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Childhood gonadal germ cell tumor

MedGen UID:
859251
•Concept ID:
C3899657
•
Neoplastic Process
Synonym: Gonadal germ cell tumors
 
Monarch Initiative: MONDO:0020577

Definition

A germ cell tumor that arises from the testis or ovary and occurs during childhood. [from NCI]

Professional guidelines

PubMed

Assessment of Puberty and Hypothalamic-Pituitary-Gonadal Axis Function After Childhood Brain Tumor Treatment.
Rosimont M, Kariyawasam D, Samara-Boustani D, Giani E, Beltrand J, Bolle S, Fresneau B, Puget S, Sainte-Rose C, Alapetite C, Pinto G, Touraine P, Piketty ML, Brabant S, Abbou S, Aerts I, Beccaria K, Bourgeois M, Roujeau T, Blauwblomme T, Rocco FD, Thalassinos C, Rigaud C, James S, Busiah K, Simon A, Bourdeaut F, Lemelle L, Guerrini-Rousseau L, Orbach D, Doz F, Dufour C, Grill J, Polak M, Briceño LG
J Clin Endocrinol Metab 2023 Aug 18;108(9):e823-e831. doi: 10.1210/clinem/dgad097. PMID: 36810692
Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Management of germ cell tumors in children: approaches to cure.
Göbel U, Calaminus G, Schneider DT, Schmidt P, Haas RJ; MAKEI and MAHO Study Groups of the German Society of Pediatric Oncology and Hematology, and the SIOP CNS GCT Study Group
Onkologie 2002 Feb;25(1):14-22. doi: 10.1159/000055197. PMID: 11893878

Recent clinical studies

Etiology

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Assessment of Puberty and Hypothalamic-Pituitary-Gonadal Axis Function After Childhood Brain Tumor Treatment.
Rosimont M, Kariyawasam D, Samara-Boustani D, Giani E, Beltrand J, Bolle S, Fresneau B, Puget S, Sainte-Rose C, Alapetite C, Pinto G, Touraine P, Piketty ML, Brabant S, Abbou S, Aerts I, Beccaria K, Bourgeois M, Roujeau T, Blauwblomme T, Rocco FD, Thalassinos C, Rigaud C, James S, Busiah K, Simon A, Bourdeaut F, Lemelle L, Guerrini-Rousseau L, Orbach D, Doz F, Dufour C, Grill J, Polak M, Briceño LG
J Clin Endocrinol Metab 2023 Aug 18;108(9):e823-e831. doi: 10.1210/clinem/dgad097. PMID: 36810692
Primary mediastinal germ cell tumors.
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Non-epithelial Ovarian Cancer: Elucidating Uncommon Gynaecological Malignancies.
Boussios S, Zarkavelis G, Seraj E, Zerdes I, Tatsi K, Pentheroudakis G
Anticancer Res 2016 Oct;36(10):5031-5042. doi: 10.21873/anticanres.11072. PMID: 27798862
Androgen insensitivity syndrome.
Hughes IA, Werner R, Bunch T, Hiort O
Semin Reprod Med 2012 Oct;30(5):432-42. Epub 2012 Oct 8 doi: 10.1055/s-0032-1324728. PMID: 23044881

Diagnosis

Assessment of Puberty and Hypothalamic-Pituitary-Gonadal Axis Function After Childhood Brain Tumor Treatment.
Rosimont M, Kariyawasam D, Samara-Boustani D, Giani E, Beltrand J, Bolle S, Fresneau B, Puget S, Sainte-Rose C, Alapetite C, Pinto G, Touraine P, Piketty ML, Brabant S, Abbou S, Aerts I, Beccaria K, Bourgeois M, Roujeau T, Blauwblomme T, Rocco FD, Thalassinos C, Rigaud C, James S, Busiah K, Simon A, Bourdeaut F, Lemelle L, Guerrini-Rousseau L, Orbach D, Doz F, Dufour C, Grill J, Polak M, Briceño LG
J Clin Endocrinol Metab 2023 Aug 18;108(9):e823-e831. doi: 10.1210/clinem/dgad097. PMID: 36810692
Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort.
Masliukaite I, Ntemou E, Feijen EAM, van de Wetering M, Meissner A, Soufan AT, Repping S, Kremer LMC, Jahnukainen K, Goossens E, van Pelt AMM
Hum Reprod 2023 Mar 1;38(3):359-370. doi: 10.1093/humrep/dead004. PMID: 36708005Free PMC Article
Non-epithelial Ovarian Cancer: Elucidating Uncommon Gynaecological Malignancies.
Boussios S, Zarkavelis G, Seraj E, Zerdes I, Tatsi K, Pentheroudakis G
Anticancer Res 2016 Oct;36(10):5031-5042. doi: 10.21873/anticanres.11072. PMID: 27798862
Androgen insensitivity syndrome.
Hughes IA, Werner R, Bunch T, Hiort O
Semin Reprod Med 2012 Oct;30(5):432-42. Epub 2012 Oct 8 doi: 10.1055/s-0032-1324728. PMID: 23044881
Gonadal and extragonadal germ cell neoplasia of childhood.
Dehner LP
Hum Pathol 1983 Jun;14(6):493-511. doi: 10.1016/s0046-8177(83)80004-5. PMID: 6343221

Therapy

Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort.
Masliukaite I, Ntemou E, Feijen EAM, van de Wetering M, Meissner A, Soufan AT, Repping S, Kremer LMC, Jahnukainen K, Goossens E, van Pelt AMM
Hum Reprod 2023 Mar 1;38(3):359-370. doi: 10.1093/humrep/dead004. PMID: 36708005Free PMC Article
Outcomes and prognostic variables of extracranial germ cell tumors in children and adolescents treated over a decade: A developing world perspective.
Ramanathan S, Prasad M, Vora T, Parambil BC, Kembhavi S, Ramadwar M, Khanna N, Laskar S, Kurkure P, Qureshi S, Banavali S, Chinnaswamy G
Pediatr Blood Cancer 2022 Jul;69(7):e29765. Epub 2022 May 13 doi: 10.1002/pbc.29765. PMID: 35561025
Outcome of pediatric germ cell tumor with comparison of carboplatin and cisplatin based regimens: A 10-year analysis.
Jain R, Menon P, Bansal D, Kakkar N, Radhika S, Rao KLN, Trehan A
Pediatr Hematol Oncol 2022 Apr;39(3):267-277. Epub 2021 Oct 19 doi: 10.1080/08880018.2021.1980164. PMID: 34665989
Early and late endocrine effects in pediatric central nervous system diseases.
Aslan IR, Cheung CC
J Pediatr Rehabil Med 2014;7(4):281-94. doi: 10.3233/PRM-140299. PMID: 25547881
Reproductive outcomes for survivors of childhood cancer.
Hudson MM
Obstet Gynecol 2010 Nov;116(5):1171-83. doi: 10.1097/AOG.0b013e3181f87c4b. PMID: 20966703Free PMC Article

Prognosis

Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Primary mediastinal germ cell tumors.
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Non-epithelial Ovarian Cancer: Elucidating Uncommon Gynaecological Malignancies.
Boussios S, Zarkavelis G, Seraj E, Zerdes I, Tatsi K, Pentheroudakis G
Anticancer Res 2016 Oct;36(10):5031-5042. doi: 10.21873/anticanres.11072. PMID: 27798862
Gonadal malignancy risk and prophylactic gonadectomy in disorders of sexual development.
Abacı A, Çatlı G, Berberoğlu M
J Pediatr Endocrinol Metab 2015 Sep;28(9-10):1019-27. doi: 10.1515/jpem-2014-0522. PMID: 25879315
Gonadal and extragonadal germ cell neoplasia of childhood.
Dehner LP
Hum Pathol 1983 Jun;14(6):493-511. doi: 10.1016/s0046-8177(83)80004-5. PMID: 6343221

Clinical prediction guides

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Outcome of pediatric germ cell tumor with comparison of carboplatin and cisplatin based regimens: A 10-year analysis.
Jain R, Menon P, Bansal D, Kakkar N, Radhika S, Rao KLN, Trehan A
Pediatr Hematol Oncol 2022 Apr;39(3):267-277. Epub 2021 Oct 19 doi: 10.1080/08880018.2021.1980164. PMID: 34665989
Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Gonadal malignancy risk and prophylactic gonadectomy in disorders of sexual development.
Abacı A, Çatlı G, Berberoğlu M
J Pediatr Endocrinol Metab 2015 Sep;28(9-10):1019-27. doi: 10.1515/jpem-2014-0522. PMID: 25879315
Teratomas in childhood.
Azizkhan RG, Caty MG
Curr Opin Pediatr 1996 Jun;8(3):287-92. doi: 10.1097/00008480-199606000-00018. PMID: 8814409

Recent systematic reviews

Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors: a systematic review.
Braam KI, Overbeek A, Kaspers GJ, Ronckers CM, Schouten-van Meeteren AY, Van Dulmen-Den Broeder E, Veening MA
Pediatr Blood Cancer 2012 May;58(5):665-74. Epub 2012 Jan 9 doi: 10.1002/pbc.24023. PMID: 22232079

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