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Abnormal 2nd finger morphology

MedGen UID:
867320
•Concept ID:
C4021683
•
Anatomical Abnormality
Synonyms: Abnormality of index finger; Abnormality of the 2nd finger
 
HPO: HP:0004100

Definition

An anomaly of the second finger, also known as the index finger. [from HPO]

Recent clinical studies

Etiology

Classification for Thumb Opposition in Children with Thumb Hypoplasia.
Vergara-Amador E, Herrera-Rodríguez J, López-Rincón L
J Hand Surg Asian Pac Vol 2021 Jun;26(2):214-217. doi: 10.1142/S242483552150020X. PMID: 33928854
Investigation of FANCA mutations in Greek patients.
Selenti N, Sofocleous C, Kattamis A, Kolialexi A, Kitsiou S, Fryssira E, Polychronopoulou S, Kanavakis E, Mavrou A
Anticancer Res 2013 Aug;33(8):3369-74. PMID: 23898106
Different effect of IgA nephropathy and polycystic kidney disease on arterial stiffness.
Késoi I, Sági B, Tóth OI, Vas T, Fazekas A, Kovács T, Pintér T, Wittmann I, Nagy J
Kidney Blood Press Res 2011;34(3):158-66. Epub 2011 Apr 7 doi: 10.1159/000326802. PMID: 21474963
Metal ring on 4th or 5th finger markedly increases both cardiac troponin I at left ventricle and cancer-related parameters such as oncogen C-fosAb2 & integrin α₅β₁[corrected] by 4-12 times. Thus these metal rings appear to promote both heart problems & cancer.
Omura Y, Hines H, Jones M, O'Young B, Duvvi H, Lu DP, Pallos A, Shimotsuura Y, Ohki M
Acupunct Electrother Res 2010;35(1-2):45-69. doi: 10.3727/036012910803860977. PMID: 20578646
Increased ratio of 2nd to 4th digit (2D:4D) in schizophrenia.
Collinson SL, Lim M, Chaw JH, Verma S, Sim K, Rapisarda A, Chong SA
Psychiatry Res 2010 Mar 30;176(1):8-12. Epub 2010 Jan 18 doi: 10.1016/j.psychres.2009.08.023. PMID: 20083312

Diagnosis

Foot Macrodactyly Associated with Klippel-Trenaunay Syndrome.
De Pellegrin M, Moharamzadeh D, Placella G, Salini V
Ortop Traumatol Rehabil 2021 Oct 31;23(5):375-380. doi: 10.5604/01.3001.0015.4358. PMID: 34734561
Hypertrophic Osteoarthropathy: Clinical and Imaging Features.
Yap FY, Skalski MR, Patel DB, Schein AJ, White EA, Tomasian A, Masih S, Matcuk GR Jr
Radiographics 2017 Jan-Feb;37(1):157-195. Epub 2016 Dec 9 doi: 10.1148/rg.2017160052. PMID: 27935768
Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review.
Angkathunyakul N, Treepongkaruna S, Molagool S, Ruangwattanapaisarn N
World J Gastroenterol 2015 Jun 14;21(22):7059-64. doi: 10.3748/wjg.v21.i22.7059. PMID: 26078585Free PMC Article
Investigation of FANCA mutations in Greek patients.
Selenti N, Sofocleous C, Kattamis A, Kolialexi A, Kitsiou S, Fryssira E, Polychronopoulou S, Kanavakis E, Mavrou A
Anticancer Res 2013 Aug;33(8):3369-74. PMID: 23898106
Different microvascular involvement in dermatomyositis and systemic sclerosis. A preliminary study by a tight videocapillaroscopic assessment.
De Angelis R, Cutolo M, Gutierrez M, Bertolazzi C, Salaffi F, Grassi W
Clin Exp Rheumatol 2012 Mar-Apr;30(2 Suppl 71):S67-70. Epub 2012 May 29 PMID: 22691212

Therapy

Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review.
Angkathunyakul N, Treepongkaruna S, Molagool S, Ruangwattanapaisarn N
World J Gastroenterol 2015 Jun 14;21(22):7059-64. doi: 10.3748/wjg.v21.i22.7059. PMID: 26078585Free PMC Article
Metal ring on 4th or 5th finger markedly increases both cardiac troponin I at left ventricle and cancer-related parameters such as oncogen C-fosAb2 & integrin α₅β₁[corrected] by 4-12 times. Thus these metal rings appear to promote both heart problems & cancer.
Omura Y, Hines H, Jones M, O'Young B, Duvvi H, Lu DP, Pallos A, Shimotsuura Y, Ohki M
Acupunct Electrother Res 2010;35(1-2):45-69. doi: 10.3727/036012910803860977. PMID: 20578646
Multiple malformations in a male and maternal osteopathia strata with cranial sclerosis (OSCS).
Rott HD, Krieg P, Rütschle H, Kraus C
Genet Couns 2003;14(3):281-8. PMID: 14577672
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

Hypertrophic Osteoarthropathy: Clinical and Imaging Features.
Yap FY, Skalski MR, Patel DB, Schein AJ, White EA, Tomasian A, Masih S, Matcuk GR Jr
Radiographics 2017 Jan-Feb;37(1):157-195. Epub 2016 Dec 9 doi: 10.1148/rg.2017160052. PMID: 27935768
Different microvascular involvement in dermatomyositis and systemic sclerosis. A preliminary study by a tight videocapillaroscopic assessment.
De Angelis R, Cutolo M, Gutierrez M, Bertolazzi C, Salaffi F, Grassi W
Clin Exp Rheumatol 2012 Mar-Apr;30(2 Suppl 71):S67-70. Epub 2012 May 29 PMID: 22691212
Different effect of IgA nephropathy and polycystic kidney disease on arterial stiffness.
Késoi I, Sági B, Tóth OI, Vas T, Fazekas A, Kovács T, Pintér T, Wittmann I, Nagy J
Kidney Blood Press Res 2011;34(3):158-66. Epub 2011 Apr 7 doi: 10.1159/000326802. PMID: 21474963
A rare anomaly of abductor digiti minimi.
Sañudo JR, Mirapeix RM, Ferreira B
J Anat 1993 Jun;182 ( Pt 3)(Pt 3):439-42. PMID: 8226300Free PMC Article
The Fryns syndrome: diaphragmatic defects, craniofacial dysmorphism, and distal digital hypoplasia. Further evidence for autosomal recessive inheritance.
Meinecke P, Fryns JP
Clin Genet 1985 Dec;28(6):516-20. doi: 10.1111/j.1399-0004.1985.tb00419.x. PMID: 4075561

Clinical prediction guides

Classification for Thumb Opposition in Children with Thumb Hypoplasia.
Vergara-Amador E, Herrera-Rodríguez J, López-Rincón L
J Hand Surg Asian Pac Vol 2021 Jun;26(2):214-217. doi: 10.1142/S242483552150020X. PMID: 33928854
Cartilage evaluation in finger joints in healthy controls and early hand osteoarthritis patients using high-resolution MRI.
Saltzherr MS, Muradin GSR, Haugen IK, Selles RW, van Neck JW, Coert JH, Hazes JMW, Luime JJ
Osteoarthritis Cartilage 2019 Aug;27(8):1148-1151. Epub 2019 May 18 doi: 10.1016/j.joca.2019.05.003. PMID: 31108225
Different microvascular involvement in dermatomyositis and systemic sclerosis. A preliminary study by a tight videocapillaroscopic assessment.
De Angelis R, Cutolo M, Gutierrez M, Bertolazzi C, Salaffi F, Grassi W
Clin Exp Rheumatol 2012 Mar-Apr;30(2 Suppl 71):S67-70. Epub 2012 May 29 PMID: 22691212
A case of symbrachydactyly with oligodactyly.
Seven M, Yuksel A, Ozkilic A
Genet Couns 2001;12(1):77-83. PMID: 11332981
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

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