U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atrial cardiomyopathy

MedGen UID:
867504
•Concept ID:
C4021885
•
Disease or Syndrome
HPO: HP:0200127

Definition

Any complex of structural, architectural, contractile or electrophysiological changes affecting the atria with the potential to produce clinically relevant manifestations. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtrial cardiomyopathy

Conditions with this feature

Atrial standstill 2
MedGen UID:
816731
•Concept ID:
C3810401
•
Disease or Syndrome
Atrial standstill (AS) is a rare condition characterized by the absence of electrical and mechanical activity in the atria. On surface ECG, AS is distinguished by bradycardia, junctional (usually narrow complex) escape rhythm, and absence of the P wave. Nearly 50% of patients with AS experience syncope. AS can be persistent or transient, and diffuse or partial (summary by Fazelifar et al., 2005).
See: Condition Record
Atrial standstill 1
MedGen UID:
1646392
•Concept ID:
C4551959
•
Disease or Syndrome
Atrial standstill (AS) is a rare condition characterized by the absence of electrical and mechanical activity in the atria. On surface ECG, AS is distinguished by bradycardia, junctional (usually narrow complex) escape rhythm, and absence of the P wave. Nearly 50% of patients with AS experience syncope. AS can be persistent or transient, and diffuse or partial (summary by Fazelifar et al., 2005).
See: Condition Record
Atrial standstill 1
Atrial standstill 2

Professional guidelines

PubMed

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference.
Schnabel RB, Marinelli EA, Arbelo E, Boriani G, Boveda S, Buckley CM, Camm AJ, Casadei B, Chua W, Dagres N, de Melis M, Desteghe L, Diederichsen SZ, Duncker D, Eckardt L, Eisert C, Engler D, Fabritz L, Freedman B, Gillet L, Goette A, Guasch E, Svendsen JH, Hatem SN, Haeusler KG, Healey JS, Heidbuchel H, Hindricks G, Hobbs FDR, Hübner T, Kotecha D, Krekler M, Leclercq C, Lewalter T, Lin H, Linz D, Lip GYH, Løchen ML, Lucassen W, Malaczynska-Rajpold K, Massberg S, Merino JL, Meyer R, Mont L, Myers MC, Neubeck L, Niiranen T, Oeff M, Oldgren J, Potpara TS, Psaroudakis G, Pürerfellner H, Ravens U, Rienstra M, Rivard L, Scherr D, Schotten U, Shah D, Sinner MF, Smolnik R, Steinbeck G, Steven D, Svennberg E, Thomas D, True Hills M, van Gelder IC, Vardar B, Palà E, Wakili R, Wegscheider K, Wieloch M, Willems S, Witt H, Ziegler A, Daniel Zink M, Kirchhof P
Europace 2023 Feb 8;25(1):6-27. doi: 10.1093/europace/euac062. PMID: 35894842Free PMC Article
P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research-A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology.
Chen LY, Ribeiro ALP, Platonov PG, Cygankiewicz I, Soliman EZ, Gorenek B, Ikeda T, Vassilikos VP, Steinberg JS, Varma N, Bayés-de-Luna A, Baranchuk A
Circ Arrhythm Electrophysiol 2022 Apr;15(4):e010435. Epub 2022 Mar 25 doi: 10.1161/CIRCEP.121.010435. PMID: 35333097Free PMC Article
The management of atrial fibrillation in heart failure: an expert panel consensus.
Farmakis D, Chrysohoou C, Giamouzis G, Giannakoulas G, Hamilos M, Naka K, Tzeis S, Xydonas S, Karavidas A, Parissis J
Heart Fail Rev 2021 Nov;26(6):1345-1358. doi: 10.1007/s10741-020-09978-0. PMID: 32468277

Recent clinical studies

Etiology

P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research-A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology.
Chen LY, Ribeiro ALP, Platonov PG, Cygankiewicz I, Soliman EZ, Gorenek B, Ikeda T, Vassilikos VP, Steinberg JS, Varma N, Bayés-de-Luna A, Baranchuk A
Circ Arrhythm Electrophysiol 2022 Apr;15(4):e010435. Epub 2022 Mar 25 doi: 10.1161/CIRCEP.121.010435. PMID: 35333097Free PMC Article
The AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke randomized trial: Rationale and methods.
Kamel H, Longstreth WT Jr, Tirschwell DL, Kronmal RA, Broderick JP, Palesch YY, Meinzer C, Dillon C, Ewing I, Spilker JA, Di Tullio MR, Hod EA, Soliman EZ, Chaturvedi S, Moy CS, Janis S, Elkind MS
Int J Stroke 2019 Feb;14(2):207-214. Epub 2018 Sep 10 doi: 10.1177/1747493018799981. PMID: 30196789Free PMC Article
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO, Thorsteinsdottir U, Baras A, O'Dushlaine C, Holst AG, Wen X, Hornsby W, Dewey FE, Boehnke M, Kheterpal S, Mukherjee B, Lee S, Kang HM, Holm H, Kitzman J, Shavit JA, Jalife J, Brummett CM, Teslovich TM, Carey DJ, Gudbjartsson DF, Stefansson K, Abecasis GR, Hveem K, Willer CJ
Nat Genet 2018 Sep;50(9):1234-1239. Epub 2018 Jul 30 doi: 10.1038/s41588-018-0171-3. PMID: 30061737Free PMC Article
Cardioembolic Stroke.
Kamel H, Healey JS
Circ Res 2017 Feb 3;120(3):514-526. doi: 10.1161/CIRCRESAHA.116.308407. PMID: 28154101Free PMC Article
Atrial Fibrillation and Mechanisms of Stroke: Time for a New Model.
Kamel H, Okin PM, Elkind MS, Iadecola C
Stroke 2016 Mar;47(3):895-900. Epub 2016 Jan 19 doi: 10.1161/STROKEAHA.115.012004. PMID: 26786114Free PMC Article

Diagnosis

Atrial cardiomyopathy: from cell to bedside.
Li M, Ning Y, Tse G, Saguner AM, Wei M, Day JD, Luo G, Li G
ESC Heart Fail 2022 Dec;9(6):3768-3784. Epub 2022 Aug 3 doi: 10.1002/ehf2.14089. PMID: 35920287Free PMC Article
P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research-A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology.
Chen LY, Ribeiro ALP, Platonov PG, Cygankiewicz I, Soliman EZ, Gorenek B, Ikeda T, Vassilikos VP, Steinberg JS, Varma N, Bayés-de-Luna A, Baranchuk A
Circ Arrhythm Electrophysiol 2022 Apr;15(4):e010435. Epub 2022 Mar 25 doi: 10.1161/CIRCEP.121.010435. PMID: 35333097Free PMC Article
Left atrial strain - a current clinical perspective.
Kupczyńska K, Mandoli GE, Cameli M, Kasprzak JD
Kardiol Pol 2021;79(9):955-964. doi: 10.33963/KP.a2021.0105. PMID: 34599503
Cardioembolic Stroke.
Kamel H, Healey JS
Circ Res 2017 Feb 3;120(3):514-526. doi: 10.1161/CIRCRESAHA.116.308407. PMID: 28154101Free PMC Article
Atrial Fibrillation and Mechanisms of Stroke: Time for a New Model.
Kamel H, Okin PM, Elkind MS, Iadecola C
Stroke 2016 Mar;47(3):895-900. Epub 2016 Jan 19 doi: 10.1161/STROKEAHA.115.012004. PMID: 26786114Free PMC Article

Therapy

Atrial cardiomyopathy: Diagnosis, clinical implications and unresolved issues in anticoagulation therapy.
Kariki O, Vlachos K, Dragasis S, Tsetika EG, Perlepe K, Saplaouras A, Nyktari E, Efremidis M, Letsas KP
J Electrocardiol 2023 Jan-Feb;76:1-10. Epub 2022 Nov 4 doi: 10.1016/j.jelectrocard.2022.10.012. PMID: 36370545
From cryptogenic to ESUS: Toward precision medicine?
Timsit S
Rev Neurol (Paris) 2022 Nov;178(9):939-952. Epub 2022 May 18 doi: 10.1016/j.neurol.2022.01.016. PMID: 35597610
Clinical importance of atrial cardiomyopathy.
Hammwöhner M, Bukowska A, Mahardika W, Goette A
Int J Cardiol 2019 Jul 15;287:174-180. Epub 2018 Nov 28 doi: 10.1016/j.ijcard.2018.11.121. PMID: 30527991
The AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke randomized trial: Rationale and methods.
Kamel H, Longstreth WT Jr, Tirschwell DL, Kronmal RA, Broderick JP, Palesch YY, Meinzer C, Dillon C, Ewing I, Spilker JA, Di Tullio MR, Hod EA, Soliman EZ, Chaturvedi S, Moy CS, Janis S, Elkind MS
Int J Stroke 2019 Feb;14(2):207-214. Epub 2018 Sep 10 doi: 10.1177/1747493018799981. PMID: 30196789Free PMC Article
Cardioembolic Stroke.
Kamel H, Healey JS
Circ Res 2017 Feb 3;120(3):514-526. doi: 10.1161/CIRCRESAHA.116.308407. PMID: 28154101Free PMC Article

Prognosis

Atrial cardiomyopathy and incident ischemic stroke risk: a systematic review and meta-analysis.
Guo J, Wang D, Jia J, Zhang J, Peng F, Lu J, Zhao X, Liu Y
J Neurol 2023 Jul;270(7):3391-3401. Epub 2023 Apr 4 doi: 10.1007/s00415-023-11693-3. PMID: 37014420Free PMC Article
P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research-A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology.
Chen LY, Ribeiro ALP, Platonov PG, Cygankiewicz I, Soliman EZ, Gorenek B, Ikeda T, Vassilikos VP, Steinberg JS, Varma N, Bayés-de-Luna A, Baranchuk A
Circ Arrhythm Electrophysiol 2022 Apr;15(4):e010435. Epub 2022 Mar 25 doi: 10.1161/CIRCEP.121.010435. PMID: 35333097Free PMC Article
Left atrial strain - a current clinical perspective.
Kupczyńska K, Mandoli GE, Cameli M, Kasprzak JD
Kardiol Pol 2021;79(9):955-964. doi: 10.33963/KP.a2021.0105. PMID: 34599503
Thromboembolism in the Absence of Atrial Fibrillation.
Smietana J, Plitt A, Halperin JL
Am J Cardiol 2019 Jul 15;124(2):303-311. Epub 2019 Apr 25 doi: 10.1016/j.amjcard.2019.04.027. PMID: 31060729
Clinical importance of atrial cardiomyopathy.
Hammwöhner M, Bukowska A, Mahardika W, Goette A
Int J Cardiol 2019 Jul 15;287:174-180. Epub 2018 Nov 28 doi: 10.1016/j.ijcard.2018.11.121. PMID: 30527991

Clinical prediction guides

Atrial cardiomyopathy and incident ischemic stroke risk: a systematic review and meta-analysis.
Guo J, Wang D, Jia J, Zhang J, Peng F, Lu J, Zhao X, Liu Y
J Neurol 2023 Jul;270(7):3391-3401. Epub 2023 Apr 4 doi: 10.1007/s00415-023-11693-3. PMID: 37014420Free PMC Article
Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference.
Schnabel RB, Marinelli EA, Arbelo E, Boriani G, Boveda S, Buckley CM, Camm AJ, Casadei B, Chua W, Dagres N, de Melis M, Desteghe L, Diederichsen SZ, Duncker D, Eckardt L, Eisert C, Engler D, Fabritz L, Freedman B, Gillet L, Goette A, Guasch E, Svendsen JH, Hatem SN, Haeusler KG, Healey JS, Heidbuchel H, Hindricks G, Hobbs FDR, Hübner T, Kotecha D, Krekler M, Leclercq C, Lewalter T, Lin H, Linz D, Lip GYH, Løchen ML, Lucassen W, Malaczynska-Rajpold K, Massberg S, Merino JL, Meyer R, Mont L, Myers MC, Neubeck L, Niiranen T, Oeff M, Oldgren J, Potpara TS, Psaroudakis G, Pürerfellner H, Ravens U, Rienstra M, Rivard L, Scherr D, Schotten U, Shah D, Sinner MF, Smolnik R, Steinbeck G, Steven D, Svennberg E, Thomas D, True Hills M, van Gelder IC, Vardar B, Palà E, Wakili R, Wegscheider K, Wieloch M, Willems S, Witt H, Ziegler A, Daniel Zink M, Kirchhof P
Europace 2023 Feb 8;25(1):6-27. doi: 10.1093/europace/euac062. PMID: 35894842Free PMC Article
P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research-A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology.
Chen LY, Ribeiro ALP, Platonov PG, Cygankiewicz I, Soliman EZ, Gorenek B, Ikeda T, Vassilikos VP, Steinberg JS, Varma N, Bayés-de-Luna A, Baranchuk A
Circ Arrhythm Electrophysiol 2022 Apr;15(4):e010435. Epub 2022 Mar 25 doi: 10.1161/CIRCEP.121.010435. PMID: 35333097Free PMC Article
Atrial Cardiomyopathy: Pathophysiology and Clinical Consequences.
Goette A, Lendeckel U
Cells 2021 Sep 30;10(10) doi: 10.3390/cells10102605. PMID: 34685585Free PMC Article
Clinical importance of atrial cardiomyopathy.
Hammwöhner M, Bukowska A, Mahardika W, Goette A
Int J Cardiol 2019 Jul 15;287:174-180. Epub 2018 Nov 28 doi: 10.1016/j.ijcard.2018.11.121. PMID: 30527991

Recent systematic reviews

Atrial cardiomyopathy and incident ischemic stroke risk: a systematic review and meta-analysis.
Guo J, Wang D, Jia J, Zhang J, Peng F, Lu J, Zhao X, Liu Y
J Neurol 2023 Jul;270(7):3391-3401. Epub 2023 Apr 4 doi: 10.1007/s00415-023-11693-3. PMID: 37014420Free PMC Article
Prevalence of markers of atrial cardiomyopathy in embolic stroke of undetermined source: A systematic review.
Stalikas N, Doundoulakis I, Karagiannidis E, Kartas A, Gavriilaki M, Sofidis G, Panteris E, Papazoglou AS, Haidich AB, Sianos G, Giannakoulas G
Eur J Intern Med 2022 May;99:38-44. Epub 2022 Jan 20 doi: 10.1016/j.ejim.2022.01.024. PMID: 35065879
P-Wave Indices and Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis.
He J, Tse G, Korantzopoulos P, Letsas KP, Ali-Hasan-Al-Saegh S, Kamel H, Li G, Lip GYH, Liu T
Stroke 2017 Aug;48(8):2066-2072. Epub 2017 Jul 5 doi: 10.1161/STROKEAHA.117.017293. PMID: 28679858

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...