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BCLC Stage B Hepatocellular Carcinoma

MedGen UID:
859573
•Concept ID:
C3899979
•
Neoplastic Process
Synonym: Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma

Definition

Intermediate hepatocellular carcinoma. Patients may benefit from chemoembolization. (HPB (Oxford) 2005; 7(1):35-41) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBCLC Stage B Hepatocellular Carcinoma

Professional guidelines

PubMed

Management of people with intermediate-stage hepatocellular carcinoma: an attempted network meta-analysis.
Roccarina D, Majumdar A, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 10;3(3):CD011649. doi: 10.1002/14651858.CD011649.pub2. PMID: 28281295Free PMC Article
Validation of Kinki Criteria, a Modified Substaging System, in Patients with Intermediate Stage Hepatocellular Carcinoma.
Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Minami Y, Ida H, Sakurai T, Kitano M, Nishida N, Kudo M
Dig Dis 2016;34(6):671-678. Epub 2016 Oct 17 doi: 10.1159/000448834. PMID: 27750236
Subclassification of BCLC B Stage Hepatocellular Carcinoma and Treatment Strategies: Proposal of Modified Bolondi's Subclassification (Kinki Criteria).
Kudo M, Arizumi T, Ueshima K, Sakurai T, Kitano M, Nishida N
Dig Dis 2015 Oct;33(6):751-8. Epub 2015 Oct 21 doi: 10.1159/000439290. PMID: 26488473

Recent clinical studies

Etiology

Efficacy Investigation of TACE Combined with Lenvatinib and Sintilimab in Intermediate-Stage Hepatocellular Carcinoma.
Zhang M, Lai W, Zhang J, Hu B, Huang L, Chu C
Dis Markers 2022;2022:6957580. Epub 2022 Jul 6 doi: 10.1155/2022/6957580. PMID: 35845129Free PMC Article
A new ALBI-based model to predict survival after transarterial chemoembolization for BCLC stage B hepatocellular carcinoma.
Lee IC, Hung YW, Liu CA, Lee RC, Su CW, Huo TI, Li CP, Chao Y, Lin HC, Hou MC, Huang YH
Liver Int 2019 Sep;39(9):1704-1712. Epub 2019 Jul 30 doi: 10.1111/liv.14194. PMID: 31319016
Combined transarterial chemoembolization and microwave ablation versus transarterial chemoembolization in BCLC stage B hepatocellular carcinoma.
Zhang R, Shen L, Zhao L, Guan Z, Chen Q, Li W
Diagn Interv Radiol 2018 Jul;24(4):219-224. doi: 10.5152/dir.2018.17528. PMID: 29792289Free PMC Article
BCLC stage B hepatocellular carcinoma and transcatheter arterial chemoembolization: a 20-year survey by the Italian Liver Cancer group.
Farinati F, Vanin V, Giacomin A, Pozzan C, Cillo U, Vitale A, Di Nolfo AM, Del Poggio P, Benvegnu' L, Rapaccini G, Zoli M, Borzio F, Giannini EG, Caturelli E, Trevisani F; Italian Liver Cancer (ITA.LI.CA) group
Liver Int 2015 Jan;35(1):223-31. Epub 2014 Aug 27 doi: 10.1111/liv.12649. PMID: 25074434
Barcelona clinic liver cancer stage B hepatocellular carcinoma: transarterial chemoembolization or hepatic resection?
Jianyong L, Lunan Y, Wentao W, Yong Z, Bo L, Tianfu W, Minqing X, Jiaying Y
Medicine (Baltimore) 2014 Nov;93(26):e180. doi: 10.1097/MD.0000000000000180. PMID: 25474433Free PMC Article

Diagnosis

Radioembolisation with Y90-resin microspheres followed by nivolumab for advanced hepatocellular carcinoma (CA 209-678): a single arm, single centre, phase 2 trial.
Tai D, Loke K, Gogna A, Kaya NA, Tan SH, Hennedige T, Ng D, Irani F, Lee J, Lim JQ, Too CW, Ng MCH, Tham CK, Lam J, Koo SL, Chong HS, Goh GB, Huang HL, Venkatanarasimha N, Lo R, Chow PKH, Goh BKP, Chung A, Toh HC, Thng CH, Lim TKH, Yeong J, Zhai W, Chan CY, Choo SP
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1025-1035. Epub 2021 Oct 23 doi: 10.1016/S2468-1253(21)00305-8. PMID: 34695377
A new ALBI-based model to predict survival after transarterial chemoembolization for BCLC stage B hepatocellular carcinoma.
Lee IC, Hung YW, Liu CA, Lee RC, Su CW, Huo TI, Li CP, Chao Y, Lin HC, Hou MC, Huang YH
Liver Int 2019 Sep;39(9):1704-1712. Epub 2019 Jul 30 doi: 10.1111/liv.14194. PMID: 31319016
Hepatic Resection Improved the Long-Term Survival of Patients with BCLC Stage B Hepatocellular Carcinoma in Asia: a Systematic Review and Meta-Analysis.
Liu W, Zhou JG, Sun Y, Zhang L, Xing BC
J Gastrointest Surg 2015 Jul;19(7):1271-80. Epub 2015 May 6 doi: 10.1007/s11605-015-2811-6. PMID: 25943910
BCLC stage B hepatocellular carcinoma and transcatheter arterial chemoembolization: a 20-year survey by the Italian Liver Cancer group.
Farinati F, Vanin V, Giacomin A, Pozzan C, Cillo U, Vitale A, Di Nolfo AM, Del Poggio P, Benvegnu' L, Rapaccini G, Zoli M, Borzio F, Giannini EG, Caturelli E, Trevisani F; Italian Liver Cancer (ITA.LI.CA) group
Liver Int 2015 Jan;35(1):223-31. Epub 2014 Aug 27 doi: 10.1111/liv.12649. PMID: 25074434
A scoring system for prediction of early recurrence after liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma.
Qian H, Wei M, Qiu H, Wu J, Liu B, Lyu A, Liu Q, Li C, Leng J, Zhang J, Hao C
Chin Med J (Engl) 2014;127(24):4171-6. PMID: 25533817

Therapy

Impact of skeletal muscle volume on patients with BCLC stage-B hepatocellular carcinoma undergoing sorafenib therapy.
Saeki I, Yamasaki T, Yamauchi Y, Kawaoka T, Uchikawa S, Hiramatsu A, Aikata H, Kobayashi K, Kondo T, Ogasawara S, Chiba T, Kawano R, Chayama K, Kato N, Takami T
Cancer Med 2023 May;12(9):10625-10635. Epub 2023 Mar 23 doi: 10.1002/cam4.5810. PMID: 36951579Free PMC Article
Radioembolization for Intermediate-Stage Hepatocellular Carcinoma Maintains Liver Function and Permits Systemic Therapy at Progression.
Ranganathan S, Gabr A, Entezari P, Gordon AC, Riaz A, Desai K, Thornburg B, Kulik L, Kalyan A, Salem R, Lewandowski RJ
J Vasc Interv Radiol 2023 Jun;34(6):968-975. Epub 2023 Feb 13 doi: 10.1016/j.jvir.2022.11.036. PMID: 36791957
Overall survival in response to sorafenib with transarterial chemoembolization for BCLC stage B hepatocellular carcinoma: propensity score analysis
.
Huang Y, Chen B, Liu N, Li N, Dao H, Chen W, Yang J
Int J Clin Pharmacol Ther 2017 Jun;55(6):498-508. doi: 10.5414/CP202787. PMID: 28157070
Hepatic Resection Improved the Long-Term Survival of Patients with BCLC Stage B Hepatocellular Carcinoma in Asia: a Systematic Review and Meta-Analysis.
Liu W, Zhou JG, Sun Y, Zhang L, Xing BC
J Gastrointest Surg 2015 Jul;19(7):1271-80. Epub 2015 May 6 doi: 10.1007/s11605-015-2811-6. PMID: 25943910
Barcelona clinic liver cancer stage B hepatocellular carcinoma: transarterial chemoembolization or hepatic resection?
Jianyong L, Lunan Y, Wentao W, Yong Z, Bo L, Tianfu W, Minqing X, Jiaying Y
Medicine (Baltimore) 2014 Nov;93(26):e180. doi: 10.1097/MD.0000000000000180. PMID: 25474433Free PMC Article

Prognosis

A new ALBI-based model to predict survival after transarterial chemoembolization for BCLC stage B hepatocellular carcinoma.
Lee IC, Hung YW, Liu CA, Lee RC, Su CW, Huo TI, Li CP, Chao Y, Lin HC, Hou MC, Huang YH
Liver Int 2019 Sep;39(9):1704-1712. Epub 2019 Jul 30 doi: 10.1111/liv.14194. PMID: 31319016
Combined transarterial chemoembolization and microwave ablation versus transarterial chemoembolization in BCLC stage B hepatocellular carcinoma.
Zhang R, Shen L, Zhao L, Guan Z, Chen Q, Li W
Diagn Interv Radiol 2018 Jul;24(4):219-224. doi: 10.5152/dir.2018.17528. PMID: 29792289Free PMC Article
Hepatic Resection Improved the Long-Term Survival of Patients with BCLC Stage B Hepatocellular Carcinoma in Asia: a Systematic Review and Meta-Analysis.
Liu W, Zhou JG, Sun Y, Zhang L, Xing BC
J Gastrointest Surg 2015 Jul;19(7):1271-80. Epub 2015 May 6 doi: 10.1007/s11605-015-2811-6. PMID: 25943910
BCLC stage B hepatocellular carcinoma and transcatheter arterial chemoembolization: a 20-year survey by the Italian Liver Cancer group.
Farinati F, Vanin V, Giacomin A, Pozzan C, Cillo U, Vitale A, Di Nolfo AM, Del Poggio P, Benvegnu' L, Rapaccini G, Zoli M, Borzio F, Giannini EG, Caturelli E, Trevisani F; Italian Liver Cancer (ITA.LI.CA) group
Liver Int 2015 Jan;35(1):223-31. Epub 2014 Aug 27 doi: 10.1111/liv.12649. PMID: 25074434
Subgrouping of intermediate-stage (BCLC stage B) hepatocellular carcinoma based on tumor number and size and Child-Pugh grade correlated with prognosis after transarterial chemoembolization.
Yamakado K, Miyayama S, Hirota S, Mizunuma K, Nakamura K, Inaba Y, Maeda H, Matsuo K, Nishida N, Aramaki T, Anai H, Koura S, Oikawa S, Watanabe K, Yasumoto T, Furuichi K, Yamaguchi M
Jpn J Radiol 2014 May;32(5):260-5. Epub 2014 Mar 11 doi: 10.1007/s11604-014-0298-9. PMID: 24615165

Clinical prediction guides

Efficacy Investigation of TACE Combined with Lenvatinib and Sintilimab in Intermediate-Stage Hepatocellular Carcinoma.
Zhang M, Lai W, Zhang J, Hu B, Huang L, Chu C
Dis Markers 2022;2022:6957580. Epub 2022 Jul 6 doi: 10.1155/2022/6957580. PMID: 35845129Free PMC Article
A new ALBI-based model to predict survival after transarterial chemoembolization for BCLC stage B hepatocellular carcinoma.
Lee IC, Hung YW, Liu CA, Lee RC, Su CW, Huo TI, Li CP, Chao Y, Lin HC, Hou MC, Huang YH
Liver Int 2019 Sep;39(9):1704-1712. Epub 2019 Jul 30 doi: 10.1111/liv.14194. PMID: 31319016
Combined transarterial chemoembolization and microwave ablation versus transarterial chemoembolization in BCLC stage B hepatocellular carcinoma.
Zhang R, Shen L, Zhao L, Guan Z, Chen Q, Li W
Diagn Interv Radiol 2018 Jul;24(4):219-224. doi: 10.5152/dir.2018.17528. PMID: 29792289Free PMC Article
BCLC stage B hepatocellular carcinoma and transcatheter arterial chemoembolization: a 20-year survey by the Italian Liver Cancer group.
Farinati F, Vanin V, Giacomin A, Pozzan C, Cillo U, Vitale A, Di Nolfo AM, Del Poggio P, Benvegnu' L, Rapaccini G, Zoli M, Borzio F, Giannini EG, Caturelli E, Trevisani F; Italian Liver Cancer (ITA.LI.CA) group
Liver Int 2015 Jan;35(1):223-31. Epub 2014 Aug 27 doi: 10.1111/liv.12649. PMID: 25074434
Barcelona clinic liver cancer stage B hepatocellular carcinoma: transarterial chemoembolization or hepatic resection?
Jianyong L, Lunan Y, Wentao W, Yong Z, Bo L, Tianfu W, Minqing X, Jiaying Y
Medicine (Baltimore) 2014 Nov;93(26):e180. doi: 10.1097/MD.0000000000000180. PMID: 25474433Free PMC Article

Recent systematic reviews

Hepatic Resection Improved the Long-Term Survival of Patients with BCLC Stage B Hepatocellular Carcinoma in Asia: a Systematic Review and Meta-Analysis.
Liu W, Zhou JG, Sun Y, Zhang L, Xing BC
J Gastrointest Surg 2015 Jul;19(7):1271-80. Epub 2015 May 6 doi: 10.1007/s11605-015-2811-6. PMID: 25943910

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