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Elevated tissue non-specific alkaline phosphatase

MedGen UID:
866885
Concept ID:
C4021240
Finding
Synonyms: Elevated alkaline phosphatase, liver/bone/kidney; Elevated tissue non-specific ALP
 
HPO: HP:0010679

Definition

An abnormally increased level of alkaline phosphatase, tissue-nonspecific isozyme in the blood. [from HPO]

Professional guidelines

PubMed

Tornai D, Ven PL, Lakatos PL, Papp M
World J Gastroenterol 2022 Jun 7;28(21):2291-2301. doi: 10.3748/wjg.v28.i21.2291. PMID: 35800183Free PMC Article
Khan AA, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg CR
Osteoporos Int 2019 Sep;30(9):1713-1722. Epub 2019 Mar 26 doi: 10.1007/s00198-019-04921-y. PMID: 30915507

Recent clinical studies

Etiology

Larid G, Vix J, Preuss P, Robin F, Tison A, Delaveau C, Krajewski F, Bouvard B, Chu Miow Lin D, Guggenbuhl P, Maugars Y, Saraux A, Debiais F
RMD Open 2024 Apr 4;10(2) doi: 10.1136/rmdopen-2024-004316. PMID: 38580346Free PMC Article
Shaver M, Gomez K, Kaiser K, Hutcheson JD
BMC Mol Cell Biol 2024 Mar 14;25(1):8. doi: 10.1186/s12860-024-00504-w. PMID: 38486163Free PMC Article
Whyte MP, Coburn SP, Ryan LM, Ericson KL, Zhang F
Bone 2018 May;110:96-106. Epub 2018 Jan 31 doi: 10.1016/j.bone.2018.01.022. PMID: 29360619
Girschick HJ, Haubitz I, Hiort O, Schneider P
Joint Bone Spine 2007 May;74(3):263-9. Epub 2007 Mar 15 doi: 10.1016/j.jbspin.2006.06.017. PMID: 17420150
Berruti A, Piovesan A, Torta M, Raucci CA, Gorzegno G, Paccotti P, Dogliotti L, Angeli A
Br J Cancer 1996 Jun;73(12):1581-7. doi: 10.1038/bjc.1996.298. PMID: 8664134Free PMC Article

Diagnosis

Alsarraf F, Ali DS, Almonaei K, Al-Alwani H, Khan AA, Brandi ML
Osteoporos Int 2024 Apr;35(4):717-725. Epub 2023 Nov 23 doi: 10.1007/s00198-023-06943-z. PMID: 37993691
Tornai D, Ven PL, Lakatos PL, Papp M
World J Gastroenterol 2022 Jun 7;28(21):2291-2301. doi: 10.3748/wjg.v28.i21.2291. PMID: 35800183Free PMC Article
Khan AA, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg CR
Osteoporos Int 2019 Sep;30(9):1713-1722. Epub 2019 Mar 26 doi: 10.1007/s00198-019-04921-y. PMID: 30915507
Salles JP
Subcell Biochem 2015;76:3-24. doi: 10.1007/978-94-017-7197-9_1. PMID: 26219704
Hickey AJ, Gounder L, Moosa MY, Drain PK
BMC Infect Dis 2015 May 6;15:209. doi: 10.1186/s12879-015-0944-6. PMID: 25943103Free PMC Article

Therapy

Alsarraf F, Ali DS, Almonaei K, Al-Alwani H, Khan AA, Brandi ML
Osteoporos Int 2024 Apr;35(4):717-725. Epub 2023 Nov 23 doi: 10.1007/s00198-023-06943-z. PMID: 37993691
Khan AA, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg CR
Osteoporos Int 2019 Sep;30(9):1713-1722. Epub 2019 Mar 26 doi: 10.1007/s00198-019-04921-y. PMID: 30915507
Hortells L, Sosa C, Guillén N, Lucea S, Millán Á, Sorribas V
Kidney Int 2017 Dec;92(6):1384-1394. Epub 2017 Aug 23 doi: 10.1016/j.kint.2017.06.019. PMID: 28844316
Girschick HJ, Haubitz I, Hiort O, Schneider P
Joint Bone Spine 2007 May;74(3):263-9. Epub 2007 Mar 15 doi: 10.1016/j.jbspin.2006.06.017. PMID: 17420150
Waymire KG, Mahuren JD, Jaje JM, Guilarte TR, Coburn SP, MacGregor GR
Nat Genet 1995 Sep;11(1):45-51. doi: 10.1038/ng0995-45. PMID: 7550313

Prognosis

Tornai D, Ven PL, Lakatos PL, Papp M
World J Gastroenterol 2022 Jun 7;28(21):2291-2301. doi: 10.3748/wjg.v28.i21.2291. PMID: 35800183Free PMC Article
Salles JP
Subcell Biochem 2015;76:3-24. doi: 10.1007/978-94-017-7197-9_1. PMID: 26219704
Kumarasinghe DD, Sullivan T, Kuliwaba JS, Fazzalari NL, Atkins GJ
Osteoarthritis Cartilage 2012 Nov;20(11):1357-66. Epub 2012 Jul 20 doi: 10.1016/j.joca.2012.07.005. PMID: 22820497
Girschick HJ, Haubitz I, Hiort O, Schneider P
Joint Bone Spine 2007 May;74(3):263-9. Epub 2007 Mar 15 doi: 10.1016/j.jbspin.2006.06.017. PMID: 17420150

Clinical prediction guides

Tornai D, Ven PL, Lakatos PL, Papp M
World J Gastroenterol 2022 Jun 7;28(21):2291-2301. doi: 10.3748/wjg.v28.i21.2291. PMID: 35800183Free PMC Article
Nwafor DC, Chakraborty S, Brichacek AL, Jun S, Gambill CA, Wang W, Engler-Chiurazzi EB, Dakhlallah D, Pinkerton AB, Millán JL, Benkovic SA, Brown CM
Brain Behav Immun 2020 Feb;84:115-131. Epub 2019 Nov 25 doi: 10.1016/j.bbi.2019.11.016. PMID: 31778743Free PMC Article
Khan AA, Josse R, Kannu P, Villeneuve J, Paul T, Van Uum S, Greenberg CR
Osteoporos Int 2019 Sep;30(9):1713-1722. Epub 2019 Mar 26 doi: 10.1007/s00198-019-04921-y. PMID: 30915507
Beck-Nielsen SS, Mughal Z, Haffner D, Nilsson O, Levtchenko E, Ariceta G, de Lucas Collantes C, Schnabel D, Jandhyala R, Mäkitie O
Orphanet J Rare Dis 2019 Feb 26;14(1):58. doi: 10.1186/s13023-019-1014-8. PMID: 30808384Free PMC Article
Hortells L, Sosa C, Guillén N, Lucea S, Millán Á, Sorribas V
Kidney Int 2017 Dec;92(6):1384-1394. Epub 2017 Aug 23 doi: 10.1016/j.kint.2017.06.019. PMID: 28844316

Recent systematic reviews

Hickey AJ, Gounder L, Moosa MY, Drain PK
BMC Infect Dis 2015 May 6;15:209. doi: 10.1186/s12879-015-0944-6. PMID: 25943103Free PMC Article

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