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Mucosal telangiectasiae

MedGen UID:
867631
•Concept ID:
C4022020
•
Anatomical Abnormality
HPO: HP:0100579

Definition

Telangiectasia of the mucosa, the mucous membranes which are involved in absorption and secretion that line cavities that are exposed to the external environment and internal organs. [from HPO]

Professional guidelines

PubMed

Clinical Practice Guideline: Nosebleed (Epistaxis) Executive Summary.
Tunkel DE, Anne S, Payne SC, Ishman SL, Rosenfeld RM, Abramson PJ, Alikhaani JD, Benoit MM, Bercovitz RS, Brown MD, Chernobilsky B, Feldstein DA, Hackell JM, Holbrook EH, Holdsworth SM, Lin KW, Lind MM, Poetker DM, Riley CA, Schneider JS, Seidman MD, Vadlamudi V, Valdez TA, Nnacheta LC, Monjur TM
Otolaryngol Head Neck Surg 2020 Jan;162(1):8-25. doi: 10.1177/0194599819889955. PMID: 31910122
Clinical Practice Guideline: Nosebleed (Epistaxis).
Tunkel DE, Anne S, Payne SC, Ishman SL, Rosenfeld RM, Abramson PJ, Alikhaani JD, Benoit MM, Bercovitz RS, Brown MD, Chernobilsky B, Feldstein DA, Hackell JM, Holbrook EH, Holdsworth SM, Lin KW, Lind MM, Poetker DM, Riley CA, Schneider JS, Seidman MD, Vadlamudi V, Valdez TA, Nnacheta LC, Monjur TM
Otolaryngol Head Neck Surg 2020 Jan;162(1_suppl):S1-S38. doi: 10.1177/0194599819890327. PMID: 31910111
Clinical features and treatment of hereditary hemorrhagic telangiectasia.
Li S, Wang SJ, Zhao YQ
Medicine (Baltimore) 2018 Aug;97(31):e11687. doi: 10.1097/MD.0000000000011687. PMID: 30075565Free PMC Article

Recent clinical studies

Etiology

Identifying racial disparities in hereditary hemorrhagic telangiectasia.
Yusuf H, Rasheed A, Kim H, Conrad MB, Hetts SW
J Neurointerv Surg 2023 Oct;15(10):1050-1054. Epub 2022 Sep 22 doi: 10.1136/jnis-2022-019162. PMID: 36137744
Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.
Hammill AM, Wusik K, Kasthuri RS
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):469-477. doi: 10.1182/hematology.2021000281. PMID: 34889398Free PMC Article
Hereditary Haemorrhagic Telangiectasia, an Inherited Vascular Disorder in Need of Improved Evidence-Based Pharmaceutical Interventions.
Snodgrass RO, Chico TJA, Arthur HM
Genes (Basel) 2021 Jan 27;12(2) doi: 10.3390/genes12020174. PMID: 33513792Free PMC Article
Clinical Practice Guideline: Nosebleed (Epistaxis).
Tunkel DE, Anne S, Payne SC, Ishman SL, Rosenfeld RM, Abramson PJ, Alikhaani JD, Benoit MM, Bercovitz RS, Brown MD, Chernobilsky B, Feldstein DA, Hackell JM, Holbrook EH, Holdsworth SM, Lin KW, Lind MM, Poetker DM, Riley CA, Schneider JS, Seidman MD, Vadlamudi V, Valdez TA, Nnacheta LC, Monjur TM
Otolaryngol Head Neck Surg 2020 Jan;162(1_suppl):S1-S38. doi: 10.1177/0194599819890327. PMID: 31910111
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.
Nougayrède JP, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E
Science 2006 Aug 11;313(5788):848-51. doi: 10.1126/science.1127059. PMID: 16902142

Diagnosis

Skin and mucosal telangiectatic lesions in hereditary hemorrhagic telangiectasia patients.
Hyldahl SJ, El-Jaji MQ, Schuster A, Kjeldsen AD
Int J Dermatol 2022 Dec;61(12):1497-1505. Epub 2022 Jul 6 doi: 10.1111/ijd.16320. PMID: 35792874Free PMC Article
Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.
Hammill AM, Wusik K, Kasthuri RS
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):469-477. doi: 10.1182/hematology.2021000281. PMID: 34889398Free PMC Article
Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Clinical Practice Guideline: Nosebleed (Epistaxis).
Tunkel DE, Anne S, Payne SC, Ishman SL, Rosenfeld RM, Abramson PJ, Alikhaani JD, Benoit MM, Bercovitz RS, Brown MD, Chernobilsky B, Feldstein DA, Hackell JM, Holbrook EH, Holdsworth SM, Lin KW, Lind MM, Poetker DM, Riley CA, Schneider JS, Seidman MD, Vadlamudi V, Valdez TA, Nnacheta LC, Monjur TM
Otolaryngol Head Neck Surg 2020 Jan;162(1_suppl):S1-S38. doi: 10.1177/0194599819890327. PMID: 31910111
Hereditary haemorrhagic telangiectasia.
Sharathkumar AA, Shapiro A
Haemophilia 2008 Nov;14(6):1269-80. doi: 10.1111/j.1365-2516.2008.01774.x. PMID: 19141168

Therapy

Ado-trastuzumab emtansine associated spider telangiectasia.
Gursoy P, Acar A, Acikalin T
J Oncol Pharm Pract 2022 Jun;28(4):986-988. Epub 2022 Jan 18 doi: 10.1177/10781552211073878. PMID: 35040682
Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced/metastatic melanoma who have failed prior anti-PD-1 therapy.
Kim R, Kwon M, An M, Kim ST, Smith SA, Loembé AB, Mortimer PGS, Armenia J, Lukashchuk N, Shah N, Dean E, Park WY, Lee J
Ann Oncol 2022 Feb;33(2):193-203. Epub 2021 Oct 25 doi: 10.1016/j.annonc.2021.10.009. PMID: 34710570
Clinical Practice Guideline: Nosebleed (Epistaxis).
Tunkel DE, Anne S, Payne SC, Ishman SL, Rosenfeld RM, Abramson PJ, Alikhaani JD, Benoit MM, Bercovitz RS, Brown MD, Chernobilsky B, Feldstein DA, Hackell JM, Holbrook EH, Holdsworth SM, Lin KW, Lind MM, Poetker DM, Riley CA, Schneider JS, Seidman MD, Vadlamudi V, Valdez TA, Nnacheta LC, Monjur TM
Otolaryngol Head Neck Surg 2020 Jan;162(1_suppl):S1-S38. doi: 10.1177/0194599819890327. PMID: 31910111
Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors.
Vigarios E, Epstein JB, Sibaud V
Support Care Cancer 2017 May;25(5):1713-1739. Epub 2017 Feb 22 doi: 10.1007/s00520-017-3629-4. PMID: 28224235
Nodular cutaneous amyloidosis.
Borowicz J, Shama L, Miller R
Skinmed 2011 Sep-Oct;9(5):316-8. PMID: 22165048

Prognosis

Skin and mucosal telangiectatic lesions in hereditary hemorrhagic telangiectasia patients.
Hyldahl SJ, El-Jaji MQ, Schuster A, Kjeldsen AD
Int J Dermatol 2022 Dec;61(12):1497-1505. Epub 2022 Jul 6 doi: 10.1111/ijd.16320. PMID: 35792874Free PMC Article
Ado-trastuzumab emtansine associated spider telangiectasia.
Gursoy P, Acar A, Acikalin T
J Oncol Pharm Pract 2022 Jun;28(4):986-988. Epub 2022 Jan 18 doi: 10.1177/10781552211073878. PMID: 35040682
Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.
Hammill AM, Wusik K, Kasthuri RS
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):469-477. doi: 10.1182/hematology.2021000281. PMID: 34889398Free PMC Article
Clinical Practice Guideline: Nosebleed (Epistaxis) Executive Summary.
Tunkel DE, Anne S, Payne SC, Ishman SL, Rosenfeld RM, Abramson PJ, Alikhaani JD, Benoit MM, Bercovitz RS, Brown MD, Chernobilsky B, Feldstein DA, Hackell JM, Holbrook EH, Holdsworth SM, Lin KW, Lind MM, Poetker DM, Riley CA, Schneider JS, Seidman MD, Vadlamudi V, Valdez TA, Nnacheta LC, Monjur TM
Otolaryngol Head Neck Surg 2020 Jan;162(1):8-25. doi: 10.1177/0194599819889955. PMID: 31910122
Nodular cutaneous amyloidosis.
Borowicz J, Shama L, Miller R
Skinmed 2011 Sep-Oct;9(5):316-8. PMID: 22165048

Clinical prediction guides

Identifying racial disparities in hereditary hemorrhagic telangiectasia.
Yusuf H, Rasheed A, Kim H, Conrad MB, Hetts SW
J Neurointerv Surg 2023 Oct;15(10):1050-1054. Epub 2022 Sep 22 doi: 10.1136/jnis-2022-019162. PMID: 36137744
Skin and mucosal telangiectatic lesions in hereditary hemorrhagic telangiectasia patients.
Hyldahl SJ, El-Jaji MQ, Schuster A, Kjeldsen AD
Int J Dermatol 2022 Dec;61(12):1497-1505. Epub 2022 Jul 6 doi: 10.1111/ijd.16320. PMID: 35792874Free PMC Article
Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced/metastatic melanoma who have failed prior anti-PD-1 therapy.
Kim R, Kwon M, An M, Kim ST, Smith SA, Loembé AB, Mortimer PGS, Armenia J, Lukashchuk N, Shah N, Dean E, Park WY, Lee J
Ann Oncol 2022 Feb;33(2):193-203. Epub 2021 Oct 25 doi: 10.1016/j.annonc.2021.10.009. PMID: 34710570
Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors.
Vigarios E, Epstein JB, Sibaud V
Support Care Cancer 2017 May;25(5):1713-1739. Epub 2017 Feb 22 doi: 10.1007/s00520-017-3629-4. PMID: 28224235

Recent systematic reviews

Sclerotherapy for Hereditary Hemorrhagic Telangiectasia-Related Epistaxis: A Systematic Review.
Thiele B, Abdel-Aty Y, Marks L, Lal D, Marino M
Ann Otol Rhinol Laryngol 2023 Jan;132(1):82-90. Epub 2022 Feb 12 doi: 10.1177/00034894221078075. PMID: 35152768
Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Laser-Assisted Control of Epistaxis in Hereditary Hemorrhagic Telangiectasia: A Systematic Review.
Abiri A, Goshtasbi K, Maducdoc M, Sahyouni R, Wang MB, Kuan EC
Lasers Surg Med 2020 Apr;52(4):293-300. Epub 2019 Aug 22 doi: 10.1002/lsm.23147. PMID: 31441079Free PMC Article
Systematic review: anal and rectal changes after radiotherapy for prostate cancer.
Krol R, Smeenk RJ, van Lin EN, Yeoh EE, Hopman WP
Int J Colorectal Dis 2014 Mar;29(3):273-83. Epub 2013 Oct 23 doi: 10.1007/s00384-013-1784-8. PMID: 24150230

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