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Abnormal circulating creatine concentration

MedGen UID:
866482
•Concept ID:
C4020731
•
Finding
Synonyms: Abnormality of creatine metabolism; Creatine metabolism abnormal
 
HPO: HP:0012113

Definition

A deviation from the normal concentration of creatine in the blood circulation. Creatine is a derivative of glycine having methyl and amidino groups attached to the nitrogen. Creatine is naturally produced from amino acids, primarily in liver and kidney, and acts as an energy source for cells, primarly for muscle cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating creatine concentration

Recent clinical studies

Etiology

Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382Free PMC Article
Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581
Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.
Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K
Circulation 2003 Jun 24;107(24):3040-6. Epub 2003 Jun 16 doi: 10.1161/01.CIR.0000072789.89096.10. PMID: 12810608
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Circulating cardiac troponin T in myocardial contusion.
Ferjani M, Droc G, Dreux S, Arthaud M, Goarin JP, Riou B, Coriat P
Chest 1997 Feb;111(2):427-33. doi: 10.1378/chest.111.2.427. PMID: 9041992

Diagnosis

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.
Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K
Circulation 2003 Jun 24;107(24):3040-6. Epub 2003 Jun 16 doi: 10.1161/01.CIR.0000072789.89096.10. PMID: 12810608
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Imaging and epilepsy.
Duncan JS
Brain 1997 Feb;120 ( Pt 2):339-77. doi: 10.1093/brain/120.2.339. PMID: 9117380
Circulating cardiac troponin T in myocardial contusion.
Ferjani M, Droc G, Dreux S, Arthaud M, Goarin JP, Riou B, Coriat P
Chest 1997 Feb;111(2):427-33. doi: 10.1378/chest.111.2.427. PMID: 9041992
Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.
Moser H
Hum Genet 1984;66(1):17-40. doi: 10.1007/BF00275183. PMID: 6365739

Therapy

Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382Free PMC Article
Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581
High-dose aprotinin does not affect troponin I, N-Terminal pro-B-type natriuretic peptid and renal function in children submitted to surgical correction with extracorporeal circulation.
Ferreira CA, Vicente WV, Evora PR, Rodrigues AJ, Klamt JG, Carlotti AP, Carmona F, Manso PH
Rev Bras Cir Cardiovasc 2009 Oct-Dec;24(4):519-32. doi: 10.1590/s0102-76382009000500014. PMID: 20305926
Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes.
Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K
Circulation 2003 Jun 24;107(24):3040-6. Epub 2003 Jun 16 doi: 10.1161/01.CIR.0000072789.89096.10. PMID: 12810608
Inflammatory myopathy, IgA deficiency, and intestinal malabsorption.
Carroll JE, Silverman A, Isobe Y, Brown WR, Kelts KA, Brooke MH
J Pediatr 1976 Aug;89(2):216-9. doi: 10.1016/s0022-3476(76)80451-9. PMID: 940014

Prognosis

Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581
Incidence, predictors, and significance of abnormal cardiac enzyme rise in patients treated with bypass surgery in the arterial revascularization therapies study (ARTS).
Costa MA, Carere RG, Lichtenstein SV, Foley DP, de Valk V, Lindenboom W, Roose PC, van Geldorp TR, Macaya C, Castanon JL, Fernandez-Avilèz F, Gonzáles JH, Heyer G, Unger F, Serruys PW
Circulation 2001 Nov 27;104(22):2689-93. doi: 10.1161/hc4701.099789. PMID: 11723020
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Tumor necrosis factor system activity is associated with insulin resistance and dyslipidemia in myotonic dystrophy.
Fernández-Real JM, Molina A, Broch M, Ricart W, Gutiérrez C, Casamitjana R, Vendrell J, Soler J, Gómez-Sáez JM
Diabetes 1999 May;48(5):1108-12. doi: 10.2337/diabetes.48.5.1108. PMID: 10331417
Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.
Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM
Circulation 1986 Mar;73(3):396-400. doi: 10.1161/01.cir.73.3.396. PMID: 3948350

Clinical prediction guides

Markers of peripheral perfusion during high-flow regional cerebral perfusion for aortic arch repair.
Sughimoto K, Kohira S, Hayashi H, Torii S, Kitamura T, Horai T, Miyaji K
J Thorac Cardiovasc Surg 2018 Dec;156(6):2251-2257. Epub 2018 Sep 28 doi: 10.1016/j.jtcvs.2018.08.097. PMID: 30449581
Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma.
Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, Joubert P, Poupard P, Fabbro-Peray P, Monpeyroux F, Poirey S, Ledermann B, Raczka F, Brunet J, Nigond J, de la Coussaye JE
J Trauma 2000 May;48(5):924-31. doi: 10.1097/00005373-200005000-00018. PMID: 10823538
Tumor necrosis factor system activity is associated with insulin resistance and dyslipidemia in myotonic dystrophy.
Fernández-Real JM, Molina A, Broch M, Ricart W, Gutiérrez C, Casamitjana R, Vendrell J, Soler J, Gómez-Sáez JM
Diabetes 1999 May;48(5):1108-12. doi: 10.2337/diabetes.48.5.1108. PMID: 10331417
Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.
Moser H
Hum Genet 1984;66(1):17-40. doi: 10.1007/BF00275183. PMID: 6365739
Muscle cell leakage due to long distance training.
Hansen KN, Bjerre-Knudsen J, Brodthagen U, Jordal R, Paulev PE
Eur J Appl Physiol Occup Physiol 1982;48(2):177-88. doi: 10.1007/BF00422979. PMID: 7200006

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