Hyperplastic labia majora

MedGen UID:: 866713
•Concept ID:: C4021060
•: Anatomical Abnormality

Synonyms:	Enlarged labia majora; Hyperplasia of labia majora

HPO:	HP:0012882

Definition

Overgrowth of the outer labia. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHyperplastic labia majora

Abnormality of the genital system
- Abnormal reproductive system morphology
  - Abnormality of the female genitalia
    - Abnormal female external genitalia morphology
      - Abnormal labia morphology
        Abnormal labia majora morphology
        Hyperplastic labia majora

Recent clinical studies

Etiology

45 years' experience with early childhood anatomical technique of feminising genitoplasty for 46 XX Congenital Adrenal Hyperplasia -observations of vaginal introital anatomy and its relationship to the perineal body.

Hennayake S, Barnes A, Mariotto A, Goyal A, Ajao A, Cserni T, Busby G, Patel L, Skae M, Nicholson J, Bianchi A
J Pediatr Urol 2022 Oct;18(5):611.e1-611.e8. Epub 2022 Jul 19 doi: 10.1016/j.jpurol.2022.07.007. PMID: 35970739

Corporeal sparing dismembered clitoroplasty: an alternative technique for feminizing genitoplasty.

Pippi Salle JL, Braga LP, Macedo N, Rosito N, Bagli D
J Urol 2007 Oct;178(4 Pt 2):1796-800; discussion 1801. Epub 2007 Aug 17 doi: 10.1016/j.juro.2007.03.167. PMID: 17707426

Passerini-glazel feminizing genitoplasty: modifications in 17 years of experience with 82 cases.

Lesma A, Bocciardi A, Montorsi F, Rigatti P
Eur Urol 2007 Dec;52(6):1638-44. Epub 2007 Mar 20 doi: 10.1016/j.eururo.2007.02.068. PMID: 17408848

1-Stage feminizing genitoplasty: 8 years of experience with 49 cases.

Farkas A, Chertin B, Hadas-Halpren I
J Urol 2001 Jun;165(6 Pt 2):2341-6. doi: 10.1016/S0022-5347(05)66199-X. PMID: 11371974

See all (4)

Diagnosis

Adenoid cystic carcinoma of the Bartholin's gland is easily misdiagnosed: A case report and literature review.

Wang W, Chen H, Guo H, Chen L, Zhu M, Zhu Y
Medicine (Baltimore) 2022 Nov 11;101(45):e31744. doi: 10.1097/MD.0000000000031744. PMID: 36397326 Free PMC Article

Clitoral reduction: Technical note.

Uzan C, Marchand F, Schmidt M, Meningaud JP, Hersant B
Ann Chir Plast Esthet 2020 Jul;65(4):e7-e13. Epub 2020 May 29 doi: 10.1016/j.anplas.2019.10.002. PMID: 32482351

17α-hydroxylase deficiency diagnosed in early infancy caused by a novel mutation of the CYP17A1 gene.

Petri C, Wudy SA, Riepe FG, Holterhus PM, Siegel J, Hartmann MF, Kulle AE, Welzel M, Grötzinger J, Schild RL, Heger S
Horm Res Paediatr 2014;81(5):350-5. Epub 2014 Apr 4 doi: 10.1159/000357065. PMID: 24714196

Labial aggressive angiomyxoma associated with endometrial hyperplasia and uterine leiomyoma: a case report and review of the literature.

Larbcharoensub N, Karnsombut P, Mathuramon P, Tingthanatikul Y
J Med Assoc Thai 2008 Jul;91(7):1141-5. PMID: 18839858

Acantholytic dermatosis localized to the vulvocrural area.

Cooper PH
J Cutan Pathol 1989 Apr;16(2):81-4. doi: 10.1111/j.1600-0560.1989.tb00015.x. PMID: 2760291

See all (11)

Therapy

Congenital adrenal hyperplasia: Results of medical therapy on appearance of external genitalia.

Kulshreshtha B, Khadgawat R, Eunice M, Ammini AC
J Pediatr Urol 2010 Dec;6(6):555-9. Epub 2010 Feb 8 doi: 10.1016/j.jpurol.2010.01.001. PMID: 20117057

Systemic contact dermatitis to copper-containing IUD.

Purello D'Ambrosio F, Ricciardi L, Isola S, Gangemi S, Cilia M, Levanti C, Marcazzò A
Allergy 1996 Sep;51(9):658-9. doi: 10.1111/j.1398-9995.1996.tb04688.x. PMID: 8899120

See all (2)

Prognosis

Passerini-glazel feminizing genitoplasty: modifications in 17 years of experience with 82 cases.

Lesma A, Bocciardi A, Montorsi F, Rigatti P
Eur Urol 2007 Dec;52(6):1638-44. Epub 2007 Mar 20 doi: 10.1016/j.eururo.2007.02.068. PMID: 17408848

See all (1)

Clinical prediction guides

Adenoid cystic carcinoma of the Bartholin's gland is easily misdiagnosed: A case report and literature review.

Wang W, Chen H, Guo H, Chen L, Zhu M, Zhu Y
Medicine (Baltimore) 2022 Nov 11;101(45):e31744. doi: 10.1097/MD.0000000000031744. PMID: 36397326 Free PMC Article

Acquired lymphangiectasia: a rare mimic of genital warts.

Simeonovski V, Kostovski M, Gjoric I, Damevska S, Igor P
Dermatol Online J 2020 Dec 15;26(12) PMID: 33423429

1-Stage feminizing genitoplasty: 8 years of experience with 49 cases.

Farkas A, Chertin B, Hadas-Halpren I
J Urol 2001 Jun;165(6 Pt 2):2341-6. doi: 10.1016/S0022-5347(05)66199-X. PMID: 11371974

Acantholytic dermatosis localized to the vulvocrural area.

Cooper PH
J Cutan Pathol 1989 Apr;16(2):81-4. doi: 10.1111/j.1600-0560.1989.tb00015.x. PMID: 2760291

See all (6)