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Adult germ cell tumor

MedGen UID:
859695
•Concept ID:
C3900101
•
Neoplastic Process
Synonyms: Adult Germ Cell Tumor; adult germ cell tumor; Adult germ cell tumour; germ cell tumor of adults; germ cell tumour of adults
 
Monarch Initiative: MONDO:0044878

Definition

A germ cell tumor that occurs during adulthood. [from NCI]

Professional guidelines

PubMed

Clinical practice guidelines for the management of adult diffuse gliomas.
Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D, Mao Y, Ma W, Mao Q, You Y, Jiang C, Yang X, Kang C, Qiu X, Li W, Li S, Chen L, Li X, Liu Z, Wang W, Bai H, Yao Y, Li S, Wu A, Sai K, Li G, Yao K, Wei X, Liu X, Zhang Z, Dai Y, Lv S, Wang L, Lin Z, Dong J, Xu G, Ma X, Zhang W, Zhang C, Chen B, You G, Wang Y, Wang Y, Bao Z, Yang P, Fan X, Liu X, Zhao Z, Wang Z, Li Y, Wang Z, Li G, Fang S, Li L, Liu Y, Liu S, Shan X, Liu Y, Chai R, Hu H, Chen J, Yan W, Cai J, Wang H, Chen L, Yang Y, Wang Y, Han L, Wang Q; Chinese Glioma Cooperative Group (CGCG); Society for Neuro‐Oncology of China (SNO-China); Chinese Brain Cancer Association (CBCA); Chinese Glioma Genome Atlas (CGGA); Asian Glioma Genome Atlas (AGGA) network
Cancer Lett 2021 Feb 28;499:60-72. Epub 2020 Nov 6 doi: 10.1016/j.canlet.2020.10.050. PMID: 33166616
Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897
Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management.
Sturm D, Pfister SM, Jones DTW
J Clin Oncol 2017 Jul 20;35(21):2370-2377. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.73.0242. PMID: 28640698

Recent clinical studies

Etiology

Testicular germ cell tumors: Genomic alternations and RAS-dependent signaling.
Nakhaei-Rad S, Soleimani Z, Vahedi S, Gorjinia Z
Crit Rev Oncol Hematol 2023 Mar;183:103928. Epub 2023 Jan 27 doi: 10.1016/j.critrevonc.2023.103928. PMID: 36717007
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Treatment of germ cell testicular cancer.
Koši Kunac A, Gnjidić M, Antunac Golubić Z, Gamulin M
Acta Clin Croat 2020 Sep;59(3):496-504. doi: 10.20471/acc.2020.59.03.14. PMID: 34177060Free PMC Article
Testicular cancer.
Nichols CR
Curr Probl Cancer 1998 Jul-Aug;22(4):187-274. doi: 10.1016/s0147-0272(98)90012-5. PMID: 9743088
Testicular cancer.
Oliver RT
Curr Opin Oncol 1996 May;8(3):252-8. doi: 10.1097/00001622-199605000-00015. PMID: 8804810

Diagnosis

EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Treatment of germ cell testicular cancer.
Koši Kunac A, Gnjidić M, Antunac Golubić Z, Gamulin M
Acta Clin Croat 2020 Sep;59(3):496-504. doi: 10.20471/acc.2020.59.03.14. PMID: 34177060Free PMC Article
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Spermatocytic seminoma.
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257
Testicular cancer.
Nichols CR
Curr Probl Cancer 1998 Jul-Aug;22(4):187-274. doi: 10.1016/s0147-0272(98)90012-5. PMID: 9743088

Therapy

Current Management of Refractory Germ Cell Tumors.
Abughanimeh O, Teply BA
Curr Oncol Rep 2021 Jul 16;23(9):101. doi: 10.1007/s11912-021-01093-z. PMID: 34269906
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276
Combination of paclitaxel, ifosfamide, and cisplatin is an effective second-line therapy for patients with relapsed testicular germ cell tumors.
Kondagunta GV, Bacik J, Donadio A, Bajorin D, Marion S, Sheinfeld J, Bosl GJ, Motzer RJ
J Clin Oncol 2005 Sep 20;23(27):6549-55. doi: 10.1200/JCO.2005.19.638. PMID: 16170162
Testicular cancer.
Nichols CR
Curr Probl Cancer 1998 Jul-Aug;22(4):187-274. doi: 10.1016/s0147-0272(98)90012-5. PMID: 9743088

Prognosis

Potential biomarkers for testicular germ cell tumour: Risk assessment, diagnostic, prognostic and monitoring of recurrence.
Lakpour N, Saliminejad K, Ghods R, Reza Sadeghi M, Pilatz A, Khosravi F, Madjd Z
Andrologia 2021 May;53(4):e13998. Epub 2021 Feb 3 doi: 10.1111/and.13998. PMID: 33534171
Germ Cell Tumors in Adolescents and Young Adults.
Calaminus G, Joffe J
Prog Tumor Res 2016;43:115-27. Epub 2016 Sep 5 doi: 10.1159/000447081. PMID: 27595361
Male Extragonadal Germ Cell Tumors of the Adult.
Busch J, Seidel C, Zengerling F
Oncol Res Treat 2016;39(3):140-4. Epub 2016 Feb 23 doi: 10.1159/000444271. PMID: 27032104
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276
Testicular cancer.
Nichols CR
Curr Probl Cancer 1998 Jul-Aug;22(4):187-274. doi: 10.1016/s0147-0272(98)90012-5. PMID: 9743088

Clinical prediction guides

Updates in 2022 on the staging of testicular germ cell tumors.
Canete Portillo S, Rais-Bahrami S, Magi-Galluzzi C
Hum Pathol 2022 Oct;128:152-160. Epub 2022 Aug 1 doi: 10.1016/j.humpath.2022.07.009. PMID: 35926809
Potential biomarkers for testicular germ cell tumour: Risk assessment, diagnostic, prognostic and monitoring of recurrence.
Lakpour N, Saliminejad K, Ghods R, Reza Sadeghi M, Pilatz A, Khosravi F, Madjd Z
Andrologia 2021 May;53(4):e13998. Epub 2021 Feb 3 doi: 10.1111/and.13998. PMID: 33534171
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Molecular biology of testicular germ cell tumors: unique features awaiting clinical application.
Boublikova L, Buchler T, Stary J, Abrahamova J, Trka J
Crit Rev Oncol Hematol 2014 Mar;89(3):366-85. Epub 2013 Oct 11 doi: 10.1016/j.critrevonc.2013.10.001. PMID: 24182421

Recent systematic reviews

Quality of Life in Craniopharyngioma: A Systematic Review.
Castle-Kirszbaum M, Shi MDY, Goldschlager T
World Neurosurg 2022 Aug;164:424-435.e2. Epub 2022 May 14 doi: 10.1016/j.wneu.2022.05.038. PMID: 35580780
Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
Skin cancer risk among testicular germ-cell cancer survivors: a systematic review and meta-analysis.
Reiter O, Voss VB, Fluss R, Boyce LM, DeFazio JL, Halpern AC, Marghoob AA
J Eur Acad Dermatol Venereol 2022 Jul;36(7):1025-1033. Epub 2022 Feb 9 doi: 10.1111/jdv.17932. PMID: 35034398
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Use of sunscreen and risk of melanoma and non-melanoma skin cancer: a systematic review and meta-analysis.
Silva ESD, Tavares R, Paulitsch FDS, Zhang L
Eur J Dermatol 2018 Apr 1;28(2):186-201. doi: 10.1684/ejd.2018.3251. PMID: 29620003

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