U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Childhood gonadal germ cell tumor

MedGen UID:
859251
•Concept ID:
C3899657
•
Neoplastic Process
Synonym: Gonadal germ cell tumors
 
Monarch Initiative: MONDO:0020577

Definition

A germ cell tumor that arises from the testis or ovary and occurs during childhood. [from NCI]

Professional guidelines

PubMed

Assessment of Puberty and Hypothalamic-Pituitary-Gonadal Axis Function After Childhood Brain Tumor Treatment.
Rosimont M, Kariyawasam D, Samara-Boustani D, Giani E, Beltrand J, Bolle S, Fresneau B, Puget S, Sainte-Rose C, Alapetite C, Pinto G, Touraine P, Piketty ML, Brabant S, Abbou S, Aerts I, Beccaria K, Bourgeois M, Roujeau T, Blauwblomme T, Rocco FD, Thalassinos C, Rigaud C, James S, Busiah K, Simon A, Bourdeaut F, Lemelle L, Guerrini-Rousseau L, Orbach D, Doz F, Dufour C, Grill J, Polak M, Briceño LG
J Clin Endocrinol Metab 2023 Aug 18;108(9):e823-e831. doi: 10.1210/clinem/dgad097. PMID: 36810692
Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Management of germ cell tumors in children: approaches to cure.
Göbel U, Calaminus G, Schneider DT, Schmidt P, Haas RJ; MAKEI and MAHO Study Groups of the German Society of Pediatric Oncology and Hematology, and the SIOP CNS GCT Study Group
Onkologie 2002 Feb;25(1):14-22. doi: 10.1159/000055197. PMID: 11893878

Recent clinical studies

Etiology

Primary mediastinal germ cell tumors.
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Ovarian teratoma in children: a plea for collaborative clinical study.
Łuczak J, Bagłaj M
J Ovarian Res 2018 Aug 30;11(1):75. doi: 10.1186/s13048-018-0448-2. PMID: 30165903Free PMC Article
Mature and immature teratoma: A report from the second Italian pediatric study.
Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL, Conte M, Dall' Igna P, De Pasquale MD, Indolfi P, Piva L, Riccipetitoni G, Siracusa F, Spreafico F, Tamaro P, Cecchetto G
Pediatr Blood Cancer 2015 Jul;62(7):1202-8. Epub 2015 Jan 28 doi: 10.1002/pbc.25423. PMID: 25631333
Androgen insensitivity syndrome.
Hughes IA, Werner R, Bunch T, Hiort O
Semin Reprod Med 2012 Oct;30(5):432-42. Epub 2012 Oct 8 doi: 10.1055/s-0032-1324728. PMID: 23044881
Pediatric germ cell tumors.
Rescorla FJ
Semin Surg Oncol 1999 Mar;16(2):144-58. doi: 10.1002/(sici)1098-2388(199903)16:2<144::aid-ssu6>3.0.co;2-m. PMID: 9988869

Diagnosis

Ovarian teratoma in children: a plea for collaborative clinical study.
Łuczak J, Bagłaj M
J Ovarian Res 2018 Aug 30;11(1):75. doi: 10.1186/s13048-018-0448-2. PMID: 30165903Free PMC Article
Mature and immature teratoma: A report from the second Italian pediatric study.
Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL, Conte M, Dall' Igna P, De Pasquale MD, Indolfi P, Piva L, Riccipetitoni G, Siracusa F, Spreafico F, Tamaro P, Cecchetto G
Pediatr Blood Cancer 2015 Jul;62(7):1202-8. Epub 2015 Jan 28 doi: 10.1002/pbc.25423. PMID: 25631333
Androgen insensitivity syndrome.
Hughes IA, Werner R, Bunch T, Hiort O
Semin Reprod Med 2012 Oct;30(5):432-42. Epub 2012 Oct 8 doi: 10.1055/s-0032-1324728. PMID: 23044881
Pediatric germ cell tumors.
Rescorla FJ
Semin Surg Oncol 1999 Mar;16(2):144-58. doi: 10.1002/(sici)1098-2388(199903)16:2<144::aid-ssu6>3.0.co;2-m. PMID: 9988869
Teratomas in childhood.
Azizkhan RG, Caty MG
Curr Opin Pediatr 1996 Jun;8(3):287-92. doi: 10.1097/00008480-199606000-00018. PMID: 8814409

Therapy

Outcomes and prognostic variables of extracranial germ cell tumors in children and adolescents treated over a decade: A developing world perspective.
Ramanathan S, Prasad M, Vora T, Parambil BC, Kembhavi S, Ramadwar M, Khanna N, Laskar S, Kurkure P, Qureshi S, Banavali S, Chinnaswamy G
Pediatr Blood Cancer 2022 Jul;69(7):e29765. Epub 2022 May 13 doi: 10.1002/pbc.29765. PMID: 35561025
Outcome of pediatric germ cell tumor with comparison of carboplatin and cisplatin based regimens: A 10-year analysis.
Jain R, Menon P, Bansal D, Kakkar N, Radhika S, Rao KLN, Trehan A
Pediatr Hematol Oncol 2022 Apr;39(3):267-277. Epub 2021 Oct 19 doi: 10.1080/08880018.2021.1980164. PMID: 34665989
Early and late endocrine effects in pediatric central nervous system diseases.
Aslan IR, Cheung CC
J Pediatr Rehabil Med 2014;7(4):281-94. doi: 10.3233/PRM-140299. PMID: 25547881
Reproductive outcomes for survivors of childhood cancer.
Hudson MM
Obstet Gynecol 2010 Nov;116(5):1171-83. doi: 10.1097/AOG.0b013e3181f87c4b. PMID: 20966703Free PMC Article
Management of germ cell tumors in children: approaches to cure.
Göbel U, Calaminus G, Schneider DT, Schmidt P, Haas RJ; MAKEI and MAHO Study Groups of the German Society of Pediatric Oncology and Hematology, and the SIOP CNS GCT Study Group
Onkologie 2002 Feb;25(1):14-22. doi: 10.1159/000055197. PMID: 11893878

Prognosis

Primary mediastinal germ cell tumors.
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Ovarian teratoma in children: a plea for collaborative clinical study.
Łuczak J, Bagłaj M
J Ovarian Res 2018 Aug 30;11(1):75. doi: 10.1186/s13048-018-0448-2. PMID: 30165903Free PMC Article
Mature and immature teratoma: A report from the second Italian pediatric study.
Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL, Conte M, Dall' Igna P, De Pasquale MD, Indolfi P, Piva L, Riccipetitoni G, Siracusa F, Spreafico F, Tamaro P, Cecchetto G
Pediatr Blood Cancer 2015 Jul;62(7):1202-8. Epub 2015 Jan 28 doi: 10.1002/pbc.25423. PMID: 25631333
Pediatric germ cell tumors.
Rescorla FJ
Semin Surg Oncol 1999 Mar;16(2):144-58. doi: 10.1002/(sici)1098-2388(199903)16:2<144::aid-ssu6>3.0.co;2-m. PMID: 9988869
Teratomas in childhood.
Azizkhan RG, Caty MG
Curr Opin Pediatr 1996 Jun;8(3):287-92. doi: 10.1097/00008480-199606000-00018. PMID: 8814409

Clinical prediction guides

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624
Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Gonadal malignancy risk and prophylactic gonadectomy in disorders of sexual development.
Abacı A, Çatlı G, Berberoğlu M
J Pediatr Endocrinol Metab 2015 Sep;28(9-10):1019-27. doi: 10.1515/jpem-2014-0522. PMID: 25879315
Pediatric germ cell tumors.
Rescorla FJ
Semin Surg Oncol 1999 Mar;16(2):144-58. doi: 10.1002/(sici)1098-2388(199903)16:2<144::aid-ssu6>3.0.co;2-m. PMID: 9988869
Teratomas in childhood.
Azizkhan RG, Caty MG
Curr Opin Pediatr 1996 Jun;8(3):287-92. doi: 10.1097/00008480-199606000-00018. PMID: 8814409

Recent systematic reviews

Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors: a systematic review.
Braam KI, Overbeek A, Kaspers GJ, Ronckers CM, Schouten-van Meeteren AY, Van Dulmen-Den Broeder E, Veening MA
Pediatr Blood Cancer 2012 May;58(5):665-74. Epub 2012 Jan 9 doi: 10.1002/pbc.24023. PMID: 22232079

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...