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Empyema

MedGen UID:
8597
•Concept ID:
C0014009
•
Disease or Syndrome
Synonyms: collection of pus; empyema
SNOMED CT: Empyema (66696003); Empyema (312682007)
 
Monarch Initiative: MONDO:0005242

Definition

An accumulation of pus in the pleural space. [from NCI]

Professional guidelines

PubMed

Medical and Surgical Management of Empyema.
Godfrey MS, Bramley KT, Detterbeck F
Semin Respir Crit Care Med 2019 Jun;40(3):361-374. Epub 2019 Sep 16 doi: 10.1055/s-0039-1694699. PMID: 31525811
Pleural Effusion in Adults-Etiology, Diagnosis, and Treatment.
Jany B, Welte T
Dtsch Arztebl Int 2019 May 24;116(21):377-386. doi: 10.3238/arztebl.2019.0377. PMID: 31315808Free PMC Article
Update in the Management of Pleural Effusions.
Aboudara M, Maldonado F
Med Clin North Am 2019 May;103(3):475-485. doi: 10.1016/j.mcna.2018.12.007. PMID: 30955515

Recent clinical studies

Etiology

Parapneumonic Effusion and Empyema.
Addala DN, Bedawi EO, Rahman NM
Clin Chest Med 2021 Dec;42(4):637-647. doi: 10.1016/j.ccm.2021.08.001. PMID: 34774171
Use of fibrinolytics and deoxyribonuclease in adult patients with pleural empyema: a consensus statement.
Chaddha U, Agrawal A, Feller-Kopman D, Kaul V, Shojaee S, Maldonado F, Ferguson MK, Blyth KG, Grosu HB, Corcoran JP, Sachdeva A, West A, Bedawi EO, Majid A, Mehta RM, Folch E, Liberman M, Wahidi MM, Gangadharan SP, Roberts ME, DeCamp MM, Rahman NM
Lancet Respir Med 2021 Sep;9(9):1050-1064. Epub 2021 Feb 2 doi: 10.1016/S2213-2600(20)30533-6. PMID: 33545086
Epidemiology of pleural empyema in English hospitals and the impact of influenza.
Arnold DT, Hamilton FW, Morris TT, Suri T, Morley A, Frost V, Vipond IB, Medford AR, Payne RA, Muir P, Maskell NA
Eur Respir J 2021 Jun;57(6) Epub 2021 Jun 17 doi: 10.1183/13993003.03546-2020. PMID: 33334937Free PMC Article
Postpneumonectomy empyema.
Abbas Ael-S, Deschamps C
Curr Opin Pulm Med 2002 Jul;8(4):327-33. doi: 10.1097/00063198-200207000-00015. PMID: 12055398
Empyema thoracis.
de la Rocha AG
Surg Gynecol Obstet 1982 Dec;155(6):839-45. PMID: 7147165

Diagnosis

Parapneumonic Effusion and Empyema.
Addala DN, Bedawi EO, Rahman NM
Clin Chest Med 2021 Dec;42(4):637-647. doi: 10.1016/j.ccm.2021.08.001. PMID: 34774171
Update in the Management of Pleural Effusions.
Aboudara M, Maldonado F
Med Clin North Am 2019 May;103(3):475-485. doi: 10.1016/j.mcna.2018.12.007. PMID: 30955515
Pleural Disease.
Feller-Kopman D, Light R
N Engl J Med 2018 Feb 22;378(8):740-751. doi: 10.1056/NEJMra1403503. PMID: 29466146
Stage-directed therapy of pleural empyema.
Reichert M, Hecker M, Witte B, Bodner J, Padberg W, Weigand MA, Hecker A
Langenbecks Arch Surg 2017 Feb;402(1):15-26. Epub 2016 Nov 4 doi: 10.1007/s00423-016-1498-9. PMID: 27815709
Subdural empyema.
Brennan MR
Am Fam Physician 1995 Jan;51(1):157-62. PMID: 7810468

Therapy

Parapneumonic Effusion and Empyema.
Addala DN, Bedawi EO, Rahman NM
Clin Chest Med 2021 Dec;42(4):637-647. doi: 10.1016/j.ccm.2021.08.001. PMID: 34774171
Use of fibrinolytics and deoxyribonuclease in adult patients with pleural empyema: a consensus statement.
Chaddha U, Agrawal A, Feller-Kopman D, Kaul V, Shojaee S, Maldonado F, Ferguson MK, Blyth KG, Grosu HB, Corcoran JP, Sachdeva A, West A, Bedawi EO, Majid A, Mehta RM, Folch E, Liberman M, Wahidi MM, Gangadharan SP, Roberts ME, DeCamp MM, Rahman NM
Lancet Respir Med 2021 Sep;9(9):1050-1064. Epub 2021 Feb 2 doi: 10.1016/S2213-2600(20)30533-6. PMID: 33545086
Comparison of pulmonary segmentectomy and lobectomy: Safety results of a randomized trial.
Suzuki K, Saji H, Aokage K, Watanabe SI, Okada M, Mizusawa J, Nakajima R, Tsuboi M, Nakamura S, Nakamura K, Mitsudomi T, Asamura H; West Japan Oncology Group; Japan Clinical Oncology Group
J Thorac Cardiovasc Surg 2019 Sep;158(3):895-907. Epub 2019 Apr 9 doi: 10.1016/j.jtcvs.2019.03.090. PMID: 31078312
Surgical versus non-surgical management for pleural empyema.
Redden MD, Chin TY, van Driel ML
Cochrane Database Syst Rev 2017 Mar 17;3(3):CD010651. doi: 10.1002/14651858.CD010651.pub2. PMID: 28304084Free PMC Article
Stage-directed therapy of pleural empyema.
Reichert M, Hecker M, Witte B, Bodner J, Padberg W, Weigand MA, Hecker A
Langenbecks Arch Surg 2017 Feb;402(1):15-26. Epub 2016 Nov 4 doi: 10.1007/s00423-016-1498-9. PMID: 27815709

Prognosis

Increase in invasive group A streptococcal infection notifications, England, 2022.
Guy R, Henderson KL, Coelho J, Hughes H, Mason EL, Gerver SM, Demirjian A, Watson C, Sharp A, Brown CS, Lamagni T
Euro Surveill 2023 Jan;28(1) doi: 10.2807/1560-7917.ES.2023.28.1.2200942. PMID: 36695450Free PMC Article
Lung Resection in Children with Necrotizing Pneumonia: Outcome and Follow-up.
Frybova B, Koucky V, Pohunek P, Cejnarova K, Coufal S, Kokesova A, Dotlacil V, Petrasova N, Pos L, Snajdauf J, Hlava S, Polivka N, Rygl M
Eur J Pediatr Surg 2022 Jun;32(3):280-286. Epub 2021 Mar 7 doi: 10.1055/s-0041-1725188. PMID: 33677824
Group A Streptococcal Infections in Children.
Ahmed MI, Saunders RV, Bandi S
Curr Pediatr Rev 2021;17(1):70-73. doi: 10.2174/1573396316666200704152246. PMID: 32621721
Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial.
Nakagawa K, Garon EB, Seto T, Nishio M, Ponce Aix S, Paz-Ares L, Chiu CH, Park K, Novello S, Nadal E, Imamura F, Yoh K, Shih JY, Au KH, Moro-Sibilot D, Enatsu S, Zimmermann A, Frimodt-Moller B, Visseren-Grul C, Reck M; RELAY Study Investigators
Lancet Oncol 2019 Dec;20(12):1655-1669. Epub 2019 Oct 4 doi: 10.1016/S1470-2045(19)30634-5. PMID: 31591063
Clinical characteristics and outcome of brain abscess: systematic review and meta-analysis.
Brouwer MC, Coutinho JM, van de Beek D
Neurology 2014 Mar 4;82(9):806-13. Epub 2014 Jan 29 doi: 10.1212/WNL.0000000000000172. PMID: 24477107

Clinical prediction guides

Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema: A Randomized Clinical Trial.
Livingston MH, Mahant S, Connolly B, MacLusky I, Laberge S, Giglia L, Yang C, Roberts A, Shawyer A, Brindle M, Parsons S, Stoian C, Walton JM, Thorpe KE, Chen Y, Zuo F, Mamdani M, Chan C, Loong D, Isaranuwatchai W, Ratjen F, Cohen E
JAMA Pediatr 2020 Apr 1;174(4):332-340. doi: 10.1001/jamapediatrics.2019.5863. PMID: 32011642Free PMC Article
Hepatic Hydrothorax.
Lv Y, Han G, Fan D
Ann Hepatol 2018 January-February;17(1):33-46. doi: 10.5604/01.3001.0010.7533. PMID: 29311408
Surgical versus non-surgical management for pleural empyema.
Redden MD, Chin TY, van Driel ML
Cochrane Database Syst Rev 2017 Mar 17;3(3):CD010651. doi: 10.1002/14651858.CD010651.pub2. PMID: 28304084Free PMC Article
IMMEDIATE AND LATE RESULTS OF THE COMBINED GASTRECTOMY PERFORMANCE FOR LOCALLY—SPREAD GASTRIC CANCER.
Oliynyk YY
Klin Khir 2016 Oct;(10):9-11. PMID: 30479104
Spontaneous bacterial empyema.
Tu CY, Chen CH
Curr Opin Pulm Med 2012 Jul;18(4):355-8. doi: 10.1097/MCP.0b013e328352b50f. PMID: 22450302

Recent systematic reviews

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis.
Tan E, Braithwaite I, McKinlay CJD, Dalziel SR
JAMA Netw Open 2020 Oct 1;3(10):e2022398. doi: 10.1001/jamanetworkopen.2020.22398. PMID: 33125495Free PMC Article
Intra-pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema.
Altmann ES, Crossingham I, Wilson S, Davies HR
Cochrane Database Syst Rev 2019 Oct 30;2019(10) doi: 10.1002/14651858.CD002312.pub4. PMID: 31684683Free PMC Article
Surgical versus non-surgical management for pleural empyema.
Redden MD, Chin TY, van Driel ML
Cochrane Database Syst Rev 2017 Mar 17;3(3):CD010651. doi: 10.1002/14651858.CD010651.pub2. PMID: 28304084Free PMC Article
Subtotal cholecystectomy for "difficult gallbladders": systematic review and meta-analysis.
Elshaer M, Gravante G, Thomas K, Sorge R, Al-Hamali S, Ebdewi H
JAMA Surg 2015 Feb;150(2):159-68. doi: 10.1001/jamasurg.2014.1219. PMID: 25548894
Clinical characteristics and outcome of brain abscess: systematic review and meta-analysis.
Brouwer MC, Coutinho JM, van de Beek D
Neurology 2014 Mar 4;82(9):806-13. Epub 2014 Jan 29 doi: 10.1212/WNL.0000000000000172. PMID: 24477107

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