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Sensitivity to genotoxic agents

MedGen UID:
863901
•Concept ID:
C4015464
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSensitivity to genotoxic agents

Professional guidelines

PubMed

Future directions and treatment strategies for head and neck squamous cell carcinomas.
Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI
Transl Res 2012 Sep;160(3):167-77. Epub 2012 Feb 28 doi: 10.1016/j.trsl.2012.02.002. PMID: 22683420Free PMC Article

Recent clinical studies

Etiology

Factors Affecting the Nuclei in Newborn and Children.
Arnaoutoglou C, Keivanidou A, Dragoutsos G, Tentas I, Meditskou S, Zarogoulidis P, Matthaios D, Sardeli C, Ioannidis A, Perdikouri EI, Giannopoulos A
Int J Environ Res Public Health 2022 Apr 1;19(7) doi: 10.3390/ijerph19074226. PMID: 35409906Free PMC Article
Chromosomal aberrations, clastogens vs aneugens.
Mishima M
Front Biosci (Schol Ed) 2017 Jan 1;9(1):1-16. doi: 10.2741/s468. PMID: 27814570
Rothmund-Thomson syndrome.
Larizza L, Roversi G, Volpi L
Orphanet J Rare Dis 2010 Jan 29;5:2. doi: 10.1186/1750-1172-5-2. PMID: 20113479Free PMC Article
Is metronidazole carcinogenic?
Bendesky A, Menéndez D, Ostrosky-Wegman P
Mutat Res 2002 Jun;511(2):133-44. doi: 10.1016/s1383-5742(02)00007-8. PMID: 12052431
N-acetyl-l-cysteine.
De Vries N, De Flora S
J Cell Biochem Suppl 1993;17F:270-7. doi: 10.1002/jcb.240531040. PMID: 8412205

Diagnosis

Targeting the Ubiquitin-Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer.
Majeed S, Aparnathi MK, Nixon KCJ, Venkatasubramanian V, Rahman F, Song L, Weiss J, Barayan R, Sugumar V, Barghout SH, Pearson JD, Bremner R, Schimmer AD, Tsao MS, Liu G, Lok BH
Clin Cancer Res 2022 May 2;28(9):1966-1978. doi: 10.1158/1078-0432.CCR-21-0344. PMID: 35165102Free PMC Article
Chromosomal aberrations, clastogens vs aneugens.
Mishima M
Front Biosci (Schol Ed) 2017 Jan 1;9(1):1-16. doi: 10.2741/s468. PMID: 27814570
The comet assay for DNA damage and repair: principles, applications, and limitations.
Collins AR
Mol Biotechnol 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. PMID: 15004294
Is metronidazole carcinogenic?
Bendesky A, Menéndez D, Ostrosky-Wegman P
Mutat Res 2002 Jun;511(2):133-44. doi: 10.1016/s1383-5742(02)00007-8. PMID: 12052431
N-acetyl-l-cysteine.
De Vries N, De Flora S
J Cell Biochem Suppl 1993;17F:270-7. doi: 10.1002/jcb.240531040. PMID: 8412205

Therapy

Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors.
Lappin KM, Barros EM, Jhujh SS, Irwin GW, McMillan H, Liberante FG, Latimer C, La Bonte MJ, Mills KI, Harkin DP, Stewart GS, Savage KI
Cancer Res 2022 Mar 1;82(5):819-830. doi: 10.1158/0008-5472.CAN-21-1843. PMID: 35027467Free PMC Article
Categorizing the characteristics of human carcinogens: a need for specificity.
Smith CJ, Perfetti TA, Hayes AW, Berry SC, Trosko JE, King JA, Goodman JI, Begley CG, Dayan A
Arch Toxicol 2021 Aug;95(8):2883-2889. Epub 2021 Jun 20 doi: 10.1007/s00204-021-03109-w. PMID: 34148101
Biological effects of essential oils--a review.
Bakkali F, Averbeck S, Averbeck D, Idaomar M
Food Chem Toxicol 2008 Feb;46(2):446-75. Epub 2007 Sep 29 doi: 10.1016/j.fct.2007.09.106. PMID: 17996351
Is metronidazole carcinogenic?
Bendesky A, Menéndez D, Ostrosky-Wegman P
Mutat Res 2002 Jun;511(2):133-44. doi: 10.1016/s1383-5742(02)00007-8. PMID: 12052431
N-acetyl-l-cysteine.
De Vries N, De Flora S
J Cell Biochem Suppl 1993;17F:270-7. doi: 10.1002/jcb.240531040. PMID: 8412205

Prognosis

Cytokinesis Blocked Micronuclei Aberration Analysis.
Kato TA
Methods Mol Biol 2023;2519:83-91. doi: 10.1007/978-1-0716-2433-3_9. PMID: 36066712
Factors Affecting the Nuclei in Newborn and Children.
Arnaoutoglou C, Keivanidou A, Dragoutsos G, Tentas I, Meditskou S, Zarogoulidis P, Matthaios D, Sardeli C, Ioannidis A, Perdikouri EI, Giannopoulos A
Int J Environ Res Public Health 2022 Apr 1;19(7) doi: 10.3390/ijerph19074226. PMID: 35409906Free PMC Article
Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens.
Bhagat J
J Appl Toxicol 2018 Jan;38(1):81-99. Epub 2017 Jul 11 doi: 10.1002/jat.3496. PMID: 28695982
Sister chromatid exchange assay as a predictor of tumor chemoresponse.
Mourelatos D
Mutat Res Genet Toxicol Environ Mutagen 2016 Jun;803-804:1-12. Epub 2016 May 7 doi: 10.1016/j.mrgentox.2016.03.011. PMID: 27265374
Radiation induced apoptosis.
Harms-Ringdahl M, Nicotera P, Radford IR
Mutat Res 1996 Nov;366(2):171-9. doi: 10.1016/s0165-1110(96)90038-x. PMID: 9001584

Clinical prediction guides

Factors Affecting the Nuclei in Newborn and Children.
Arnaoutoglou C, Keivanidou A, Dragoutsos G, Tentas I, Meditskou S, Zarogoulidis P, Matthaios D, Sardeli C, Ioannidis A, Perdikouri EI, Giannopoulos A
Int J Environ Res Public Health 2022 Apr 1;19(7) doi: 10.3390/ijerph19074226. PMID: 35409906Free PMC Article
Targeting the Ubiquitin-Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer.
Majeed S, Aparnathi MK, Nixon KCJ, Venkatasubramanian V, Rahman F, Song L, Weiss J, Barayan R, Sugumar V, Barghout SH, Pearson JD, Bremner R, Schimmer AD, Tsao MS, Liu G, Lok BH
Clin Cancer Res 2022 May 2;28(9):1966-1978. doi: 10.1158/1078-0432.CCR-21-0344. PMID: 35165102Free PMC Article
Comet assay in ecogenotoxicology: Applications in Mytilus sp.
Bolognesi C, Cirillo S, Chipman JK
Mutat Res Genet Toxicol Environ Mutagen 2019 Jun;842:50-59. Epub 2019 May 8 doi: 10.1016/j.mrgentox.2019.05.004. PMID: 31255226
The comet assay for DNA damage and repair: principles, applications, and limitations.
Collins AR
Mol Biotechnol 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. PMID: 15004294
Radiation induced apoptosis.
Harms-Ringdahl M, Nicotera P, Radford IR
Mutat Res 1996 Nov;366(2):171-9. doi: 10.1016/s0165-1110(96)90038-x. PMID: 9001584

Recent systematic reviews

The role of the enzyme-modified comet assay in in vivo studies.
Collins A, Vettorazzi A, Azqueta A
Toxicol Lett 2020 Jul 1;327:58-68. Epub 2020 Apr 2 doi: 10.1016/j.toxlet.2020.03.016. PMID: 32247831

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