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Abnormal 5th finger morphology

MedGen UID:
867315
•Concept ID:
C4021678
•
Anatomical Abnormality
Synonyms: Abnormality of the 5th finger; Abnormality of the little finger; Abnormality of the pinkie finger; Abnormality of the pinky finger
 
HPO: HP:0004207

Definition

An abnormality affecting one or both 5th fingers. [from HPO]

Professional guidelines

PubMed

Identification of a novel mutation of NOG in family with proximal symphalangism and early genetic counseling.
Ma C, Liu L, Wang FN, Tian HS, Luo Y, Yu R, Fan LL, Li YL
BMC Med Genet 2019 Nov 6;20(1):169. doi: 10.1186/s12881-019-0917-5. PMID: 31694554Free PMC Article
Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations in SMARCB1, SMARCA4, SMARCE1, and ARID1A.
Kosho T, Okamoto N; Coffin-Siris Syndrome International Collaborators
Am J Med Genet C Semin Med Genet 2014 Sep;166C(3):262-75. Epub 2014 Aug 28 doi: 10.1002/ajmg.c.31407. PMID: 25168959

Recent clinical studies

Etiology

Classification for Thumb Opposition in Children with Thumb Hypoplasia.
Vergara-Amador E, Herrera-Rodríguez J, López-Rincón L
J Hand Surg Asian Pac Vol 2021 Jun;26(2):214-217. doi: 10.1142/S242483552150020X. PMID: 33928854
Evaluation of qualitative methods for phenotyping brachymesophalangia-V from radiographs of children.
Williams KD, Nahhas RW, Cottom CR, Lawrence S, Subedi J, Jha B, Czerwinski SA, Blangero J, Williams-Blangero S, Towne B
Am J Hum Biol 2012 Jan-Feb;24(1):68-73. Epub 2011 Dec 1 doi: 10.1002/ajhb.22205. PMID: 22131202Free PMC Article
Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes.
Malik S, Afzal M, Gul S, Wahab A, Ahmad M
Am J Med Genet A 2010 Sep;152A(9):2313-7. doi: 10.1002/ajmg.a.33552. PMID: 20683984
Metal ring on 4th or 5th finger markedly increases both cardiac troponin I at left ventricle and cancer-related parameters such as oncogen C-fosAb2 & integrin α₅β₁[corrected] by 4-12 times. Thus these metal rings appear to promote both heart problems & cancer.
Omura Y, Hines H, Jones M, O'Young B, Duvvi H, Lu DP, Pallos A, Shimotsuura Y, Ohki M
Acupunct Electrother Res 2010;35(1-2):45-69. doi: 10.3727/036012910803860977. PMID: 20578646
Valproate embryopathy: clinical and cognitive profile in 5 siblings.
Schorry EK, Oppenheimer SG, Saal HM
Am J Med Genet A 2005 Mar 1;133A(2):202-6. doi: 10.1002/ajmg.a.30494. PMID: 15669094

Diagnosis

MRI of Transcallosal White Matter Helps to Predict Motor Impairment in Multiple Sclerosis.
Cordani C, Preziosa P, Valsasina P, Meani A, Pagani E, Morozumi T, Rocca MA, Filippi M
Radiology 2022 Mar;302(3):639-649. Epub 2021 Nov 30 doi: 10.1148/radiol.2021210922. PMID: 34846201
A Rare Cause of Hyperinsulinemic Hypoglycemia: Kabuki Syndrome.
Mısırlıgil M, Yıldız Y, Akın O, Odabaşı Güneş S, Arslan M, Ünay B
J Clin Res Pediatr Endocrinol 2021 Nov 25;13(4):452-455. Epub 2020 Aug 24 doi: 10.4274/jcrpe.galenos.2020.2020.0065. PMID: 32830475Free PMC Article
Ophthalmo-acromelic syndrome in an infant.
Ürel-Demir G, Taşkıran EZ, Akgün-Doğan Ö, Şimşek-Kiper PÖ, Utine GE
Eur J Med Genet 2019 Jul;62(7):103664. Epub 2019 May 5 doi: 10.1016/j.ejmg.2019.05.003. PMID: 31067494
Digital Artery Aneurysm - Case Report.
Vidoedo J, Teixeira J
Rev Port Cir Cardiotorac Vasc 2017 Jul-Dec;24(3-4):181. PMID: 29701410
A patient with WT syndrome and Castleman disease.
Vergin C, Cetingül N, Kavakli K, Oztop S, Ozkinay F, Coker M, Nişli G, Soydan S, Balik E, Akar O
Acta Paediatr Jpn 1995 Feb;37(1):108-12. doi: 10.1111/j.1442-200x.1995.tb03700.x. PMID: 7754753

Therapy

MRI of Transcallosal White Matter Helps to Predict Motor Impairment in Multiple Sclerosis.
Cordani C, Preziosa P, Valsasina P, Meani A, Pagani E, Morozumi T, Rocca MA, Filippi M
Radiology 2022 Mar;302(3):639-649. Epub 2021 Nov 30 doi: 10.1148/radiol.2021210922. PMID: 34846201
Metal ring on 4th or 5th finger markedly increases both cardiac troponin I at left ventricle and cancer-related parameters such as oncogen C-fosAb2 & integrin α₅β₁[corrected] by 4-12 times. Thus these metal rings appear to promote both heart problems & cancer.
Omura Y, Hines H, Jones M, O'Young B, Duvvi H, Lu DP, Pallos A, Shimotsuura Y, Ohki M
Acupunct Electrother Res 2010;35(1-2):45-69. doi: 10.3727/036012910803860977. PMID: 20578646
Pseudoaminopterin syndrome: clinical report with new characteristics.
Sobreira N, Cernach M, Batista D, Brunoni D, Perez A
Am J Med Genet A 2009 Dec;149A(12):2843-8. doi: 10.1002/ajmg.a.33125. PMID: 19938091
Olmsted syndrome.
Ali ME, Sikdar AU, Akhtar N, Islam ZM
Mymensingh Med J 2007 Jan;16(1):100-3. doi: 10.3329/mmj.v16i1.262. PMID: 17344790
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

MRI of Transcallosal White Matter Helps to Predict Motor Impairment in Multiple Sclerosis.
Cordani C, Preziosa P, Valsasina P, Meani A, Pagani E, Morozumi T, Rocca MA, Filippi M
Radiology 2022 Mar;302(3):639-649. Epub 2021 Nov 30 doi: 10.1148/radiol.2021210922. PMID: 34846201
The prevalence of the extensor digitorum communis tendon and its insertion variants: a systematic review and meta-analysis.
Yammine K
Clin Anat 2014 Nov;27(8):1284-90. Epub 2014 Jun 23 doi: 10.1002/ca.22429. PMID: 24953717
Different microvascular involvement in dermatomyositis and systemic sclerosis. A preliminary study by a tight videocapillaroscopic assessment.
De Angelis R, Cutolo M, Gutierrez M, Bertolazzi C, Salaffi F, Grassi W
Clin Exp Rheumatol 2012 Mar-Apr;30(2 Suppl 71):S67-70. Epub 2012 May 29 PMID: 22691212
Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes.
Malik S, Afzal M, Gul S, Wahab A, Ahmad M
Am J Med Genet A 2010 Sep;152A(9):2313-7. doi: 10.1002/ajmg.a.33552. PMID: 20683984
Adults with VATER association: long-term prognosis.
Wheeler PG, Weaver DD
Am J Med Genet A 2005 Oct 15;138A(3):212-7. doi: 10.1002/ajmg.a.30938. PMID: 16152641

Clinical prediction guides

MRI of Transcallosal White Matter Helps to Predict Motor Impairment in Multiple Sclerosis.
Cordani C, Preziosa P, Valsasina P, Meani A, Pagani E, Morozumi T, Rocca MA, Filippi M
Radiology 2022 Mar;302(3):639-649. Epub 2021 Nov 30 doi: 10.1148/radiol.2021210922. PMID: 34846201
Classification for Thumb Opposition in Children with Thumb Hypoplasia.
Vergara-Amador E, Herrera-Rodríguez J, López-Rincón L
J Hand Surg Asian Pac Vol 2021 Jun;26(2):214-217. doi: 10.1142/S242483552150020X. PMID: 33928854
Metal ring on 4th or 5th finger markedly increases both cardiac troponin I at left ventricle and cancer-related parameters such as oncogen C-fosAb2 & integrin α₅β₁[corrected] by 4-12 times. Thus these metal rings appear to promote both heart problems & cancer.
Omura Y, Hines H, Jones M, O'Young B, Duvvi H, Lu DP, Pallos A, Shimotsuura Y, Ohki M
Acupunct Electrother Res 2010;35(1-2):45-69. doi: 10.3727/036012910803860977. PMID: 20578646
Early androgen deficiency in infants and young boys with 47,XXY Klinefelter syndrome.
Ross JL, Samango-Sprouse C, Lahlou N, Kowal K, Elder FF, Zinn A
Horm Res 2005;64(1):39-45. Epub 2005 Aug 3 doi: 10.1159/000087313. PMID: 16088206
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Recent systematic reviews

The prevalence of the extensor digitorum communis tendon and its insertion variants: a systematic review and meta-analysis.
Yammine K
Clin Anat 2014 Nov;27(8):1284-90. Epub 2014 Jun 23 doi: 10.1002/ca.22429. PMID: 24953717

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