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Neoplasm of the male external genitalia

MedGen UID:
866604
•Concept ID:
C4020950
•
Neoplastic Process
Synonym: Neoplasia of the male external genitalia
 
HPO: HP:0100848

Definition

A tumor (abnormal growth of tissue) of the male external genitalia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of the male external genitalia

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592Free PMC Article
EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease.
Arbyn M, de Sanjosé S, Saraiya M, Sideri M, Palefsky J, Lacey C, Gillison M, Bruni L, Ronco G, Wentzensen N, Brotherton J, Qiao YL, Denny L, Bornstein J, Abramowitz L, Giuliano A, Tommasino M, Monsonego J
Int J Cancer 2012 Nov 1;131(9):1969-82. Epub 2012 Jul 2 doi: 10.1002/ijc.27650. PMID: 22623137Free PMC Article

Recent clinical studies

Etiology

Human Papillomavirus-related Cancers and Mitochondria.
Cruz-Gregorio A, Aranda-Rivera AK, Pedraza-Chaverri J
Virus Res 2020 Sep;286:198016. Epub 2020 May 20 doi: 10.1016/j.virusres.2020.198016. PMID: 32445871
Extramammary Paget Disease.
Marcoval J, Penín RM, Vidal A, Bermejo J
Actas Dermosifiliogr (Engl Ed) 2020 May;111(4):306-312. Epub 2020 Apr 9 doi: 10.1016/j.ad.2019.09.003. PMID: 32278442
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187
HPV vaccination in boys and men.
Stanley M
Hum Vaccin Immunother 2014;10(7):2109-11. doi: 10.4161/hv.29137. PMID: 25424825Free PMC Article

Diagnosis

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Extramammary Paget Disease.
Marcoval J, Penín RM, Vidal A, Bermejo J
Actas Dermosifiliogr (Engl Ed) 2020 May;111(4):306-312. Epub 2020 Apr 9 doi: 10.1016/j.ad.2019.09.003. PMID: 32278442
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187
Atypical genital nevus.
Brenn T
Arch Pathol Lab Med 2011 Mar;135(3):317-20. doi: 10.5858/2009-0382-RA.1. PMID: 21366454

Therapy

New Perspectives in Therapeutic Vaccines for HPV: A Critical Review.
Gardella B, Gritti A, Soleymaninejadian E, Pasquali MF, Riemma G, La Verde M, Schettino MT, Fortunato N, Torella M, Dominoni M
Medicina (Kaunas) 2022 Jun 28;58(7) doi: 10.3390/medicina58070860. PMID: 35888579Free PMC Article
Editor's picks.
J Eur Acad Dermatol Venereol 2020 Apr;34(4):665. doi: 10.1111/jdv.16353. PMID: 32227421
Therapeutic Vaccines Against Human Papilloma Viruses: Achievements and Prospects.
Vonsky MS, Runov AL, Gordeychuk IV, Isaguliants MG
Biochemistry (Mosc) 2019 Jul;84(7):800-816. doi: 10.1134/S0006297919070101. PMID: 31509730
Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592Free PMC Article
HPV vaccination in boys and men.
Stanley M
Hum Vaccin Immunother 2014;10(7):2109-11. doi: 10.4161/hv.29137. PMID: 25424825Free PMC Article

Prognosis

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187
Global burden of human papillomavirus and related diseases.
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955

Clinical prediction guides

Dermoscopy of genital diseases: a review.
Lacarrubba F, Borghi A, Verzì AE, Corazza M, Stinco G, Micali G
J Eur Acad Dermatol Venereol 2020 Oct;34(10):2198-2207. Epub 2020 Jul 13 doi: 10.1111/jdv.16723. PMID: 32531092
Extramammary Paget Disease.
Marcoval J, Penín RM, Vidal A, Bermejo J
Actas Dermosifiliogr (Engl Ed) 2020 May;111(4):306-312. Epub 2020 Apr 9 doi: 10.1016/j.ad.2019.09.003. PMID: 32278442
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Regulation of masculinization: androgen signalling for external genitalia development.
Matsushita S, Suzuki K, Murashima A, Kajioka D, Acebedo AR, Miyagawa S, Haraguchi R, Ogino Y, Yamada G
Nat Rev Urol 2018 Jun;15(6):358-368. doi: 10.1038/s41585-018-0008-y. PMID: 29670181
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

Recent systematic reviews

Real-world impact and effectiveness assessment of the quadrivalent HPV vaccine: a systematic review of study designs and data sources.
Wang W, Kothari S, Baay M, Garland SM, Giuliano AR, Nygård M, Velicer C, Tota J, Sinha A, Skufca J, Verstraeten T, Sundström K
Expert Rev Vaccines 2022 Feb;21(2):227-240. Epub 2021 Dec 13 doi: 10.1080/14760584.2022.2008243. PMID: 34845951
Anogenital warts and relationship to child sexual abuse: Systematic review and meta-analysis.
Awasthi S, Ornelas J, Armstrong A, Johnson JA, Eisen DB
Pediatr Dermatol 2021 Jul;38(4):842-850. Epub 2021 Jun 1 doi: 10.1111/pde.14650. PMID: 34060139
Granular cell tumor a study of 42 cases and systemic review of the literature.
Mobarki M, Dumollard JM, Dal Col P, Camy F, Peoc'h M, Karpathiou G
Pathol Res Pract 2020 Apr;216(4):152865. Epub 2020 Feb 12 doi: 10.1016/j.prp.2020.152865. PMID: 32089415
The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis.
Song L, Wang Y, Zhang J, Song N, Xu X, Lu Y
Arthritis Res Ther 2018 Dec 6;20(1):270. doi: 10.1186/s13075-018-1760-3. PMID: 30522515Free PMC Article
Pregnancy and genital sarcoma: a systematic review of the literature.
Matsuo K, Eno ML, Im DD, Rosenshein NB
Am J Perinatol 2009 Aug;26(7):507-18. Epub 2009 Mar 13 doi: 10.1055/s-0029-1215428. PMID: 19288396

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