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Absence of secondary sex characteristics

MedGen UID:
867193
•Concept ID:
C4021551
•
Finding
Synonym: No secondary sexual characteristics at puberty
 
HPO: HP:0008187

Definition

No secondary sexual characteristics are present at puberty. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbsence of secondary sex characteristics

Conditions with this feature

46,XY sex reversal 1
MedGen UID:
412662
•Concept ID:
C2748896
•
Disease or Syndrome
Sex reversal in an individual with 46,XY karyotype caused by point mutations or deletions in the SRY gene, encoding sex-determining region Y protein.
See: Condition Record
46,XY sex reversal 1

Professional guidelines

PubMed

Androgen Treatment in Adolescent Males With Hypogonadism.
Rey RA, Grinspon RP
Am J Mens Health 2020 May-Jun;14(3):1557988320922443. doi: 10.1177/1557988320922443. PMID: 32448030Free PMC Article
Treatment of irritable bowel syndrome: sex and gender specific aspects.
Voß U, Lewerenz A, Nieber K
Handb Exp Pharmacol 2012;(214):473-97. doi: 10.1007/978-3-642-30726-3_21. PMID: 23027463
Ascertainment and treatment of delayed puberty.
Pozo J, Argente J
Horm Res 2003;60 Suppl 3:35-48. doi: 10.1159/000074498. PMID: 14671394

Recent clinical studies

Etiology

Nomogram prediction for cervical lymph node metastasis in multifocal papillary thyroid microcarcinoma.
Li WH, Yu WY, Du JR, Teng DK, Lin YQ, Sui GQ, Wang H
Front Endocrinol (Lausanne) 2023;14:1140360. Epub 2023 May 26 doi: 10.3389/fendo.2023.1140360. PMID: 37305060Free PMC Article
Sinus Barotraumas in Commercial Aircrew.
Lindfors OH, Ketola KS, Klockars TK, Leino TK, Sinkkonen ST
Aerosp Med Hum Perform 2021 Nov 1;92(11):857-863. doi: 10.3357/AMHP.5849.2021. PMID: 34819211
Sex and gender differences in control of blood pressure.
Maranon R, Reckelhoff JF
Clin Sci (Lond) 2013 Oct;125(7):311-8. doi: 10.1042/CS20130140. PMID: 23746374Free PMC Article
Prevention of acute knee injuries in adolescent female football players: cluster randomised controlled trial.
Waldén M, Atroshi I, Magnusson H, Wagner P, Hägglund M
BMJ 2012 May 3;344:e3042. doi: 10.1136/bmj.e3042. PMID: 22556050Free PMC Article
A standard procedure for creating a frailty index.
Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K
BMC Geriatr 2008 Sep 30;8:24. doi: 10.1186/1471-2318-8-24. PMID: 18826625Free PMC Article

Diagnosis

Androgen insensitivity syndrome: a review.
Delli Paoli E, Di Chiano S, Paoli D, Lenzi A, Lombardo F, Pallotti F
J Endocrinol Invest 2023 Nov;46(11):2237-2245. Epub 2023 Jun 10 doi: 10.1007/s40618-023-02127-y. PMID: 37300628
Clinical characteristics and prognostic analysis of SMARCA4-deficient non-small cell lung cancer.
Liang X, Gao X, Wang F, Li S, Zhou Y, Guo P, Meng Y, Lu T
Cancer Med 2023 Jul;12(13):14171-14182. Epub 2023 May 15 doi: 10.1002/cam4.6083. PMID: 37184108Free PMC Article
Malignant Insulinoma: A Rare Form of Neuroendocrine Tumor.
Sada A, Glasgow AE, Vella A, Thompson GB, McKenzie TJ, Habermann EB
World J Surg 2020 Jul;44(7):2288-2294. doi: 10.1007/s00268-020-05445-x. PMID: 32128613Free PMC Article
Disorders of puberty.
Sultan C, Gaspari L, Maimoun L, Kalfa N, Paris F
Best Pract Res Clin Obstet Gynaecol 2018 Apr;48:62-89. Epub 2017 Nov 14 doi: 10.1016/j.bpobgyn.2017.11.004. PMID: 29422239
A standard procedure for creating a frailty index.
Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K
BMC Geriatr 2008 Sep 30;8:24. doi: 10.1186/1471-2318-8-24. PMID: 18826625Free PMC Article

Therapy

Knowledge Update on the Economic Evaluation of Pacemaker Telemonitoring Systems.
Lopez-Villegas A, Leal-Costa C, Perez-Heredia M, Villegas-Tripiana I, Catalán-Matamoros D
Int J Environ Res Public Health 2021 Nov 18;18(22) doi: 10.3390/ijerph182212120. PMID: 34831876Free PMC Article
Sex-Disaggregated Data on Clinical Characteristics and Outcomes of Hospitalized Patients With COVID-19: A Retrospective Study.
Wang M, Jiang N, Li C, Wang J, Yang H, Liu L, Tan X, Chen Z, Gong Y, Yin X, Zong Q, Xiong N, Zhang G
Front Cell Infect Microbiol 2021;11:680422. Epub 2021 May 26 doi: 10.3389/fcimb.2021.680422. PMID: 34123876Free PMC Article
Androgen Treatment in Adolescent Males With Hypogonadism.
Rey RA, Grinspon RP
Am J Mens Health 2020 May-Jun;14(3):1557988320922443. doi: 10.1177/1557988320922443. PMID: 32448030Free PMC Article
Treatment of irritable bowel syndrome: sex and gender specific aspects.
Voß U, Lewerenz A, Nieber K
Handb Exp Pharmacol 2012;(214):473-97. doi: 10.1007/978-3-642-30726-3_21. PMID: 23027463
Prevention of acute knee injuries in adolescent female football players: cluster randomised controlled trial.
Waldén M, Atroshi I, Magnusson H, Wagner P, Hägglund M
BMJ 2012 May 3;344:e3042. doi: 10.1136/bmj.e3042. PMID: 22556050Free PMC Article

Prognosis

Nomogram prediction for cervical lymph node metastasis in multifocal papillary thyroid microcarcinoma.
Li WH, Yu WY, Du JR, Teng DK, Lin YQ, Sui GQ, Wang H
Front Endocrinol (Lausanne) 2023;14:1140360. Epub 2023 May 26 doi: 10.3389/fendo.2023.1140360. PMID: 37305060Free PMC Article
Clinical characteristics and prognostic analysis of SMARCA4-deficient non-small cell lung cancer.
Liang X, Gao X, Wang F, Li S, Zhou Y, Guo P, Meng Y, Lu T
Cancer Med 2023 Jul;12(13):14171-14182. Epub 2023 May 15 doi: 10.1002/cam4.6083. PMID: 37184108Free PMC Article
Evaluation of factors predicting postoperative recurrence and metastasis of parathyroid cancer: a single-center study.
Ohkuwa K, Katoh R, Sugino K, Nagahama M, Kitagawa W, Matsuzu K, Fukunari N, Ito K
World J Surg Oncol 2023 Feb 3;21(1):32. doi: 10.1186/s12957-023-02912-2. PMID: 36737774Free PMC Article
Malignant Insulinoma: A Rare Form of Neuroendocrine Tumor.
Sada A, Glasgow AE, Vella A, Thompson GB, McKenzie TJ, Habermann EB
World J Surg 2020 Jul;44(7):2288-2294. doi: 10.1007/s00268-020-05445-x. PMID: 32128613Free PMC Article
A standard procedure for creating a frailty index.
Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K
BMC Geriatr 2008 Sep 30;8:24. doi: 10.1186/1471-2318-8-24. PMID: 18826625Free PMC Article

Clinical prediction guides

Nomogram prediction for cervical lymph node metastasis in multifocal papillary thyroid microcarcinoma.
Li WH, Yu WY, Du JR, Teng DK, Lin YQ, Sui GQ, Wang H
Front Endocrinol (Lausanne) 2023;14:1140360. Epub 2023 May 26 doi: 10.3389/fendo.2023.1140360. PMID: 37305060Free PMC Article
Clinical characteristics and prognostic analysis of SMARCA4-deficient non-small cell lung cancer.
Liang X, Gao X, Wang F, Li S, Zhou Y, Guo P, Meng Y, Lu T
Cancer Med 2023 Jul;12(13):14171-14182. Epub 2023 May 15 doi: 10.1002/cam4.6083. PMID: 37184108Free PMC Article
Sex-Disaggregated Data on Clinical Characteristics and Outcomes of Hospitalized Patients With COVID-19: A Retrospective Study.
Wang M, Jiang N, Li C, Wang J, Yang H, Liu L, Tan X, Chen Z, Gong Y, Yin X, Zong Q, Xiong N, Zhang G
Front Cell Infect Microbiol 2021;11:680422. Epub 2021 May 26 doi: 10.3389/fcimb.2021.680422. PMID: 34123876Free PMC Article
Malignant Insulinoma: A Rare Form of Neuroendocrine Tumor.
Sada A, Glasgow AE, Vella A, Thompson GB, McKenzie TJ, Habermann EB
World J Surg 2020 Jul;44(7):2288-2294. doi: 10.1007/s00268-020-05445-x. PMID: 32128613Free PMC Article
A standard procedure for creating a frailty index.
Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K
BMC Geriatr 2008 Sep 30;8:24. doi: 10.1186/1471-2318-8-24. PMID: 18826625Free PMC Article

Recent systematic reviews

Knowledge Update on the Economic Evaluation of Pacemaker Telemonitoring Systems.
Lopez-Villegas A, Leal-Costa C, Perez-Heredia M, Villegas-Tripiana I, Catalán-Matamoros D
Int J Environ Res Public Health 2021 Nov 18;18(22) doi: 10.3390/ijerph182212120. PMID: 34831876Free PMC Article
Gastric syphilis: a systematic review of published cases of the last 50 years.
Mylona EE, Baraboutis IG, Papastamopoulos V, Tsagalou EP, Vryonis E, Samarkos M, Fanourgiakis P, Skoutelis A
Sex Transm Dis 2010 Mar;37(3):177-83. doi: 10.1097/OLQ.0b013e3181c0d51f. PMID: 20023597

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