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Sclerosis of distal finger phalanx

MedGen UID:
866594
•Concept ID:
C4020940
•
Anatomical Abnormality
Synonyms: Increased bone density in outermost finger bone; Sclerosis of the distal phalanges of the hand
 
HPO: HP:0100915

Definition

An elevation in bone density in one or more distal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity. [from HPO]

Professional guidelines

PubMed

Imaging Helps Guide Physical Therapy Treatment in a Patient With Diffuse Systemic Sclerosis (Scleroderma).
Curley RA, Markowski A
J Orthop Sports Phys Ther 2018 Mar;48(3):226. doi: 10.2519/jospt.2018.7662. PMID: 29490598

Recent clinical studies

Etiology

Optimizing finger systolic blood pressure measurements with laser Doppler: Validation of the second phalanx site.
Blaise S, Constans J, Pellegrini L, Senet P, Lazareth I, Cracowski JL, Carpentier P
Microvasc Res 2020 Sep;131:104029. Epub 2020 Jun 9 doi: 10.1016/j.mvr.2020.104029. PMID: 32531354
The Role of Angiogenesis Factors in the Formation of Vascular Changes in Scleroderma by Assessment of the Concentrations of VEGF and sVEGFR2 in Blood Serum and Tear Fluid.
Waszczykowska A, Goś R, Waszczykowska E, Dziankowska-Bartkowiak B, Podgórski M, Jurowski P
Mediators Inflamm 2020;2020:7649480. Epub 2020 Jan 24 doi: 10.1155/2020/7649480. PMID: 32410862Free PMC Article
Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086
Acro-osteolysis.
Botou A, Bangeas A, Alexiou I, Sakkas LI
Clin Rheumatol 2017 Jan;36(1):9-14. Epub 2016 Oct 29 doi: 10.1007/s10067-016-3459-7. PMID: 27796661
Digital Ulcers in Systemic Sclerosis - Frequency, Subtype Distribution and Clinical Outcome.
Lambova S, Batalov A, Sapundzhiev L, Müller-Ladner U
Curr Rheumatol Rev 2013;9(4):268-73. doi: 10.2174/157339710904140417125627. PMID: 26932292

Diagnosis

Optimizing finger systolic blood pressure measurements with laser Doppler: Validation of the second phalanx site.
Blaise S, Constans J, Pellegrini L, Senet P, Lazareth I, Cracowski JL, Carpentier P
Microvasc Res 2020 Sep;131:104029. Epub 2020 Jun 9 doi: 10.1016/j.mvr.2020.104029. PMID: 32531354
A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Fingolimod-Associated Peripheral Vascular Adverse Effects.
Russo M, Guarneri C, Mazzon E, Sessa E, Bramanti P, Calabrò RS
Mayo Clin Proc 2015 Oct;90(10):1424-7. Epub 2015 Sep 5 doi: 10.1016/j.mayocp.2015.07.019. PMID: 26349949
Radiological hand involvement in systemic sclerosis.
Avouac J, Guerini H, Wipff J, Assous N, Chevrot A, Kahan A, Allanore Y
Ann Rheum Dis 2006 Aug;65(8):1088-92. Epub 2006 Jan 13 doi: 10.1136/ard.2005.044602. PMID: 16414976Free PMC Article
Ulcerative and mutilating variant of carpal tunnel syndrome.
Natale M, Spennato P, Bocchetti A, Fratta M, Savarese L, Rotondo M
Acta Neurochir (Wien) 2005 Aug;147(8):905-8. doi: 10.1007/s00701-004-0478-y. PMID: 15696265

Therapy

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Fingolimod-Associated Peripheral Vascular Adverse Effects.
Russo M, Guarneri C, Mazzon E, Sessa E, Bramanti P, Calabrò RS
Mayo Clin Proc 2015 Oct;90(10):1424-7. Epub 2015 Sep 5 doi: 10.1016/j.mayocp.2015.07.019. PMID: 26349949
Multiple malformations in a male and maternal osteopathia strata with cranial sclerosis (OSCS).
Rott HD, Krieg P, Rütschle H, Kraus C
Genet Couns 2003;14(3):281-8. PMID: 14577672
Sonographic imaging of the distal phalanx.
Grassi W, Filippucci E, Farina A, Cervini C
Semin Arthritis Rheum 2000 Jun;29(6):379-84. doi: 10.1053/sarh.2000.7002. PMID: 10924024

Prognosis

Optimizing finger systolic blood pressure measurements with laser Doppler: Validation of the second phalanx site.
Blaise S, Constans J, Pellegrini L, Senet P, Lazareth I, Cracowski JL, Carpentier P
Microvasc Res 2020 Sep;131:104029. Epub 2020 Jun 9 doi: 10.1016/j.mvr.2020.104029. PMID: 32531354
A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article

Clinical prediction guides

Optimizing finger systolic blood pressure measurements with laser Doppler: Validation of the second phalanx site.
Blaise S, Constans J, Pellegrini L, Senet P, Lazareth I, Cracowski JL, Carpentier P
Microvasc Res 2020 Sep;131:104029. Epub 2020 Jun 9 doi: 10.1016/j.mvr.2020.104029. PMID: 32531354
A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.
Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106Free PMC Article
Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086
Digital Ulcers in Systemic Sclerosis - Frequency, Subtype Distribution and Clinical Outcome.
Lambova S, Batalov A, Sapundzhiev L, Müller-Ladner U
Curr Rheumatol Rev 2013;9(4):268-73. doi: 10.2174/157339710904140417125627. PMID: 26932292
Reliability and repeatability of the Hoffmann sign.
Annaswamy TM, Sakai T, Goetz LL, Pacheco FM, Ozarkar T
PM R 2012 Jul;4(7):498-503. Epub 2012 Apr 28 doi: 10.1016/j.pmrj.2012.02.019. PMID: 22543037

Recent systematic reviews

Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086

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