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Aplasia of the middle ear ossicles

MedGen UID:
867016
Concept ID:
C4021374
Finding
Synonyms: Absent middle ear bones; Absent middle ear ossicles
 
HPO: HP:0009910

Definition

Absence of the middle ear ossicles, malleus, incus, and stapes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAplasia of the middle ear ossicles

Professional guidelines

PubMed

Yoshida A, Hosoya M, Kanzaki S, Fujioka M, Ozawa H
Acta Otolaryngol 2022 Feb;142(2):154-160. Epub 2022 Mar 2 doi: 10.1080/00016489.2022.2039406. PMID: 35232332
Kan T, Ueda H, Kishimoto M, Tsuchiya Y, Ogawa T, Uchida Y
Auris Nasus Larynx 2020 Jun;47(3):343-347. Epub 2020 May 4 doi: 10.1016/j.anl.2020.03.009. PMID: 32370914
Glasscock ME 3rd, Schwaber MK, Nissen AJ, Jackson CG
Ann Otol Rhinol Laryngol 1983 Sep-Oct;92(5 Pt 1):504-9. doi: 10.1177/000348948309200519. PMID: 6625450

Recent clinical studies

Etiology

Henkemans SE, Smit AL, Stokroos RJ, Thomeer HGXM
Ann Otol Rhinol Laryngol 2022 Apr;131(4):388-396. Epub 2021 Jun 11 doi: 10.1177/00034894211025405. PMID: 34116598Free PMC Article
Kan T, Ueda H, Kishimoto M, Tsuchiya Y, Ogawa T, Uchida Y
Auris Nasus Larynx 2020 Jun;47(3):343-347. Epub 2020 May 4 doi: 10.1016/j.anl.2020.03.009. PMID: 32370914
Marques LHS, Martins DV, Juares GL, Lorenzetti FTM, Monsanto RDC
Int J Pediatr Otorhinolaryngol 2017 Oct;101:223-229. Epub 2017 Aug 22 doi: 10.1016/j.ijporl.2017.08.020. PMID: 28964299
Kakehata S
Otolaryngol Clin North Am 2013 Apr;46(2):227-32. doi: 10.1016/j.otc.2012.10.006. PMID: 23566908
House JW, Sheehy JL, Antunez JC
Laryngoscope 1980 Nov;90(11 Pt 1):1804-9. doi: 10.1288/00005537-198011000-00007. PMID: 7432061

Diagnosis

Henkemans SE, Smit AL, Stokroos RJ, Thomeer HGXM
Ann Otol Rhinol Laryngol 2022 Apr;131(4):388-396. Epub 2021 Jun 11 doi: 10.1177/00034894211025405. PMID: 34116598Free PMC Article
Scarpa A, Ralli M, Cassandro C, Gioacchini FM, Greco A, Di Stadio A, Cavaliere M, Troisi D, de Vincentiis M, Cassandro E
J Int Adv Otol 2020 Apr;16(1):111-116. doi: 10.5152/iao.2020.7764. PMID: 32401207Free PMC Article
Kan T, Ueda H, Kishimoto M, Tsuchiya Y, Ogawa T, Uchida Y
Auris Nasus Larynx 2020 Jun;47(3):343-347. Epub 2020 May 4 doi: 10.1016/j.anl.2020.03.009. PMID: 32370914
Juliano AF, Ginat DT, Moonis G
Radiology 2015 Sep;276(3):655-72. doi: 10.1148/radiol.2015140800. PMID: 26302389
Kakehata S
Otolaryngol Clin North Am 2013 Apr;46(2):227-32. doi: 10.1016/j.otc.2012.10.006. PMID: 23566908

Therapy

Nguyen T, Pulickal G, Singh A, Lingam R
Eur J Radiol 2019 Jan;110:74-80. Epub 2018 Nov 22 doi: 10.1016/j.ejrad.2018.11.024. PMID: 30599877
Marques LHS, Martins DV, Juares GL, Lorenzetti FTM, Monsanto RDC
Int J Pediatr Otorhinolaryngol 2017 Oct;101:223-229. Epub 2017 Aug 22 doi: 10.1016/j.ijporl.2017.08.020. PMID: 28964299
Mattingly JK, Uhler KM, Cass SP
Otol Neurotol 2016 Oct;37(9):1255-62. doi: 10.1097/MAO.0000000000001171. PMID: 27518207
Sridhara SK, Rivera A, Littlefield P
Otolaryngol Head Neck Surg 2013 Jan;148(1):103-7. Epub 2012 Sep 5 doi: 10.1177/0194599812459326. PMID: 22951430
Takeda Y, Nishizaki K, Masuda Y, Watanabe S
Auris Nasus Larynx 1996;23:1-12. doi: 10.1016/s0385-8146(96)80002-2. PMID: 8809317

Prognosis

Henkemans SE, Smit AL, Stokroos RJ, Thomeer HGXM
Ann Otol Rhinol Laryngol 2022 Apr;131(4):388-396. Epub 2021 Jun 11 doi: 10.1177/00034894211025405. PMID: 34116598Free PMC Article
da Costa Monsanto R, Knoll RM, de Oliveira Penido N, Song G, Santos F, Paparella MM, Cureoglu S
Otolaryngol Head Neck Surg 2022 Feb;166(2):363-372. Epub 2021 Apr 20 doi: 10.1177/01945998211008911. PMID: 33874787
MacDonald B, Bommakanti K, Mallo M, Carvalho D
Ear Nose Throat J 2021 Jun;100(3_suppl):243S-248S. Epub 2020 Nov 25 doi: 10.1177/0145561320973785. PMID: 33237827
Nakasato T, Nakayama T, Nakayama M, Ehara S, Ohtsuka H, Sato H
J Comput Assist Tomogr 2014 Sep-Oct;38(5):655-61. doi: 10.1097/RCT.0000000000000093. PMID: 24834890
Park K, Choung YH
Acta Otolaryngol 2009 Apr;129(4):419-22. doi: 10.1080/00016480802587846. PMID: 19116789

Clinical prediction guides

Zhang M, Lin J, Zhang J, Han Z, Liu C, Zou Y
Acta Otolaryngol 2023 Nov;143(sup1):S17-S24. Epub 2024 Feb 13 doi: 10.1080/00016489.2023.2276348. PMID: 38071650
Yoshida A, Hosoya M, Kanzaki S, Fujioka M, Ozawa H
Acta Otolaryngol 2022 Feb;142(2):154-160. Epub 2022 Mar 2 doi: 10.1080/00016489.2022.2039406. PMID: 35232332
Elias TGA, Santos F
Otol Neurotol 2022 Apr 1;43(4):e461-e466. doi: 10.1097/MAO.0000000000003490. PMID: 35120079Free PMC Article
Guneri EA, Cakir Cetin A
J Laryngol Otol 2020 Dec;134(12):1108-1114. Epub 2021 Jan 7 doi: 10.1017/S0022215120002728. PMID: 33407956
Burford CM, Mason MJ
J Anat 2016 Dec;229(6):857-870. Epub 2016 Jul 26 doi: 10.1111/joa.12520. PMID: 27456698Free PMC Article

Recent systematic reviews

Daniel A, Budiono G, Rao A, Low GK, Ellis MP, Lee J
Int J Pediatr Otorhinolaryngol 2023 Mar;166:111418. Epub 2022 Dec 30 doi: 10.1016/j.ijporl.2022.111418. PMID: 36709714
Marques LHS, Martins DV, Juares GL, Lorenzetti FTM, Monsanto RDC
Int J Pediatr Otorhinolaryngol 2017 Oct;101:223-229. Epub 2017 Aug 22 doi: 10.1016/j.ijporl.2017.08.020. PMID: 28964299

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