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Abnormal surface-connected open canalicular system

MedGen UID:
Concept ID:
Anatomical Abnormality
HPO: HP:0012485


An anomaly of the invaginations of the surface membrane that form the open canalicular system (OCS). The OCS serve as the pathway for transport of substances into the cells and as conduits for the discharge of alpha granule products secreted during the platelet release reaction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal surface-connected open canalicular system

Recent clinical studies

Clinical prediction guides

Selvadurai MV, Hamilton JR
Platelets 2018 Jun;29(4):319-325. Epub 2018 Feb 14 doi: 10.1080/09537104.2018.1431388. PMID: 29442528

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