, Olsen IC, van Vollenhoven R; NORD-STAR study group
BMJ 2020 Dec 2;371:m4328. doi: 10.1136/bmj.m4328. PMID: 33268527Free PMC Article
Efficacy and Safety of Upadacitinib Monotherapy in Methotrexate-Naive Patients With Moderately-to-Severely Active Rheumatoid Arthritis (SELECT-EARLY): A Multicenter, Multi-Country, Randomized, Double-Blind, Active Comparator-Controlled Trial.
van Vollenhoven R, Takeuchi T, Pangan AL, Friedman A, Mohamed MF, Chen S, Rischmueller M, Blanco R, Xavier RM, Strand V
Arthritis Rheumatol 2020 Oct;72(10):1607-1620. Epub 2020 Sep 8 doi: 10.1002/art.41384. PMID: 32638504Free PMC Article
Early rheumatoid arthritis.
Machold KP, Nell V, Stamm T, Aletaha D, Smolen JS
Curr Opin Rheumatol 2006 May;18(3):282-8. doi: 10.1097/01.bor.0000218950.27483.80. PMID: 16582693

Prognosis

Methotrexate in early rheumatoid arthritis: Is the anchor drug still holding?
Giollo A, Fuzzi E, Doria A
Autoimmun Rev 2022 Apr;21(4):103031. Epub 2022 Jan 4 doi: 10.1016/j.autrev.2022.103031. PMID: 34995761
Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network.
Ifesemen OS, McWilliams DF, Norton S, Kiely PDW, Young A, Walsh DA
Rheumatology (Oxford) 2022 Aug 30;61(9):3737-3745. doi: 10.1093/rheumatology/keab947. PMID: 34958376Free PMC Article
Imaging in early rheumatoid arthritis.
McQueen FM
Best Pract Res Clin Rheumatol 2013 Aug;27(4):499-522. Epub 2013 Oct 4 doi: 10.1016/j.berh.2013.09.005. PMID: 24315051
Early rheumatoid arthritis.
Machold KP, Nell V, Stamm T, Aletaha D, Smolen JS
Curr Opin Rheumatol 2006 May;18(3):282-8. doi: 10.1097/01.bor.0000218950.27483.80. PMID: 16582693
Early rheumatoid arthritis.
Young A
Rheum Dis Clin North Am 2005 Nov;31(4):659-79. doi: 10.1016/j.rdc.2005.07.011. PMID: 16287590

Clinical prediction guides

Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium.
Murray-Brown W, Guo Y, Small A, Lowe K, Weedon H, Smith MD, Lester SE, Proudman SM, Rao NL, Hao LY, Nagpal S, Wechalekar MD
RMD Open 2022 Oct;8(2) doi: 10.1136/rmdopen-2022-002563. PMID: 36270740Free PMC Article
Pro musculoskeletal ultrasonography in rheumatoid arthritis.
Ohrndorf S, Backhaus M
Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 92):S50-3. Epub 2015 Oct 12 PMID: 26457337
Remission in early rheumatoid arthritis.
Ma MH, Scott IC, Kingsley GH, Scott DL
J Rheumatol 2010 Jul;37(7):1444-53. Epub 2010 Jun 1 doi: 10.3899/jrheum.091131. PMID: 20516031
Early rheumatoid arthritis.
Machold KP, Nell V, Stamm T, Aletaha D, Smolen JS
Curr Opin Rheumatol 2006 May;18(3):282-8. doi: 10.1097/01.bor.0000218950.27483.80. PMID: 16582693
Early rheumatoid arthritis.
Young A
Rheum Dis Clin North Am 2005 Nov;31(4):659-79. doi: 10.1016/j.rdc.2005.07.011. PMID: 16287590

Recent systematic reviews

What is the added value of ultrasound joint examination for monitoring synovitis in rheumatoid arthritis and can it be used to guide treatment decisions? A systematic review and cost-effectiveness analysis.
Simpson E, Hock E, Stevenson M, Wong R, Dracup N, Wailoo A, Conaghan P, Estrach C, Edwards C, Wakefield R
Health Technol Assess 2018 Apr;22(20):1-258. doi: 10.3310/hta22200. PMID: 29712616Free PMC Article
Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for the treatment of rheumatoid arthritis not previously treated with disease-modifying antirheumatic drugs and after the failure of conventional disease-modifying antirheumatic drugs only: systematic review and economic evaluation.
Stevenson M, Archer R, Tosh J, Simpson E, Everson-Hock E, Stevens J, Hernandez-Alava M, Paisley S, Dickinson K, Scott D, Young A, Wailoo A
Health Technol Assess 2016 Apr;20(35):1-610. doi: 10.3310/hta20350. PMID: 27140438Free PMC Article
Combination therapy for early rheumatoid arthritis: a treatment holiday perspective.
Hirata S, Tanaka Y
Expert Rev Clin Pharmacol 2015 Jan;8(1):115-22. Epub 2014 Nov 25 doi: 10.1586/17512433.2015.984689. PMID: 25420554
Does early arthritis clinic organisation improve outcomes? What evidence is there? A systematic review.
Govoni M, Sciré CA, Manara M, Malavolta N, Mancarella L, Sandri G, Mascella F, Macchioni PL, Delsante G, Padovan M
Clin Exp Rheumatol 2013 May-Jun;31(3):443-51. Epub 2013 Feb 15 PMID: 23415051
Systematic review: comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritis.
Donahue KE, Gartlehner G, Jonas DE, Lux LJ, Thieda P, Jonas BL, Hansen RA, Morgan LC, Lohr KN
Ann Intern Med 2008 Jan 15;148(2):124-34. Epub 2007 Nov 19 doi: 10.7326/0003-4819-148-2-200801150-00192. PMID: 18025440

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