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Midline sinus of philtrum

MedGen UID:: 866765
•Concept ID:: C4021116
•: Anatomical Abnormality

Synonyms:	Central sinus of philtrum; Philtrum, Midline Sinus

HPO:	HP:0011828

Definition

Pit in the midline of the philtral groove. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMidline sinus of philtrum

Abnormality of the mouth
- Abnormal oral morphology
  - Abnormal oral cavity morphology
    - Abnormal lip morphology
      - Abnormal upper lip morphology
        Abnormality of the philtrum
        Midline sinus of philtrum

Recent clinical studies

Etiology

The Role of Preoperative Imaging for Midline Congenital Upper Lip Sinus Tracts.

Jung C, Gall EK, Scott AR
Ann Otol Rhinol Laryngol 2024 Oct;133(10):902-909. Epub 2024 Jul 25 doi: 10.1177/00034894241266499. PMID: 39054808

Congenital midline upper lip sinuses with intracranial extension - A variant of nasal dermoid? An embryology-based concept.

Kotowski M, Szydlowski J
Int J Pediatr Otorhinolaryngol 2023 Jan;164:111394. Epub 2022 Nov 19 doi: 10.1016/j.ijporl.2022.111394. PMID: 36459726

Unusual variants of midline nasal dermoid cysts: a series of three cases.

Locke R, Kubba H
J Laryngol Otol 2012 Jan;126(1):83-7. Epub 2011 Nov 4 doi: 10.1017/S0022215111002891. PMID: 22051034

Midline facial defects with hypertelorism and low-grade astrocytoma: a previously undescribed association.

Giffoni SD, Cendes F, Valente M, Gil-da-Silva-Lopes VL
Cleft Palate Craniofac J 2006 Nov;43(6):748-51. doi: 10.1597/05-099. PMID: 17105323

Congenital midline cervical cleft.

Bergevin MA, Sheft S, Myer C 3rd, McAdams AJ
Pediatr Pathol 1989;9(6):731-9. doi: 10.3109/15513818909022380. PMID: 2602229

See all (11)

Diagnosis

Nasofrontal dermoid cyst: rare presentation of a philtrum sinus.

Donnell CC, McKeague KF, Cooper A, Stenhouse J
Br J Oral Maxillofac Surg 2020 Jun;58(5):608-610. Epub 2020 Mar 20 doi: 10.1016/j.bjoms.2020.03.004. PMID: 32201047

Congenital meningocele associated with corpus callosum agenesis and midline superior labial cleft due to Tessier 0-14 facial fissure: A case report.

Fandiño A, Herrera AJ, Feo OE, Ronderos AM, Ospina JC, De León O
Int J Pediatr Otorhinolaryngol 2020 Feb;129:109764. Epub 2019 Nov 1 doi: 10.1016/j.ijporl.2019.109764. PMID: 31706112

Ultrasound Evaluation of Dermal Sinuses/Fistulas in Pediatric Patients.

Hosokawa T, Takahashi H, Miyasaka Y, Ohira K, Tanami Y, Sato Y, Ishimaru T, Kawashima H, Hosokawa M, Oguma E, Yamada Y
J Ultrasound Med 2019 Dec;38(12):3107-3122. Epub 2019 May 7 doi: 10.1002/jum.15016. PMID: 31063247

A More Favorable Lower-Lip Incision for the Removal of Deep Intraoral Malignancies.

Xiang XW, Feng da J, Chen X, Chen CJ
J Craniofac Surg 2016 May;27(3):e228-9. doi: 10.1097/SCS.0000000000002360. PMID: 27159868

Dermoid sinus and cyst of the lip.

Kormanik KE, Bersu ET, Bentz ML
J Craniofac Surg 2006 Jan;17(1):162-6. doi: 10.1097/01.scs.0000168997.12634.16. PMID: 16432426

See all (7)

Therapy

Infraorbital nerve block in children: a computerized tomographic measurement of the location of the infraorbital foramen.

Suresh S, Voronov P, Curran J
Reg Anesth Pain Med 2006 May-Jun;31(3):211-4. doi: 10.1016/j.rapm.2005.11.017. PMID: 16701185

A new surgical approach to extensive tumors in the pterygomaxillary fossa and the skull base.

Jian XC, Liu JP
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 Feb;95(2):156-62. doi: 10.1067/moe.2003.41. PMID: 12582354

Nasolabial esthetics after Le Fort I osteotomy and V-Y closure: a statistical evaluation.

Rosenberg A, Muradin MS, van der Bilt A
Int J Adult Orthodon Orthognath Surg 2002;17(1):29-39. PMID: 11934053

See all (3)

Prognosis

Congenital Upper Lip Sinus.

Zhang J, Li Z, Pang P
J Craniofac Surg 2024 Jul-Aug 01;35(5):e438-e441. Epub 2024 May 2 doi: 10.1097/SCS.0000000000010138. PMID: 38688013

Midline facial defects with hypertelorism and low-grade astrocytoma: a previously undescribed association.

Giffoni SD, Cendes F, Valente M, Gil-da-Silva-Lopes VL
Cleft Palate Craniofac J 2006 Nov;43(6):748-51. doi: 10.1597/05-099. PMID: 17105323

Nasolabial esthetics after Le Fort I osteotomy and V-Y closure: a statistical evaluation.

Rosenberg A, Muradin MS, van der Bilt A
Int J Adult Orthodon Orthognath Surg 2002;17(1):29-39. PMID: 11934053

Rhinologic computed tomographic evaluation in patients with cleft lip and palate.

Suzuki H, Yamaguchi T, Furukawa M
Arch Otolaryngol Head Neck Surg 1999 Sep;125(9):1000-4. doi: 10.1001/archotol.125.9.1000. PMID: 10488986

Congenital midline cervical cleft.

Bergevin MA, Sheft S, Myer C 3rd, McAdams AJ
Pediatr Pathol 1989;9(6):731-9. doi: 10.3109/15513818909022380. PMID: 2602229

See all (8)

Clinical prediction guides

Infraorbital nerve block in children: a computerized tomographic measurement of the location of the infraorbital foramen.

Suresh S, Voronov P, Curran J
Reg Anesth Pain Med 2006 May-Jun;31(3):211-4. doi: 10.1016/j.rapm.2005.11.017. PMID: 16701185

The face does predict the brain--midline facial and forebrain defects uncovered during the investigation of nasal obstruction and rhinorrhea. Case report and a review of holoprosencephaly and its classifications.

El-Hawrani A, Sohn M, Noga M, El-Hakim H
Int J Pediatr Otorhinolaryngol 2006 May;70(5):935-40. Epub 2005 Nov 8 doi: 10.1016/j.ijporl.2005.09.020. PMID: 16280170

Congenital sinus of the upper lip with idiopathic precocious puberty.

Sumitomo S, Ogawa S, Hirai K, Takai Y
Oral Dis 2002 Nov;8(6):308-9. doi: 10.1034/j.1601-0825.2002.02871.x. PMID: 12477063

Nasolabial esthetics after Le Fort I osteotomy and V-Y closure: a statistical evaluation.

Rosenberg A, Muradin MS, van der Bilt A
Int J Adult Orthodon Orthognath Surg 2002;17(1):29-39. PMID: 11934053

See all (4)