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Pituitary thyrotropic cell adenoma

MedGen UID:
866770
•Concept ID:
C4021121
•
Neoplastic Process
Synonym: Pituitary thyrotropinoma
 
HPO: HP:0011762

Definition

A type of pituitary adenoma that produces thyroid stimulating hormone (TSH). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary thyrotropic cell adenoma

Recent clinical studies

Etiology

Refractory Pit1 plurihormonal tumours and thyrotroph adenomas.
Nf L, Ai M
Pituitary 2023 Apr;26(2):182-186. Epub 2023 Apr 29 doi: 10.1007/s11102-023-01312-9. PMID: 37117845Free PMC Article
Surgical Outcome and Treatment of Thyrotropin-Secreting Pituitary Tumors in a Tertiary Referral Center.
Herguido NG, Fuentes ED, Venegas-Moreno E, Maorad LB, Flores-Martinez A, Ruiz PR, Dueñas MC, Roldán F, Fajardo E, Ruiz-Valdepeñas EC, Kaen A, Martín Schrader I, Cano DA, Soto-Moreno A
World Neurosurg 2019 Oct;130:e634-e639. Epub 2019 Jul 2 doi: 10.1016/j.wneu.2019.06.180. PMID: 31276853
Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile.
Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR
World Neurosurg 2018 Dec;120:e241-e246. Epub 2018 Aug 20 doi: 10.1016/j.wneu.2018.08.043. PMID: 30138730
Mono- and plurihormonal thyrotropic pituitary adenomas: pathological, hormonal and clinical studies in 12 patients.
Bertholon-Grégoire M, Trouillas J, Guigard MP, Loras B, Tourniaire J
Eur J Endocrinol 1999 Jun;140(6):519-27. doi: 10.1530/eje.0.1400519. PMID: 10366408
The pituitary gland in hyperthyroidism.
Scheithauer BW, Kovacs KT, Young WF Jr, Randall RV
Mayo Clin Proc 1992 Jan;67(1):22-6. doi: 10.1016/s0025-6196(12)60272-9. PMID: 1732687

Diagnosis

The molecular biology of thyrotroph pituitary neuroendocrine tumors.
Horiguchi K
Endocr J 2023 Feb 28;70(2):135-139. Epub 2023 Jan 19 doi: 10.1507/endocrj.EJ22-0514. PMID: 36653153
Somatostatin receptor profile in pituitary thyrotroph adenomas.
Thodou E, Kontogeorgos G
Clin Neurol Neurosurg 2020 Aug;195:105865. Epub 2020 Apr 22 doi: 10.1016/j.clineuro.2020.105865. PMID: 32416325
Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens-An Insight From Translational Studies.
Šošić-Jurjević B, Ajdžanović V, Miljić D, Trifunović S, Filipović B, Stanković S, Bolevich S, Jakovljević V, Milošević V
Int J Mol Sci 2020 Mar 16;21(6) doi: 10.3390/ijms21062024. PMID: 32188093Free PMC Article
Surgical Outcome and Treatment of Thyrotropin-Secreting Pituitary Tumors in a Tertiary Referral Center.
Herguido NG, Fuentes ED, Venegas-Moreno E, Maorad LB, Flores-Martinez A, Ruiz PR, Dueñas MC, Roldán F, Fajardo E, Ruiz-Valdepeñas EC, Kaen A, Martín Schrader I, Cano DA, Soto-Moreno A
World Neurosurg 2019 Oct;130:e634-e639. Epub 2019 Jul 2 doi: 10.1016/j.wneu.2019.06.180. PMID: 31276853
Mono- and plurihormonal thyrotropic pituitary adenomas: pathological, hormonal and clinical studies in 12 patients.
Bertholon-Grégoire M, Trouillas J, Guigard MP, Loras B, Tourniaire J
Eur J Endocrinol 1999 Jun;140(6):519-27. doi: 10.1530/eje.0.1400519. PMID: 10366408

Therapy

Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens-An Insight From Translational Studies.
Šošić-Jurjević B, Ajdžanović V, Miljić D, Trifunović S, Filipović B, Stanković S, Bolevich S, Jakovljević V, Milošević V
Int J Mol Sci 2020 Mar 16;21(6) doi: 10.3390/ijms21062024. PMID: 32188093Free PMC Article
In vivo and in vitro response to octreotide LAR in a TSH-secreting adenoma: characterization of somatostatin receptor expression and role of subtype 5.
Gatto F, Barbieri F, Castelletti L, Arvigo M, Pattarozzi A, Annunziata F, Saveanu A, Minuto F, Castellan L, Zona G, Florio T, Ferone D
Pituitary 2011 Jun;14(2):141-7. doi: 10.1007/s11102-010-0271-2. PMID: 21086053
A case of atypical thyrotroph cell adenoma, which re-grew within 3 months after surgery and required multimodal treatment.
Ogawa Y, Tominaga T
J Neurooncol 2008 Mar;87(1):91-5. Epub 2007 Nov 7 doi: 10.1007/s11060-007-9492-2. PMID: 17987261
Morphology of the pituitary gland in ferrets (Mustela putorius furo) with hyperadrenocorticism.
Schoemaker NJ, van der Hage MH, Flik G, Lumeij JT, Rijnberk A
J Comp Pathol 2004 May;130(4):255-65. doi: 10.1016/j.jcpa.2003.11.004. PMID: 15053928
Mono- and plurihormonal thyrotropic pituitary adenomas: pathological, hormonal and clinical studies in 12 patients.
Bertholon-Grégoire M, Trouillas J, Guigard MP, Loras B, Tourniaire J
Eur J Endocrinol 1999 Jun;140(6):519-27. doi: 10.1530/eje.0.1400519. PMID: 10366408

Prognosis

Clinical and Therapeutic Characteristics of Pituitary TSH-Secreting Adenoma in Adolescent-Onset Patients: Six Case Studies and Literature Review.
Yang Y, Liu J, Deng K, Lu L, Zhu H, Lian X, Bao X, Duan L, Yao Y
Front Endocrinol (Lausanne) 2021;12:771673. Epub 2021 Dec 23 doi: 10.3389/fendo.2021.771673. PMID: 35002961Free PMC Article
Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile.
Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR
World Neurosurg 2018 Dec;120:e241-e246. Epub 2018 Aug 20 doi: 10.1016/j.wneu.2018.08.043. PMID: 30138730
Epidemiology and biomarker profile of pituitary adenohypophysial tumors.
Mete O, Cintosun A, Pressman I, Asa SL
Mod Pathol 2018 Jun;31(6):900-909. Epub 2018 Feb 12 doi: 10.1038/s41379-018-0016-8. PMID: 29434339
In vivo and in vitro response to octreotide LAR in a TSH-secreting adenoma: characterization of somatostatin receptor expression and role of subtype 5.
Gatto F, Barbieri F, Castelletti L, Arvigo M, Pattarozzi A, Annunziata F, Saveanu A, Minuto F, Castellan L, Zona G, Florio T, Ferone D
Pituitary 2011 Jun;14(2):141-7. doi: 10.1007/s11102-010-0271-2. PMID: 21086053
Thyrotropin-secreting pituitary adenomas: clinical and biochemical heterogeneity. Case reports and follow-up of nine patients.
Gesundheit N, Petrick PA, Nissim M, Dahlberg PA, Doppman JL, Emerson CH, Braverman LE, Oldfield EH, Weintraub BD
Ann Intern Med 1989 Nov 15;111(10):827-35. doi: 10.7326/0003-4819-111-10-827. PMID: 2479309

Clinical prediction guides

Somatostatin receptor profile in pituitary thyrotroph adenomas.
Thodou E, Kontogeorgos G
Clin Neurol Neurosurg 2020 Aug;195:105865. Epub 2020 Apr 22 doi: 10.1016/j.clineuro.2020.105865. PMID: 32416325
Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile.
Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR
World Neurosurg 2018 Dec;120:e241-e246. Epub 2018 Aug 20 doi: 10.1016/j.wneu.2018.08.043. PMID: 30138730
Epidemiology and biomarker profile of pituitary adenohypophysial tumors.
Mete O, Cintosun A, Pressman I, Asa SL
Mod Pathol 2018 Jun;31(6):900-909. Epub 2018 Feb 12 doi: 10.1038/s41379-018-0016-8. PMID: 29434339
Expression of neurotensin and its receptors in pituitary adenomas.
Giorgi RR, Chile T, Bello AR, Reyes R, Fortes MA, Machado MC, Cescato VA, Musolino NR, Bronstein MD, Giannella-Neto D, Corrêa-Giannella ML
J Neuroendocrinol 2008 Sep;20(9):1052-7. Epub 2008 Jul 8 doi: 10.1111/j.1365-2826.2008.01761.x. PMID: 18624930
Coexpression of galanin and adrenocorticotropic hormone in human pituitary and pituitary adenomas.
Hsu DW, Hooi SC, Hedley-Whyte ET, Strauss RM, Kaplan LM
Am J Pathol 1991 Apr;138(4):897-909. PMID: 1707237Free PMC Article

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