U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Giant cell granuloma of mandible

MedGen UID:
867529
Concept ID:
C4021912
Anatomical Abnormality
HPO: HP:0100955

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant cell granuloma of mandible

Conditions with this feature

Toriello-Lacassie-Droste syndrome
MedGen UID:
333068
Concept ID:
C1838329
Disease or Syndrome
Oculoectodermal syndrome (OES) is characterized by the association of epibulbar dermoids and aplasia cutis congenita. Affected individuals exhibit congenital scalp lesions which are atrophic, nonscarring, hairless regions that are often multiple and asymmetric in distribution, and may have associated hamartomas. Ectodermal changes include linear hyperpigmentation that may follow the lines of Blaschko and, rarely, epidermal nevus-like lesions. Epibulbar dermoids may be uni- or bilateral. Additional ocular anomalies such as skin tags of the upper eyelid and rarely optic nerve or retinal changes or microphthalmia can be present. Phenotypic expression is highly variable, and various other abnormalities have occasionally been reported, including growth failure, lymphedema, and cardiovascular defects, as well as neurodevelopmental symptoms such as developmental delay, epilepsy, learning difficulties, and behavioral abnormalities. Benign tumor-like lesions such as nonossifying fibromas of the long bones and giant cell granulomas of the jaws have repeatedly been observed and appear to be age-dependent, becoming a common manifestation in individuals aged 5 years or older (summary by Boppudi et al., 2016).

Professional guidelines

PubMed

Yanik S, Aras MH
J Oral Maxillofac Surg 2013 Apr;71(4):721-2. Epub 2012 Dec 21 doi: 10.1016/j.joms.2012.10.013. PMID: 23265848

Recent clinical studies

Etiology

Choe M, Smith V, Okcu MF, Wulff J, Gruner S, Huisman TAGM, Venkatramani R
Pediatr Blood Cancer 2021 Mar;68(3):e28778. Epub 2020 Oct 21 doi: 10.1002/pbc.28778. PMID: 33089644
Akinyamoju AO, Soyele OO, Saiki TE, Adesina OM
West Afr J Med 2020 Jan-Mar;37(1):26-31. PMID: 32030708
Etoz M, Asantogrol F, Akyol R
Oral Radiol 2020 Jan;36(1):60-68. Epub 2019 Mar 1 doi: 10.1007/s11282-019-00380-7. PMID: 30825099
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Suárez-Roa Mde L, Reveiz L, Ruíz-Godoy Rivera LM, Asbun-Bojalil J, Dávila-Serapio JE, Menjívar-Rubio AH, Meneses-García A
Cochrane Database Syst Rev 2009 Oct 7;(4):CD007404. doi: 10.1002/14651858.CD007404.pub2. PMID: 19821413

Diagnosis

Richardson J, Stanbouly D, Litman E, Lee KC, Philipone E
J Stomatol Oral Maxillofac Surg 2022 Sep;123(4):e161-e168. Epub 2021 Aug 17 doi: 10.1016/j.jormas.2021.08.004. PMID: 34411774
Akinyamoju AO, Soyele OO, Saiki TE, Adesina OM
West Afr J Med 2020 Jan-Mar;37(1):26-31. PMID: 32030708
Etoz M, Asantogrol F, Akyol R
Oral Radiol 2020 Jan;36(1):60-68. Epub 2019 Mar 1 doi: 10.1007/s11282-019-00380-7. PMID: 30825099
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Heithersay GS, Cohn SA, Parkins DJ
Aust Endod J 2002 Apr;28(1):18-23. doi: 10.1111/j.1747-4477.2002.tb00362.x. PMID: 12360677

Therapy

Richardson J, Stanbouly D, Litman E, Lee KC, Philipone E
J Stomatol Oral Maxillofac Surg 2022 Sep;123(4):e161-e168. Epub 2021 Aug 17 doi: 10.1016/j.jormas.2021.08.004. PMID: 34411774
Said Ahmed WM, Haggag MA
J Stomatol Oral Maxillofac Surg 2022 Feb;123(1):37-43. Epub 2021 Jan 5 doi: 10.1016/j.jormas.2020.12.011. PMID: 33412339
Román-Quesada N, González-Navarro B, Izquierdo-Gómez K, Jané-Salas E, Marí-Roig A, Estrugo-Devesa A, López-López J
BMC Oral Health 2021 Apr 23;21(1):204. doi: 10.1186/s12903-021-01566-4. PMID: 33892689Free PMC Article
Choe M, Smith V, Okcu MF, Wulff J, Gruner S, Huisman TAGM, Venkatramani R
Pediatr Blood Cancer 2021 Mar;68(3):e28778. Epub 2020 Oct 21 doi: 10.1002/pbc.28778. PMID: 33089644
Suárez-Roa Mde L, Reveiz L, Ruíz-Godoy Rivera LM, Asbun-Bojalil J, Dávila-Serapio JE, Menjívar-Rubio AH, Meneses-García A
Cochrane Database Syst Rev 2009 Oct 7;(4):CD007404. doi: 10.1002/14651858.CD007404.pub2. PMID: 19821413

Prognosis

Román-Quesada N, González-Navarro B, Izquierdo-Gómez K, Jané-Salas E, Marí-Roig A, Estrugo-Devesa A, López-López J
BMC Oral Health 2021 Apr 23;21(1):204. doi: 10.1186/s12903-021-01566-4. PMID: 33892689Free PMC Article
Choe M, Smith V, Okcu MF, Wulff J, Gruner S, Huisman TAGM, Venkatramani R
Pediatr Blood Cancer 2021 Mar;68(3):e28778. Epub 2020 Oct 21 doi: 10.1002/pbc.28778. PMID: 33089644
de Mendonça RP, Mitre GP, Real FH, da Silva Kataoka MS, de Melo Alves Júnior S, Vianna P, Da Silva Júnior NG, de Jesus Viana Pinheiro J
Head Neck Pathol 2020 Jun;14(2):497-502. Epub 2019 Jul 11 doi: 10.1007/s12105-019-01053-x. PMID: 31297738Free PMC Article
Yamaguchi T, Dorfman HD, Eisig S
Skeletal Radiol 1999 Jun;28(6):350-3. doi: 10.1007/s002560050530. PMID: 10450884
Tallan EM, Olsen KD, McCaffrey TV, Unni KK, Lund BA
Otolaryngol Head Neck Surg 1994 Apr;110(4):413-8. doi: 10.1177/019459989411000411. PMID: 8170686

Clinical prediction guides

Capucha T, Krasovsky A, Abdalla-Aslan R, Ginini JG, Noy D, Emodi O, Rachmiel A, Shilo D
Clin Oral Investig 2024 Mar 7;28(3):200. doi: 10.1007/s00784-024-05585-7. PMID: 38453790Free PMC Article
Akerzoul N, Touré B
Pan Afr Med J 2023;44:141. Epub 2023 Mar 20 doi: 10.11604/pamj.2023.44.141.34835. PMID: 37396697Free PMC Article
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Franco A, Segato AV, Couto SA, Rodrigues Johann AC, Friedlander AH, Couto Souza PH
J Dent Child (Chic) 2016;83(2):102-5. PMID: 27620523
de Lange J, Rosenberg AJ, van den Akker HP, Koole R, Wirds JJ, van den Berg H
Int J Oral Maxillofac Surg 1999 Oct;28(5):372-6. doi: 10.1034/j.1399-0020.1999.285280513.x. PMID: 10535540

Recent systematic reviews

Richardson J, Stanbouly D, Litman E, Lee KC, Philipone E
J Stomatol Oral Maxillofac Surg 2022 Sep;123(4):e161-e168. Epub 2021 Aug 17 doi: 10.1016/j.jormas.2021.08.004. PMID: 34411774
Alsufyani NA, Aldosary RM, Alrasheed RS, Alsaif RF
Acta Odontol Scand 2021 Mar;79(2):124-131. Epub 2020 Jul 30 doi: 10.1080/00016357.2020.1797160. PMID: 32730731
Chrcanovic BR, Gomes CC, Gomez RS
J Stomatol Oral Maxillofac Surg 2019 Nov;120(5):456-461. Epub 2019 Jan 21 doi: 10.1016/j.jormas.2019.01.010. PMID: 30677564
Chrcanovic BR, Gomes CC, Gomez RS
J Oral Pathol Med 2018 Sep;47(8):731-739. Epub 2018 May 29 doi: 10.1111/jop.12730. PMID: 29751369
Suárez-Roa Mde L, Reveiz L, Ruíz-Godoy Rivera LM, Asbun-Bojalil J, Dávila-Serapio JE, Menjívar-Rubio AH, Meneses-García A
Cochrane Database Syst Rev 2009 Oct 7;(4):CD007404. doi: 10.1002/14651858.CD007404.pub2. PMID: 19821413

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...