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Abnormality of renin-angiotensin system

MedGen UID:
867421
•Concept ID:
C4021793
•
Anatomical Abnormality
Synonym: Abnormality of the renin-aldosterone axis
 
HPO: HP:0000847

Definition

An abnormality of the renin-angiotensin system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of renin-angiotensin system

Professional guidelines

PubMed

C3G and Ig-MPGN-treatment standard.
Noris M, Remuzzi G
Nephrol Dial Transplant 2024 Jan 31;39(2):202-214. doi: 10.1093/ndt/gfad182. PMID: 37604793Free PMC Article
Advances in the management of chronic kidney disease.
Chen TK, Hoenig MP, Nitsch D, Grams ME
BMJ 2023 Dec 5;383:e074216. doi: 10.1136/bmj-2022-074216. PMID: 38052474
Clinical Management of Hyperkalemia.
Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, Hain DJ, Lerma E, Onuigbo M, Rastogi A, Roger SD, Spinowitz BS, Weir MR
Mayo Clin Proc 2021 Mar;96(3):744-762. Epub 2020 Nov 5 doi: 10.1016/j.mayocp.2020.06.014. PMID: 33160639

Recent clinical studies

Etiology

Obesity, kidney dysfunction, and inflammation: interactions in hypertension.
Hall JE, Mouton AJ, da Silva AA, Omoto ACM, Wang Z, Li X, do Carmo JM
Cardiovasc Res 2021 Jul 7;117(8):1859-1876. doi: 10.1093/cvr/cvaa336. PMID: 33258945Free PMC Article
Clinical Management of Hyperkalemia.
Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, Hain DJ, Lerma E, Onuigbo M, Rastogi A, Roger SD, Spinowitz BS, Weir MR
Mayo Clin Proc 2021 Mar;96(3):744-762. Epub 2020 Nov 5 doi: 10.1016/j.mayocp.2020.06.014. PMID: 33160639
Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity.
Jia G, Hill MA, Sowers JR
Circ Res 2018 Feb 16;122(4):624-638. doi: 10.1161/CIRCRESAHA.117.311586. PMID: 29449364Free PMC Article
Calcific aortic stenosis.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P
Nat Rev Dis Primers 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. PMID: 27188578Free PMC Article
Hypertension: physiology and pathophysiology.
Hall JE, Granger JP, do Carmo JM, da Silva AA, Dubinion J, George E, Hamza S, Speed J, Hall ME
Compr Physiol 2012 Oct;2(4):2393-442. doi: 10.1002/cphy.c110058. PMID: 23720252

Diagnosis

C3G and Ig-MPGN-treatment standard.
Noris M, Remuzzi G
Nephrol Dial Transplant 2024 Jan 31;39(2):202-214. doi: 10.1093/ndt/gfad182. PMID: 37604793Free PMC Article
Infantile hemangioma. Part 1: Epidemiology, pathogenesis, clinical presentation and assessment.
Rodríguez Bandera AI, Sebaratnam DF, Wargon O, Wong LF
J Am Acad Dermatol 2021 Dec;85(6):1379-1392. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.019. PMID: 34419524
Chronic kidney disease.
Romagnani P, Remuzzi G, Glassock R, Levin A, Jager KJ, Tonelli M, Massy Z, Wanner C, Anders HJ
Nat Rev Dis Primers 2017 Nov 23;3:17088. doi: 10.1038/nrdp.2017.88. PMID: 29168475
Calcific aortic stenosis.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P
Nat Rev Dis Primers 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. PMID: 27188578Free PMC Article
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Hubers SA, Brown NJ
Circulation 2016 Mar 15;133(11):1115-24. doi: 10.1161/CIRCULATIONAHA.115.018622. PMID: 26976916Free PMC Article

Therapy

Advances in the management of chronic kidney disease.
Chen TK, Hoenig MP, Nitsch D, Grams ME
BMJ 2023 Dec 5;383:e074216. doi: 10.1136/bmj-2022-074216. PMID: 38052474
Clinical Management of Hyperkalemia.
Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, Hain DJ, Lerma E, Onuigbo M, Rastogi A, Roger SD, Spinowitz BS, Weir MR
Mayo Clin Proc 2021 Mar;96(3):744-762. Epub 2020 Nov 5 doi: 10.1016/j.mayocp.2020.06.014. PMID: 33160639
Calcific aortic stenosis.
Lindman BR, Clavel MA, Mathieu P, Iung B, Lancellotti P, Otto CM, Pibarot P
Nat Rev Dis Primers 2016 Mar 3;2:16006. doi: 10.1038/nrdp.2016.6. PMID: 27188578Free PMC Article
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Hubers SA, Brown NJ
Circulation 2016 Mar 15;133(11):1115-24. doi: 10.1161/CIRCULATIONAHA.115.018622. PMID: 26976916Free PMC Article
Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms.
Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME
Circ Res 2015 Mar 13;116(6):991-1006. doi: 10.1161/CIRCRESAHA.116.305697. PMID: 25767285Free PMC Article

Prognosis

C3G and Ig-MPGN-treatment standard.
Noris M, Remuzzi G
Nephrol Dial Transplant 2024 Jan 31;39(2):202-214. doi: 10.1093/ndt/gfad182. PMID: 37604793Free PMC Article
Advances in the management of chronic kidney disease.
Chen TK, Hoenig MP, Nitsch D, Grams ME
BMJ 2023 Dec 5;383:e074216. doi: 10.1136/bmj-2022-074216. PMID: 38052474
Podocytopathies.
Kopp JB, Anders HJ, Susztak K, Podestà MA, Remuzzi G, Hildebrandt F, Romagnani P
Nat Rev Dis Primers 2020 Aug 13;6(1):68. doi: 10.1038/s41572-020-0196-7. PMID: 32792490Free PMC Article
Abnormalities of Potassium in Heart Failure: JACC State-of-the-Art Review.
Ferreira JP, Butler J, Rossignol P, Pitt B, Anker SD, Kosiborod M, Lund LH, Bakris GL, Weir MR, Zannad F
J Am Coll Cardiol 2020 Jun 9;75(22):2836-2850. doi: 10.1016/j.jacc.2020.04.021. PMID: 32498812
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Hubers SA, Brown NJ
Circulation 2016 Mar 15;133(11):1115-24. doi: 10.1161/CIRCULATIONAHA.115.018622. PMID: 26976916Free PMC Article

Clinical prediction guides

C3G and Ig-MPGN-treatment standard.
Noris M, Remuzzi G
Nephrol Dial Transplant 2024 Jan 31;39(2):202-214. doi: 10.1093/ndt/gfad182. PMID: 37604793Free PMC Article
Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy.
Azushima K, Kovalik JP, Yamaji T, Ching J, Chng TW, Guo J, Liu JJ, Nguyen M, Sakban RB, George SE, Tan PH, Lim SC, Gurley SB, Coffman TM
Kidney Int 2023 Dec;104(6):1135-1149. Epub 2023 Oct 16 doi: 10.1016/j.kint.2023.08.006. PMID: 37843477
Abnormalities of Potassium in Heart Failure: JACC State-of-the-Art Review.
Ferreira JP, Butler J, Rossignol P, Pitt B, Anker SD, Kosiborod M, Lund LH, Bakris GL, Weir MR, Zannad F
J Am Coll Cardiol 2020 Jun 9;75(22):2836-2850. doi: 10.1016/j.jacc.2020.04.021. PMID: 32498812
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
Jia G, DeMarco VG, Sowers JR
Nat Rev Endocrinol 2016 Mar;12(3):144-53. Epub 2015 Dec 18 doi: 10.1038/nrendo.2015.216. PMID: 26678809Free PMC Article
Hypertension: physiology and pathophysiology.
Hall JE, Granger JP, do Carmo JM, da Silva AA, Dubinion J, George E, Hamza S, Speed J, Hall ME
Compr Physiol 2012 Oct;2(4):2393-442. doi: 10.1002/cphy.c110058. PMID: 23720252

Recent systematic reviews

Effectiveness of renin-angiotensin-aldosterone system blockers in patients with Alport syndrome: a systematic review and meta-analysis.
Zeng M, Di H, Liang J, Liu Z
Nephrol Dial Transplant 2023 Oct 31;38(11):2485-2493. doi: 10.1093/ndt/gfad105. PMID: 37218713
Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis.
Smyth LJ, Cañadas-Garre M, Cappa RC, Maxwell AP, McKnight AJ
BMJ Open 2019 May 1;9(4):e026777. doi: 10.1136/bmjopen-2018-026777. PMID: 31048445Free PMC Article
Renoprotection by Direct Renin Inhibition: A Systematic Review and Meta- Analysis.
Louvis N, Coulson J
Curr Vasc Pharmacol 2018 Jan 26;16(2):157-167. doi: 10.2174/1570161115666170502104809. PMID: 28464775
Effects of aliskiren on mortality, cardiovascular outcomes and adverse events in patients with diabetes and cardiovascular disease or risk: A systematic review and meta-analysis of 13,395 patients.
Zheng SL, Roddick AJ, Ayis S
Diab Vasc Dis Res 2017 Sep;14(5):400-406. Epub 2017 Aug 27 doi: 10.1177/1479164117715854. PMID: 28844155Free PMC Article
Current evidence on the use of anti-RAAS agents in congenital or acquired solitary kidney.
Simeoni M, Armeni A, Summaria C, Cerantonio A, Fuiano G
Ren Fail 2017 Nov;39(1):660-670. doi: 10.1080/0886022X.2017.1361840. PMID: 28805480Free PMC Article

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