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Adult germ cell tumor

MedGen UID:
859695
•Concept ID:
C3900101
•
Neoplastic Process
Synonyms: Adult Germ Cell Tumor; adult germ cell tumor; Adult germ cell tumour; germ cell tumor of adults; germ cell tumour of adults
 
Monarch Initiative: MONDO:0044878

Definition

A germ cell tumor that occurs during adulthood. [from NCI]

Professional guidelines

PubMed

Adolescent and Young Adult Germ Cell Tumors: Epidemiology, Genomics, Treatment, and Survivorship.
Travis LB, Feldman DR, Fung C, Poynter JN, Lockley M, Frazier AL
J Clin Oncol 2024 Feb 20;42(6):696-706. Epub 2023 Oct 11 doi: 10.1200/JCO.23.01099. PMID: 37820296
Clinical practice guidelines for the management of adult diffuse gliomas.
Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q; Chinese Glioma Cooperative Group (CGCG); Society for Neuro‐Oncology of China (SNO-China); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
Cancer Lett 2021 Feb 28;499:60-72. Epub 2020 Nov 6 doi: 10.1016/j.canlet.2020.10.050. PMID: 33166616
Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897

Recent clinical studies

Etiology

Intracranial Germ Cell Tumors.
Yeoh TDYY, Nga V, Kimpo M, Lo SS, Vellayappan B
Semin Neurol 2023 Dec;43(6):897-908. Epub 2023 Nov 14 doi: 10.1055/s-0043-1776763. PMID: 37963583
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Treatment of germ cell testicular cancer.
Koši Kunac A, Gnjidić M, Antunac Golubić Z, Gamulin M
Acta Clin Croat 2020 Sep;59(3):496-504. doi: 10.20471/acc.2020.59.03.14. PMID: 34177060Free PMC Article
Testicular cancer.
Nichols CR
Curr Probl Cancer 1998 Jul-Aug;22(4):187-274. doi: 10.1016/s0147-0272(98)90012-5. PMID: 9743088
Long-term follow-up of a phase III study of three versus four cycles of bleomycin, etoposide, and cisplatin in favorable-prognosis germ-cell tumors: the Indian University experience.
Saxman SB, Finch D, Gonin R, Einhorn LH
J Clin Oncol 1998 Feb;16(2):702-6. doi: 10.1200/JCO.1998.16.2.702. PMID: 9469360

Diagnosis

EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Treatment of germ cell testicular cancer.
Koši Kunac A, Gnjidić M, Antunac Golubić Z, Gamulin M
Acta Clin Croat 2020 Sep;59(3):496-504. doi: 10.20471/acc.2020.59.03.14. PMID: 34177060Free PMC Article
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Spermatocytic seminoma.
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276

Therapy

Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy.
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276
Combination of paclitaxel, ifosfamide, and cisplatin is an effective second-line therapy for patients with relapsed testicular germ cell tumors.
Kondagunta GV, Bacik J, Donadio A, Bajorin D, Marion S, Sheinfeld J, Bosl GJ, Motzer RJ
J Clin Oncol 2005 Sep 20;23(27):6549-55. doi: 10.1200/JCO.2005.19.638. PMID: 16170162
Testicular cancer.
Nichols CR
Curr Probl Cancer 1998 Jul-Aug;22(4):187-274. doi: 10.1016/s0147-0272(98)90012-5. PMID: 9743088

Prognosis

Germ Cell Tumors in Adolescents and Young Adults.
Calaminus G, Joffe J
Prog Tumor Res 2016;43:115-27. Epub 2016 Sep 5 doi: 10.1159/000447081. PMID: 27595361
Male Extragonadal Germ Cell Tumors of the Adult.
Busch J, Seidel C, Zengerling F
Oncol Res Treat 2016;39(3):140-4. Epub 2016 Feb 23 doi: 10.1159/000444271. PMID: 27032104
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276
Testicular cancer.
Nichols CR
Curr Probl Cancer 1998 Jul-Aug;22(4):187-274. doi: 10.1016/s0147-0272(98)90012-5. PMID: 9743088
Long-term follow-up of a phase III study of three versus four cycles of bleomycin, etoposide, and cisplatin in favorable-prognosis germ-cell tumors: the Indian University experience.
Saxman SB, Finch D, Gonin R, Einhorn LH
J Clin Oncol 1998 Feb;16(2):702-6. doi: 10.1200/JCO.1998.16.2.702. PMID: 9469360

Clinical prediction guides

Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Potential biomarkers for testicular germ cell tumour: Risk assessment, diagnostic, prognostic and monitoring of recurrence.
Lakpour N, Saliminejad K, Ghods R, Reza Sadeghi M, Pilatz A, Khosravi F, Madjd Z
Andrologia 2021 May;53(4):e13998. Epub 2021 Feb 3 doi: 10.1111/and.13998. PMID: 33534171
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Long-term follow-up of a phase III study of three versus four cycles of bleomycin, etoposide, and cisplatin in favorable-prognosis germ-cell tumors: the Indian University experience.
Saxman SB, Finch D, Gonin R, Einhorn LH
J Clin Oncol 1998 Feb;16(2):702-6. doi: 10.1200/JCO.1998.16.2.702. PMID: 9469360
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

Recent systematic reviews

Neoadjuvant treatment for stage III and IV cutaneous melanoma.
Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Palliative care and end-of-life care in adults with malignant brain tumors.
Koekkoek JAF, van der Meer PB, Pace A, Hertler C, Harrison R, Leeper HE, Forst DA, Jalali R, Oliver K, Philip J, Taphoorn MJB, Dirven L, Walbert T
Neuro Oncol 2023 Mar 14;25(3):447-456. doi: 10.1093/neuonc/noac216. PMID: 36271873Free PMC Article
Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Use of sunscreen and risk of melanoma and non-melanoma skin cancer: a systematic review and meta-analysis.
Silva ESD, Tavares R, Paulitsch FDS, Zhang L
Eur J Dermatol 2018 Apr 1;28(2):186-201. doi: 10.1684/ejd.2018.3251. PMID: 29620003

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