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Testicular fibrosis

MedGen UID:
866714
•Concept ID:
C4021061
•
Pathologic Function
Synonyms: Fibrotic testes; Fibrotic testicle
 
HPO: HP:0012860

Definition

Formation of excess connective tissue in the testicle. [from HPO]

Professional guidelines

PubMed

Management of Klinefelter syndrome during transition.
Gies I, Unuane D, Velkeniers B, De Schepper J
Eur J Endocrinol 2014 Aug;171(2):R67-77. Epub 2014 May 6 doi: 10.1530/EJE-14-0213. PMID: 24801585

Recent clinical studies

Etiology

Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling.
Wang X, Liu Q, Zhuang Z, Cheng J, Zhang W, Jiang Q, Guo Y, Li R, Lu X, Cui L, Weng J, Tang Y, Yue J, Gao S, Hong K, Qiao J, Jiang H, Guo J, Zhang Z
Cell Rep Med 2024 Sep 17;5(9):101709. Epub 2024 Sep 2 doi: 10.1016/j.xcrm.2024.101709. PMID: 39226895Free PMC Article
Transcriptomic differences between fibrotic and non-fibrotic testicular tissue reveal possible key players in Klinefelter syndrome-related testicular fibrosis.
Willems M, Olsen C, Caljon B, Vloeberghs V, De Schepper J, Tournaye H, Van Saen D, Goossens E
Sci Rep 2022 Dec 13;12(1):21518. doi: 10.1038/s41598-022-26011-6. PMID: 36513788Free PMC Article
Intratesticular xenografting of Klinefelter pre-pubertal testis tissue as potential model to study testicular fibrosis.
Willems M, Seβenhausen P, Gies I, Vloeberghs V, Tournaye H, Van Saen D, Goossens E
Reprod Biomed Online 2022 May;44(5):896-906. Epub 2022 Jan 31 doi: 10.1016/j.rbmo.2022.01.009. PMID: 35282995
Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis.
Kauerhof AC, Nicolas N, Bhushan S, Wahle E, Loveland KA, Fietz D, Bergmann M, Groome NP, Kliesch S, Schuppe HC, Pilatz A, Meinhardt A, Hedger MP, Fijak M
Hum Reprod 2019 Aug 1;34(8):1536-1550. doi: 10.1093/humrep/dez109. PMID: 31340036
Diffusion-weighted MRI of the testes in patients with varicocele: a preliminary study.
Karakas E, Karakas O, Cullu N, Badem OF, Boyacı FN, Gulum M, Cece H
AJR Am J Roentgenol 2014 Feb;202(2):324-8. doi: 10.2214/AJR.13.10594. PMID: 24450672

Diagnosis

Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling.
Wang X, Liu Q, Zhuang Z, Cheng J, Zhang W, Jiang Q, Guo Y, Li R, Lu X, Cui L, Weng J, Tang Y, Yue J, Gao S, Hong K, Qiao J, Jiang H, Guo J, Zhang Z
Cell Rep Med 2024 Sep 17;5(9):101709. Epub 2024 Sep 2 doi: 10.1016/j.xcrm.2024.101709. PMID: 39226895Free PMC Article
Germ cell loss in Klinefelter syndrome: When and why?
Willems M, Gies I, Van Saen D
Am J Med Genet C Semin Med Genet 2020 Jun;184(2):356-370. Epub 2020 May 15 doi: 10.1002/ajmg.c.31787. PMID: 32412180
Management of Klinefelter syndrome during transition.
Gies I, Unuane D, Velkeniers B, De Schepper J
Eur J Endocrinol 2014 Aug;171(2):R67-77. Epub 2014 May 6 doi: 10.1530/EJE-14-0213. PMID: 24801585
Diffusion-weighted MRI of the testes in patients with varicocele: a preliminary study.
Karakas E, Karakas O, Cullu N, Badem OF, Boyacı FN, Gulum M, Cece H
AJR Am J Roentgenol 2014 Feb;202(2):324-8. doi: 10.2214/AJR.13.10594. PMID: 24450672
46, XX SRY-positive male syndrome presenting with primary hypogonadism in the setting of scleroderma.
Velasco G, Savarese V, Sandorfi N, Jimenez SA, Jabbour S
Endocr Pract 2011 Jan-Feb;17(1):95-8. doi: 10.4158/EP10184.CR. PMID: 20841307

Therapy

Management of Klinefelter syndrome during transition.
Gies I, Unuane D, Velkeniers B, De Schepper J
Eur J Endocrinol 2014 Aug;171(2):R67-77. Epub 2014 May 6 doi: 10.1530/EJE-14-0213. PMID: 24801585
Sudden or unnatural deaths involving anabolic-androgenic steroids.
Darke S, Torok M, Duflou J
J Forensic Sci 2014 Jul;59(4):1025-8. Epub 2014 Feb 19 doi: 10.1111/1556-4029.12424. PMID: 24611438
Effect of Carissa opaca leaves extract on lipid peroxidation, antioxidant activity and reproductive hormones in male rats.
Sahreen S, Khan MR, Khan RA, Shah NA
Lipids Health Dis 2013 Jun 20;12:90. doi: 10.1186/1476-511X-12-90. PMID: 23786717Free PMC Article
46, XX SRY-positive male syndrome presenting with primary hypogonadism in the setting of scleroderma.
Velasco G, Savarese V, Sandorfi N, Jimenez SA, Jabbour S
Endocr Pract 2011 Jan-Feb;17(1):95-8. doi: 10.4158/EP10184.CR. PMID: 20841307
Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis.
Hoffman WH, Kovacs KT, Gala RR, Keel BA, Jarrell TS, Ellegood JO, Burek CL
J Endocrinol Invest 1991 Jul-Aug;14(7):609-16. doi: 10.1007/BF03346881. PMID: 1940067

Prognosis

Age-related presence of spermatogonia in patients with Klinefelter syndrome: a systematic review and meta-analysis.
Deebel NA, Galdon G, Zarandi NP, Stogner-Underwood K, Howards S, Lovato J, Kogan S, Atala A, Lue Y, Sadri-Ardekani H
Hum Reprod Update 2020 Jan 1;26(1):58-72. doi: 10.1093/humupd/dmz038. PMID: 31822886
Mast cell numbers negatively correlate with fibrosis in cryptorchid testes.
Mechlin CW, Levesque J, Feustel P, Kogan BA
J Pediatr Urol 2014 Jun;10(3):527-31. Epub 2013 Dec 25 doi: 10.1016/j.jpurol.2013.11.014. PMID: 24406204
Age at orchiopexy and testis palpability predict germ and Leydig cell loss: clinical predictors of adverse histological features of cryptorchidism.
Tasian GE, Hittelman AB, Kim GE, DiSandro MJ, Baskin LS
J Urol 2009 Aug;182(2):704-9. Epub 2009 Jun 17 doi: 10.1016/j.juro.2009.04.032. PMID: 19539332

Clinical prediction guides

Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitis.
Peng W, Kepsch A, Kracht TO, Hasan H, Wijayarathna R, Wahle E, Pleuger C, Bhushan S, Günther S, Kauerhof AC, Planinić A, Fietz D, Schuppe HC, Wygrecka M, Loveland KL, Ježek D, Meinhardt A, Hedger MP, Fijak M
Cell Mol Life Sci 2022 Nov 24;79(12):602. doi: 10.1007/s00018-022-04632-4. PMID: 36434305Free PMC Article
Intratesticular xenografting of Klinefelter pre-pubertal testis tissue as potential model to study testicular fibrosis.
Willems M, Seβenhausen P, Gies I, Vloeberghs V, Tournaye H, Van Saen D, Goossens E
Reprod Biomed Online 2022 May;44(5):896-906. Epub 2022 Jan 31 doi: 10.1016/j.rbmo.2022.01.009. PMID: 35282995
Testicular immune cells and vasculature in Klinefelter syndrome from childhood up to adulthood.
Willems M, Vloeberghs V, Gies I, De Schepper J, Tournaye H, Goossens E, Van Saen D
Hum Reprod 2020 Aug 1;35(8):1753-1764. doi: 10.1093/humrep/deaa132. PMID: 32649748
Germ cell loss in Klinefelter syndrome: When and why?
Willems M, Gies I, Van Saen D
Am J Med Genet C Semin Med Genet 2020 Jun;184(2):356-370. Epub 2020 May 15 doi: 10.1002/ajmg.c.31787. PMID: 32412180
Age at orchiopexy and testis palpability predict germ and Leydig cell loss: clinical predictors of adverse histological features of cryptorchidism.
Tasian GE, Hittelman AB, Kim GE, DiSandro MJ, Baskin LS
J Urol 2009 Aug;182(2):704-9. Epub 2009 Jun 17 doi: 10.1016/j.juro.2009.04.032. PMID: 19539332

Recent systematic reviews

Examining potential mechanisms of testicular fibrosis in Klinefelter Syndrome: A review of current understanding.
Bradshaw AW, Deebel NA, Xu MC, Kogan S, Atala A, Sadri-Ardekani H
Andrology 2023 Mar;11(3):435-443. Epub 2022 Oct 27 doi: 10.1111/andr.13327. PMID: 36252136
Age-related presence of spermatogonia in patients with Klinefelter syndrome: a systematic review and meta-analysis.
Deebel NA, Galdon G, Zarandi NP, Stogner-Underwood K, Howards S, Lovato J, Kogan S, Atala A, Lue Y, Sadri-Ardekani H
Hum Reprod Update 2020 Jan 1;26(1):58-72. doi: 10.1093/humupd/dmz038. PMID: 31822886

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