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Abnormality of the costochondral junction

MedGen UID:: 867419
•Concept ID:: C4021791
•: Anatomical Abnormality

Synonym:	Costochondral juctions abnormal

HPO:	HP:0000919

Definition

Any anomaly of the costochondral junction. The costochondral junctions are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Abnormality of the costochondral junction

Abnormality of the skeletal system
- Abnormal skeletal morphology
  - Abnormal axial skeleton morphology
    - Abnormal thorax morphology
      - Abnormal rib cage morphology
        Abnormal rib morphology
        Abnormality of the costochondral junction
        Bulging of the costochondral junction
        Costochondral joint sclerosis
        Enlargement of the costochondral junction
        Irregular chondrocostal junctions
        Rachitic rosary
        Wide-cupped costochondral junctions

Recent clinical studies

Etiology

Quantitative Analysis on Cartilage Growth Between Ipsilateral and Contralateral Donor Sites in Microtia Patients.

Lu Z, Hu Z, Miao Y, Jia J, Mao X, Huang W
Ann Plast Surg 2023 Apr 1;90(4):319-324. Epub 2023 Feb 15 doi: 10.1097/SAP.0000000000003467. PMID: 37093770

The morphological changes of thorax in pediatric microtia patients after costal cartilage harvesting.

Wang C, Xin G, Chen W, Zhang Y, Jiang H
Int J Pediatr Otorhinolaryngol 2021 Dec;151:110965. Epub 2021 Oct 28 doi: 10.1016/j.ijporl.2021.110965. PMID: 34736014

Osteomyelitis of the ribs in children: a rare and potentially challenging diagnosis.

Crone AM, Wanner MR, Cooper ML, Fox TG, Jennings SG, Karmazyn B
Pediatr Radiol 2020 Jan;50(1):68-74. Epub 2019 Aug 24 doi: 10.1007/s00247-019-04505-2. PMID: 31446454

Bone-cartilage proportion in deformed ribs of male pectus excavatum patients.

Nagasao T, Aizezi N, Noguchi M, Morotomi T, Kudo H, Kogure T
J Plast Surg Hand Surg 2019 Jun;53(3):143-148. Epub 2019 Mar 19 doi: 10.1080/2000656X.2018.1554532. PMID: 30889996

Costochondral changes in the chest wall after the Nuss procedure: ultrasonographic findings.

Zeng Q, Lai JY, Wang XM, Lee JL, Chia ST, Wang CJ, Chen JC, Chang PY
J Pediatr Surg 2008 Dec;43(12):2147-50. doi: 10.1016/j.jpedsurg.2008.08.070. PMID: 19040923

See all (12)

Diagnosis

Rickets manifestations in a child with metaphyseal anadysplasia, report of a spontaneously resolving case.

Diaz Escagedo P, Fiscaletti M, Olivier P, Hudon C, Miranda V, Miron MC, Campeau PM, Alos N
BMC Pediatr 2021 May 22;21(1):248. doi: 10.1186/s12887-021-02716-x. PMID: 34022834 Free PMC Article

Osteomyelitis of the ribs in children: a rare and potentially challenging diagnosis.

Crone AM, Wanner MR, Cooper ML, Fox TG, Jennings SG, Karmazyn B
Pediatr Radiol 2020 Jan;50(1):68-74. Epub 2019 Aug 24 doi: 10.1007/s00247-019-04505-2. PMID: 31446454

Osteochondral junction lesions in stillborn fetuses and their relationship to autopsy diagnoses.

da Cunha Castro EC, Popek EJ
Early Hum Dev 2007 Sep;83(9):593-9. Epub 2007 Feb 12 doi: 10.1016/j.earlhumdev.2006.12.007. PMID: 17293062

Short stature/short limb skeletal dysplasia with severe combined immunodeficiency and bowing of the femora: report of two patients and review.

MacDermot KD, Winter RM, Wigglesworth JS, Strobel S
J Med Genet 1991 Jan;28(1):10-7. doi: 10.1136/jmg.28.1.10. PMID: 1999827 Free PMC Article

Computed tomography of the sternum and its articulations.

Hatfield MK, Gross BH, Glazer GM, Martel W
Skeletal Radiol 1984;11(3):197-203. doi: 10.1007/BF00349494. PMID: 6719144

See all (9)

Therapy

Costochondral changes in the chest wall after the Nuss procedure: ultrasonographic findings.

Zeng Q, Lai JY, Wang XM, Lee JL, Chia ST, Wang CJ, Chen JC, Chang PY
J Pediatr Surg 2008 Dec;43(12):2147-50. doi: 10.1016/j.jpedsurg.2008.08.070. PMID: 19040923

Preliminary study on the effects of bar placement on the thorax after the nuss procedure for pectus excavatum using bone scintigraphy.

Ohno K, Morotomi Y, Harumoto K, Ueda M, Nakahira M, Nakamura T, Azuma T, Moriuchi T, Yoshida T, Shiokawa C, Nakaoka T
Eur J Pediatr Surg 2006 Jun;16(3):155-9. doi: 10.1055/s-2006-924309. PMID: 16909352

Acquired deformities of the anterior chest wall.

Fokin AA, Robicsek F
Thorac Cardiovasc Surg 2006 Feb;54(1):57-61. doi: 10.1055/s-2005-865840. PMID: 16485191

Patterns of bone diseases in transfusion-dependent homozygous thalassaemia major: predominance of osteoporosis and desferrioxamine-induced bone dysplasia.

Chan YL, Pang LM, Chik KW, Cheng JC, Li CK
Pediatr Radiol 2002 Jul;32(7):492-7. Epub 2002 Apr 10 doi: 10.1007/s00247-002-0664-0. PMID: 12107582

Chest wall deformities and thoracic scoliosis after costal cartilage graft harvesting.

Ohara K, Nakamura K, Ohta E
Plast Reconstr Surg 1997 Apr;99(4):1030-6. doi: 10.1097/00006534-199704000-00017. PMID: 9091899

See all (6)

Prognosis

Rickets manifestations in a child with metaphyseal anadysplasia, report of a spontaneously resolving case.

Diaz Escagedo P, Fiscaletti M, Olivier P, Hudon C, Miranda V, Miron MC, Campeau PM, Alos N
BMC Pediatr 2021 May 22;21(1):248. doi: 10.1186/s12887-021-02716-x. PMID: 34022834 Free PMC Article

Rib Bone Graft Adjusted to Fit the Facial Asymmetry: A Frame Structure Graft.

Lee YH, Choi JH, Hwang K, Choi JH
J Craniofac Surg 2015 Oct;26(7):2160-2. doi: 10.1097/SCS.0000000000002065. PMID: 26468802

Costochondral changes in the chest wall after the Nuss procedure: ultrasonographic findings.

Zeng Q, Lai JY, Wang XM, Lee JL, Chia ST, Wang CJ, Chen JC, Chang PY
J Pediatr Surg 2008 Dec;43(12):2147-50. doi: 10.1016/j.jpedsurg.2008.08.070. PMID: 19040923

Chest wall deformities and thoracic scoliosis after costal cartilage graft harvesting.

Ohara K, Nakamura K, Ohta E
Plast Reconstr Surg 1997 Apr;99(4):1030-6. doi: 10.1097/00006534-199704000-00017. PMID: 9091899

Short stature/short limb skeletal dysplasia with severe combined immunodeficiency and bowing of the femora: report of two patients and review.

MacDermot KD, Winter RM, Wigglesworth JS, Strobel S
J Med Genet 1991 Jan;28(1):10-7. doi: 10.1136/jmg.28.1.10. PMID: 1999827 Free PMC Article

See all (6)

Clinical prediction guides

Quantitative Analysis on Cartilage Growth Between Ipsilateral and Contralateral Donor Sites in Microtia Patients.

Lu Z, Hu Z, Miao Y, Jia J, Mao X, Huang W
Ann Plast Surg 2023 Apr 1;90(4):319-324. Epub 2023 Feb 15 doi: 10.1097/SAP.0000000000003467. PMID: 37093770

Helsmoortel-Van der Aa Syndrome-Cardiothoracic and Ectodermal Manifestations in Two Patients as Further Support of a Previous Observation on Phenotypic Overlap with RASopathies.

Szabó TM, Balogh I, Ujfalusi A, Szűcs Z, Madar L, Koczok K, Bessenyei B, Csürke I, Szakszon K
Genes (Basel) 2022 Dec 15;13(12) doi: 10.3390/genes13122367. PMID: 36553633 Free PMC Article

Costochondral changes in the chest wall after the Nuss procedure: ultrasonographic findings.

Zeng Q, Lai JY, Wang XM, Lee JL, Chia ST, Wang CJ, Chen JC, Chang PY
J Pediatr Surg 2008 Dec;43(12):2147-50. doi: 10.1016/j.jpedsurg.2008.08.070. PMID: 19040923

Acquired deformities of the anterior chest wall.

Fokin AA, Robicsek F
Thorac Cardiovasc Surg 2006 Feb;54(1):57-61. doi: 10.1055/s-2005-865840. PMID: 16485191

Evidence of duration and type of illness in children found unexpectedly dead.

Sinclair-Smith C, Dinsdale F, Emery J
Arch Dis Child 1976 Jun;51(6):424-9. doi: 10.1136/adc.51.6.424. PMID: 942235 Free PMC Article

See all (10)

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Abnormality of the costochondral junction

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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