U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fulminant hepatitis

MedGen UID:
86223
Concept ID:
C0302809
Disease or Syndrome
Synonyms: Fulminant Hepatitides; Fulminant Hepatitis; Hepatitis, Fulminant
SNOMED CT: Fulminant hepatitis (427044009)
 
HPO: HP:0004787

Definition

Acute hepatitis complicated by acute liver failure with hepatic encephalopathy occurring less than 8 weeks after the onset of jaundice. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFulminant hepatitis

Conditions with this feature

Cirrhosis, familial
MedGen UID:
350049
Concept ID:
C1861556
Disease or Syndrome
Cirrhosis in which no causative agent can be identified.
Hepatitis, fulminant viral, susceptibility to
MedGen UID:
1684882
Concept ID:
C5231406
Finding
X-linked lymphoproliferative disease due to SH2D1A deficiency
MedGen UID:
1770239
Concept ID:
C5399825
Disease or Syndrome
X-linked lymphoproliferative disease (XLP) has two recognizable subtypes, XLP1 and XLP2. XLP1 is characterized predominantly by one of three commonly recognized phenotypes: Inappropriate immune response to Epstein-Barr virus (EBV) infection leading to hemophagocytic lymphohistiocytosis (HLH) or severe mononucleosis. Dysgammaglobulinemia. Lymphoproliferative disease (malignant lymphoma). XLP2 is most often characterized by HLH (often associated with EBV), dysgammaglobulinemia, and inflammatory bowel disease. HLH resulting from EBV infection is associated with an unregulated and exaggerated immune response with widespread proliferation of cytotoxic T cells, EBV-infected B cells, and macrophages. Dysgammaglobulinemia is typically hypogammaglobulinemia of one or more immunoglobulin subclasses. The malignant lymphomas are typically B-cell lymphomas, non-Hodgkin type, often extranodal, and in particular involving the intestine.

Professional guidelines

PubMed

Cunningham M, Gupta R, Butler M
Hepatology 2024 Jan 1;79(1):198-212. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000045. PMID: 36633259
Gabrielli F, Alberti F, Russo C, Cursaro C, Seferi H, Margotti M, Andreone P
Viruses 2023 Apr 28;15(5) doi: 10.3390/v15051080. PMID: 37243166Free PMC Article
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336

Recent clinical studies

Etiology

Peron JM, Larrue H, Izopet J, Buti M
J Hepatol 2023 Sep;79(3):876-880. Epub 2023 Mar 30 doi: 10.1016/j.jhep.2023.03.024. PMID: 37003442
Saitta C, Pollicino T, Raimondo G
Viruses 2022 Jul 8;14(7) doi: 10.3390/v14071504. PMID: 35891484Free PMC Article
Miao Z, Zhang S, Ou X, Li S, Ma Z, Wang W, Peppelenbosch MP, Liu J, Pan Q
J Infect Dis 2020 Apr 27;221(10):1677-1687. doi: 10.1093/infdis/jiz633. PMID: 31778167Free PMC Article
Tosone G, Simeone D, Spera AM, Viceconte G, Bianco V, Orlando R
Minerva Ginecol 2018 Aug;70(4):480-486. Epub 2017 Oct 9 doi: 10.23736/S0026-4784.17.04107-7. PMID: 28994560
Larrey D
J Hepatol 2000;32(1 Suppl):77-88. doi: 10.1016/s0168-8278(00)80417-1. PMID: 10728796

Diagnosis

Songtanin B, Molehin AJ, Brittan K, Manatsathit W, Nugent K
Viruses 2023 Jun 17;15(6) doi: 10.3390/v15061389. PMID: 37376687Free PMC Article
Van Wagoner N, Qushair F, Johnston C
Infect Dis Clin North Am 2023 Jun;37(2):351-367. doi: 10.1016/j.idc.2023.02.011. PMID: 37105647
Saitta C, Pollicino T, Raimondo G
Viruses 2022 Jul 8;14(7) doi: 10.3390/v14071504. PMID: 35891484Free PMC Article
Jurčić D, Gabrić M, Troskot Perić R, Liberati Pršo AM, Mirat J, Včev A, Alerić I, Ebling B
Acta Clin Croat 2019 Dec;58(4):771-776. doi: 10.20471/acc.2019.58.04.26. PMID: 32595263Free PMC Article
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336

Therapy

Cunningham M, Gupta R, Butler M
Hepatology 2024 Jan 1;79(1):198-212. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000045. PMID: 36633259
Peron JM, Larrue H, Izopet J, Buti M
J Hepatol 2023 Sep;79(3):876-880. Epub 2023 Mar 30 doi: 10.1016/j.jhep.2023.03.024. PMID: 37003442
Miao Z, Zhang S, Ou X, Li S, Ma Z, Wang W, Peppelenbosch MP, Liu J, Pan Q
J Infect Dis 2020 Apr 27;221(10):1677-1687. doi: 10.1093/infdis/jiz633. PMID: 31778167Free PMC Article
Scherpereel A, Mazieres J, Greillier L, Lantuejoul S, Dô P, Bylicki O, Monnet I, Corre R, Audigier-Valette C, Locatelli-Sanchez M, Molinier O, Guisier F, Urban T, Ligeza-Poisson C, Planchard D, Amour E, Morin F, Moro-Sibilot D, Zalcman G; French Cooperative Thoracic Intergroup
Lancet Oncol 2019 Feb;20(2):239-253. Epub 2019 Jan 16 doi: 10.1016/S1470-2045(18)30765-4. PMID: 30660609
Yurdaydin C, Idilman R
Cold Spring Harb Perspect Med 2015 Aug 7;5(10) doi: 10.1101/cshperspect.a021543. PMID: 26253093Free PMC Article

Prognosis

Sausen DG, Shechter O, Bietsch W, Shi Z, Miller SM, Gallo ES, Dahari H, Borenstein R
Int J Mol Sci 2022 Dec 15;23(24) doi: 10.3390/ijms232415973. PMID: 36555623Free PMC Article
Freshwater DA
J R Army Med Corps 2013 Sep;159(3):167-8. Epub 2013 May 30 doi: 10.1136/jramc-2013-000095. PMID: 24109137
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336
Ichai P, Samuel D
Liver Transpl 2008 Oct;14 Suppl 2:S67-79. doi: 10.1002/lt.21612. PMID: 18825677
Larrey D
J Hepatol 2000;32(1 Suppl):77-88. doi: 10.1016/s0168-8278(00)80417-1. PMID: 10728796

Clinical prediction guides

Primadharsini PP, Nagashima S, Tanaka T, Jirintai S, Takahashi M, Murata K, Okamoto H
Viruses 2023 Mar 26;15(4) doi: 10.3390/v15040845. PMID: 37112827Free PMC Article
Chouik Y, Francoz C, De Martin E, Guillaud O, Abergel A, Altieri M, Barbier L, Besch C, Chazouillères O, Conti F, Corpechot C, Dharancy S, Durand F, Duvoux C, Gugenheim J, Hardwigsen J, Hilleret MN, Houssel-Debry P, Kamar N, Minello A, Neau-Cransac M, Pageaux GP, Radenne S, Roux O, Saliba F, Samuel D, Vanlemmens C, Woehl-Jaegle ML, Leroy V, Duclos-Vallée JC, Dumortier J
Liver Int 2023 Apr;43(4):906-916. Epub 2023 Jan 6 doi: 10.1111/liv.15500. PMID: 36577700
Jeong SH, Lee HS
Intervirology 2010;53(1):15-9. Epub 2010 Jan 5 doi: 10.1159/000252779. PMID: 20068336
Hu KQ
J Viral Hepat 2002 Jul;9(4):243-57. doi: 10.1046/j.1365-2893.2002.00344.x. PMID: 12081601
Larrey D
J Hepatol 2000;32(1 Suppl):77-88. doi: 10.1016/s0168-8278(00)80417-1. PMID: 10728796

Recent systematic reviews

Nacif LS, Fernandes MR, Waisberg DR, Pinheiro RS, Rocha-Santos V, Galvão F, Andraus W, Carneiro-D'Albuquerque L
Clinics (Sao Paulo) 2022 Jan-Dec;77:100042. Epub 2022 Apr 26 doi: 10.1016/j.clinsp.2022.100042. PMID: 35870265Free PMC Article
Miao Z, Zhang S, Ou X, Li S, Ma Z, Wang W, Peppelenbosch MP, Liu J, Pan Q
J Infect Dis 2020 Apr 27;221(10):1677-1687. doi: 10.1093/infdis/jiz633. PMID: 31778167Free PMC Article
Leblebicioglu H, Ozaras R
Ann Clin Microbiol Antimicrob 2018 May 2;17(1):17. doi: 10.1186/s12941-018-0269-6. PMID: 29716597Free PMC Article
Haffar S, Bazerbachi F, Prokop L, Watt KD, Murad MH, Chari ST
Pancreatology 2017 Mar-Apr;17(2):166-175. Epub 2017 Feb 17 doi: 10.1016/j.pan.2017.02.008. PMID: 28236520
Haffar S, Bazerbachi F, Garg S, Lake JR, Freeman ML
Pancreatology 2015 Jul-Aug;15(4):321-6. Epub 2015 May 22 doi: 10.1016/j.pan.2015.05.460. PMID: 26049260

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...