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Sclerosis of proximal finger phalanx

MedGen UID:
866592
•Concept ID:
C4020938
•
Anatomical Abnormality
Synonyms: Increased bone density in innermost finger bone; Sclerosis of the proximal phalanges of the hand
 
HPO: HP:0100917

Definition

An elevation in bone density in one or more proximal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity. [from HPO]

Recent clinical studies

Etiology

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
In vivo study of skin mechanical properties in Raynaud's phenomenon.
Dobrev H
Skin Res Technol 2007 Feb;13(1):91-4. doi: 10.1111/j.1600-0846.2007.00197.x. PMID: 17250538
Radiographic changes in the hands and fingers of young, high-level climbers.
Schöffl V, Hochholzer T, Imhoff A
Am J Sports Med 2004 Oct-Nov;32(7):1688-94. doi: 10.1177/0363546503262805. PMID: 15494334

Diagnosis

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.
Di Geso L, Filippucci E, Girolimetti R, Tardella M, Gutierrez M, De Angelis R, Salaffi F, Grassi W
Clin Exp Rheumatol 2011 Nov-Dec;29(6):926-32. Epub 2011 Dec 22 PMID: 22032470
In vivo study of skin mechanical properties in Raynaud's phenomenon.
Dobrev H
Skin Res Technol 2007 Feb;13(1):91-4. doi: 10.1111/j.1600-0846.2007.00197.x. PMID: 17250538
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article
Quantification of acrosclerosis: measurement of skin thickness and skin-phalanx distance in females with 15 MHz pulsed ultrasound.
Serup J
Acta Derm Venereol 1984;64(1):35-40. PMID: 6203279

Therapy

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article

Prognosis

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article

Clinical prediction guides

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.
Di Geso L, Filippucci E, Girolimetti R, Tardella M, Gutierrez M, De Angelis R, Salaffi F, Grassi W
Clin Exp Rheumatol 2011 Nov-Dec;29(6):926-32. Epub 2011 Dec 22 PMID: 22032470
In vivo study of skin mechanical properties in Raynaud's phenomenon.
Dobrev H
Skin Res Technol 2007 Feb;13(1):91-4. doi: 10.1111/j.1600-0846.2007.00197.x. PMID: 17250538
Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.
Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573Free PMC Article
The treatment of dorsal fracture-dislocation of the proximal interphalangeal joint by closed reduction and Kirschner wire fixation: a 16-year follow up.
Newington DP, Davis TR, Barton NJ
J Hand Surg Br 2001 Dec;26(6):537-40. doi: 10.1054/jhsb.2001.0698. PMID: 11884107

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