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Childhood Unfavorable Prognosis Hodgkin Lymphoma

MedGen UID:
859231
•Concept ID:
C3899637
•
Neoplastic Process

Definition

A Hodgkin lymphoma with unfavorable prognosis that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Unfavorable Prognosis Hodgkin Lymphoma

Professional guidelines

PubMed

Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil.
Hsu SC, Metzger ML, Hudson MM, Pedrosa F, Lins M, Pedrosa M, Barros C, Maciel K, Pui CH, Ribeiro RC, Howard SC
Pediatr Blood Cancer 2007 Aug;49(2):139-44. doi: 10.1002/pbc.20883. PMID: 16642484
Serum levels and differential expression of CD44 in childhood leukemia and malignant lymphoma: correlation with prognostic criteria and survival.
Taçyildiz N, Cavdar AO, Yavuz G, Gözdaşoglu S, Unal E, Ertem U, Duru F, Ikinciogullari A, Babacan E, Kuzu I, Cin S
Pediatr Int 2001 Aug;43(4):354-60. doi: 10.1046/j.1442-200x.2001.01415.x. PMID: 11472578

Recent clinical studies

Etiology

Detection of prognostic factors in children and adolescents with Burkitt and Diffuse Large B-Cell Lymphoma treated with the AIEOP LNH-97 protocol.
Pillon M, Mussolin L, Carraro E, Conter V, Aricò M, Vinti L, Garaventa A, Piglione M, Buffardi S, Sala A, Santoro N, Lo Nigro L, Mura R, Tondo A, Casale F, Farruggia P, Pierani P, Cesaro S, d'Amore ES, Basso G
Br J Haematol 2016 Nov;175(3):467-475. Epub 2016 Jul 8 doi: 10.1111/bjh.14240. PMID: 27392319
Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence.
Bonn BR, Rohde M, Zimmermann M, Krieger D, Oschlies I, Niggli F, Wrobel G, Attarbaschi A, Escherich G, Klapper W, Reiter A, Burkhardt B
Blood 2013 Apr 18;121(16):3153-60. Epub 2013 Feb 8 doi: 10.1182/blood-2012-12-474148. PMID: 23396305
Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil.
Hsu SC, Metzger ML, Hudson MM, Pedrosa F, Lins M, Pedrosa M, Barros C, Maciel K, Pui CH, Ribeiro RC, Howard SC
Pediatr Blood Cancer 2007 Aug;49(2):139-44. doi: 10.1002/pbc.20883. PMID: 16642484
Serum levels and differential expression of CD44 in childhood leukemia and malignant lymphoma: correlation with prognostic criteria and survival.
Taçyildiz N, Cavdar AO, Yavuz G, Gözdaşoglu S, Unal E, Ertem U, Duru F, Ikinciogullari A, Babacan E, Kuzu I, Cin S
Pediatr Int 2001 Aug;43(4):354-60. doi: 10.1046/j.1442-200x.2001.01415.x. PMID: 11472578
Hodgkin disease in children: results of a prospective randomized trial in a single institution in Argentina.
Sackmann-Muriel F, Zubizarreta P, Gallo G, Scopinaro M, Alderete D, Alfaro E, Casak S, Chantada G, Felice MS, Quinteros R
Med Pediatr Oncol 1997 Dec;29(6):544-52. doi: 10.1002/(sici)1096-911x(199712)29:6<544::aid-mpo5>3.0.co;2-k. PMID: 9324342

Diagnosis

Detection of prognostic factors in children and adolescents with Burkitt and Diffuse Large B-Cell Lymphoma treated with the AIEOP LNH-97 protocol.
Pillon M, Mussolin L, Carraro E, Conter V, Aricò M, Vinti L, Garaventa A, Piglione M, Buffardi S, Sala A, Santoro N, Lo Nigro L, Mura R, Tondo A, Casale F, Farruggia P, Pierani P, Cesaro S, d'Amore ES, Basso G
Br J Haematol 2016 Nov;175(3):467-475. Epub 2016 Jul 8 doi: 10.1111/bjh.14240. PMID: 27392319
Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence.
Bonn BR, Rohde M, Zimmermann M, Krieger D, Oschlies I, Niggli F, Wrobel G, Attarbaschi A, Escherich G, Klapper W, Reiter A, Burkhardt B
Blood 2013 Apr 18;121(16):3153-60. Epub 2013 Feb 8 doi: 10.1182/blood-2012-12-474148. PMID: 23396305
Serum soluble interleukin-2 receptor, beta2-microglobulin, lactate dehydrogenase and erythrocyte sedimentation rate in children with Hodgkin's lymphoma.
Bien E, Balcerska A
Scand J Immunol 2009 Nov;70(5):490-500. doi: 10.1111/j.1365-3083.2009.02313.x. PMID: 19874554
Treatment of unfavorable childhood Hodgkin's disease with VEPA and low-dose, involved-field radiation.
Friedmann AM, Hudson MM, Weinstein HJ, Donaldson SS, Kun L, Tarbell NJ, Link MP
J Clin Oncol 2002 Jul 15;20(14):3088-94. doi: 10.1200/JCO.2002.03.051. PMID: 12118022
Serum levels and differential expression of CD44 in childhood leukemia and malignant lymphoma: correlation with prognostic criteria and survival.
Taçyildiz N, Cavdar AO, Yavuz G, Gözdaşoglu S, Unal E, Ertem U, Duru F, Ikinciogullari A, Babacan E, Kuzu I, Cin S
Pediatr Int 2001 Aug;43(4):354-60. doi: 10.1046/j.1442-200x.2001.01415.x. PMID: 11472578

Therapy

Detection of prognostic factors in children and adolescents with Burkitt and Diffuse Large B-Cell Lymphoma treated with the AIEOP LNH-97 protocol.
Pillon M, Mussolin L, Carraro E, Conter V, Aricò M, Vinti L, Garaventa A, Piglione M, Buffardi S, Sala A, Santoro N, Lo Nigro L, Mura R, Tondo A, Casale F, Farruggia P, Pierani P, Cesaro S, d'Amore ES, Basso G
Br J Haematol 2016 Nov;175(3):467-475. Epub 2016 Jul 8 doi: 10.1111/bjh.14240. PMID: 27392319
Serum soluble interleukin-2 receptor, beta2-microglobulin, lactate dehydrogenase and erythrocyte sedimentation rate in children with Hodgkin's lymphoma.
Bien E, Balcerska A
Scand J Immunol 2009 Nov;70(5):490-500. doi: 10.1111/j.1365-3083.2009.02313.x. PMID: 19874554
Comparison of treatment outcomes of childhood Hodgkin lymphoma in two US centers and a center in Recife, Brazil.
Hsu SC, Metzger ML, Hudson MM, Pedrosa F, Lins M, Pedrosa M, Barros C, Maciel K, Pui CH, Ribeiro RC, Howard SC
Pediatr Blood Cancer 2007 Aug;49(2):139-44. doi: 10.1002/pbc.20883. PMID: 16642484
Salvage therapy of progressive and recurrent Hodgkin's disease: results from a multicenter study of the pediatric DAL/GPOH-HD study group.
Schellong G, Dörffel W, Claviez A, Körholz D, Mann G, Scheel-Walter HG, Bökkerink JP, Riepenhausen M, Lüders H, Pötter R, Rühl U; DAL/GPOH
J Clin Oncol 2005 Sep 1;23(25):6181-9. doi: 10.1200/JCO.2005.07.930. PMID: 16135485
Treatment of unfavorable childhood Hodgkin's disease with VEPA and low-dose, involved-field radiation.
Friedmann AM, Hudson MM, Weinstein HJ, Donaldson SS, Kun L, Tarbell NJ, Link MP
J Clin Oncol 2002 Jul 15;20(14):3088-94. doi: 10.1200/JCO.2002.03.051. PMID: 12118022

Prognosis

Pediatric T-cell lymphoblastic lymphomas but not leukemias harbor TRB::NOTCH1 fusions with unfavorable outcome.
Te Vrugt M, Wessolowski J, Randau G, Alfert A, Mueller S, Scholten K, Sopalla C, Lanvers-Kaminsky C, Hotfilder M, Lamp F, Damm-Welk C, Luedersen J, Escherich G, Zur Stadt U, Behrmann L, Woessmann W, Oschlies I, Marzi M, Zimmermann M, Burkhardt B
Blood 2024 Sep 26;144(13):1412-1417. doi: 10.1182/blood.2024025307. PMID: 39024510
Detection of prognostic factors in children and adolescents with Burkitt and Diffuse Large B-Cell Lymphoma treated with the AIEOP LNH-97 protocol.
Pillon M, Mussolin L, Carraro E, Conter V, Aricò M, Vinti L, Garaventa A, Piglione M, Buffardi S, Sala A, Santoro N, Lo Nigro L, Mura R, Tondo A, Casale F, Farruggia P, Pierani P, Cesaro S, d'Amore ES, Basso G
Br J Haematol 2016 Nov;175(3):467-475. Epub 2016 Jul 8 doi: 10.1111/bjh.14240. PMID: 27392319
Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence.
Bonn BR, Rohde M, Zimmermann M, Krieger D, Oschlies I, Niggli F, Wrobel G, Attarbaschi A, Escherich G, Klapper W, Reiter A, Burkhardt B
Blood 2013 Apr 18;121(16):3153-60. Epub 2013 Feb 8 doi: 10.1182/blood-2012-12-474148. PMID: 23396305
Serum soluble interleukin-2 receptor, beta2-microglobulin, lactate dehydrogenase and erythrocyte sedimentation rate in children with Hodgkin's lymphoma.
Bien E, Balcerska A
Scand J Immunol 2009 Nov;70(5):490-500. doi: 10.1111/j.1365-3083.2009.02313.x. PMID: 19874554
Serum levels and differential expression of CD44 in childhood leukemia and malignant lymphoma: correlation with prognostic criteria and survival.
Taçyildiz N, Cavdar AO, Yavuz G, Gözdaşoglu S, Unal E, Ertem U, Duru F, Ikinciogullari A, Babacan E, Kuzu I, Cin S
Pediatr Int 2001 Aug;43(4):354-60. doi: 10.1046/j.1442-200x.2001.01415.x. PMID: 11472578

Clinical prediction guides

Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence.
Bonn BR, Rohde M, Zimmermann M, Krieger D, Oschlies I, Niggli F, Wrobel G, Attarbaschi A, Escherich G, Klapper W, Reiter A, Burkhardt B
Blood 2013 Apr 18;121(16):3153-60. Epub 2013 Feb 8 doi: 10.1182/blood-2012-12-474148. PMID: 23396305
Serum soluble interleukin-2 receptor, beta2-microglobulin, lactate dehydrogenase and erythrocyte sedimentation rate in children with Hodgkin's lymphoma.
Bien E, Balcerska A
Scand J Immunol 2009 Nov;70(5):490-500. doi: 10.1111/j.1365-3083.2009.02313.x. PMID: 19874554
Survival rates of childhood cancer patients in Osaka, Japan, 1975-1984.
Ajiki W, Hanai A, Tsukuma H, Hiyama T, Fujimoto I
Jpn J Cancer Res 1995 Jan;86(1):13-20. doi: 10.1111/j.1349-7006.1995.tb02982.x. PMID: 7737905Free PMC Article
The Lukes-Collins and Kiel classifications for non-Hodgkin lymphomas. A retrospective study considering both classifications and their relationships to stage, sex, age, and survival.
Blanco G, Alavaikko M, Apaja-Sarkkinen M, Taskinen PJ
Anticancer Res 1986 Mar-Apr;6(2):267-79. PMID: 3707063

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