U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal palate morphology

MedGen UID:
867440
•Concept ID:
C4021815
•
Finding
Synonym: Abnormality of the palate
 
HPO: HP:0000174

Definition

Any abnormality of the palate, i.e., of roof of the mouth. [from HPO]

Professional guidelines

PubMed

International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
Management of the protuberant premaxilla: where does it fit in?
Morris L
Curr Opin Otolaryngol Head Neck Surg 2019 Aug;27(4):302-309. doi: 10.1097/MOO.0000000000000558. PMID: 31219831
Velopharyngeal Dysfunction Evaluation and Treatment.
Meier JD, Muntz HR
Facial Plast Surg Clin North Am 2016 Nov;24(4):477-485. doi: 10.1016/j.fsc.2016.06.016. PMID: 27712815

Recent clinical studies

Etiology

Tongue-palate contact patterns for Japanese speakers with and without cleft lip and palate.
Yamamoto I
Int J Speech Lang Pathol 2020 Feb;22(1):70-77. Epub 2019 Apr 23 doi: 10.1080/17549507.2019.1593505. PMID: 31014123
Bone and soft tissue palatal morphology and potential anchorage sides in cleft palate patients.
Moscarino S, Scholz J, Bastian A, Knaup I, Wolf M
Ann Anat 2019 Jul;224:41-46. Epub 2019 Apr 3 doi: 10.1016/j.aanat.2019.02.005. PMID: 30953811
Development of Hard and Soft Palate During the Fetal Period and Hard Palate Asymmetry.
Dursun A, Öztürk K, Albay S
J Craniofac Surg 2018 Nov;29(8):2358-2362. doi: 10.1097/SCS.0000000000005016. PMID: 30320695
Palatal and oral manifestations of Muenke syndrome (FGFR3-related craniosynostosis).
Agochukwu NB, Solomon BD, Doherty ES, Muenke M
J Craniofac Surg 2012 May;23(3):664-8. doi: 10.1097/SCS.0b013e31824db8bb. PMID: 22565872Free PMC Article
Cleft lip and palate: current status from the literature and our experience.
Manna F, Pensiero S, Clarich G, Guarneri GF, Parodi PC
J Craniofac Surg 2009 Sep;20(5):1383-7. doi: 10.1097/SCS.0b013e3181b0daa3. PMID: 19816262

Diagnosis

The ontogeny of Robin sequence.
Logjes RJH, Breugem CC, Van Haaften G, Paes EC, Sperber GH, van den Boogaard MH, Farlie PG
Am J Med Genet A 2018 Jun;176(6):1349-1368. Epub 2018 Apr 25 doi: 10.1002/ajmg.a.38718. PMID: 29696787
Torus Mandibularis.
Chaubal TV, Bapat R, Poonja K
Am J Med 2017 Oct;130(10):e451. Epub 2017 May 19 doi: 10.1016/j.amjmed.2017.04.026. PMID: 28528920
Facial cleft detected: is the palate normal?
Hassan WA, Lees CC
Best Pract Res Clin Obstet Gynaecol 2014 Apr;28(3):379-89. Epub 2014 Jan 30 doi: 10.1016/j.bpobgyn.2014.01.010. PMID: 24613229
Anatomy and physiology of the velopharyngeal mechanism.
Perry JL
Semin Speech Lang 2011 May;32(2):83-92. Epub 2011 Sep 26 doi: 10.1055/s-0031-1277712. PMID: 21948636
Velopharyngeal insufficiency.
Hirschberg J
Folia Phoniatr (Basel) 1986;38(2-4):221-76. doi: 10.1159/000265828. PMID: 3527897

Therapy

International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
Biomaterials for Cleft Lip and Palate Regeneration.
Martín-Del-Campo M, Rosales-Ibañez R, Rojo L
Int J Mol Sci 2019 May 2;20(9) doi: 10.3390/ijms20092176. PMID: 31052503Free PMC Article
Orthognathic Surgery for Patients with Cleft Lip and Palate.
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Palatogenesis: engineering, pathways and pathologies.
Levi B, Brugman S, Wong VW, Grova M, Longaker MT, Wan DC
Organogenesis 2011 Oct-Dec;7(4):242-54. Epub 2011 Oct 1 doi: 10.4161/org.7.4.17926. PMID: 21964245Free PMC Article
Phenocopies.
Lenz W
J Med Genet 1973 Mar;10(1):34-49. doi: 10.1136/jmg.10.1.34. PMID: 4354695Free PMC Article

Prognosis

The ontogeny of Robin sequence.
Logjes RJH, Breugem CC, Van Haaften G, Paes EC, Sperber GH, van den Boogaard MH, Farlie PG
Am J Med Genet A 2018 Jun;176(6):1349-1368. Epub 2018 Apr 25 doi: 10.1002/ajmg.a.38718. PMID: 29696787
Management of knee deformities in children with arthrogryposis.
Lampasi M, Antonioli D, Donzelli O
Musculoskelet Surg 2012 Dec;96(3):161-9. Epub 2012 Aug 9 doi: 10.1007/s12306-012-0218-z. PMID: 22875688
Palatal and oral manifestations of Muenke syndrome (FGFR3-related craniosynostosis).
Agochukwu NB, Solomon BD, Doherty ES, Muenke M
J Craniofac Surg 2012 May;23(3):664-8. doi: 10.1097/SCS.0b013e31824db8bb. PMID: 22565872Free PMC Article
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
Palate morphology after unilateral and bilateral cleft lip and palate closure.
Schliephake H, Donnerstag F, Berten JL, Lönquist N
Int J Oral Maxillofac Surg 2006 Jan;35(1):25-30. Epub 2005 Sep 9 doi: 10.1016/j.ijom.2005.06.007. PMID: 16154317

Clinical prediction guides

The correlative hypotheses between Pitchfork and Kif3a in palate development.
Li S, Jin S, Jin C
Med Hypotheses 2019 May;126:23-25. Epub 2019 Mar 12 doi: 10.1016/j.mehy.2019.03.005. PMID: 31010494
Bone and soft tissue palatal morphology and potential anchorage sides in cleft palate patients.
Moscarino S, Scholz J, Bastian A, Knaup I, Wolf M
Ann Anat 2019 Jul;224:41-46. Epub 2019 Apr 3 doi: 10.1016/j.aanat.2019.02.005. PMID: 30953811
Periderm: Life-cycle and function during orofacial and epidermal development.
Hammond NL, Dixon J, Dixon MJ
Semin Cell Dev Biol 2019 Jul;91:75-83. Epub 2017 Aug 10 doi: 10.1016/j.semcdb.2017.08.021. PMID: 28803895
KBG syndrome.
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article
The telecanthus-hypospadias syndrome.
Stevens CA, Wilroy RS Jr
J Med Genet 1988 Aug;25(8):536-42. doi: 10.1136/jmg.25.8.536. PMID: 3050099Free PMC Article

Recent systematic reviews

Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis.
Alam MK, Alfawzan AA, Srivastava KC, Shrivastava D, Ganji KK, Manay SM
Sci Rep 2022 Apr 5;12(1):5708. doi: 10.1038/s41598-022-09764-y. PMID: 35383244Free PMC Article
Cervical vertebrae anomalies and cleft lip and palate: a systematic review and meta-analysis.
Berrocal C, Terrero-Pérez Á, Peralta-Mamani M, Fischer Rubira-Bullen IR, Honório HM, de Carvalho IMM, Alvares Capelozza AL
Dentomaxillofac Radiol 2019 Dec;48(8):20190085. Epub 2019 Jul 23 doi: 10.1259/dmfr.20190085. PMID: 31271540Free PMC Article
Craniofacial and upper airway morphology in adult obstructive sleep apnea patients: A systematic review and meta-analysis of cephalometric studies.
Neelapu BC, Kharbanda OP, Sardana HK, Balachandran R, Sardana V, Kapoor P, Gupta A, Vasamsetti S
Sleep Med Rev 2017 Feb;31:79-90. Epub 2016 Jan 30 doi: 10.1016/j.smrv.2016.01.007. PMID: 27039222
Dental implants in cleft lip, alveolus, and palate patients: a systematic review.
Wermker K, Jung S, Joos U, Kleinheinz J
Int J Oral Maxillofac Implants 2014 Mar-Apr;29(2):384-90. doi: 10.11607/jomi.3303. PMID: 24683564
Dental and oral anomalies in incontinentia pigmenti: a systematic review.
Minić S, Trpinac D, Gabriel H, Gencik M, Obradović M
Clin Oral Investig 2013 Jan;17(1):1-8. Epub 2012 Mar 28 doi: 10.1007/s00784-012-0721-5. PMID: 22453515

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...