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Increased risk of hematologic malignancy

MedGen UID:
862294
•Concept ID:
C4013857
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of hematologic malignancy

Professional guidelines

PubMed

High-risk and silent clonal hematopoietic genotypes in patients with nonhematologic cancer.
Stonestrom AJ, Menghrajani KN, Devlin SM, Franch-Expósito S, Ptashkin RN, Patel SY, Spitzer B, Wu X, Jee J, Sánchez Vela P, Milbank JH, Shah RH, Mohanty AS, Brannon AR, Xiao W, Berger MF, Mantha S, Levine RL
Blood Adv 2024 Feb 27;8(4):846-856. doi: 10.1182/bloodadvances.2023011262. PMID: 38147626Free PMC Article
Treatment and outcomes of hepatocellular carcinoma in patients with Sickle cell disease: a population-based study in the U.S.
Barbetta A, Goldbeck C, Lim A, Martin SP, Kahn JA, Sheikh MR, Emamaullee J
HPB (Oxford) 2022 Feb;24(2):234-243. Epub 2021 Jul 6 doi: 10.1016/j.hpb.2021.06.420. PMID: 34294525Free PMC Article

Recent clinical studies

Etiology

Approach to febrile neutropenia in patients undergoing treatments for hematologic malignancies.
Stohs EJ, Abbas A, Freifeld A
Transpl Infect Dis 2024 Apr;26(2):e14236. Epub 2024 Feb 13 doi: 10.1111/tid.14236. PMID: 38349035
CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors.
Reed SC, Croessmann S, Park BH
Clin Cancer Res 2023 Apr 14;29(8):1403-1411. doi: 10.1158/1078-0432.CCR-22-2598. PMID: 36454121Free PMC Article
CAR-T cell therapy and infection: a review.
Bupha-Intr O, Haeusler G, Chee L, Thursky K, Slavin M, Teh B
Expert Rev Anti Infect Ther 2021 Jun;19(6):749-758. Epub 2020 Dec 31 doi: 10.1080/14787210.2021.1855143. PMID: 33249873
Epidemiology and Clinical Manifestations of Immune Thrombocytopenia.
Kohli R, Chaturvedi S
Hamostaseologie 2019 Aug;39(3):238-249. Epub 2019 Mar 13 doi: 10.1055/s-0039-1683416. PMID: 30868551
Hematologic malignancies and Li-Fraumeni syndrome.
Swaminathan M, Bannon SA, Routbort M, Naqvi K, Kadia TM, Takahashi K, Alvarado Y, Ravandi-Kashani F, Patel KP, Champlin R, Kantarjian H, Strong L, DiNardo CD
Cold Spring Harb Mol Case Stud 2019 Feb;5(1) Epub 2019 Feb 1 doi: 10.1101/mcs.a003210. PMID: 30709875Free PMC Article

Diagnosis

How I treat AML incorporating the updated classifications and guidelines.
El Chaer F, Hourigan CS, Zeidan AM
Blood 2023 Jun 8;141(23):2813-2823. doi: 10.1182/blood.2022017808. PMID: 36758209Free PMC Article
CAR-T cell therapy and infection: a review.
Bupha-Intr O, Haeusler G, Chee L, Thursky K, Slavin M, Teh B
Expert Rev Anti Infect Ther 2021 Jun;19(6):749-758. Epub 2020 Dec 31 doi: 10.1080/14787210.2021.1855143. PMID: 33249873
Epidemiology and Clinical Manifestations of Immune Thrombocytopenia.
Kohli R, Chaturvedi S
Hamostaseologie 2019 Aug;39(3):238-249. Epub 2019 Mar 13 doi: 10.1055/s-0039-1683416. PMID: 30868551
Hematologic malignancies and Li-Fraumeni syndrome.
Swaminathan M, Bannon SA, Routbort M, Naqvi K, Kadia TM, Takahashi K, Alvarado Y, Ravandi-Kashani F, Patel KP, Champlin R, Kantarjian H, Strong L, DiNardo CD
Cold Spring Harb Mol Case Stud 2019 Feb;5(1) Epub 2019 Feb 1 doi: 10.1101/mcs.a003210. PMID: 30709875Free PMC Article
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article

Therapy

Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults.
Bosch de Basea Gomez M, Thierry-Chef I, Harbron R, Hauptmann M, Byrnes G, Bernier MO, Le Cornet L, Dabin J, Ferro G, Istad TS, Jahnen A, Lee C, Maccia C, Malchair F, Olerud H, Simon SL, Figuerola J, Peiro A, Engels H, Johansen C, Blettner M, Kaijser M, Kjaerheim K, Berrington de Gonzalez A, Journy N, Meulepas JM, Moissonnier M, Nordenskjold A, Pokora R, Ronckers C, Schüz J, Kesminiene A, Cardis E
Nat Med 2023 Dec;29(12):3111-3119. Epub 2023 Nov 9 doi: 10.1038/s41591-023-02620-0. PMID: 37946058Free PMC Article
Combining post-transplant cyclophosphamide with antithymocyte globulin for graft-versus-host disease prophylaxis in hematological malignancies.
Duléry R, Brissot E, Mohty M
Blood Rev 2023 Nov;62:101080. Epub 2023 Apr 11 doi: 10.1016/j.blre.2023.101080. PMID: 37085459
Recommendations on the use of azole antifungals in hematology-oncology patients.
Azanza JR, Mensa J, Barberán J, Vázquez L, Pérez de Oteyza J, Kwon M, Yáñez L, Aguado JM, Cubillo Gracian A, Solano C, Ruiz Camps I, Fortún J, Salavert Lletí M, Gudiol C, Olave Rubio T, Solano C, García-Vidal C, Rovira Tarrats M, Suárez-Lledó Grande M, González-Sierra P, Dueñas Gutiérrez C
Rev Esp Quimioter 2023 Jun;36(3):236-258. Epub 2023 Apr 5 doi: 10.37201/req/013.2023. PMID: 37017117Free PMC Article
Graft-versus-host disease risk after chimeric antigen receptor T-cell therapy: the diametric opposition of T cells.
Sanber K, Savani B, Jain T
Br J Haematol 2021 Dec;195(5):660-668. Epub 2021 May 25 doi: 10.1111/bjh.17544. PMID: 34036558
CAR-T cell therapy and infection: a review.
Bupha-Intr O, Haeusler G, Chee L, Thursky K, Slavin M, Teh B
Expert Rev Anti Infect Ther 2021 Jun;19(6):749-758. Epub 2020 Dec 31 doi: 10.1080/14787210.2021.1855143. PMID: 33249873

Prognosis

Clonal Hematopoiesis and Its Impact on Human Health.
Ahmad H, Jahn N, Jaiswal S
Annu Rev Med 2023 Jan 27;74:249-260. Epub 2022 Nov 30 doi: 10.1146/annurev-med-042921-112347. PMID: 36450282
Impact of a Best Practice Prevention Bundle on Central Line-associated Bloodstream Infection (CLABSI) Rates and Outcomes in Pediatric Hematology, Oncology, and Hematopoietic Cell Transplantation Patients in Inpatient and Ambulatory Settings.
Ardura MI, Bibart MJ, Mayer LC, Guinipero T, Stanek J, Olshefski RS, Auletta JJ
J Pediatr Hematol Oncol 2021 Jan;43(1):e64-e72. doi: 10.1097/MPH.0000000000001950. PMID: 32960848
Clonal hematopoiesis and risk for hematologic malignancy.
Warren JT, Link DC
Blood 2020 Oct 1;136(14):1599-1605. doi: 10.1182/blood.2019000991. PMID: 32736382Free PMC Article
Isavuconazole Prophylaxis in Patients With Hematologic Malignancies and Hematopoietic Cell Transplant Recipients.
Fontana L, Perlin DS, Zhao Y, Noble BN, Lewis JS, Strasfeld L, Hakki M
Clin Infect Dis 2020 Feb 14;70(5):723-730. doi: 10.1093/cid/ciz282. PMID: 30958538Free PMC Article
Epidemiology and Clinical Manifestations of Immune Thrombocytopenia.
Kohli R, Chaturvedi S
Hamostaseologie 2019 Aug;39(3):238-249. Epub 2019 Mar 13 doi: 10.1055/s-0039-1683416. PMID: 30868551

Clinical prediction guides

Causes and consequences of clonal hematopoiesis.
Weeks LD, Ebert BL
Blood 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. PMID: 37931207Free PMC Article
Clonal Hematopoiesis and Its Impact on Human Health.
Ahmad H, Jahn N, Jaiswal S
Annu Rev Med 2023 Jan 27;74:249-260. Epub 2022 Nov 30 doi: 10.1146/annurev-med-042921-112347. PMID: 36450282
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.
Genovese G, Kähler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, Chambert K, Mick E, Neale BM, Fromer M, Purcell SM, Svantesson O, Landén M, Höglund M, Lehmann S, Gabriel SB, Moran JL, Lander ES, Sullivan PF, Sklar P, Grönberg H, Hultman CM, McCarroll SA
N Engl J Med 2014 Dec 25;371(26):2477-87. Epub 2014 Nov 26 doi: 10.1056/NEJMoa1409405. PMID: 25426838Free PMC Article
Age-related clonal hematopoiesis associated with adverse outcomes.
Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL
N Engl J Med 2014 Dec 25;371(26):2488-98. Epub 2014 Nov 26 doi: 10.1056/NEJMoa1408617. PMID: 25426837Free PMC Article

Recent systematic reviews

Toxicity profiles of antibody-drug conjugates for anticancer treatment: a systematic review and meta-analysis.
Suzuki Y, Zhou S, Ota Y, Harrington M, Miyagi E, Takagi H, Kuno T, Wright JD
JNCI Cancer Spectr 2023 Aug 31;7(5) doi: 10.1093/jncics/pkad069. PMID: 37756687Free PMC Article
Risk of Hematologic Malignancies in Elderly Patients With Ankylosing Spondylitis: A Cohort Study and Systematic Review.
Alehashemi S, Ward MM
Mayo Clin Proc 2023 Jan;98(1):100-110. Epub 2022 Dec 2 doi: 10.1016/j.mayocp.2022.06.030. PMID: 36470752Free PMC Article
Cancer Risk in Hashimoto's Thyroiditis: a Systematic Review and Meta-Analysis.
Hu X, Wang X, Liang Y, Chen X, Zhou S, Fei W, Yang Y, Que H
Front Endocrinol (Lausanne) 2022;13:937871. Epub 2022 Jul 12 doi: 10.3389/fendo.2022.937871. PMID: 35903279Free PMC Article
Primary Sjögren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis.
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials.
Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration
J Clin Oncol 2008 Dec 10;26(35):5802-12. Epub 2008 Nov 10 doi: 10.1200/JCO.2008.16.4368. PMID: 19001332Free PMC Article

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