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Abnormal dentin morphology

MedGen UID:
866943
•Concept ID:
C4021299
•
Anatomical Abnormality
Synonyms: Abnormal dentin; Abnormality of dentin; Abnormality of dentine; Dentin anomaly
 
HPO: HP:0010299

Definition

Any abnormality of dentin. [from HPO]

Conditions with this feature

Amelogenesis imperfecta type 1E
MedGen UID:
336847
•Concept ID:
C1845053
•
Disease or Syndrome
Amelogenesis imperfecta is an inherited defect of dental enamel formation that shows both clinical and genetic heterogeneity. In the hypoplastic type of AI, the enamel is of normal hardness but does not develop to normal thickness. The thinness of the enamel makes the teeth appear small. Radiographically, enamel contrasts normally from dentin. The surface of the enamel can vary, showing smooth, rough, pitted, or local forms (Witkop, 1988).
See: Condition Record
Amelogenesis imperfecta, type 1J
MedGen UID:
934597
•Concept ID:
C4310630
•
Congenital Abnormality
Amelogenesis imperfecta is an inherited defect of dental enamel formation that shows both clinical and genetic heterogeneity. In the hypoplastic type of AI, the enamel is of normal hardness but does not develop to normal thickness. The thinness of the enamel makes the teeth appear small. Radiographically, enamel contrasts normally from dentin. The surface of the enamel can vary, showing smooth, rough, pitted, or local forms (Witkop, 1988).
See: Condition Record
Amelogenesis imperfecta type 1E
Amelogenesis imperfecta, type 1J

Professional guidelines

PubMed

Current Management of Dens Evaginatus Teeth Based on Pulpal Diagnosis.
Lerdrungroj K, Banomyong D, Songtrakul K, Porkaew P, Nakornchai S
J Endod 2023 Oct;49(10):1230-1237. Epub 2023 Jul 26 doi: 10.1016/j.joen.2023.07.017. PMID: 37506764
A novel DSPP frameshift mutation causing dentin dysplasia type 2 and disease management strategies.
Yuan M, Zheng X, Xue Y, He Z, Song G, Song Y
Oral Dis 2023 Sep;29(6):2394-2400. Epub 2023 Jan 13 doi: 10.1111/odi.14494. PMID: 36597617
Developmental defects of enamel and dentine: challenges for basic science research and clinical management.
Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394

Recent clinical studies

Etiology

Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia.
Lira Dos Santos EJ, Nakajima K, Po J, Hanai A, Zhukouskaya V, Biosse Duplan M, Linglart A, Shimada T, Chaussain C, Bardet C
Int J Oral Sci 2023 Dec 6;15(1):53. doi: 10.1038/s41368-023-00259-8. PMID: 38052774Free PMC Article
Investigation of prevalence of dental anomalies by using digital panoramic radiographs.
Bilge NH, Yeşiltepe S, Törenek Ağırman K, Çağlayan F, Bilge OM
Folia Morphol (Warsz) 2018;77(2):323-328. Epub 2017 Sep 21 doi: 10.5603/FM.a2017.0087. PMID: 28933802
Hypophosphatasia: oral cavity and dental disorders.
Bloch-Zupan A, Vaysse F
Arch Pediatr 2017 May;24(5S2):5S80-5S84. doi: 10.1016/S0929-693X(18)30020-4. PMID: 29405938
Developmental defects of enamel and dentine: challenges for basic science research and clinical management.
Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394
Hereditary dentine disorders: dentinogenesis imperfecta and dentine dysplasia.
Barron MJ, McDonnell ST, Mackie I, Dixon MJ
Orphanet J Rare Dis 2008 Nov 20;3:31. doi: 10.1186/1750-1172-3-31. PMID: 19021896Free PMC Article

Diagnosis

Current Management of Dens Evaginatus Teeth Based on Pulpal Diagnosis.
Lerdrungroj K, Banomyong D, Songtrakul K, Porkaew P, Nakornchai S
J Endod 2023 Oct;49(10):1230-1237. Epub 2023 Jul 26 doi: 10.1016/j.joen.2023.07.017. PMID: 37506764
Hereditary dentin defects with systemic diseases.
Su T, Zhu Y, Wang X, Zhu Q, Duan X
Oral Dis 2023 Sep;29(6):2376-2393. Epub 2023 Apr 24 doi: 10.1111/odi.14589. PMID: 37094075
Investigation of prevalence of dental anomalies by using digital panoramic radiographs.
Bilge NH, Yeşiltepe S, Törenek Ağırman K, Çağlayan F, Bilge OM
Folia Morphol (Warsz) 2018;77(2):323-328. Epub 2017 Sep 21 doi: 10.5603/FM.a2017.0087. PMID: 28933802
Developmental defects of enamel and dentine: challenges for basic science research and clinical management.
Seow WK
Aust Dent J 2014 Jun;59 Suppl 1:143-54. Epub 2013 Oct 27 doi: 10.1111/adj.12104. PMID: 24164394
Hereditary dentine disorders: dentinogenesis imperfecta and dentine dysplasia.
Barron MJ, McDonnell ST, Mackie I, Dixon MJ
Orphanet J Rare Dis 2008 Nov 20;3:31. doi: 10.1186/1750-1172-3-31. PMID: 19021896Free PMC Article

Therapy

Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia.
Lira Dos Santos EJ, Nakajima K, Po J, Hanai A, Zhukouskaya V, Biosse Duplan M, Linglart A, Shimada T, Chaussain C, Bardet C
Int J Oral Sci 2023 Dec 6;15(1):53. doi: 10.1038/s41368-023-00259-8. PMID: 38052774Free PMC Article
ODONTOLOGICAL EFFECTS OF IONIZING RADIATION (review).
Afanasyev DE, Liubarets SF
Probl Radiac Med Radiobiol 2020 Dec;25:18-55. doi: 10.33145/2304-8336-2020-25-18-55. PMID: 33361828
Risk Factors for Early Childhood Caries: A Systematic Review and Meta-Analysis of Case Control and Cohort Studies.
Kirthiga M, Murugan M, Saikia A, Kirubakaran R
Pediatr Dent 2019 Mar 15;41(2):95-112. PMID: 30992106Free PMC Article
Osteogenesis Imperfecta: A Pediatric Orthopedic Perspective.
Franzone JM, Shah SA, Wallace MJ, Kruse RW
Orthop Clin North Am 2019 Apr;50(2):193-209. doi: 10.1016/j.ocl.2018.10.003. PMID: 30850078
Protein-mediated enamel mineralization.
Moradian-Oldak J
Front Biosci (Landmark Ed) 2012 Jun 1;17(6):1996-2023. doi: 10.2741/4034. PMID: 22652761Free PMC Article

Prognosis

Unequal Impact of COL1A1 and COL1A2 Variants on Dentinogenesis Imperfecta.
Yamaguti PM, de La Dure-Molla M, Monnot S, Cardozo-Amaya YJ, Baujat G, Michot C, Fournier BPJ, Riou MC, Caldas Rosa ECC, Soares de Lima Y, Dos Santos PAC, Alcaraz G, Guerra ENS, Castro LC, de Oliveira SF, Pogue R, Berdal A, de Paula LM, Mazzeu JF, Cormier-Daire V, Acevedo AC
J Dent Res 2023 Jun;102(6):616-625. Epub 2023 Mar 23 doi: 10.1177/00220345231154569. PMID: 36951356
A novel DSPP frameshift mutation causing dentin dysplasia type 2 and disease management strategies.
Yuan M, Zheng X, Xue Y, He Z, Song G, Song Y
Oral Dis 2023 Sep;29(6):2394-2400. Epub 2023 Jan 13 doi: 10.1111/odi.14494. PMID: 36597617
Peripheral compound odontoma: A rare case report and literature review.
da Silva Rocha OKM, da Silva Barros CC, da Silva LAB, de Souza Júnior EF, de Morais HHA, da Costa Miguel MC
J Cutan Pathol 2020 Aug;47(8):720-724. Epub 2020 Mar 31 doi: 10.1111/cup.13676. PMID: 32134132
Clinical procedures for revitalization: current knowledge and considerations.
Galler KM
Int Endod J 2016 Oct;49(10):926-36. Epub 2016 Feb 1 doi: 10.1111/iej.12606. PMID: 26715631
Unilateral odontodysplasia.
Anneroth G, Ramström G
Swed Dent J 1980;4(3):93-100. PMID: 6254190

Clinical prediction guides

Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia.
Lira Dos Santos EJ, Nakajima K, Po J, Hanai A, Zhukouskaya V, Biosse Duplan M, Linglart A, Shimada T, Chaussain C, Bardet C
Int J Oral Sci 2023 Dec 6;15(1):53. doi: 10.1038/s41368-023-00259-8. PMID: 38052774Free PMC Article
A novel DSPP frameshift mutation causing dentin dysplasia type 2 and disease management strategies.
Yuan M, Zheng X, Xue Y, He Z, Song G, Song Y
Oral Dis 2023 Sep;29(6):2394-2400. Epub 2023 Jan 13 doi: 10.1111/odi.14494. PMID: 36597617
A Review of Dentinogenesis Imperfecta and Primary Dentin Disorders in Dogs.
Mack Wilson J, Bell C, Queck K, Scott K
J Vet Dent 2022 Dec;39(4):376-390. Epub 2022 Sep 15 doi: 10.1177/08987564221123419. PMID: 36113440
CRAC channels in dental enamel cells.
Eckstein M, Lacruz RS
Cell Calcium 2018 Nov;75:14-20. Epub 2018 Aug 9 doi: 10.1016/j.ceca.2018.07.012. PMID: 30114531Free PMC Article
Isolated dentinogenesis imperfecta and dentin dysplasia: revision of the classification.
de La Dure-Molla M, Philippe Fournier B, Berdal A
Eur J Hum Genet 2015 Apr;23(4):445-51. Epub 2014 Aug 13 doi: 10.1038/ejhg.2014.159. PMID: 25118030Free PMC Article

Recent systematic reviews

Risk Factors for Early Childhood Caries: A Systematic Review and Meta-Analysis of Case Control and Cohort Studies.
Kirthiga M, Murugan M, Saikia A, Kirubakaran R
Pediatr Dent 2019 Mar 15;41(2):95-112. PMID: 30992106Free PMC Article
Structural, mechanical and chemical evaluation of molar-incisor hypomineralization-affected enamel: A systematic review.
Elhennawy K, Manton DJ, Crombie F, Zaslansky P, Radlanski RJ, Jost-Brinkmann PG, Schwendicke F
Arch Oral Biol 2017 Nov;83:272-281. Epub 2017 Aug 19 doi: 10.1016/j.archoralbio.2017.08.008. PMID: 28843745
Amelogenesis imperfecta - a systematic literature review of associated dental and oro-facial abnormalities and their impact on patients.
Poulsen S, Gjørup H, Haubek D, Haukali G, Hintze H, Løvschall H, Errboe M
Acta Odontol Scand 2008 Aug;66(4):193-9. doi: 10.1080/00016350802192071. PMID: 18615322

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