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Abnormal ventricular septum morphology

MedGen UID:
866908
Concept ID:
C4021264
Anatomical Abnormality
Synonyms: Abnormal interventricular septum morphology; Abnormality of the ventricular septum; Ventricular septum abnormality
 
HPO: HP:0010438

Definition

A structural abnormality of the interventricular septum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormal ventricular septum morphology

Conditions with this feature

Interventricular septum aneurysm
MedGen UID:
234648
Concept ID:
C1387721
Disease or Syndrome
Interventricular septum aneurysm is a rare, non-syndromic, congenital heart malformation characterized by the presence of a congenital aneurysm of the membranous portion of the interventricular septum. Patients may be asymptomatic or may present with ventricular or supraventricular tachycardia, fatigue, exertional dyspnea, palpitations, and cardiac murmur. Ventricular septal defects and conduction defects, such as first-degree atrio-ventricular block or incomplete right bundle branch block, may also be also associated.

Professional guidelines

PubMed

Wolter A, Nosbüsch S, Kawecki A, Degenhardt J, Enzensberger C, Graupner O, Vorisek C, Akintürk H, Yerebakan C, Khalil M, Schranz D, Ritgen J, Stressig R, Axt-Fliedner R
Prenat Diagn 2016 Jun;36(6):545-54. Epub 2016 May 10 doi: 10.1002/pd.4821. PMID: 27061183
Satomi G, Yasukochi S, Imai T, Takigiku K, Tekehiko I, Harada Y, Takeuchi T, Watanabe M, Ishikawa S
Pediatr Int 2001 Oct;43(5):553-7. doi: 10.1046/j.1442-200x.2001.01463.x. PMID: 11737727
Rao PS
Ann Thorac Surg 1985 Oct;40(4):409-13. doi: 10.1016/s0003-4975(10)60082-3. PMID: 3901947

Recent clinical studies

Etiology

Friedman KG, Tworetzky W
Arch Cardiovasc Dis 2020 Feb;113(2):121-128. Epub 2020 Feb 26 doi: 10.1016/j.acvd.2019.06.007. PMID: 32113817
Liu L, Wang H, Cui C, Li Y, Liu Y, Wang Y, Fan T, Peng B
Medicine (Baltimore) 2019 Oct;98(42):e17492. doi: 10.1097/MD.0000000000017492. PMID: 31626103Free PMC Article
Bharucha T, Hlavacek AM, Spicer DE, Theocharis P, Anderson RH
Cardiol Young 2017 Jan;27(1):1-15. Epub 2016 Sep 19 doi: 10.1017/S1047951116001190. PMID: 27641710
Eltayeb O, Mongé MC, Popescu AR, Sarwark AE, Harris T, Backer CL
World J Pediatr Congenit Heart Surg 2017 Jan;8(1):106-110. Epub 2016 Jun 22 doi: 10.1177/2150135115618871. PMID: 26993757
Philip S, Cherian KM, Wu MH, Lue HC
Pediatr Neonatol 2011 Oct;52(5):279-86. doi: 10.1016/j.pedneo.2011.06.007. PMID: 22036224

Diagnosis

Sukhavasi A, McHugh-Grant S, Glatz AC, Mondal A, Griffis H, Burnham N, Chen JM, Mascio CE, Gaynor JW, Spray TL, Fuller SM
J Thorac Cardiovasc Surg 2022 Nov;164(5):1277-1288. Epub 2022 Mar 16 doi: 10.1016/j.jtcvs.2021.11.104. PMID: 35414413
Andrushchuk U, Niavyhlas A, Adzintsou V, Haidzel I, Model H, Shket A
Interact Cardiovasc Thorac Surg 2022 Jan 6;34(1):9-15. Epub 2021 Aug 15 doi: 10.1093/icvts/ivab213. PMID: 34999797Free PMC Article
Eltayeb O, Mongé MC, Popescu AR, Sarwark AE, Harris T, Backer CL
World J Pediatr Congenit Heart Surg 2017 Jan;8(1):106-110. Epub 2016 Jun 22 doi: 10.1177/2150135115618871. PMID: 26993757
Anderson RH, Spicer DE, Henry GW, Rigsby C, Hlavacek AM, Mohun TJ
Cardiol Young 2015 Apr;25(4):612-25. Epub 2014 Jul 1 doi: 10.1017/S1047951114001139. PMID: 24983250
Calabrò R, Limongelli G
Orphanet J Rare Dis 2006 Apr 5;1:8. doi: 10.1186/1750-1172-1-8. PMID: 16722604Free PMC Article

Therapy

Leali M, Aimo A, Ricci G, Torri F, Todiere G, Vergaro G, Grigoratos C, Giannoni A, Aquaro GD, Siciliano G, Emdin M, Passino C, Barison A
J Cardiovasc Med (Hagerstown) 2023 Jun 1;24(6):340-347. Epub 2023 Apr 27 doi: 10.2459/JCM.0000000000001476. PMID: 37129928
Corno AF, Zhou Z, Uppu SC, Huang S, Marino B, Milewicz DM, Salazar JD
Pediatr Cardiol 2022 Oct;43(7):1471-1480. Epub 2022 Mar 15 doi: 10.1007/s00246-022-02870-8. PMID: 35290490
Friedman KG, Tworetzky W
Arch Cardiovasc Dis 2020 Feb;113(2):121-128. Epub 2020 Feb 26 doi: 10.1016/j.acvd.2019.06.007. PMID: 32113817
Wick MR
Semin Diagn Pathol 2019 Jan;36(1):2-10. Epub 2018 Nov 16 doi: 10.1053/j.semdp.2018.11.002. PMID: 30473462
Santos Mateo JJ, Sabater Molina M, Gimeno Blanes JR
Med Clin (Barc) 2018 Jun 8;150(11):434-442. Epub 2017 Nov 14 doi: 10.1016/j.medcli.2017.09.013. PMID: 29150126

Prognosis

Manhem S, Hanséus K, Berggren H, Ekman-Joelsson BM
World J Pediatr Congenit Heart Surg 2021 Jan;12(1):27-34. doi: 10.1177/2150135120958641. PMID: 33407024
Liu L, Wang H, Cui C, Li Y, Liu Y, Wang Y, Fan T, Peng B
Medicine (Baltimore) 2019 Oct;98(42):e17492. doi: 10.1097/MD.0000000000017492. PMID: 31626103Free PMC Article
Yoshimura N, Yamaguchi M
Gen Thorac Cardiovasc Surg 2009 Jul;57(7):338-46. Epub 2009 Jul 14 doi: 10.1007/s11748-008-0415-8. PMID: 19597923
Calabrò R, Limongelli G
Orphanet J Rare Dis 2006 Apr 5;1:8. doi: 10.1186/1750-1172-1-8. PMID: 16722604Free PMC Article
Kimball TR
Pediatr Cardiol 2002 May-Jun;23(3):347-57. doi: 10.1007/s00246-001-0198-5. PMID: 11976781

Clinical prediction guides

Leali M, Aimo A, Ricci G, Torri F, Todiere G, Vergaro G, Grigoratos C, Giannoni A, Aquaro GD, Siciliano G, Emdin M, Passino C, Barison A
J Cardiovasc Med (Hagerstown) 2023 Jun 1;24(6):340-347. Epub 2023 Apr 27 doi: 10.2459/JCM.0000000000001476. PMID: 37129928
Sukhavasi A, McHugh-Grant S, Glatz AC, Mondal A, Griffis H, Burnham N, Chen JM, Mascio CE, Gaynor JW, Spray TL, Fuller SM
J Thorac Cardiovasc Surg 2022 Nov;164(5):1277-1288. Epub 2022 Mar 16 doi: 10.1016/j.jtcvs.2021.11.104. PMID: 35414413
Liu L, Wang H, Cui C, Li Y, Liu Y, Wang Y, Fan T, Peng B
Medicine (Baltimore) 2019 Oct;98(42):e17492. doi: 10.1097/MD.0000000000017492. PMID: 31626103Free PMC Article
Lin HY, Chen MR, Lin SM, Hung CL, Niu DM, Chang TM, Chuang CK, Lin SP
Orphanet J Rare Dis 2019 Jun 13;14(1):140. doi: 10.1186/s13023-019-1112-7. PMID: 31196149Free PMC Article
Braga VL, da Costa MDS, Riera R, Dos Santos Rocha LP, de Oliveira Santos BF, Matsumura Hondo TT, de Oliveira Chagas M, Cavalheiro S
Pediatr Neurol 2018 Oct;87:23-29. Epub 2018 Aug 8 doi: 10.1016/j.pediatrneurol.2018.08.001. PMID: 30501885

Recent systematic reviews

Li FF, Du XL, Chen S
J Huazhong Univ Sci Technolog Med Sci 2015 Oct;35(5):656-661. Epub 2015 Oct 22 doi: 10.1007/s11596-015-1485-3. PMID: 26489617

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